YKL111C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL111C / YKL111C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-8.64|P-value:3.51E-20 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.57|P-value:6.89E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:-2.96|P-value:8.82E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:4.01|P-value:1.17E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:3.06|P-value:6.35E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.84|P-value:1.64E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.33|P-value:2.16E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.41|P-value:1.64E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.45|P-value:1.39E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.03|P-value:7.03E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.21|P-value:3.41E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.21|P-value:3.59E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.94|P-value:1.65E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.75|P-value:3.75E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:2.99|P-value:8.15E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.91|P-value:2.16E-10 ID:SGTC_829|Compound:1635-0120|FD-Score:5.64|P-value:1.30E-9 ID:SGTC_839|Compound:0122-0028|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.89|P-value:1.23E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:3.06|P-value:6.24E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-4.46|P-value:1.24E-6 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.21|P-value:3.59E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.77|P-value:2.41E-7 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.89|P-value:2.01E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.45|P-value:1.38E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.10|P-value:5.36E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.48|P-value:1.22E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.12|P-value:5.05E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-4.83|P-value:1.69E-7 ID:SGTC_1652|Compound:st011932|FD-Score:3.05|P-value:6.53E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-3.29|P-value:2.47E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.32|P-value:2.36E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.65|P-value:5.62E-5 ID:SGTC_1783|Compound:st039459|FD-Score:-3.06|P-value:6.02E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.89|P-value:1.97E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.15|P-value:4.45E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.16|P-value:4.25E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.04|P-value:6.58E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.05|P-value:6.40E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.38|P-value:1.76E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.29|P-value:2.60E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.19|P-value:3.78E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.57|P-value:7.19E-7 ID:SGTC_2342|Compound:7990637|FD-Score:3.30|P-value:2.47E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.03|P-value:7.04E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_2505|Compound:galangin|FD-Score:4.09|P-value:7.83E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-5.24|P-value:1.54E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:5.87|P-value:3.01E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.83|P-value:2.62E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:7.84|P-value:6.47E-17 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.25|P-value:3.02E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.63|P-value:6.23E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.64|P-value:6.10E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-4.03|P-value:1.02E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-4.26|P-value:3.37E-6 ID:SGTC_2921|Compound:7974240|FD-Score:5.12|P-value:3.39E-8 ID:SGTC_2923|Compound:7992654|FD-Score:3.05|P-value:6.41E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.07|P-value:5.98E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.00|P-value:7.63E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-2.95|P-value:8.94E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.08|P-value:5.82E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.13|P-value:4.75E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.71|P-value:4.51E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.07|P-value:5.95E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.89|P-value:1.92E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.29|P-value:2.59E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.16|P-value:5.62E-6 ID:SGTC_3220|Compound:9131269|FD-Score:-3.10|P-value:5.29E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.27|P-value:3.37E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.42|P-value:1.48E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.98|P-value:7.64E-8 ID:SGTC_66|Compound:0109-0187|FD-Score:-8.64|P-value:3.51E-20 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.57|P-value:6.89E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:-2.96|P-value:8.82E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:4.01|P-value:1.17E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:3.06|P-value:6.35E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.84|P-value:1.64E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.33|P-value:2.16E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.41|P-value:1.64E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.45|P-value:1.39E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.03|P-value:7.03E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.21|P-value:3.41E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.21|P-value:3.59E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.94|P-value:1.65E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.75|P-value:3.75E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:2.99|P-value:8.15E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.91|P-value:2.16E-10 ID:SGTC_829|Compound:1635-0120|FD-Score:5.64|P-value:1.30E-9 ID:SGTC_839|Compound:0122-0028|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.89|P-value:1.23E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:3.06|P-value:6.24E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-4.46|P-value:1.24E-6 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.21|P-value:3.59E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.77|P-value:2.41E-7 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.89|P-value:2.01E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.45|P-value:1.38E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.10|P-value:5.36E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.48|P-value:1.22E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.12|P-value:5.05E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-4.83|P-value:1.69E-7 ID:SGTC_1652|Compound:st011932|FD-Score:3.05|P-value:6.53E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-3.29|P-value:2.47E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.32|P-value:2.36E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.65|P-value:5.62E-5 ID:SGTC_1783|Compound:st039459|FD-Score:-3.06|P-value:6.02E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.89|P-value:1.97E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.15|P-value:4.45E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.16|P-value:4.25E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.04|P-value:6.58E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.05|P-value:6.40E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.38|P-value:1.76E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.29|P-value:2.60E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.19|P-value:3.78E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.57|P-value:7.19E-7 ID:SGTC_2342|Compound:7990637|FD-Score:3.30|P-value:2.47E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.03|P-value:7.04E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_2505|Compound:galangin|FD-Score:4.09|P-value:7.83E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-5.24|P-value:1.54E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:5.87|P-value:3.01E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.83|P-value:2.62E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:7.84|P-value:6.47E-17 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.25|P-value:3.02E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.63|P-value:6.23E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.64|P-value:6.10E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-4.03|P-value:1.02E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-4.26|P-value:3.37E-6 ID:SGTC_2921|Compound:7974240|FD-Score:5.12|P-value:3.39E-8 ID:SGTC_2923|Compound:7992654|FD-Score:3.05|P-value:6.41E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.07|P-value:5.98E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.00|P-value:7.63E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-2.95|P-value:8.94E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.08|P-value:5.82E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.13|P-value:4.75E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.71|P-value:4.51E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.07|P-value:5.95E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.89|P-value:1.92E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.29|P-value:2.59E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.16|P-value:5.62E-6 ID:SGTC_3220|Compound:9131269|FD-Score:-3.10|P-value:5.29E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.27|P-value:3.37E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.42|P-value:1.48E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.98|P-value:7.64E-8

Top fitness defect scores for YKL111C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 7.84 100.0 µM 6.47E-17 60S ribosome export 2 2.25E-15 0.00
2 SGTC_2584 androsterone 5.87 48.7 µM 3.01E-10 cell wall 13 2.22E-9 0.05
3 SGTC_829 1635-0120 5.64 117.0 µM 1.30E-9 DNA damage response 28 8.30E-9 0.14
4 SGTC_2921 7974240 5.12 10.7 µM 3.39E-8 7 1.57E-7 0.19
5 SGTC_3266 9136860 4.98 49.5 µM 7.64E-8 cell wall 8 3.25E-7 0.42
6 SGTC_916 4466-0038 4.89 42.0 nM 1.23E-7 cell wall 18 5.00E-7 0.08
7 SGTC_138 0850-0259 4.84 40.9 µM 1.64E-7 cell wall 42 6.46E-7 0.05
8 SGTC_1282 0886-0010 4.77 32.4 µM 2.41E-7 endomembrane recycling 10 9.15E-7 0.07
9 SGTC_2257 7960413 4.57 200.0 µM 7.19E-7 NEO1-PIK1 15 2.45E-6 0.04
10 SGTC_3222 9128301 4.27 49.5 µM 3.37E-6 60S ribosome export 6 9.86E-6 0.29
11 SGTC_3219 9131112 4.16 49.5 µM 5.62E-6 Golgi 16 1.57E-5 0.07
12 SGTC_2505 galangin 4.09 7.9 µM 7.83E-6 RPP1 & pyrimidine depletion 4 2.11E-5 0.03
13 SGTC_75 0159-0059 4.01 199.0 µM 1.17E-5 fatty acid desaturase (OLE1) 9 3.02E-5 0.07
14 SGTC_632 0781-2353 3.94 4.7 µM 1.65E-5 Golgi 17 4.14E-5 0.02
15 SGTC_1320 1313-0481 3.89 95.3 µM 2.01E-5 4 4.95E-5 0.19
16 SGTC_2588 indole-3-carbinol 3.83 100.0 µM 2.62E-5 8 6.29E-5 0.03
17 SGTC_718 1130-0073 3.75 349.0 µM 3.75E-5 6 8.68E-5 0.04
18 SGTC_3062 9077494 3.71 49.5 µM 4.51E-5 mitochondrial response to ROS 9 1.03E-4 0.01
19 SGTC_2779 methotrexate 3.64 400.0 µM 6.10E-5 18 1.35E-4 0.13
20 SGTC_1523 st012844 3.48 44.7 µM 1.22E-4 60S ribosome export 7 2.52E-4 0.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 2.77E-32 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.178 3.25E-25 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.152 7.45E-19 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.150 2.07E-18 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.148 5.13E-18 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.147 1.16E-17 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.145 3.25E-17 YER136W GDI1 het GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
0.145 3.42E-17 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.143 9.08E-17 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.139 4.94E-16 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.139 5.54E-16 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.139 5.71E-16 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.139 7.34E-16 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.138 9.92E-16 YDR483W KRE2 hom Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
0.138 1.26E-15 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth