YKL108W / SLD2

Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL108W / SLD2

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-2.87|P-value:2.63E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:2.95|P-value:1.74E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:2.77|P-value:3.88E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:2.66|P-value:6.34E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:2.77|P-value:3.98E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:2.65|P-value:6.76E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:2.87|P-value:2.59E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:2.56|P-value:9.80E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.09|P-value:9.61E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.08|P-value:9.59E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.91|P-value:1.09E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.58|P-value:9.27E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.92|P-value:1.02E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.32|P-value:2.97E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.01|P-value:1.36E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.25|P-value:4.11E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:2.55|P-value:9.95E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.31|P-value:3.32E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:4.10|P-value:3.57E-7 ID:SGTC_1628|Compound:st004252|FD-Score:-3.26|P-value:4.20E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.73|P-value:4.78E-4 ID:SGTC_1673|Compound:st016611|FD-Score:2.82|P-value:3.22E-4 ID:SGTC_1701|Compound:st028638|FD-Score:5.54|P-value:1.04E-11 ID:SGTC_1705|Compound:st027868|FD-Score:2.79|P-value:3.55E-4 ID:SGTC_1710|Compound:st031758|FD-Score:4.00|P-value:6.59E-7 ID:SGTC_1712|Compound:st032288|FD-Score:2.61|P-value:7.73E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.11|P-value:8.45E-5 ID:SGTC_1746|Compound:st038117|FD-Score:2.95|P-value:1.80E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.12|P-value:3.08E-7 ID:SGTC_1911|Compound:st060208|FD-Score:-4.17|P-value:2.43E-7 ID:SGTC_1914|Compound:st062367|FD-Score:4.26|P-value:1.29E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-3.16|P-value:6.76E-5 ID:SGTC_1938|Compound:st074717|FD-Score:2.77|P-value:3.97E-4 ID:SGTC_1953|Compound:st076800|FD-Score:2.93|P-value:1.90E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.84|P-value:3.10E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.30|P-value:3.36E-5 ID:SGTC_2046|Compound:4110841|FD-Score:2.64|P-value:6.93E-4 ID:SGTC_2065|Compound:5221596|FD-Score:2.94|P-value:1.87E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-2.95|P-value:1.91E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-2.61|P-value:8.38E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-2.97|P-value:1.71E-4 ID:SGTC_2078|Compound:5212016|FD-Score:2.80|P-value:3.54E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-5.71|P-value:2.68E-12 ID:SGTC_2085|Compound:5307070|FD-Score:-3.14|P-value:7.50E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-5.71|P-value:2.75E-12 ID:SGTC_2334|Compound:9017922|FD-Score:-5.45|P-value:2.33E-11 ID:SGTC_2335|Compound:9018011|FD-Score:3.01|P-value:1.36E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.89|P-value:1.31E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-2.96|P-value:1.75E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.07|P-value:4.21E-7 ID:SGTC_2463|Compound:5473429|FD-Score:4.21|P-value:1.79E-7 ID:SGTC_2467|Compound:5474540|FD-Score:-2.64|P-value:7.31E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:2.58|P-value:8.85E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.68|P-value:6.18E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.40|P-value:1.96E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.43|P-value:1.64E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.93|P-value:1.00E-6 ID:SGTC_2794|Compound:7785382|FD-Score:2.70|P-value:5.36E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-2.81|P-value:3.46E-4 ID:SGTC_2813|Compound:7971799|FD-Score:5.23|P-value:1.24E-10 ID:SGTC_2931|Compound:9014674|FD-Score:-2.70|P-value:5.75E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.85|P-value:1.73E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-2.92|P-value:2.10E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-2.65|P-value:7.09E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-2.61|P-value:8.35E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.67|P-value:6.21E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.11|P-value:8.28E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.66|P-value:4.69E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-2.87|P-value:2.63E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:2.95|P-value:1.74E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:2.77|P-value:3.88E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:2.66|P-value:6.34E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:2.77|P-value:3.98E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:2.65|P-value:6.76E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:2.87|P-value:2.59E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:2.56|P-value:9.80E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.09|P-value:9.61E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.08|P-value:9.59E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.91|P-value:1.09E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.58|P-value:9.27E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.92|P-value:1.02E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.32|P-value:2.97E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.01|P-value:1.36E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.25|P-value:4.11E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:2.55|P-value:9.95E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.31|P-value:3.32E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:4.10|P-value:3.57E-7 ID:SGTC_1628|Compound:st004252|FD-Score:-3.26|P-value:4.20E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.73|P-value:4.78E-4 ID:SGTC_1673|Compound:st016611|FD-Score:2.82|P-value:3.22E-4 ID:SGTC_1701|Compound:st028638|FD-Score:5.54|P-value:1.04E-11 ID:SGTC_1705|Compound:st027868|FD-Score:2.79|P-value:3.55E-4 ID:SGTC_1710|Compound:st031758|FD-Score:4.00|P-value:6.59E-7 ID:SGTC_1712|Compound:st032288|FD-Score:2.61|P-value:7.73E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.11|P-value:8.45E-5 ID:SGTC_1746|Compound:st038117|FD-Score:2.95|P-value:1.80E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.12|P-value:3.08E-7 ID:SGTC_1911|Compound:st060208|FD-Score:-4.17|P-value:2.43E-7 ID:SGTC_1914|Compound:st062367|FD-Score:4.26|P-value:1.29E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-3.16|P-value:6.76E-5 ID:SGTC_1938|Compound:st074717|FD-Score:2.77|P-value:3.97E-4 ID:SGTC_1953|Compound:st076800|FD-Score:2.93|P-value:1.90E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.84|P-value:3.10E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.30|P-value:3.36E-5 ID:SGTC_2046|Compound:4110841|FD-Score:2.64|P-value:6.93E-4 ID:SGTC_2065|Compound:5221596|FD-Score:2.94|P-value:1.87E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-2.95|P-value:1.91E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-2.61|P-value:8.38E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-2.97|P-value:1.71E-4 ID:SGTC_2078|Compound:5212016|FD-Score:2.80|P-value:3.54E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-5.71|P-value:2.68E-12 ID:SGTC_2085|Compound:5307070|FD-Score:-3.14|P-value:7.50E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-5.71|P-value:2.75E-12 ID:SGTC_2334|Compound:9017922|FD-Score:-5.45|P-value:2.33E-11 ID:SGTC_2335|Compound:9018011|FD-Score:3.01|P-value:1.36E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.89|P-value:1.31E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-2.96|P-value:1.75E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.07|P-value:4.21E-7 ID:SGTC_2463|Compound:5473429|FD-Score:4.21|P-value:1.79E-7 ID:SGTC_2467|Compound:5474540|FD-Score:-2.64|P-value:7.31E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:2.58|P-value:8.85E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.68|P-value:6.18E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.40|P-value:1.96E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.43|P-value:1.64E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.93|P-value:1.00E-6 ID:SGTC_2794|Compound:7785382|FD-Score:2.70|P-value:5.36E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-2.81|P-value:3.46E-4 ID:SGTC_2813|Compound:7971799|FD-Score:5.23|P-value:1.24E-10 ID:SGTC_2931|Compound:9014674|FD-Score:-2.70|P-value:5.75E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.85|P-value:1.73E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-2.92|P-value:2.10E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-2.65|P-value:7.09E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-2.61|P-value:8.35E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.67|P-value:6.21E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.11|P-value:8.28E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.66|P-value:4.69E-6

Top fitness defect scores for YKL108W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1701 st028638 5.54 40.4 µM 1.04E-11 1 1.54E-8 1.59
2 SGTC_2813 7971799 5.23 71.4 µM 1.24E-10 4 8.53E-8 0.99
3 SGTC_1914 st062367 4.26 72.6 µM 1.29E-7 5 1.04E-5 0.40
4 SGTC_2463 5473429 4.21 200.0 µM 1.79E-7 ERG2 2 1.31E-5 0.07
5 SGTC_1868 st057644 4.12 42.7 µM 3.08E-7 6 1.90E-5 0.32
6 SGTC_1570 verbenone 4.10 133.0 µM 3.57E-7 3 2.11E-5 0.20
7 SGTC_2382 9035899 4.07 200.0 µM 4.21E-7 60S ribosome export 6 2.36E-5 0.11
8 SGTC_1710 st031758 4.00 61.5 µM 6.59E-7 2 3.23E-5 0.13
9 SGTC_2634 4'-methoxyflavone 3.93 100.0 µM 1.00E-6 8 4.33E-5 0.16
10 SGTC_1023 4482-3888 3.92 16.0 µM 1.02E-6 TSC3-RPN4 9 4.37E-5 0.17
11 SGTC_817 1391-0715 3.91 46.0 µM 1.09E-6 9 4.58E-5 0.12
12 SGTC_3327 9140648 3.66 26.9 µM 4.69E-6 19 1.26E-4 0.02
13 SGTC_2633 5,7-dihydroxyisoflavone 3.43 100.0 µM 1.64E-5 9 3.02E-4 0.10
14 SGTC_2591 skatole 3.40 100.0 µM 1.96E-5 9 3.43E-4 0.04
15 SGTC_1226 3909-7979 3.32 35.4 µM 2.97E-5 10 4.57E-4 0.01
16 SGTC_1332 1480-0653 3.25 17.5 µM 4.11E-5 TSC3-RPN4 7 5.73E-4 0.01
17 SGTC_3315 9136395 3.11 68.5 µM 8.28E-5 13 9.36E-4 0.02
18 SGTC_1727 st034309 3.11 9.9 µM 8.45E-5 30 9.49E-4 0.09
19 SGTC_764 1951-2361 3.08 146.0 µM 9.59E-5 23 0.00104 0.02
20 SGTC_2335 9018011 3.01 154.2 µM 1.36E-4 22 0.00132 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.19E-11 YMR130W_p YMR130W_p hom Putative protein of unknown function; YMR130W is not an essential gene
0.103 2.14E-9 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.099 8.90E-9 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.099 9.45E-9 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.097 1.86E-8 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.087 4.00E-7 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.086 6.23E-7 YOR177C MPC54 hom Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
0.083 1.71E-6 YOL066C RIB2 het Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
0.082 1.78E-6 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.080 3.05E-6 YGL145W TIP20 het Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
0.077 7.36E-6 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.077 7.66E-6 YJL049W_p YJL049W_p hom Putative protein of unknown function; YJL049W is a non-essential gene
0.076 1.18E-5 YNL130C-A_p DGR1_p hom Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose
0.074 1.58E-5 YBR301W PAU24 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.073 2.20E-5 YJR140C HIR3 hom Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein