YKL112W / ABF1

DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL112W / ABF1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.46|P-value:9.88E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.99|P-value:1.88E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.65|P-value:2.22E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.95|P-value:5.03E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:4.71|P-value:1.31E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.69|P-value:4.93E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.38|P-value:4.71E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.53|P-value:7.95E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.02|P-value:1.67E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.62|P-value:6.08E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.97|P-value:5.03E-8 ID:SGTC_666|Compound:0272-0154|FD-Score:3.83|P-value:3.13E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.07|P-value:1.40E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.64|P-value:5.89E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.32|P-value:1.05E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:4.55|P-value:2.43E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-4.79|P-value:9.25E-6 ID:SGTC_934|Compound:2950-0684|FD-Score:4.53|P-value:2.61E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:4.46|P-value:3.52E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.64|P-value:5.79E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.50|P-value:8.92E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.88|P-value:2.66E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.49|P-value:3.11E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:5.14|P-value:2.29E-6 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.90|P-value:2.45E-4 ID:SGTC_1521|Compound:st012942|FD-Score:8.45|P-value:2.37E-14 ID:SGTC_1611|Compound:st001856|FD-Score:3.49|P-value:9.36E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.69|P-value:4.93E-4 ID:SGTC_1745|Compound:st081495|FD-Score:7.56|P-value:7.43E-12 ID:SGTC_1800|Compound:st050079|FD-Score:4.14|P-value:1.11E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.69|P-value:4.91E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.88|P-value:2.66E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.86|P-value:2.92E-4 ID:SGTC_2221|Compound:6807166|FD-Score:4.17|P-value:9.80E-5 ID:SGTC_2257|Compound:7960413|FD-Score:7.58|P-value:6.76E-12 ID:SGTC_2297|Compound:7971671|FD-Score:3.70|P-value:4.86E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.64|P-value:5.88E-4 ID:SGTC_2393|Compound:9031399|FD-Score:5.09|P-value:2.83E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.62|P-value:6.22E-4 ID:SGTC_2433|Compound:5607874|FD-Score:5.83|P-value:9.64E-8 ID:SGTC_2435|Compound:5706476|FD-Score:3.49|P-value:9.39E-4 ID:SGTC_2436|Compound:5633522|FD-Score:6.50|P-value:3.24E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.64|P-value:5.63E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.51|P-value:8.52E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.93|P-value:2.27E-4 ID:SGTC_2906|Compound:7926292|FD-Score:7.05|P-value:1.61E-10 ID:SGTC_2954|Compound:9074818|FD-Score:3.85|P-value:2.93E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.08|P-value:1.35E-4 ID:SGTC_2997|Compound:9067075|FD-Score:7.80|P-value:1.71E-12 ID:SGTC_3075|Compound:9116269|FD-Score:5.43|P-value:6.30E-7 ID:SGTC_3131|Compound:9127911|FD-Score:3.70|P-value:4.82E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.46|P-value:9.88E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.99|P-value:1.88E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.65|P-value:2.22E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.95|P-value:5.03E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:4.71|P-value:1.31E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.69|P-value:4.93E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.38|P-value:4.71E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.53|P-value:7.95E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.02|P-value:1.67E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.62|P-value:6.08E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.97|P-value:5.03E-8 ID:SGTC_666|Compound:0272-0154|FD-Score:3.83|P-value:3.13E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.07|P-value:1.40E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.64|P-value:5.89E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.32|P-value:1.05E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:4.55|P-value:2.43E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-4.79|P-value:9.25E-6 ID:SGTC_934|Compound:2950-0684|FD-Score:4.53|P-value:2.61E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:4.46|P-value:3.52E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.64|P-value:5.79E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.50|P-value:8.92E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.88|P-value:2.66E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.49|P-value:3.11E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:5.14|P-value:2.29E-6 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.90|P-value:2.45E-4 ID:SGTC_1521|Compound:st012942|FD-Score:8.45|P-value:2.37E-14 ID:SGTC_1611|Compound:st001856|FD-Score:3.49|P-value:9.36E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.69|P-value:4.93E-4 ID:SGTC_1745|Compound:st081495|FD-Score:7.56|P-value:7.43E-12 ID:SGTC_1800|Compound:st050079|FD-Score:4.14|P-value:1.11E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.69|P-value:4.91E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.88|P-value:2.66E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.86|P-value:2.92E-4 ID:SGTC_2221|Compound:6807166|FD-Score:4.17|P-value:9.80E-5 ID:SGTC_2257|Compound:7960413|FD-Score:7.58|P-value:6.76E-12 ID:SGTC_2297|Compound:7971671|FD-Score:3.70|P-value:4.86E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.64|P-value:5.88E-4 ID:SGTC_2393|Compound:9031399|FD-Score:5.09|P-value:2.83E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.62|P-value:6.22E-4 ID:SGTC_2433|Compound:5607874|FD-Score:5.83|P-value:9.64E-8 ID:SGTC_2435|Compound:5706476|FD-Score:3.49|P-value:9.39E-4 ID:SGTC_2436|Compound:5633522|FD-Score:6.50|P-value:3.24E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.64|P-value:5.63E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.51|P-value:8.52E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.93|P-value:2.27E-4 ID:SGTC_2906|Compound:7926292|FD-Score:7.05|P-value:1.61E-10 ID:SGTC_2954|Compound:9074818|FD-Score:3.85|P-value:2.93E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.08|P-value:1.35E-4 ID:SGTC_2997|Compound:9067075|FD-Score:7.80|P-value:1.71E-12 ID:SGTC_3075|Compound:9116269|FD-Score:5.43|P-value:6.30E-7 ID:SGTC_3131|Compound:9127911|FD-Score:3.70|P-value:4.82E-4

Top fitness defect scores for YKL112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1521 st012942 8.45 49.4 µM 2.37E-14 1 1.49E-17 2.65
2 SGTC_2997 9067075 7.80 71.4 µM 1.71E-12 unfolded protein response 5 3.14E-15 0.88
3 SGTC_2257 7960413 7.58 200.0 µM 6.76E-12 NEO1-PIK1 6 1.75E-14 1.13
4 SGTC_1745 st081495 7.56 74.0 µM 7.43E-12 RNA processing & uracil transport 10 1.97E-14 0.28
5 SGTC_2906 7926292 7.05 26.4 µM 1.61E-10 1 9.19E-13 1.41
6 SGTC_2436 5633522 6.50 8.1 µM 3.24E-9 3 3.91E-11 1.43
7 SGTC_568 1193-0097 5.97 7.5 µM 5.03E-8 ERAD & cell cycle 15 1.20E-9 0.84
8 SGTC_2433 5607874 5.83 27.8 µM 9.64E-8 1 2.70E-9 1.51
9 SGTC_3075 9116269 5.43 49.5 µM 6.30E-7 5 2.80E-8 1.31
10 SGTC_863 0466-0191 5.32 129.0 µM 1.05E-6 cell wall 11 5.26E-8 0.21
11 SGTC_1333 1482-0047 5.14 286.0 µM 2.29E-6 1 1.40E-7 0.35
12 SGTC_2393 9031399 5.09 185.9 µM 2.83E-6 RNA processing & uracil transport 5 1.82E-7 0.43
13 SGTC_46 0329-0187a 4.95 2.2 µM 5.03E-6 3 3.73E-7 0.16
14 SGTC_117 lucigenin 4.71 22.1 µM 1.31E-5 redox potentiating 9 1.23E-6 0.85
15 SGTC_923 1900-2434 4.55 73.3 µM 2.43E-5 RNA processing & uracil transport 8 2.63E-6 0.29
16 SGTC_934 2950-0684 4.53 338.0 µM 2.61E-5 3 2.88E-6 0.60
17 SGTC_1328 1441-0025 4.49 69.2 µM 3.11E-5 2 3.59E-6 0.07
18 SGTC_961 1252-1571 4.46 372.0 µM 3.52E-5 2 4.18E-6 0.55
19 SGTC_390 dec-rvkr-cmk 4.38 16.7 µM 4.71E-5 calcium & mitochondrial duress 3 6.01E-6 0.02
20 SGTC_2221 6807166 4.17 181.1 µM 9.80E-5 1 1.49E-5 0.82

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.18E-18 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.126 2.77E-13 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
0.115 2.79E-11 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.111 1.08E-10 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.111 1.11E-10 YDR395W SXM1 hom Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
0.111 1.20E-10 YKL160W ELF1 hom Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
0.104 1.31E-9 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.104 1.48E-9 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.100 6.85E-9 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.099 9.81E-9 YDL071C_d YDL071C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W
0.096 2.32E-8 YDR308C SRB7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
0.096 3.01E-8 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.092 1.02E-7 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.091 1.16E-7 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.089 2.48E-7 YMR316C-B_d YMR316C-B_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data