YKL121W_p / DGR2

Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL121W / DGR2

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.42|P-value:3.73E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.90|P-value:4.03E-15 ID:SGTC_103|Compound:0844-0104|FD-Score:8.43|P-value:5.75E-17 ID:SGTC_113|Compound:0099-0221|FD-Score:4.16|P-value:2.12E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:3.62|P-value:1.85E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.26|P-value:6.69E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.34|P-value:4.95E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.83|P-value:8.58E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:5.50|P-value:3.12E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.80|P-value:1.14E-11 ID:SGTC_568|Compound:1193-0097|FD-Score:4.19|P-value:1.87E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.37|P-value:4.54E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.65|P-value:2.36E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.33|P-value:5.38E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.41|P-value:3.89E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.04|P-value:3.51E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:3.15|P-value:9.62E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.16|P-value:9.82E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.32|P-value:5.43E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:5.59|P-value:1.90E-8 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.69|P-value:1.42E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.29|P-value:6.03E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.05|P-value:3.33E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.72|P-value:1.66E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:-6.20|P-value:5.94E-10 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.22|P-value:7.70E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.85|P-value:7.40E-5 ID:SGTC_1658|Compound:st012944|FD-Score:3.63|P-value:1.77E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.17|P-value:9.27E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_1790|Compound:st045711|FD-Score:4.75|P-value:1.45E-6 ID:SGTC_1808|Compound:st050063|FD-Score:4.44|P-value:6.34E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-3.64|P-value:1.80E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.36|P-value:4.75E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.53|P-value:4.10E-6 ID:SGTC_2047|Compound:4141938|FD-Score:-3.48|P-value:3.17E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.98|P-value:4.53E-5 ID:SGTC_2195|Compound:6536160|FD-Score:-3.41|P-value:4.09E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.35|P-value:9.21E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.46|P-value:3.24E-4 ID:SGTC_2255|Compound:7941087|FD-Score:6.01|P-value:1.66E-9 ID:SGTC_2317|Compound:5986382|FD-Score:4.45|P-value:5.93E-6 ID:SGTC_2354|Compound:9060492|FD-Score:-3.20|P-value:8.64E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.50|P-value:5.12E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-4.34|P-value:1.04E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-7.91|P-value:3.98E-15 ID:SGTC_2436|Compound:5633522|FD-Score:8.41|P-value:6.42E-17 ID:SGTC_2517|Compound:totarol|FD-Score:3.67|P-value:1.51E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.36|P-value:4.99E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.23|P-value:7.44E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.02|P-value:3.78E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.20|P-value:8.48E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.31|P-value:8.84E-8 ID:SGTC_2793|Compound:7325131|FD-Score:3.34|P-value:4.97E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.58|P-value:3.29E-6 ID:SGTC_2896|Compound:9052656|FD-Score:5.36|P-value:6.82E-8 ID:SGTC_2962|Compound:9082311|FD-Score:-3.79|P-value:1.00E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.24|P-value:7.54E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.31|P-value:5.61E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.43|P-value:3.64E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-5.65|P-value:1.45E-8 ID:SGTC_3152|Compound:9099253|FD-Score:-6.32|P-value:2.70E-10 ID:SGTC_3304|Compound:9125678|FD-Score:3.95|P-value:4.95E-5 ID:SGTC_3331|Compound:9141060|FD-Score:4.47|P-value:5.41E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:3.42|P-value:3.73E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.90|P-value:4.03E-15 ID:SGTC_103|Compound:0844-0104|FD-Score:8.43|P-value:5.75E-17 ID:SGTC_113|Compound:0099-0221|FD-Score:4.16|P-value:2.12E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:3.62|P-value:1.85E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.26|P-value:6.69E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.34|P-value:4.95E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.83|P-value:8.58E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:5.50|P-value:3.12E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.80|P-value:1.14E-11 ID:SGTC_568|Compound:1193-0097|FD-Score:4.19|P-value:1.87E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.37|P-value:4.54E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.65|P-value:2.36E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.33|P-value:5.38E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.41|P-value:3.89E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.04|P-value:3.51E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:3.15|P-value:9.62E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.16|P-value:9.82E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.32|P-value:5.43E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:5.59|P-value:1.90E-8 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.69|P-value:1.42E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.29|P-value:6.03E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.05|P-value:3.33E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.72|P-value:1.66E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:-6.20|P-value:5.94E-10 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.22|P-value:7.70E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.85|P-value:7.40E-5 ID:SGTC_1658|Compound:st012944|FD-Score:3.63|P-value:1.77E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.17|P-value:9.27E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_1790|Compound:st045711|FD-Score:4.75|P-value:1.45E-6 ID:SGTC_1808|Compound:st050063|FD-Score:4.44|P-value:6.34E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-3.64|P-value:1.80E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.36|P-value:4.75E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.53|P-value:4.10E-6 ID:SGTC_2047|Compound:4141938|FD-Score:-3.48|P-value:3.17E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.98|P-value:4.53E-5 ID:SGTC_2195|Compound:6536160|FD-Score:-3.41|P-value:4.09E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.35|P-value:9.21E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.46|P-value:3.24E-4 ID:SGTC_2255|Compound:7941087|FD-Score:6.01|P-value:1.66E-9 ID:SGTC_2317|Compound:5986382|FD-Score:4.45|P-value:5.93E-6 ID:SGTC_2354|Compound:9060492|FD-Score:-3.20|P-value:8.64E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.50|P-value:5.12E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-4.34|P-value:1.04E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-7.91|P-value:3.98E-15 ID:SGTC_2436|Compound:5633522|FD-Score:8.41|P-value:6.42E-17 ID:SGTC_2517|Compound:totarol|FD-Score:3.67|P-value:1.51E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.36|P-value:4.99E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.23|P-value:7.44E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.02|P-value:3.78E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.20|P-value:8.48E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.31|P-value:8.84E-8 ID:SGTC_2793|Compound:7325131|FD-Score:3.34|P-value:4.97E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.58|P-value:3.29E-6 ID:SGTC_2896|Compound:9052656|FD-Score:5.36|P-value:6.82E-8 ID:SGTC_2962|Compound:9082311|FD-Score:-3.79|P-value:1.00E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.24|P-value:7.54E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.31|P-value:5.61E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.43|P-value:3.64E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-5.65|P-value:1.45E-8 ID:SGTC_3152|Compound:9099253|FD-Score:-6.32|P-value:2.70E-10 ID:SGTC_3304|Compound:9125678|FD-Score:3.95|P-value:4.95E-5 ID:SGTC_3331|Compound:9141060|FD-Score:4.47|P-value:5.41E-6

Top fitness defect scores for YKL121W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 8.43 51.8 µM 5.75E-17 ERAD & cell cycle 46 1.77E-17
2 SGTC_2436 5633522 8.41 8.1 µM 6.42E-17 2 1.99E-17
3 SGTC_58 0957-0393 7.90 9.0 µM 4.03E-15 cell wall 126 1.44E-15
4 SGTC_453 enantio-paf c16 6.80 10.0 µM 1.14E-11 29 5.31E-12
5 SGTC_2255 7941087 6.01 197.4 µM 1.66E-9 9 9.18E-10
6 SGTC_1200 1643-0193 5.59 18.4 µM 1.90E-8 5 1.14E-8
7 SGTC_435 c-PAF 5.50 6.7 µM 3.12E-8 13 1.90E-8
8 SGTC_2896 9052656 5.36 71.4 µM 6.82E-8 endomembrane recycling 47 4.26E-8
9 SGTC_2752 diclazuril 5.31 33.1 µM 8.84E-8 70 5.56E-8
10 SGTC_829 1635-0120 5.04 117.0 µM 3.51E-7 DNA damage response 18 2.31E-7
11 SGTC_1790 st045711 4.75 43.5 µM 1.45E-6 8 1.00E-6
12 SGTC_1391 3442-0225 4.72 151.0 µM 1.66E-6 3 1.15E-6
13 SGTC_673 1082-0474 4.65 110.0 µM 2.36E-6 RSC complex & mRNA processing 41 1.65E-6
14 SGTC_2800 7887935 4.58 81.8 µM 3.29E-6 RPP1 & pyrimidine depletion 12 2.33E-6
15 SGTC_2017 5132927 4.53 60.6 µM 4.10E-6 18 2.93E-6
16 SGTC_3331 9141060 4.47 2.0 µM 5.41E-6 cell wall 21 3.90E-6
17 SGTC_2317 5986382 4.45 200.0 µM 5.93E-6 7 4.28E-6
18 SGTC_1808 st050063 4.44 61.5 µM 6.34E-6 6 4.59E-6
19 SGTC_2200 6600604 4.35 21.9 µM 9.21E-6 tubulin folding & SWR complex 43 6.75E-6
20 SGTC_568 1193-0097 4.19 7.5 µM 1.87E-5 ERAD & cell cycle 134 1.41E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 6.66E-43 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.206 1.94E-33 YHR104W GRE3 hom Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.201 6.64E-32 YOR034C-A_p YOR034C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.190 8.90E-29 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.184 6.27E-27 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.179 1.87E-25 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.174 2.93E-24 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.172 1.43E-23 YML017W PSP2 hom Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
0.169 6.04E-23 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.168 1.24E-22 YBR208C DUR1,2 hom Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
0.165 6.48E-22 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.163 2.38E-21 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.159 1.58E-20 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.159 2.53E-20 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.157 4.82E-20 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases