YKL118W_d

Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL118W / YKL118W

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-4.19|P-value:1.53E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:7.15|P-value:4.73E-9 ID:SGTC_50|Compound:0929-0078|FD-Score:4.27|P-value:3.77E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.76|P-value:5.60E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.40|P-value:7.68E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-4.72|P-value:2.57E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.92|P-value:3.46E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:6.17|P-value:4.10E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:4.61|P-value:1.32E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.72|P-value:6.26E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.73|P-value:5.28E-7 ID:SGTC_417|Compound:st075190|FD-Score:-3.71|P-value:6.37E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:5.47|P-value:6.58E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.06|P-value:2.27E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:4.10|P-value:6.35E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.25|P-value:1.49E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.09|P-value:2.08E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.66|P-value:1.13E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.85|P-value:1.57E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.34|P-value:3.49E-8 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.23|P-value:1.33E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.18|P-value:1.93E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.08|P-value:2.74E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-5.68|P-value:6.41E-7 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.03|P-value:7.70E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:5.59|P-value:4.18E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:5.71|P-value:2.65E-6 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.66|P-value:1.14E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:5.43|P-value:7.57E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:4.36|P-value:2.93E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.42|P-value:2.45E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.05|P-value:7.31E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.76|P-value:8.26E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-3.56|P-value:9.76E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.90|P-value:1.25E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.50|P-value:1.67E-8 ID:SGTC_1720|Compound:st037298|FD-Score:5.78|P-value:2.02E-6 ID:SGTC_1721|Compound:st082152|FD-Score:4.58|P-value:1.47E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.65|P-value:1.16E-4 ID:SGTC_1765|Compound:st044815|FD-Score:5.12|P-value:2.39E-5 ID:SGTC_1773|Compound:st048542|FD-Score:4.96|P-value:4.15E-5 ID:SGTC_1830|Compound:st055982|FD-Score:4.19|P-value:4.77E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.69|P-value:1.03E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.98|P-value:2.86E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.99|P-value:8.70E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.92|P-value:3.51E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.53|P-value:1.70E-4 ID:SGTC_1972|Compound:st070201|FD-Score:5.39|P-value:9.07E-6 ID:SGTC_1981|Compound:st071826|FD-Score:4.97|P-value:4.00E-5 ID:SGTC_2110|Compound:5483698|FD-Score:4.03|P-value:7.76E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.31|P-value:3.42E-4 ID:SGTC_2195|Compound:6536160|FD-Score:5.39|P-value:8.98E-6 ID:SGTC_2270|Compound:7924575|FD-Score:4.19|P-value:4.90E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.81|P-value:6.96E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.59|P-value:8.95E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.40|P-value:8.71E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.38|P-value:8.04E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.19|P-value:4.82E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.03|P-value:7.60E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.71|P-value:2.67E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-4.42|P-value:7.05E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-4.04|P-value:2.40E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.65|P-value:1.16E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.05|P-value:7.24E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.63|P-value:1.25E-4 ID:SGTC_3188|Compound:9110789|FD-Score:6.29|P-value:2.39E-7 ID:SGTC_3197|Compound:9113331|FD-Score:5.71|P-value:2.62E-6 ID:SGTC_3224|Compound:9130643|FD-Score:5.69|P-value:2.82E-6 ID:SGTC_3303|Compound:9125618|FD-Score:4.18|P-value:4.94E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.19|P-value:4.90E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.19|P-value:1.53E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:7.15|P-value:4.73E-9 ID:SGTC_50|Compound:0929-0078|FD-Score:4.27|P-value:3.77E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.76|P-value:5.60E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.40|P-value:7.68E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-4.72|P-value:2.57E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.92|P-value:3.46E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:6.17|P-value:4.10E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:4.61|P-value:1.32E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.72|P-value:6.26E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.73|P-value:5.28E-7 ID:SGTC_417|Compound:st075190|FD-Score:-3.71|P-value:6.37E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:5.47|P-value:6.58E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.06|P-value:2.27E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:4.10|P-value:6.35E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.25|P-value:1.49E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.09|P-value:2.08E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.66|P-value:1.13E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.85|P-value:1.57E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.34|P-value:3.49E-8 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.23|P-value:1.33E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.18|P-value:1.93E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.08|P-value:2.74E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-5.68|P-value:6.41E-7 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.03|P-value:7.70E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:5.59|P-value:4.18E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:5.71|P-value:2.65E-6 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.66|P-value:1.14E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:5.43|P-value:7.57E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:4.36|P-value:2.93E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.42|P-value:2.45E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.05|P-value:7.31E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.76|P-value:8.26E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-3.56|P-value:9.76E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.90|P-value:1.25E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.50|P-value:1.67E-8 ID:SGTC_1720|Compound:st037298|FD-Score:5.78|P-value:2.02E-6 ID:SGTC_1721|Compound:st082152|FD-Score:4.58|P-value:1.47E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.65|P-value:1.16E-4 ID:SGTC_1765|Compound:st044815|FD-Score:5.12|P-value:2.39E-5 ID:SGTC_1773|Compound:st048542|FD-Score:4.96|P-value:4.15E-5 ID:SGTC_1830|Compound:st055982|FD-Score:4.19|P-value:4.77E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.69|P-value:1.03E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.98|P-value:2.86E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.99|P-value:8.70E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.92|P-value:3.51E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.53|P-value:1.70E-4 ID:SGTC_1972|Compound:st070201|FD-Score:5.39|P-value:9.07E-6 ID:SGTC_1981|Compound:st071826|FD-Score:4.97|P-value:4.00E-5 ID:SGTC_2110|Compound:5483698|FD-Score:4.03|P-value:7.76E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.31|P-value:3.42E-4 ID:SGTC_2195|Compound:6536160|FD-Score:5.39|P-value:8.98E-6 ID:SGTC_2270|Compound:7924575|FD-Score:4.19|P-value:4.90E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.81|P-value:6.96E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.59|P-value:8.95E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.40|P-value:8.71E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.38|P-value:8.04E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.19|P-value:4.82E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.03|P-value:7.60E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.71|P-value:2.67E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-4.42|P-value:7.05E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-4.04|P-value:2.40E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.65|P-value:1.16E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.05|P-value:7.24E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.63|P-value:1.25E-4 ID:SGTC_3188|Compound:9110789|FD-Score:6.29|P-value:2.39E-7 ID:SGTC_3197|Compound:9113331|FD-Score:5.71|P-value:2.62E-6 ID:SGTC_3224|Compound:9130643|FD-Score:5.69|P-value:2.82E-6 ID:SGTC_3303|Compound:9125618|FD-Score:4.18|P-value:4.94E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.19|P-value:4.90E-4

Top fitness defect scores for YKL118W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_49 0717-0965 7.15 32.1 µM 4.73E-9 60S ribosome export 1 4.42E-13
2 SGTC_3188 9110789 6.29 49.5 µM 2.39E-7 iron homeostasis 3 1.56E-10
3 SGTC_123 0083-0120 6.17 66.7 µM 4.10E-7 18 3.49E-10
4 SGTC_1717 st033143 5.90 58.0 µM 1.25E-6 11 1.84E-9
5 SGTC_1720 st037298 5.78 9.5 µM 2.02E-6 13 3.80E-9
6 SGTC_3197 9113331 5.71 49.5 µM 2.62E-6 6 5.61E-9
7 SGTC_1483 3453-0561 5.71 55.9 µM 2.65E-6 3 5.69E-9
8 SGTC_2689 tacrolimus 5.71 100.0 µM 2.67E-6 12 5.78E-9
9 SGTC_3224 9130643 5.69 49.5 µM 2.82E-6 RPP1 & pyrimidine depletion 5 6.28E-9
10 SGTC_1470 k295-0292 5.59 231.0 µM 4.18E-6 6 1.13E-8
11 SGTC_440 fluspirilene 5.47 35.1 µM 6.58E-6 3 2.23E-8
12 SGTC_1501 4491-0275 5.43 38.4 µM 7.57E-6 2 2.75E-8
13 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 5.40 63.6 µM 8.71E-6 20 3.39E-8
14 SGTC_2195 6536160 5.39 144.2 µM 8.98E-6 60S ribosome export 1 3.55E-8
15 SGTC_1972 st070201 5.39 17.4 µM 9.07E-6 10 3.61E-8
16 SGTC_669 0108-0021 5.25 26.2 µM 1.49E-5 fatty acid desaturase (OLE1) 31 7.60E-8
17 SGTC_1000 4048-0884 5.18 8.7 µM 1.93E-5 copper-dependent oxidative stress 14 1.11E-7
18 SGTC_1765 st044815 5.12 90.4 µM 2.39E-5 9 1.54E-7
19 SGTC_1048 3161-0300 5.08 24.5 µM 2.74E-5 8 1.89E-7
20 SGTC_1981 st071826 4.97 47.0 µM 4.00E-5 5 3.33E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.43E-12 YGL071W AFT1 hom Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.120 3.27E-12 YDL185W VMA1 hom Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.105 1.08E-9 YHR026W VMA16 hom Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
0.102 3.03E-9 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.095 3.42E-8 YEL051W VMA8 hom Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
0.094 4.91E-8 YGR020C VMA7 hom Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.092 1.20E-7 YMR123W PKR1 hom V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
0.091 1.16E-7 YPR036W VMA13 hom Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
0.085 7.71E-7 YJL117W PHO86 hom Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress
0.083 1.65E-6 YEL027W VMA3 hom Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
0.082 2.05E-6 YJL176C SWI3 hom Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions
0.081 2.49E-6 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.081 2.88E-6 YPL031C PHO85 hom Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
0.079 4.52E-6 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.078 5.59E-6 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane