YKL114C / APN1

Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL114C / APN1

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.92|P-value:2.70E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:5.21|P-value:1.82E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.33|P-value:8.40E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.88|P-value:7.49E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:7.86|P-value:9.19E-13 ID:SGTC_204|Compound:1543-0184|FD-Score:4.95|P-value:5.70E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:6.18|P-value:1.79E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.80|P-value:4.05E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.05|P-value:1.75E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.87|P-value:7.68E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.45|P-value:4.16E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:4.85|P-value:8.52E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:4.00|P-value:2.09E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.85|P-value:8.44E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.93|P-value:2.07E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:5.98|P-value:4.98E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:3.85|P-value:3.46E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.94|P-value:2.61E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.88|P-value:8.05E-8 ID:SGTC_379|Compound:3970-0972|FD-Score:3.72|P-value:5.24E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.42|P-value:4.68E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.14|P-value:1.29E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.09|P-value:1.03E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.99|P-value:4.81E-6 ID:SGTC_493|Compound:zm226600|FD-Score:-3.49|P-value:4.95E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:5.48|P-value:5.32E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:5.60|P-value:3.17E-7 ID:SGTC_556|Compound:4058-0063|FD-Score:3.86|P-value:3.33E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.83|P-value:3.76E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.50|P-value:4.79E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.15|P-value:1.25E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:6.54|P-value:2.57E-9 ID:SGTC_666|Compound:0272-0154|FD-Score:5.56|P-value:3.76E-7 ID:SGTC_774|Compound:k060-0086|FD-Score:5.34|P-value:1.03E-6 ID:SGTC_776|Compound:4476-4378|FD-Score:5.62|P-value:2.84E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.39|P-value:6.83E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.87|P-value:3.23E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:6.49|P-value:3.38E-9 ID:SGTC_863|Compound:0466-0191|FD-Score:14.10|P-value:2.29E-37 ID:SGTC_928|Compound:2764-0428|FD-Score:4.02|P-value:1.98E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:5.05|P-value:3.61E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:11.40|P-value:4.00E-25 ID:SGTC_969|Compound:1313-0238|FD-Score:6.60|P-value:1.92E-9 ID:SGTC_974|Compound:1326-0144|FD-Score:7.47|P-value:1.12E-11 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.53|P-value:9.65E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.92|P-value:2.77E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.68|P-value:6.13E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.65|P-value:6.74E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.54|P-value:9.47E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:4.55|P-value:2.78E-5 ID:SGTC_1624|Compound:st003710|FD-Score:5.11|P-value:2.81E-6 ID:SGTC_1666|Compound:st014829|FD-Score:4.11|P-value:1.43E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.59|P-value:8.10E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.66|P-value:6.38E-4 ID:SGTC_1708|Compound:st033234|FD-Score:4.11|P-value:1.45E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.71|P-value:1.49E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.80|P-value:4.13E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.06|P-value:1.70E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.21|P-value:9.93E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.61|P-value:2.20E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.37|P-value:5.51E-5 ID:SGTC_2099|Compound:5377090|FD-Score:5.51|P-value:4.79E-7 ID:SGTC_2109|Compound:5483026|FD-Score:5.94|P-value:5.96E-8 ID:SGTC_2110|Compound:5483698|FD-Score:3.79|P-value:4.28E-4 ID:SGTC_2111|Compound:5486399|FD-Score:5.36|P-value:9.29E-7 ID:SGTC_2164|Compound:5685496|FD-Score:4.95|P-value:5.65E-6 ID:SGTC_2464|Compound:5717415|FD-Score:4.41|P-value:4.82E-5 ID:SGTC_2467|Compound:5474540|FD-Score:5.71|P-value:1.83E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:4.39|P-value:5.21E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.73|P-value:5.11E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.68|P-value:1.67E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.55|P-value:2.77E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.60|P-value:7.71E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.83|P-value:3.75E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.96|P-value:2.43E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.92|P-value:2.78E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.55|P-value:3.98E-7 ID:SGTC_2881|Compound:9058953|FD-Score:-4.61|P-value:8.27E-6 ID:SGTC_2887|Compound:9044784|FD-Score:-3.40|P-value:6.56E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-4.46|P-value:1.51E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.13|P-value:1.31E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.29|P-value:1.26E-6 ID:SGTC_2993|Compound:9054257|FD-Score:3.91|P-value:2.89E-4 ID:SGTC_3001|Compound:9076041|FD-Score:6.20|P-value:1.62E-8 ID:SGTC_3025|Compound:9087895|FD-Score:4.32|P-value:6.64E-5 ID:SGTC_3038|Compound:9091290|FD-Score:-4.41|P-value:1.80E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-4.34|P-value:2.40E-5 ID:SGTC_3145|Compound:9085516|FD-Score:3.79|P-value:4.22E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.11|P-value:2.85E-6 ID:SGTC_3285|Compound:9112818|FD-Score:6.14|P-value:2.19E-8 ID:SGTC_3291|Compound:9121177|FD-Score:4.71|P-value:1.49E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.11|P-value:1.43E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.36|P-value:6.71E-9 ID:SGTC_3331|Compound:9141060|FD-Score:3.89|P-value:3.08E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.71|P-value:1.51E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:3.92|P-value:2.70E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:5.21|P-value:1.82E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.33|P-value:8.40E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.88|P-value:7.49E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:7.86|P-value:9.19E-13 ID:SGTC_204|Compound:1543-0184|FD-Score:4.95|P-value:5.70E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:6.18|P-value:1.79E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.80|P-value:4.05E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.05|P-value:1.75E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.87|P-value:7.68E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.45|P-value:4.16E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:4.85|P-value:8.52E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:4.00|P-value:2.09E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.85|P-value:8.44E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.93|P-value:2.07E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:5.98|P-value:4.98E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:3.85|P-value:3.46E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.94|P-value:2.61E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.88|P-value:8.05E-8 ID:SGTC_379|Compound:3970-0972|FD-Score:3.72|P-value:5.24E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.42|P-value:4.68E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.14|P-value:1.29E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.09|P-value:1.03E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.99|P-value:4.81E-6 ID:SGTC_493|Compound:zm226600|FD-Score:-3.49|P-value:4.95E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:5.48|P-value:5.32E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:5.60|P-value:3.17E-7 ID:SGTC_556|Compound:4058-0063|FD-Score:3.86|P-value:3.33E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.83|P-value:3.76E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.50|P-value:4.79E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.15|P-value:1.25E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:6.54|P-value:2.57E-9 ID:SGTC_666|Compound:0272-0154|FD-Score:5.56|P-value:3.76E-7 ID:SGTC_774|Compound:k060-0086|FD-Score:5.34|P-value:1.03E-6 ID:SGTC_776|Compound:4476-4378|FD-Score:5.62|P-value:2.84E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.39|P-value:6.83E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.87|P-value:3.23E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:6.49|P-value:3.38E-9 ID:SGTC_863|Compound:0466-0191|FD-Score:14.10|P-value:2.29E-37 ID:SGTC_928|Compound:2764-0428|FD-Score:4.02|P-value:1.98E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:5.05|P-value:3.61E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:11.40|P-value:4.00E-25 ID:SGTC_969|Compound:1313-0238|FD-Score:6.60|P-value:1.92E-9 ID:SGTC_974|Compound:1326-0144|FD-Score:7.47|P-value:1.12E-11 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.53|P-value:9.65E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.92|P-value:2.77E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.68|P-value:6.13E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.65|P-value:6.74E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.54|P-value:9.47E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:4.55|P-value:2.78E-5 ID:SGTC_1624|Compound:st003710|FD-Score:5.11|P-value:2.81E-6 ID:SGTC_1666|Compound:st014829|FD-Score:4.11|P-value:1.43E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.59|P-value:8.10E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.66|P-value:6.38E-4 ID:SGTC_1708|Compound:st033234|FD-Score:4.11|P-value:1.45E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.71|P-value:1.49E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.80|P-value:4.13E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.06|P-value:1.70E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.21|P-value:9.93E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.61|P-value:2.20E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.37|P-value:5.51E-5 ID:SGTC_2099|Compound:5377090|FD-Score:5.51|P-value:4.79E-7 ID:SGTC_2109|Compound:5483026|FD-Score:5.94|P-value:5.96E-8 ID:SGTC_2110|Compound:5483698|FD-Score:3.79|P-value:4.28E-4 ID:SGTC_2111|Compound:5486399|FD-Score:5.36|P-value:9.29E-7 ID:SGTC_2164|Compound:5685496|FD-Score:4.95|P-value:5.65E-6 ID:SGTC_2464|Compound:5717415|FD-Score:4.41|P-value:4.82E-5 ID:SGTC_2467|Compound:5474540|FD-Score:5.71|P-value:1.83E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:4.39|P-value:5.21E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.73|P-value:5.11E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.68|P-value:1.67E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.55|P-value:2.77E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.60|P-value:7.71E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.83|P-value:3.75E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.96|P-value:2.43E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.92|P-value:2.78E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.55|P-value:3.98E-7 ID:SGTC_2881|Compound:9058953|FD-Score:-4.61|P-value:8.27E-6 ID:SGTC_2887|Compound:9044784|FD-Score:-3.40|P-value:6.56E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-4.46|P-value:1.51E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.13|P-value:1.31E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.29|P-value:1.26E-6 ID:SGTC_2993|Compound:9054257|FD-Score:3.91|P-value:2.89E-4 ID:SGTC_3001|Compound:9076041|FD-Score:6.20|P-value:1.62E-8 ID:SGTC_3025|Compound:9087895|FD-Score:4.32|P-value:6.64E-5 ID:SGTC_3038|Compound:9091290|FD-Score:-4.41|P-value:1.80E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-4.34|P-value:2.40E-5 ID:SGTC_3145|Compound:9085516|FD-Score:3.79|P-value:4.22E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.11|P-value:2.85E-6 ID:SGTC_3285|Compound:9112818|FD-Score:6.14|P-value:2.19E-8 ID:SGTC_3291|Compound:9121177|FD-Score:4.71|P-value:1.49E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.11|P-value:1.43E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.36|P-value:6.71E-9 ID:SGTC_3331|Compound:9141060|FD-Score:3.89|P-value:3.08E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.71|P-value:1.51E-5

Top fitness defect scores for YKL114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_863 0466-0191 14.10 129.0 µM 2.29E-37 cell wall 4 2.02E-45
2 SGTC_951 1171-0579 11.40 82.7 µM 4.00E-25 cell wall 6 1.58E-30
3 SGTC_138 0850-0259 7.86 40.9 µM 9.19E-13 cell wall 65 1.86E-15
4 SGTC_974 1326-0144 7.47 138.0 µM 1.12E-11 ERG2 4 3.95E-14
5 SGTC_969 1313-0238 6.60 134.0 µM 1.92E-9 mitochondrial processes 3 2.12E-11
6 SGTC_586 0957-0265 6.54 8.2 µM 2.57E-9 cell wall 14 3.03E-11
7 SGTC_839 0122-0028 6.49 230.0 µM 3.38E-9 RSC complex & mRNA processing 4 4.25E-11
8 SGTC_3311 9131146 6.36 2.9 µM 6.71E-9 cell wall 54 9.82E-11
9 SGTC_3001 9076041 6.20 71.4 µM 1.62E-8 1 2.90E-10
10 SGTC_206 4546-0025 6.18 72.0 µM 1.79E-8 NEO1 30 3.27E-10
11 SGTC_3285 9112818 6.14 20.9 µM 2.19E-8 cell wall 8 4.18E-10
12 SGTC_351 caspofungin 5.98 25.0 nM 4.98E-8 cell wall 41 1.14E-9
13 SGTC_2109 5483026 5.94 200.0 µM 5.96E-8 RSC complex & mRNA processing 3 1.43E-9
14 SGTC_360 0957-0399 5.88 1.0 µM 8.05E-8 cell wall 14 2.06E-9
15 SGTC_2467 5474540 5.71 200.0 µM 1.83E-7 2 5.63E-9
16 SGTC_776 4476-4378 5.62 112.0 µM 2.84E-7 ERG2 9 9.65E-9
17 SGTC_514 4466-0038 5.60 2.6 nM 3.17E-7 cell wall 88 1.10E-8
18 SGTC_666 0272-0154 5.56 136.0 µM 3.76E-7 cell wall 22 1.36E-8
19 SGTC_2779 methotrexate 5.55 400.0 µM 3.98E-7 14 1.46E-8
20 SGTC_2099 5377090 5.51 177.4 µM 4.79E-7 6 1.83E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.370 4.12E-109 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.349 5.36E-97 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.339 8.38E-91 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.334 5.28E-88 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.330 7.68E-86 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.279 5.15E-61 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.275 2.23E-59 YOR258W HNT3 hom DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress
0.262 7.13E-54 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.261 1.47E-53 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.261 2.23E-53 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.260 6.70E-53 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.254 2.23E-50 YMR242C RPL20A hom Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
0.247 9.43E-48 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.237 6.50E-44 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.236 7.78E-44 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly