YKL127W / PGM1

Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL127W / PGM1

Click on Significant Values for Screen Details ID:SGTC_321|Compound:4534-3890|FD-Score:3.31|P-value:8.15E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:2.74|P-value:9.20E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.64|P-value:1.75E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.27|P-value:1.09E-4 ID:SGTC_444|Compound:curcumin|FD-Score:2.89|P-value:5.10E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-2.78|P-value:8.46E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.02|P-value:3.24E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:2.73|P-value:9.45E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.65|P-value:1.84E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:-2.88|P-value:5.77E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-2.78|P-value:8.52E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.00|P-value:3.15E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.40|P-value:2.88E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.16|P-value:1.81E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.36|P-value:6.64E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:2.97|P-value:3.60E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:2.74|P-value:9.00E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-2.87|P-value:5.91E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.45|P-value:2.09E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.03|P-value:2.83E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:5.67|P-value:5.77E-11 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.17|P-value:1.58E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.95|P-value:4.34E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.91|P-value:1.37E-8 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.23|P-value:1.31E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-3.35|P-value:7.70E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.24|P-value:1.26E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-2.96|P-value:4.12E-4 ID:SGTC_1799|Compound:st045822|FD-Score:4.36|P-value:3.57E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.39|P-value:3.54E-7 ID:SGTC_1933|Compound:st074711|FD-Score:-3.44|P-value:4.98E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.51|P-value:3.33E-5 ID:SGTC_2095|Compound:5432005|FD-Score:2.97|P-value:3.59E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.29|P-value:9.28E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-3.05|P-value:2.89E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.23|P-value:1.29E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.68|P-value:1.41E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.38|P-value:6.15E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.37|P-value:7.14E-5 ID:SGTC_2421|Compound:5690543|FD-Score:4.96|P-value:8.96E-9 ID:SGTC_2436|Compound:5633522|FD-Score:2.91|P-value:4.71E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.62|P-value:7.41E-8 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.35|P-value:7.60E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.14|P-value:1.42E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.65|P-value:1.86E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.36|P-value:3.69E-7 ID:SGTC_2718|Compound:lomofungin|FD-Score:-2.98|P-value:3.78E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-4.51|P-value:1.66E-7 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.51|P-value:3.72E-5 ID:SGTC_2780|Compound:5215298|FD-Score:2.88|P-value:5.24E-4 ID:SGTC_2806|Compound:7952793|FD-Score:2.99|P-value:3.29E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-2.93|P-value:4.70E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.09|P-value:2.36E-4 ID:SGTC_2828|Compound:7998861|FD-Score:2.84|P-value:6.07E-4 ID:SGTC_2985|Compound:9022375|FD-Score:2.72|P-value:9.94E-4 ID:SGTC_3021|Compound:9087658|FD-Score:2.98|P-value:3.53E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.77|P-value:8.15E-4 ID:SGTC_3147|Compound:9097027|FD-Score:2.75|P-value:8.65E-4 ID:SGTC_3166|Compound:9102297|FD-Score:2.89|P-value:5.08E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-2.88|P-value:5.65E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.98|P-value:3.50E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.81|P-value:7.22E-6 ID:SGTC_3349|Compound:9149703|FD-Score:2.72|P-value:9.86E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.31|P-value:8.15E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:2.74|P-value:9.20E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.64|P-value:1.75E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.27|P-value:1.09E-4 ID:SGTC_444|Compound:curcumin|FD-Score:2.89|P-value:5.10E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-2.78|P-value:8.46E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.02|P-value:3.24E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:2.73|P-value:9.45E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.65|P-value:1.84E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:-2.88|P-value:5.77E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-2.78|P-value:8.52E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.00|P-value:3.15E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.40|P-value:2.88E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.16|P-value:1.81E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.36|P-value:6.64E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:2.97|P-value:3.60E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:2.74|P-value:9.00E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-2.87|P-value:5.91E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.45|P-value:2.09E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.03|P-value:2.83E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:5.67|P-value:5.77E-11 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.17|P-value:1.58E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.95|P-value:4.34E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.91|P-value:1.37E-8 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.23|P-value:1.31E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-3.35|P-value:7.70E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.24|P-value:1.26E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-2.96|P-value:4.12E-4 ID:SGTC_1799|Compound:st045822|FD-Score:4.36|P-value:3.57E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.39|P-value:3.54E-7 ID:SGTC_1933|Compound:st074711|FD-Score:-3.44|P-value:4.98E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.51|P-value:3.33E-5 ID:SGTC_2095|Compound:5432005|FD-Score:2.97|P-value:3.59E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.29|P-value:9.28E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-3.05|P-value:2.89E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.23|P-value:1.29E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.68|P-value:1.41E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.38|P-value:6.15E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.37|P-value:7.14E-5 ID:SGTC_2421|Compound:5690543|FD-Score:4.96|P-value:8.96E-9 ID:SGTC_2436|Compound:5633522|FD-Score:2.91|P-value:4.71E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.62|P-value:7.41E-8 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.35|P-value:7.60E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.14|P-value:1.42E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.65|P-value:1.86E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.36|P-value:3.69E-7 ID:SGTC_2718|Compound:lomofungin|FD-Score:-2.98|P-value:3.78E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-4.51|P-value:1.66E-7 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.51|P-value:3.72E-5 ID:SGTC_2780|Compound:5215298|FD-Score:2.88|P-value:5.24E-4 ID:SGTC_2806|Compound:7952793|FD-Score:2.99|P-value:3.29E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-2.93|P-value:4.70E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.09|P-value:2.36E-4 ID:SGTC_2828|Compound:7998861|FD-Score:2.84|P-value:6.07E-4 ID:SGTC_2985|Compound:9022375|FD-Score:2.72|P-value:9.94E-4 ID:SGTC_3021|Compound:9087658|FD-Score:2.98|P-value:3.53E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.77|P-value:8.15E-4 ID:SGTC_3147|Compound:9097027|FD-Score:2.75|P-value:8.65E-4 ID:SGTC_3166|Compound:9102297|FD-Score:2.89|P-value:5.08E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-2.88|P-value:5.65E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.98|P-value:3.50E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.81|P-value:7.22E-6 ID:SGTC_3349|Compound:9149703|FD-Score:2.72|P-value:9.86E-4

Top fitness defect scores for YKL127W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1367 1812-0510 5.67 76.9 µM 5.77E-11 3 6.98E-9
2 SGTC_2421 5690543 4.96 90.7 µM 8.96E-9 6 3.60E-7
3 SGTC_2573 2',4'-dihydroxychalcone 4.62 15.0 µM 7.41E-8 27 1.88E-6
4 SGTC_1364 1653-0028 4.45 37.6 µM 2.09E-7 12 4.24E-6
5 SGTC_1097 itavastatin 4.40 7.2 µM 2.88E-7 azole & statin 14 5.45E-6
6 SGTC_1799 st045822 4.36 46.1 µM 3.57E-7 10 6.45E-6
7 SGTC_2603 homopterocarpin 4.36 100.0 µM 3.69E-7 21 6.62E-6
8 SGTC_3344 9148862 3.81 3.9 µM 7.22E-6 13 6.82E-5
9 SGTC_2368 9071271 3.68 200.0 µM 1.41E-5 44 1.16E-4
10 SGTC_342 k048-0088 3.64 23.3 µM 1.75E-5 RSC & ERG11 28 1.37E-4
11 SGTC_2015 5119600 3.51 184.0 µM 3.33E-5 41 2.27E-4
12 SGTC_2389 9091542 3.38 195.5 µM 6.15E-5 iron homeostasis 58 3.68E-4
13 SGTC_1149 3909-7961 3.36 23.3 µM 6.64E-5 45 3.91E-4
14 SGTC_321 4534-3890 3.31 65.3 µM 8.15E-5 RPP1 & pyrimidine depletion 14 4.59E-4
15 SGTC_2098 5376439 3.29 882.5 nM 9.28E-5 29 5.08E-4
16 SGTC_1456 k015-0012 3.17 13.0 µM 1.58E-4 63 7.71E-4
17 SGTC_1365 1672-3266 3.03 55.4 µM 2.83E-4 62 0.00122
18 SGTC_774 k060-0086 3.00 136.0 µM 3.15E-4 56 0.00133
19 SGTC_2806 7952793 2.99 58.4 µM 3.29E-4 69 0.00138
20 SGTC_3323 9138564 2.98 53.9 µM 3.50E-4 61 0.00145

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.57E-22 YOR345C_d YOR345C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.124 5.57E-13 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.120 2.97E-12 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.115 2.00E-11 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.115 2.14E-11 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.113 5.77E-11 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.113 6.15E-11 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
0.112 6.97E-11 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.111 1.02E-10 YMR226C YMR226C hom NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
0.110 1.62E-10 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.107 4.69E-10 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.103 2.04E-9 YML081C-A ATP18 hom Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
0.103 2.48E-9 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.103 2.52E-9 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.102 3.56E-9 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress