YKL117W / SBA1

Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL117W / SBA1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.08|P-value:5.25E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.49|P-value:1.06E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.02|P-value:7.46E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.97|P-value:1.44E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.40|P-value:1.55E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.29|P-value:2.66E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.01|P-value:7.65E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.20|P-value:3.79E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.17|P-value:4.25E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.16|P-value:4.03E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-2.99|P-value:8.16E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.73|P-value:3.75E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-3.10|P-value:5.50E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.17|P-value:4.12E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.59|P-value:6.81E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.32|P-value:1.28E-11 ID:SGTC_1931|Compound:st074438|FD-Score:-3.34|P-value:2.15E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.59|P-value:7.73E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-6.01|P-value:1.13E-10 ID:SGTC_2101|Compound:5377231|FD-Score:2.94|P-value:8.79E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.46|P-value:1.10E-6 ID:SGTC_2393|Compound:9031399|FD-Score:3.17|P-value:3.76E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.38|P-value:1.83E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.09|P-value:5.19E-4 ID:SGTC_2424|Compound:5537928|FD-Score:2.95|P-value:8.57E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.46|P-value:1.18E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.46|P-value:3.50E-9 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.34|P-value:1.92E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.22|P-value:3.45E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.97|P-value:7.99E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.02|P-value:1.01E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:-3.25|P-value:3.03E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.40|P-value:1.70E-4 ID:SGTC_3151|Compound:9099821|FD-Score:6.17|P-value:3.09E-11 ID:SGTC_3153|Compound:9100258|FD-Score:3.32|P-value:2.14E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.31|P-value:2.45E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.01|P-value:6.85E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.08|P-value:5.25E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.49|P-value:1.06E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.02|P-value:7.46E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.97|P-value:1.44E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.40|P-value:1.55E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.29|P-value:2.66E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.01|P-value:7.65E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.20|P-value:3.79E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.17|P-value:4.25E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.16|P-value:4.03E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-2.99|P-value:8.16E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.73|P-value:3.75E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-3.10|P-value:5.50E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.17|P-value:4.12E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.59|P-value:6.81E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.32|P-value:1.28E-11 ID:SGTC_1931|Compound:st074438|FD-Score:-3.34|P-value:2.15E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.59|P-value:7.73E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-6.01|P-value:1.13E-10 ID:SGTC_2101|Compound:5377231|FD-Score:2.94|P-value:8.79E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.46|P-value:1.10E-6 ID:SGTC_2393|Compound:9031399|FD-Score:3.17|P-value:3.76E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.38|P-value:1.83E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.09|P-value:5.19E-4 ID:SGTC_2424|Compound:5537928|FD-Score:2.95|P-value:8.57E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.46|P-value:1.18E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.46|P-value:3.50E-9 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.34|P-value:1.92E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.22|P-value:3.45E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.97|P-value:7.99E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.02|P-value:1.01E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:-3.25|P-value:3.03E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.40|P-value:1.70E-4 ID:SGTC_3151|Compound:9099821|FD-Score:6.17|P-value:3.09E-11 ID:SGTC_3153|Compound:9100258|FD-Score:3.32|P-value:2.14E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.31|P-value:2.45E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.01|P-value:6.85E-4

Top fitness defect scores for YKL117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3151 9099821 6.17 49.5 µM 3.09E-11 2 3.42E-10
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.46 3.7 µM 3.50E-9 21 2.36E-8
3 SGTC_2166 5933061 4.46 31.5 µM 1.10E-6 tubulin folding & SWR complex 26 4.06E-6
4 SGTC_2736 butenafine 4.02 14.7 µM 1.01E-5 29 2.94E-5
5 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.73 14.9 µM 3.75E-5 16 9.54E-5
6 SGTC_1920 st075728 3.59 45.7 µM 6.81E-5 36 1.63E-4
7 SGTC_112 phenothiazine 3.49 287.2 µM 1.06E-4 unfolded protein response 22 2.42E-4
8 SGTC_2482 5981709 3.46 142.7 µM 1.18E-4 PDR1 54 2.67E-4
9 SGTC_649 1123-0311 3.40 367.0 µM 1.55E-4 endomembrane recycling 104 3.40E-4
10 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.34 92.6 µM 1.92E-4 47 4.13E-4
11 SGTC_802 4112-3352 3.33 742.0 µM 2.04E-4 41 4.37E-4
12 SGTC_3153 9100258 3.32 49.5 µM 2.14E-4 51 4.55E-4
13 SGTC_2393 9031399 3.17 185.9 µM 3.76E-4 RNA processing & uracil transport 63 7.53E-4
14 SGTC_1562 morin hydrate 3.16 59.1 µM 4.03E-4 47 8.02E-4
15 SGTC_2415 st077333 3.09 57.7 µM 5.19E-4 106 0.00101
16 SGTC_6 0844-0013 3.08 19.8 µM 5.25E-4 194 0.00102
17 SGTC_3329 9141233 3.01 27.6 µM 6.85E-4 42 0.00129
18 SGTC_2583 asiatic acid 2.97 100.0 µM 7.99E-4 78 0.00148
19 SGTC_2424 5537928 2.95 59.2 µM 8.57E-4 95 0.00158
20 SGTC_2101 5377231 2.94 179.2 µM 8.79E-4 34 0.00162

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.70E-28 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.148 6.98E-18 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.147 1.15E-17 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.144 4.20E-17 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.138 1.03E-15 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.138 1.08E-15 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.136 2.86E-15 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.133 1.21E-14 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.125 3.53E-13 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.125 3.98E-13 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.121 1.84E-12 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p
0.116 1.47E-11 YKL173W SNU114 het GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.116 1.65E-11 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.116 1.85E-11 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.115 2.70E-11 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids