YKL120W / OAC1

Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL120W / OAC1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.55|P-value:1.58E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.30|P-value:4.11E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.05|P-value:9.84E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.43|P-value:2.78E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-6.73|P-value:5.44E-12 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.61|P-value:1.36E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-3.58|P-value:1.52E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.21|P-value:9.87E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:4.44|P-value:3.41E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:3.95|P-value:3.13E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.69|P-value:9.78E-7 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.16|P-value:7.29E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.06|P-value:9.44E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.30|P-value:4.13E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.52|P-value:1.95E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.21|P-value:5.53E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.45|P-value:2.32E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.38|P-value:3.02E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.59|P-value:1.51E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.60|P-value:1.33E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.76|P-value:6.84E-5 ID:SGTC_1806|Compound:st050005|FD-Score:-3.69|P-value:1.02E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.74|P-value:8.28E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-4.20|P-value:1.12E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.18|P-value:6.83E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.52|P-value:2.31E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-6.18|P-value:2.29E-10 ID:SGTC_1967|Compound:st070177|FD-Score:3.42|P-value:2.63E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.27|P-value:4.54E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.99|P-value:2.62E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.13|P-value:1.40E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.02|P-value:2.33E-5 ID:SGTC_2421|Compound:5690543|FD-Score:-3.14|P-value:7.78E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.32|P-value:3.79E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.56|P-value:1.94E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.86|P-value:4.24E-7 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.15|P-value:6.95E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.51|P-value:1.82E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.12|P-value:7.78E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.85|P-value:4.69E-5 ID:SGTC_2835|Compound:9006588|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.77|P-value:6.67E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.55|P-value:1.58E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.30|P-value:4.11E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.05|P-value:9.84E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.43|P-value:2.78E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-6.73|P-value:5.44E-12 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.61|P-value:1.36E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-3.58|P-value:1.52E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.21|P-value:9.87E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:4.44|P-value:3.41E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:3.95|P-value:3.13E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.69|P-value:9.78E-7 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.16|P-value:7.29E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.06|P-value:9.44E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.30|P-value:4.13E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.52|P-value:1.95E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.21|P-value:5.53E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.45|P-value:2.32E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.38|P-value:3.02E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.59|P-value:1.51E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.60|P-value:1.33E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.76|P-value:6.84E-5 ID:SGTC_1806|Compound:st050005|FD-Score:-3.69|P-value:1.02E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.74|P-value:8.28E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-4.20|P-value:1.12E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.18|P-value:6.83E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.52|P-value:2.31E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-6.18|P-value:2.29E-10 ID:SGTC_1967|Compound:st070177|FD-Score:3.42|P-value:2.63E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.27|P-value:4.54E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.99|P-value:2.62E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.13|P-value:1.40E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.02|P-value:2.33E-5 ID:SGTC_2421|Compound:5690543|FD-Score:-3.14|P-value:7.78E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.32|P-value:3.79E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.56|P-value:1.94E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.86|P-value:4.24E-7 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.15|P-value:6.95E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.51|P-value:1.82E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.12|P-value:7.78E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.85|P-value:4.69E-5 ID:SGTC_2835|Compound:9006588|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.77|P-value:6.67E-5

Top fitness defect scores for YKL120W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.86 100.0 µM 4.24E-7 14 5.92E-7
2 SGTC_945 3381-0768 4.69 11.3 µM 9.78E-7 endomembrane recycling 18 1.34E-6
3 SGTC_2597 laccaic acid a 4.56 100.0 µM 1.94E-6 20 2.61E-6
4 SGTC_1940 st075990 4.52 51.1 µM 2.31E-6 60S ribosome export 10 3.10E-6
5 SGTC_837 0091-0265 4.44 12.5 µM 3.41E-6 ubiquinone biosynthesis & proteasome 18 4.54E-6
6 SGTC_453 enantio-paf c16 4.21 10.0 µM 9.87E-6 126 1.28E-5
7 SGTC_2426 5582046 4.17 32.2 µM 1.20E-5 24 1.55E-5
8 SGTC_2835 9006588 4.17 71.4 µM 1.20E-5 31 1.55E-5
9 SGTC_2335 9018011 4.13 154.2 µM 1.40E-5 24 1.80E-5
10 SGTC_2420 aureobasidin a 4.02 50.0 nM 2.33E-5 42 2.97E-5
11 SGTC_2146 5545642 3.99 200.0 µM 2.62E-5 16 3.32E-5
12 SGTC_859 0439-0102 3.95 54.6 µM 3.13E-5 redox potentiating 15 3.95E-5
13 SGTC_2829 7992743 3.85 58.4 µM 4.69E-5 42 5.87E-5
14 SGTC_3240 9133527 3.77 49.5 µM 6.67E-5 15 8.28E-5
15 SGTC_1791 st048313 3.76 56.1 µM 6.84E-5 18 8.48E-5
16 SGTC_1469 k284-2957 3.60 126.0 µM 1.33E-4 15 1.62E-4
17 SGTC_390 dec-rvkr-cmk 3.58 16.7 µM 1.41E-4 calcium & mitochondrial duress 40 1.73E-4
18 SGTC_10 0279-0212 3.55 42.6 µM 1.58E-4 TRP & mitochondrial translation 154 1.93E-4
19 SGTC_2684 capsaicin 3.51 100.0 µM 1.82E-4 24 2.21E-4
20 SGTC_1118 chelidonine 3.45 707.5 nM 2.32E-4 30 2.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.28E-12 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.102 2.65E-9 YBL096C_d YBL096C_d hom Non-essential protein of unknown function
0.099 9.48E-9 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.19E-8 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.094 4.49E-8 YIL020C HIS6 hom Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
0.093 6.10E-8 YPL048W CAM1 hom Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
0.089 2.38E-7 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
0.085 8.19E-7 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.083 1.41E-6 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.083 1.53E-6 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.080 3.22E-6 YOR316C-A_p YOR316C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.078 6.08E-6 YBR086C IST2 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.077 7.01E-6 YDR536W STL1 hom Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
0.077 7.66E-6 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.077 8.26E-6 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress