YKL130C / SHE2

RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL130C / SHE2

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:3.09|P-value:2.16E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.89|P-value:5.41E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-3.00|P-value:3.52E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-2.77|P-value:8.77E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-2.96|P-value:4.04E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.15|P-value:1.72E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.85|P-value:5.78E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.67|P-value:1.66E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.15|P-value:1.85E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.62|P-value:1.93E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.82|P-value:6.73E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:2.95|P-value:3.93E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.20|P-value:1.09E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.76|P-value:3.58E-8 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.51|P-value:3.52E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.67|P-value:1.49E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.43|P-value:5.33E-5 ID:SGTC_1749|Compound:st037932|FD-Score:4.46|P-value:1.91E-7 ID:SGTC_1941|Compound:st076221|FD-Score:3.27|P-value:1.00E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-6.87|P-value:3.47E-15 ID:SGTC_2242|Compound:6630449|FD-Score:3.00|P-value:3.17E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-2.94|P-value:4.41E-4 ID:SGTC_2271|Compound:7849410|FD-Score:2.93|P-value:4.23E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.28|P-value:9.59E-5 ID:SGTC_2356|Compound:9061756|FD-Score:2.90|P-value:4.78E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.25|P-value:1.08E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-5.36|P-value:6.32E-10 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.03|P-value:2.84E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.83|P-value:6.31E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.44|P-value:4.55E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.42|P-value:5.04E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.91|P-value:4.76E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.16|P-value:1.28E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.05|P-value:3.04E-12 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.74|P-value:8.90E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.40|P-value:3.19E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.50|P-value:2.10E-10 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.09|P-value:2.16E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-2.87|P-value:5.89E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.44|P-value:5.07E-5 ID:SGTC_3036|Compound:9090181|FD-Score:2.78|P-value:7.59E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.09|P-value:2.16E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.89|P-value:5.41E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-3.00|P-value:3.52E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-2.77|P-value:8.77E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-2.96|P-value:4.04E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.15|P-value:1.72E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.85|P-value:5.78E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.67|P-value:1.66E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.15|P-value:1.85E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.62|P-value:1.93E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.82|P-value:6.73E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:2.95|P-value:3.93E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.20|P-value:1.09E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.76|P-value:3.58E-8 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.51|P-value:3.52E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.67|P-value:1.49E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.43|P-value:5.33E-5 ID:SGTC_1749|Compound:st037932|FD-Score:4.46|P-value:1.91E-7 ID:SGTC_1941|Compound:st076221|FD-Score:3.27|P-value:1.00E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-6.87|P-value:3.47E-15 ID:SGTC_2242|Compound:6630449|FD-Score:3.00|P-value:3.17E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-2.94|P-value:4.41E-4 ID:SGTC_2271|Compound:7849410|FD-Score:2.93|P-value:4.23E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.28|P-value:9.59E-5 ID:SGTC_2356|Compound:9061756|FD-Score:2.90|P-value:4.78E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.25|P-value:1.08E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-5.36|P-value:6.32E-10 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.03|P-value:2.84E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.83|P-value:6.31E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.44|P-value:4.55E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.42|P-value:5.04E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.91|P-value:4.76E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.16|P-value:1.28E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.05|P-value:3.04E-12 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.74|P-value:8.90E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.40|P-value:3.19E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.50|P-value:2.10E-10 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.09|P-value:2.16E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-2.87|P-value:5.89E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.44|P-value:5.07E-5 ID:SGTC_3036|Compound:9090181|FD-Score:2.78|P-value:7.59E-4

Top fitness defect scores for YKL130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 6.05 100.0 µM 3.04E-12 redox potentiating 158 7.16E-10
2 SGTC_2621 lithochol-11-enic acid 5.50 100.0 µM 2.10E-10 4 1.95E-8
3 SGTC_1749 st037932 4.46 54.2 µM 1.91E-7 21 4.00E-6
4 SGTC_1600 coumarin 106 3.67 71.1 µM 1.49E-5 33 1.21E-4
5 SGTC_1122 capsaicin 3.62 818.6 nM 1.93E-5 38 1.49E-4
6 SGTC_2564 betulinic acid 3.44 100.0 µM 4.55E-5 49 2.92E-4
7 SGTC_2568 diosmetin 3.42 100.0 µM 5.04E-5 40 3.17E-4
8 SGTC_2325 6158266 3.28 200.0 µM 9.59E-5 50 5.25E-4
9 SGTC_1941 st076221 3.27 61.8 µM 1.00E-4 sphingolipid biosynthesis & PDR1 115 5.43E-4
10 SGTC_2389 9091542 3.25 195.5 µM 1.08E-4 iron homeostasis 65 5.78E-4
11 SGTC_545 4218-0007 3.15 221.0 µM 1.72E-4 59 8.30E-4
12 SGTC_75 0159-0059 3.09 199.0 µM 2.16E-4 fatty acid desaturase (OLE1) 55 9.93E-4
13 SGTC_2628 lathosterol 3.09 100.0 µM 2.16E-4 65 9.94E-4
14 SGTC_2420 aureobasidin a 3.03 50.0 nM 2.84E-4 95 0.00123
15 SGTC_2242 6630449 3.00 61.3 µM 3.17E-4 Golgi 79 0.00135
16 SGTC_1424 4048-1941 2.95 275.0 µM 3.93E-4 70 0.00159
17 SGTC_2271 7849410 2.93 118.6 µM 4.23E-4 47 0.00169
18 SGTC_2356 9061756 2.90 189.0 µM 4.78E-4 39 0.00186
19 SGTC_658 3253-0951 2.85 102.0 µM 5.78E-4 calcium & mitochondrial duress 126 0.00216
20 SGTC_2492 derrusnin 2.83 100.0 µM 6.31E-4 32 0.00232

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.316 2.84E-78 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.301 3.36E-71 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.290 3.41E-66 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.253 7.60E-50 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.253 4.17E-50 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.244 9.63E-47 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.241 1.22E-45 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.228 1.14E-40 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.227 3.22E-40 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.221 3.07E-38 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.219 8.23E-38 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.218 1.75E-37 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.211 5.65E-35 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.208 3.22E-34 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.204 6.09E-33 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W