YKL128C / PMU1

Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL128C / PMU1

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-3.84|P-value:5.99E-6 ID:SGTC_162|Compound:k030-0015|FD-Score:2.71|P-value:8.66E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.51|P-value:3.17E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:2.72|P-value:8.27E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.13|P-value:1.52E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.51|P-value:2.62E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:4.73|P-value:2.50E-8 ID:SGTC_549|Compound:1661-1316|FD-Score:3.86|P-value:4.34E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.00|P-value:3.18E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.54|P-value:2.19E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.28|P-value:9.23E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.06|P-value:2.45E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:2.69|P-value:9.57E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.32|P-value:6.34E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.18|P-value:1.70E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.76|P-value:2.80E-8 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.57|P-value:2.34E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.44|P-value:4.49E-5 ID:SGTC_1526|Compound:st051518|FD-Score:5.54|P-value:9.23E-11 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.49|P-value:2.81E-5 ID:SGTC_1590|Compound:st077108|FD-Score:2.83|P-value:5.37E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.22|P-value:9.96E-5 ID:SGTC_1941|Compound:st076221|FD-Score:2.95|P-value:3.23E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-2.72|P-value:9.69E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-2.98|P-value:3.41E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.23|P-value:9.67E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-4.81|P-value:1.94E-8 ID:SGTC_2490|Compound:carminic acid|FD-Score:4.57|P-value:7.04E-8 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.78|P-value:6.60E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.71|P-value:8.61E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:5.63|P-value:4.76E-11 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.77|P-value:8.81E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.66|P-value:1.50E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.28|P-value:4.12E-7 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.24|P-value:9.09E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.31|P-value:4.45E-7 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.28|P-value:7.71E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.19|P-value:1.14E-9 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.33|P-value:6.20E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.35|P-value:2.72E-7 ID:SGTC_2944|Compound:9067346|FD-Score:3.14|P-value:1.45E-4 ID:SGTC_2992|Compound:9074591|FD-Score:2.71|P-value:8.78E-4 ID:SGTC_3203|Compound:9113543|FD-Score:2.91|P-value:3.92E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.84|P-value:5.99E-6 ID:SGTC_162|Compound:k030-0015|FD-Score:2.71|P-value:8.66E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.51|P-value:3.17E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:2.72|P-value:8.27E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.13|P-value:1.52E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.51|P-value:2.62E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:4.73|P-value:2.50E-8 ID:SGTC_549|Compound:1661-1316|FD-Score:3.86|P-value:4.34E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.00|P-value:3.18E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.54|P-value:2.19E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.28|P-value:9.23E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.06|P-value:2.45E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:2.69|P-value:9.57E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.32|P-value:6.34E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.18|P-value:1.70E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.76|P-value:2.80E-8 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.57|P-value:2.34E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.44|P-value:4.49E-5 ID:SGTC_1526|Compound:st051518|FD-Score:5.54|P-value:9.23E-11 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.49|P-value:2.81E-5 ID:SGTC_1590|Compound:st077108|FD-Score:2.83|P-value:5.37E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.22|P-value:9.96E-5 ID:SGTC_1941|Compound:st076221|FD-Score:2.95|P-value:3.23E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-2.72|P-value:9.69E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-2.98|P-value:3.41E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.23|P-value:9.67E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-4.81|P-value:1.94E-8 ID:SGTC_2490|Compound:carminic acid|FD-Score:4.57|P-value:7.04E-8 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.78|P-value:6.60E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.71|P-value:8.61E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:5.63|P-value:4.76E-11 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.77|P-value:8.81E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.66|P-value:1.50E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.28|P-value:4.12E-7 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.24|P-value:9.09E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.31|P-value:4.45E-7 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.28|P-value:7.71E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.19|P-value:1.14E-9 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.33|P-value:6.20E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.35|P-value:2.72E-7 ID:SGTC_2944|Compound:9067346|FD-Score:3.14|P-value:1.45E-4 ID:SGTC_2992|Compound:9074591|FD-Score:2.71|P-value:8.78E-4 ID:SGTC_3203|Compound:9113543|FD-Score:2.91|P-value:3.92E-4

Top fitness defect scores for YKL128C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2569 tetrandrine 5.63 100.0 µM 4.76E-11 5 9.24E-9
2 SGTC_1526 st051518 5.54 75.0 µM 9.23E-11 2 1.53E-8
3 SGTC_2690 usnic acid 5.19 100.0 µM 1.14E-9 10 1.04E-7
4 SGTC_382 3229-0966 4.73 23.2 µM 2.50E-8 5 1.10E-6
5 SGTC_2490 carminic acid 4.57 95.4 µM 7.04E-8 3 2.44E-6
6 SGTC_2816 7982706 4.35 58.4 µM 2.72E-7 azole & statin 41 6.86E-6
7 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.28 100.0 µM 4.12E-7 29 9.41E-6
8 SGTC_549 1661-1316 3.86 519.0 µM 4.34E-6 22 5.71E-5
9 SGTC_827 3253-0474 3.54 693.0 µM 2.19E-5 31 1.98E-4
10 SGTC_381 3461-2219 3.51 42.7 µM 2.62E-5 copper-dependent oxidative stress 30 2.27E-4
11 SGTC_1528 arabinosylhypoxanthine 3.49 74.6 µM 2.81E-5 35 2.40E-4
12 SGTC_2697 mebhydrolin 3.33 72.4 µM 6.20E-5 NEO1 96 4.40E-4
13 SGTC_1230 0170-0365 3.32 3.8 µM 6.34E-5 endomembrane recycling 106 4.47E-4
14 SGTC_2689 tacrolimus 3.28 100.0 µM 7.71E-5 77 5.20E-4
15 SGTC_2635 hydroquinidine 3.24 100.0 µM 9.09E-5 42 5.90E-4
16 SGTC_2253 7938677 3.23 135.8 µM 9.67E-5 33 6.19E-4
17 SGTC_1630 st005209 3.22 31.3 µM 9.96E-5 60 6.34E-4
18 SGTC_2944 9067346 3.14 25.6 µM 1.45E-4 64 8.44E-4
19 SGTC_376 3970-0862 3.13 59.1 µM 1.52E-4 51 8.77E-4
20 SGTC_1941 st076221 2.95 61.8 µM 3.23E-4 sphingolipid biosynthesis & PDR1 149 0.00157

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 1.95E-43 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.231 7.94E-42 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.220 8.18E-38 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.219 8.04E-38 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.216 8.86E-37 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.207 8.71E-34 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.202 4.84E-32 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.198 5.85E-31 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.198 6.48E-31 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.197 8.14E-31 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.196 2.28E-30 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.190 1.18E-28 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.187 9.41E-28 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.185 2.82E-27 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.184 4.70E-27 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene