YKL126W / YPK1

Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL126W / YPK1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:8.93|P-value:1.42E-6 ID:SGTC_33|Compound:0986-0033|FD-Score:9.04|P-value:1.05E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:9.64|P-value:2.06E-7 ID:SGTC_39|Compound:0986-0283|FD-Score:12.10|P-value:7.95E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:7.95|P-value:1.58E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:8.82|P-value:1.86E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:7.44|P-value:5.07E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:8.23|P-value:8.10E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:14.90|P-value:1.60E-15 ID:SGTC_142|Compound:0335-0849|FD-Score:13.10|P-value:1.94E-12 ID:SGTC_146|Compound:3448-8650|FD-Score:7.48|P-value:4.68E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:6.24|P-value:5.88E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:16.60|P-value:8.45E-19 ID:SGTC_197|Compound:4544-0043|FD-Score:16.20|P-value:5.14E-18 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.51|P-value:2.93E-7 ID:SGTC_232|Compound:clozapine|FD-Score:8.42|P-value:5.12E-6 ID:SGTC_233|Compound:rapamycin|FD-Score:6.11|P-value:7.45E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:14.60|P-value:6.18E-15 ID:SGTC_266|Compound:formosanin C|FD-Score:12.20|P-value:7.06E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:14.20|P-value:2.63E-14 ID:SGTC_313|Compound:3474-0040|FD-Score:7.72|P-value:2.71E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:8.34|P-value:6.31E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:9.78|P-value:1.39E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:6.09|P-value:7.72E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:7.75|P-value:2.52E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:10.00|P-value:7.42E-8 ID:SGTC_429|Compound:1112-0049|FD-Score:8.27|P-value:7.48E-6 ID:SGTC_459|Compound:nigericin|FD-Score:6.59|P-value:3.02E-4 ID:SGTC_500|Compound:h-89|FD-Score:7.28|P-value:7.18E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:9.27|P-value:5.66E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:10.50|P-value:1.91E-8 ID:SGTC_518|Compound:1021-0119|FD-Score:13.80|P-value:1.76E-13 ID:SGTC_527|Compound:4476-4215|FD-Score:7.64|P-value:3.24E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:12.10|P-value:1.00E-10 ID:SGTC_598|Compound:3937-0236|FD-Score:6.25|P-value:5.73E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:13.50|P-value:5.12E-13 ID:SGTC_637|Compound:1181-0519|FD-Score:20.50|P-value:9.11E-28 ID:SGTC_662|Compound:k832-1615|FD-Score:6.01|P-value:8.93E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:11.50|P-value:6.32E-10 ID:SGTC_710|Compound:3448-4187|FD-Score:13.20|P-value:1.93E-12 ID:SGTC_724|Compound:3910-0327|FD-Score:21.90|P-value:1.89E-31 ID:SGTC_771|Compound:0250-0039|FD-Score:6.77|P-value:2.09E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:10.30|P-value:2.77E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:6.22|P-value:6.07E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:15.80|P-value:3.63E-17 ID:SGTC_841|Compound:0251-0215|FD-Score:17.30|P-value:3.00E-20 ID:SGTC_864|Compound:0469-0573|FD-Score:-6.03|P-value:4.56E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:8.44|P-value:4.88E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:12.40|P-value:2.98E-11 ID:SGTC_887|Compound:0885-0007|FD-Score:14.20|P-value:2.61E-14 ID:SGTC_896|Compound:0964-0007|FD-Score:8.32|P-value:6.65E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:7.26|P-value:7.59E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:8.74|P-value:2.32E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:6.39|P-value:4.40E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:6.63|P-value:2.77E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:20.10|P-value:7.96E-27 ID:SGTC_952|Compound:1185-0122|FD-Score:7.28|P-value:7.14E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:8.52|P-value:4.01E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:8.95|P-value:1.34E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:7.17|P-value:9.07E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:15.70|P-value:5.72E-17 ID:SGTC_995|Compound:3931-2021|FD-Score:7.41|P-value:5.39E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:7.47|P-value:4.73E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:6.45|P-value:3.93E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.38|P-value:4.52E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:10.60|P-value:1.05E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:8.20|P-value:8.78E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:7.90|P-value:1.79E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:6.67|P-value:2.57E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.88|P-value:1.60E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:6.96|P-value:1.42E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:12.50|P-value:1.81E-11 ID:SGTC_1206|Compound:3978-0017|FD-Score:8.34|P-value:6.33E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:12.30|P-value:3.67E-11 ID:SGTC_1308|Compound:1187-1617|FD-Score:6.04|P-value:8.53E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:7.44|P-value:5.11E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:12.00|P-value:1.49E-10 ID:SGTC_1402|Compound:3909-7673|FD-Score:7.44|P-value:5.06E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:6.80|P-value:1.97E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:8.63|P-value:3.02E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:18.60|P-value:2.64E-23 ID:SGTC_1413|Compound:3910-0535|FD-Score:8.51|P-value:4.16E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:11.40|P-value:1.12E-9 ID:SGTC_1430|Compound:4049-0248|FD-Score:7.29|P-value:7.10E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:7.25|P-value:7.68E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:25.70|P-value:1.25E-42 ID:SGTC_1453|Compound:4237-0541|FD-Score:8.31|P-value:6.77E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:21.30|P-value:6.75E-30 ID:SGTC_1495|Compound:4469-0029|FD-Score:17.90|P-value:1.42E-21 ID:SGTC_1506|Compound:4226-2149|FD-Score:8.70|P-value:2.54E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:9.60|P-value:2.28E-7 ID:SGTC_1545|Compound:lovastatin|FD-Score:10.90|P-value:4.31E-9 ID:SGTC_1568|Compound:digitonin|FD-Score:15.50|P-value:1.32E-16 ID:SGTC_1573|Compound:oleylamine|FD-Score:14.10|P-value:4.19E-14 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:7.22|P-value:8.10E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:14.00|P-value:7.72E-14 ID:SGTC_1625|Compound:st003711|FD-Score:6.85|P-value:1.79E-4 ID:SGTC_1627|Compound:st003713|FD-Score:16.80|P-value:3.51E-19 ID:SGTC_1643|Compound:st009866|FD-Score:6.89|P-value:1.65E-4 ID:SGTC_1666|Compound:st014829|FD-Score:6.23|P-value:5.99E-4 ID:SGTC_1672|Compound:st016598|FD-Score:17.60|P-value:6.20E-21 ID:SGTC_1687|Compound:st020778|FD-Score:24.90|P-value:2.41E-40 ID:SGTC_1694|Compound:st024011|FD-Score:15.10|P-value:6.34E-16 ID:SGTC_1712|Compound:st032288|FD-Score:10.70|P-value:9.29E-9 ID:SGTC_1721|Compound:st082152|FD-Score:10.30|P-value:2.68E-8 ID:SGTC_1748|Compound:st037455|FD-Score:14.60|P-value:6.92E-15 ID:SGTC_1750|Compound:st081859|FD-Score:7.77|P-value:2.44E-5 ID:SGTC_1752|Compound:st044819|FD-Score:8.46|P-value:4.61E-6 ID:SGTC_1754|Compound:st042065|FD-Score:9.01|P-value:1.13E-6 ID:SGTC_1760|Compound:st045453|FD-Score:14.60|P-value:6.35E-15 ID:SGTC_1781|Compound:st038725|FD-Score:18.90|P-value:6.76E-24 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:15.90|P-value:2.33E-17 ID:SGTC_1788|Compound:fluconazole|FD-Score:12.70|P-value:1.06E-11 ID:SGTC_1826|Compound:st055655|FD-Score:18.90|P-value:8.33E-24 ID:SGTC_1859|Compound:st055998|FD-Score:6.42|P-value:4.18E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:10.40|P-value:2.24E-8 ID:SGTC_1876|Compound:myriocin|FD-Score:10.60|P-value:1.20E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.20|P-value:3.89E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:7.94|P-value:1.62E-5 ID:SGTC_1892|Compound:st058411|FD-Score:6.49|P-value:3.63E-4 ID:SGTC_1904|Compound:st060225|FD-Score:6.29|P-value:5.38E-4 ID:SGTC_1916|Compound:st067606|FD-Score:11.70|P-value:3.91E-10 ID:SGTC_1934|Compound:st074720|FD-Score:8.87|P-value:1.64E-6 ID:SGTC_1966|Compound:st070145|FD-Score:9.46|P-value:3.41E-7 ID:SGTC_1973|Compound:st070275|FD-Score:11.00|P-value:3.18E-9 ID:SGTC_1982|Compound:st072467|FD-Score:8.14|P-value:1.01E-5 ID:SGTC_1991|Compound:st073000|FD-Score:7.33|P-value:6.44E-5 ID:SGTC_2077|Compound:5212015|FD-Score:12.60|P-value:1.63E-11 ID:SGTC_2092|Compound:5303694|FD-Score:9.63|P-value:2.09E-7 ID:SGTC_2093|Compound:5331342|FD-Score:6.81|P-value:1.92E-4 ID:SGTC_2141|Compound:5621638|FD-Score:6.28|P-value:5.50E-4 ID:SGTC_2157|Compound:5649910|FD-Score:6.76|P-value:2.14E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.38|P-value:4.51E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:12.00|P-value:1.32E-10 ID:SGTC_2248|Compound:tofa|FD-Score:9.15|P-value:7.91E-7 ID:SGTC_2265|Compound:7929201|FD-Score:10.50|P-value:1.43E-8 ID:SGTC_2339|Compound:9000433|FD-Score:6.67|P-value:2.54E-4 ID:SGTC_2360|Compound:9040895|FD-Score:6.28|P-value:5.45E-4 ID:SGTC_2367|Compound:9070478|FD-Score:6.39|P-value:4.44E-4 ID:SGTC_2380|Compound:9035439|FD-Score:7.69|P-value:2.90E-5 ID:SGTC_2389|Compound:9091542|FD-Score:9.03|P-value:1.07E-6 ID:SGTC_2395|Compound:5646831|FD-Score:7.76|P-value:2.50E-5 ID:SGTC_2401|Compound:5128683|FD-Score:6.60|P-value:2.92E-4 ID:SGTC_2403|Compound:6032726|FD-Score:8.74|P-value:2.31E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.43|P-value:4.06E-4 ID:SGTC_2440|Compound:5628896|FD-Score:8.04|P-value:1.30E-5 ID:SGTC_2443|Compound:5493264|FD-Score:6.66|P-value:2.59E-4 ID:SGTC_2459|Compound:5811157|FD-Score:7.49|P-value:4.50E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:9.32|P-value:5.03E-7 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:9.02|P-value:1.10E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:7.73|P-value:2.68E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:7.00|P-value:1.31E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.62|P-value:3.39E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:8.67|P-value:2.78E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:8.08|P-value:1.17E-5 ID:SGTC_2585|Compound:alliin|FD-Score:11.60|P-value:5.79E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:9.02|P-value:1.12E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:10.10|P-value:5.34E-8 ID:SGTC_2618|Compound:avocadyne|FD-Score:17.40|P-value:1.48E-20 ID:SGTC_2620|Compound:irigenin|FD-Score:19.60|P-value:1.17E-25 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:7.25|P-value:7.75E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:7.03|P-value:1.22E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:9.32|P-value:4.97E-7 ID:SGTC_2740|Compound:felodipine|FD-Score:10.10|P-value:5.42E-8 ID:SGTC_2765|Compound:myclobutanil|FD-Score:13.70|P-value:2.12E-13 ID:SGTC_2766|Compound:oltipraz|FD-Score:10.60|P-value:1.13E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:15.20|P-value:4.63E-16 ID:SGTC_2862|Compound:9027634|FD-Score:6.68|P-value:2.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.41|P-value:5.32E-6 ID:SGTC_2938|Compound:9059746|FD-Score:9.97|P-value:7.97E-8 ID:SGTC_2939|Compound:9044578|FD-Score:19.20|P-value:1.04E-24 ID:SGTC_2980|Compound:9014342|FD-Score:10.00|P-value:6.74E-8 ID:SGTC_2987|Compound:9018338|FD-Score:8.63|P-value:3.01E-6 ID:SGTC_3025|Compound:9087895|FD-Score:6.29|P-value:5.33E-4 ID:SGTC_3028|Compound:9087778|FD-Score:9.43|P-value:3.69E-7 ID:SGTC_3085|Compound:9117376|FD-Score:10.50|P-value:1.61E-8 ID:SGTC_3130|Compound:9127414|FD-Score:7.01|P-value:1.27E-4 ID:SGTC_3167|Compound:9103034|FD-Score:6.62|P-value:2.82E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.27|P-value:5.52E-4 ID:SGTC_3237|Compound:9133362|FD-Score:14.40|P-value:1.29E-14 ID:SGTC_3284|Compound:9108171|FD-Score:9.10|P-value:8.87E-7 ID:SGTC_3311|Compound:9131146|FD-Score:9.36|P-value:4.42E-7 ID:SGTC_7|Compound:0192-1582|FD-Score:8.93|P-value:1.42E-6 ID:SGTC_33|Compound:0986-0033|FD-Score:9.04|P-value:1.05E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:9.64|P-value:2.06E-7 ID:SGTC_39|Compound:0986-0283|FD-Score:12.10|P-value:7.95E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:7.95|P-value:1.58E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:8.82|P-value:1.86E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:7.44|P-value:5.07E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:8.23|P-value:8.10E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:14.90|P-value:1.60E-15 ID:SGTC_142|Compound:0335-0849|FD-Score:13.10|P-value:1.94E-12 ID:SGTC_146|Compound:3448-8650|FD-Score:7.48|P-value:4.68E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:6.24|P-value:5.88E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:16.60|P-value:8.45E-19 ID:SGTC_197|Compound:4544-0043|FD-Score:16.20|P-value:5.14E-18 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.51|P-value:2.93E-7 ID:SGTC_232|Compound:clozapine|FD-Score:8.42|P-value:5.12E-6 ID:SGTC_233|Compound:rapamycin|FD-Score:6.11|P-value:7.45E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:14.60|P-value:6.18E-15 ID:SGTC_266|Compound:formosanin C|FD-Score:12.20|P-value:7.06E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:14.20|P-value:2.63E-14 ID:SGTC_313|Compound:3474-0040|FD-Score:7.72|P-value:2.71E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:8.34|P-value:6.31E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:9.78|P-value:1.39E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:6.09|P-value:7.72E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:7.75|P-value:2.52E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:10.00|P-value:7.42E-8 ID:SGTC_429|Compound:1112-0049|FD-Score:8.27|P-value:7.48E-6 ID:SGTC_459|Compound:nigericin|FD-Score:6.59|P-value:3.02E-4 ID:SGTC_500|Compound:h-89|FD-Score:7.28|P-value:7.18E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:9.27|P-value:5.66E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:10.50|P-value:1.91E-8 ID:SGTC_518|Compound:1021-0119|FD-Score:13.80|P-value:1.76E-13 ID:SGTC_527|Compound:4476-4215|FD-Score:7.64|P-value:3.24E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:12.10|P-value:1.00E-10 ID:SGTC_598|Compound:3937-0236|FD-Score:6.25|P-value:5.73E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:13.50|P-value:5.12E-13 ID:SGTC_637|Compound:1181-0519|FD-Score:20.50|P-value:9.11E-28 ID:SGTC_662|Compound:k832-1615|FD-Score:6.01|P-value:8.93E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:11.50|P-value:6.32E-10 ID:SGTC_710|Compound:3448-4187|FD-Score:13.20|P-value:1.93E-12 ID:SGTC_724|Compound:3910-0327|FD-Score:21.90|P-value:1.89E-31 ID:SGTC_771|Compound:0250-0039|FD-Score:6.77|P-value:2.09E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:10.30|P-value:2.77E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:6.22|P-value:6.07E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:15.80|P-value:3.63E-17 ID:SGTC_841|Compound:0251-0215|FD-Score:17.30|P-value:3.00E-20 ID:SGTC_864|Compound:0469-0573|FD-Score:-6.03|P-value:4.56E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:8.44|P-value:4.88E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:12.40|P-value:2.98E-11 ID:SGTC_887|Compound:0885-0007|FD-Score:14.20|P-value:2.61E-14 ID:SGTC_896|Compound:0964-0007|FD-Score:8.32|P-value:6.65E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:7.26|P-value:7.59E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:8.74|P-value:2.32E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:6.39|P-value:4.40E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:6.63|P-value:2.77E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:20.10|P-value:7.96E-27 ID:SGTC_952|Compound:1185-0122|FD-Score:7.28|P-value:7.14E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:8.52|P-value:4.01E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:8.95|P-value:1.34E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:7.17|P-value:9.07E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:15.70|P-value:5.72E-17 ID:SGTC_995|Compound:3931-2021|FD-Score:7.41|P-value:5.39E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:7.47|P-value:4.73E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:6.45|P-value:3.93E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.38|P-value:4.52E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:10.60|P-value:1.05E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:8.20|P-value:8.78E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:7.90|P-value:1.79E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:6.67|P-value:2.57E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.88|P-value:1.60E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:6.96|P-value:1.42E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:12.50|P-value:1.81E-11 ID:SGTC_1206|Compound:3978-0017|FD-Score:8.34|P-value:6.33E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:12.30|P-value:3.67E-11 ID:SGTC_1308|Compound:1187-1617|FD-Score:6.04|P-value:8.53E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:7.44|P-value:5.11E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:12.00|P-value:1.49E-10 ID:SGTC_1402|Compound:3909-7673|FD-Score:7.44|P-value:5.06E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:6.80|P-value:1.97E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:8.63|P-value:3.02E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:18.60|P-value:2.64E-23 ID:SGTC_1413|Compound:3910-0535|FD-Score:8.51|P-value:4.16E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:11.40|P-value:1.12E-9 ID:SGTC_1430|Compound:4049-0248|FD-Score:7.29|P-value:7.10E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:7.25|P-value:7.68E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:25.70|P-value:1.25E-42 ID:SGTC_1453|Compound:4237-0541|FD-Score:8.31|P-value:6.77E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:21.30|P-value:6.75E-30 ID:SGTC_1495|Compound:4469-0029|FD-Score:17.90|P-value:1.42E-21 ID:SGTC_1506|Compound:4226-2149|FD-Score:8.70|P-value:2.54E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:9.60|P-value:2.28E-7 ID:SGTC_1545|Compound:lovastatin|FD-Score:10.90|P-value:4.31E-9 ID:SGTC_1568|Compound:digitonin|FD-Score:15.50|P-value:1.32E-16 ID:SGTC_1573|Compound:oleylamine|FD-Score:14.10|P-value:4.19E-14 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:7.22|P-value:8.10E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:14.00|P-value:7.72E-14 ID:SGTC_1625|Compound:st003711|FD-Score:6.85|P-value:1.79E-4 ID:SGTC_1627|Compound:st003713|FD-Score:16.80|P-value:3.51E-19 ID:SGTC_1643|Compound:st009866|FD-Score:6.89|P-value:1.65E-4 ID:SGTC_1666|Compound:st014829|FD-Score:6.23|P-value:5.99E-4 ID:SGTC_1672|Compound:st016598|FD-Score:17.60|P-value:6.20E-21 ID:SGTC_1687|Compound:st020778|FD-Score:24.90|P-value:2.41E-40 ID:SGTC_1694|Compound:st024011|FD-Score:15.10|P-value:6.34E-16 ID:SGTC_1712|Compound:st032288|FD-Score:10.70|P-value:9.29E-9 ID:SGTC_1721|Compound:st082152|FD-Score:10.30|P-value:2.68E-8 ID:SGTC_1748|Compound:st037455|FD-Score:14.60|P-value:6.92E-15 ID:SGTC_1750|Compound:st081859|FD-Score:7.77|P-value:2.44E-5 ID:SGTC_1752|Compound:st044819|FD-Score:8.46|P-value:4.61E-6 ID:SGTC_1754|Compound:st042065|FD-Score:9.01|P-value:1.13E-6 ID:SGTC_1760|Compound:st045453|FD-Score:14.60|P-value:6.35E-15 ID:SGTC_1781|Compound:st038725|FD-Score:18.90|P-value:6.76E-24 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:15.90|P-value:2.33E-17 ID:SGTC_1788|Compound:fluconazole|FD-Score:12.70|P-value:1.06E-11 ID:SGTC_1826|Compound:st055655|FD-Score:18.90|P-value:8.33E-24 ID:SGTC_1859|Compound:st055998|FD-Score:6.42|P-value:4.18E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:10.40|P-value:2.24E-8 ID:SGTC_1876|Compound:myriocin|FD-Score:10.60|P-value:1.20E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.20|P-value:3.89E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:7.94|P-value:1.62E-5 ID:SGTC_1892|Compound:st058411|FD-Score:6.49|P-value:3.63E-4 ID:SGTC_1904|Compound:st060225|FD-Score:6.29|P-value:5.38E-4 ID:SGTC_1916|Compound:st067606|FD-Score:11.70|P-value:3.91E-10 ID:SGTC_1934|Compound:st074720|FD-Score:8.87|P-value:1.64E-6 ID:SGTC_1966|Compound:st070145|FD-Score:9.46|P-value:3.41E-7 ID:SGTC_1973|Compound:st070275|FD-Score:11.00|P-value:3.18E-9 ID:SGTC_1982|Compound:st072467|FD-Score:8.14|P-value:1.01E-5 ID:SGTC_1991|Compound:st073000|FD-Score:7.33|P-value:6.44E-5 ID:SGTC_2077|Compound:5212015|FD-Score:12.60|P-value:1.63E-11 ID:SGTC_2092|Compound:5303694|FD-Score:9.63|P-value:2.09E-7 ID:SGTC_2093|Compound:5331342|FD-Score:6.81|P-value:1.92E-4 ID:SGTC_2141|Compound:5621638|FD-Score:6.28|P-value:5.50E-4 ID:SGTC_2157|Compound:5649910|FD-Score:6.76|P-value:2.14E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.38|P-value:4.51E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:12.00|P-value:1.32E-10 ID:SGTC_2248|Compound:tofa|FD-Score:9.15|P-value:7.91E-7 ID:SGTC_2265|Compound:7929201|FD-Score:10.50|P-value:1.43E-8 ID:SGTC_2339|Compound:9000433|FD-Score:6.67|P-value:2.54E-4 ID:SGTC_2360|Compound:9040895|FD-Score:6.28|P-value:5.45E-4 ID:SGTC_2367|Compound:9070478|FD-Score:6.39|P-value:4.44E-4 ID:SGTC_2380|Compound:9035439|FD-Score:7.69|P-value:2.90E-5 ID:SGTC_2389|Compound:9091542|FD-Score:9.03|P-value:1.07E-6 ID:SGTC_2395|Compound:5646831|FD-Score:7.76|P-value:2.50E-5 ID:SGTC_2401|Compound:5128683|FD-Score:6.60|P-value:2.92E-4 ID:SGTC_2403|Compound:6032726|FD-Score:8.74|P-value:2.31E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.43|P-value:4.06E-4 ID:SGTC_2440|Compound:5628896|FD-Score:8.04|P-value:1.30E-5 ID:SGTC_2443|Compound:5493264|FD-Score:6.66|P-value:2.59E-4 ID:SGTC_2459|Compound:5811157|FD-Score:7.49|P-value:4.50E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:9.32|P-value:5.03E-7 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:9.02|P-value:1.10E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:7.73|P-value:2.68E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:7.00|P-value:1.31E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.62|P-value:3.39E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:8.67|P-value:2.78E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:8.08|P-value:1.17E-5 ID:SGTC_2585|Compound:alliin|FD-Score:11.60|P-value:5.79E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:9.02|P-value:1.12E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:10.10|P-value:5.34E-8 ID:SGTC_2618|Compound:avocadyne|FD-Score:17.40|P-value:1.48E-20 ID:SGTC_2620|Compound:irigenin|FD-Score:19.60|P-value:1.17E-25 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:7.25|P-value:7.75E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:7.03|P-value:1.22E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:9.32|P-value:4.97E-7 ID:SGTC_2740|Compound:felodipine|FD-Score:10.10|P-value:5.42E-8 ID:SGTC_2765|Compound:myclobutanil|FD-Score:13.70|P-value:2.12E-13 ID:SGTC_2766|Compound:oltipraz|FD-Score:10.60|P-value:1.13E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:15.20|P-value:4.63E-16 ID:SGTC_2862|Compound:9027634|FD-Score:6.68|P-value:2.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.41|P-value:5.32E-6 ID:SGTC_2938|Compound:9059746|FD-Score:9.97|P-value:7.97E-8 ID:SGTC_2939|Compound:9044578|FD-Score:19.20|P-value:1.04E-24 ID:SGTC_2980|Compound:9014342|FD-Score:10.00|P-value:6.74E-8 ID:SGTC_2987|Compound:9018338|FD-Score:8.63|P-value:3.01E-6 ID:SGTC_3025|Compound:9087895|FD-Score:6.29|P-value:5.33E-4 ID:SGTC_3028|Compound:9087778|FD-Score:9.43|P-value:3.69E-7 ID:SGTC_3085|Compound:9117376|FD-Score:10.50|P-value:1.61E-8 ID:SGTC_3130|Compound:9127414|FD-Score:7.01|P-value:1.27E-4 ID:SGTC_3167|Compound:9103034|FD-Score:6.62|P-value:2.82E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.27|P-value:5.52E-4 ID:SGTC_3237|Compound:9133362|FD-Score:14.40|P-value:1.29E-14 ID:SGTC_3284|Compound:9108171|FD-Score:9.10|P-value:8.87E-7 ID:SGTC_3311|Compound:9131146|FD-Score:9.36|P-value:4.42E-7

Top fitness defect scores for YKL126W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1450 4112-4260 25.70 37.6 µM 1.25E-42 calcium & mitochondrial duress 2 1.63E-145
2 SGTC_1687 st020778 24.90 55.4 µM 2.41E-40 2 1.65E-137
3 SGTC_724 3910-0327 21.90 137.0 µM 1.89E-31 ERG2 2 2.44E-106
4 SGTC_1464 k208-0027 21.30 110.0 µM 6.75E-30 1 6.73E-101
5 SGTC_637 1181-0519 20.50 7.3 µM 9.11E-28 fatty acid desaturase (OLE1) 4 1.96E-93
6 SGTC_951 1171-0579 20.10 82.7 µM 7.96E-27 cell wall 2 3.88E-90
7 SGTC_2620 irigenin 19.60 100.0 µM 1.17E-25 1 4.74E-86
8 SGTC_2939 9044578 19.20 71.4 µM 1.04E-24 2 9.99E-83
9 SGTC_1781 st038725 18.90 66.3 µM 6.76E-24 NEO1 5 7.05E-80
10 SGTC_1826 st055655 18.90 41.6 µM 8.33E-24 ERG2 3 1.46E-79
11 SGTC_1411 3909-8223 18.60 150.0 µM 2.64E-23 1 8.37E-78
12 SGTC_1495 4469-0029 17.90 237.0 µM 1.42E-21 1 9.63E-72
13 SGTC_1672 st016598 17.60 6.5 µM 6.20E-21 endomembrane recycling 2 1.67E-69
14 SGTC_2618 avocadyne 17.40 43.4 µM 1.48E-20 7 3.51E-68
15 SGTC_841 0251-0215 17.30 91.2 µM 3.00E-20 3 4.14E-67
16 SGTC_1627 st003713 16.80 25.6 µM 3.51E-19 calcium & mitochondrial duress 2 2.29E-63
17 SGTC_181 1447-1644 16.60 8.1 µM 8.45E-19 endomembrane recycling 2 4.93E-62
18 SGTC_197 4544-0043 16.20 41.6 µM 5.14E-18 endomembrane recycling 2 2.73E-59
19 SGTC_1785 bathophenanthroline 15.90 24.0 µM 2.33E-17 heme requiring 1 5.43E-57
20 SGTC_813 k007-0158 15.80 173.0 µM 3.63E-17 fatty acid desaturase (OLE1) 1 2.54E-56

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 1.19E-72 YMR202W ERG2 hom C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
0.304 1.26E-72 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.288 5.09E-65 YGL054C ERV14 hom COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
0.246 3.04E-47 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.236 1.05E-43 YKL212W SAC1 hom Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
0.230 1.89E-41 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.219 1.26E-37 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.214 6.35E-36 YLR372W SUR4 hom Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.209 2.03E-34 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.203 2.11E-32 YNL323W LEM3 hom Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
0.196 1.65E-30 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.196 1.71E-30 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.193 1.85E-29 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.192 3.96E-29 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.185 5.22E-27 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton