YKL133C_p

Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL133C / YKL133C

Click on Significant Values for Screen Details ID:SGTC_154|Compound:3389-1638|FD-Score:4.77|P-value:4.20E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.73|P-value:4.42E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:6.62|P-value:3.16E-10 ID:SGTC_532|Compound:1548-0774|FD-Score:4.55|P-value:1.11E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:4.72|P-value:5.22E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.35|P-value:8.36E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.15|P-value:5.34E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.65|P-value:3.30E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.21|P-value:4.37E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.08|P-value:6.37E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.73|P-value:2.57E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.45|P-value:5.99E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:6.53|P-value:5.31E-10 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.41|P-value:1.91E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.79|P-value:2.08E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.71|P-value:5.51E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.62|P-value:3.68E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-4.04|P-value:7.32E-5 ID:SGTC_1912|Compound:st060209|FD-Score:6.35|P-value:1.54E-9 ID:SGTC_2056|Compound:5235370|FD-Score:4.15|P-value:5.48E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.11|P-value:6.33E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.87|P-value:1.53E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.33|P-value:8.81E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.62|P-value:3.68E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.98|P-value:9.21E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:-4.25|P-value:3.29E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.88|P-value:1.96E-8 ID:SGTC_2834|Compound:9001755|FD-Score:5.37|P-value:2.71E-7 ID:SGTC_2884|Compound:9058502|FD-Score:3.41|P-value:7.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:5.08|P-value:1.05E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-3.45|P-value:5.98E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.34|P-value:8.43E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.85|P-value:1.67E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:4.77|P-value:4.20E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.73|P-value:4.42E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:6.62|P-value:3.16E-10 ID:SGTC_532|Compound:1548-0774|FD-Score:4.55|P-value:1.11E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:4.72|P-value:5.22E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.35|P-value:8.36E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.15|P-value:5.34E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.65|P-value:3.30E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.21|P-value:4.37E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.08|P-value:6.37E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.73|P-value:2.57E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.45|P-value:5.99E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:6.53|P-value:5.31E-10 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.41|P-value:1.91E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.79|P-value:2.08E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.71|P-value:5.51E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.62|P-value:3.68E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-4.04|P-value:7.32E-5 ID:SGTC_1912|Compound:st060209|FD-Score:6.35|P-value:1.54E-9 ID:SGTC_2056|Compound:5235370|FD-Score:4.15|P-value:5.48E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.11|P-value:6.33E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.87|P-value:1.53E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.33|P-value:8.81E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.62|P-value:3.68E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.98|P-value:9.21E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:-4.25|P-value:3.29E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.88|P-value:1.96E-8 ID:SGTC_2834|Compound:9001755|FD-Score:5.37|P-value:2.71E-7 ID:SGTC_2884|Compound:9058502|FD-Score:3.41|P-value:7.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:5.08|P-value:1.05E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-3.45|P-value:5.98E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.34|P-value:8.43E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.85|P-value:1.67E-4

Top fitness defect scores for YKL133C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_527 4476-4215 6.62 268.0 µM 3.16E-10 PDR1 9 1.79E-11
2 SGTC_1002 4049-0206 6.53 172.0 µM 5.31E-10 3 3.25E-11
3 SGTC_1912 st060209 6.35 90.8 µM 1.54E-9 9 1.09E-10
4 SGTC_2566 crystal violet carbinol 5.88 226.0 nM 1.96E-8 10 1.99E-9
5 SGTC_2834 9001755 5.37 58.4 µM 2.71E-7 11 3.98E-8
6 SGTC_2969 9091408 5.08 28.7 µM 1.05E-6 9 1.87E-7
7 SGTC_154 3389-1638 4.77 511.1 µM 4.20E-6 11 9.02E-7
8 SGTC_540 1187-0821 4.72 17.3 µM 5.22E-6 7 1.16E-6
9 SGTC_1436 4092-1007 4.71 8.3 µM 5.51E-6 4 1.23E-6
10 SGTC_532 1548-0774 4.55 215.0 µM 1.11E-5 8 2.74E-6
11 SGTC_1144 3486-0183 4.41 12.5 µM 1.91E-5 16 5.07E-6
12 SGTC_881 0833-0569 4.21 170.0 µM 4.37E-5 19 1.30E-5
13 SGTC_770 0389-1121 4.15 67.2 µM 5.34E-5 RPP1 & pyrimidine depletion 23 1.63E-5
14 SGTC_2056 5235370 4.15 200.0 µM 5.48E-5 32 1.68E-5
15 SGTC_2089 5281248 4.11 129.7 µM 6.33E-5 superoxide 18 1.98E-5
16 SGTC_2401 5128683 3.87 200.0 µM 1.53E-4 43 5.40E-5
17 SGTC_3159 9100096 3.85 49.5 µM 1.67E-4 21 5.97E-5
18 SGTC_1249 0481-0015 3.79 10.2 µM 2.08E-4 28 7.67E-5
19 SGTC_994 3910-0338 3.73 138.0 µM 2.57E-4 calcium & mitochondrial duress 55 9.76E-5
20 SGTC_785 1270-0111 3.65 65.3 µM 3.30E-4 39 1.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.22E-11 YIR029W DAL2 hom Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.105 1.25E-9 YNL137C NAM9 het Mitochondrial ribosomal component of the small subunit
0.093 7.40E-8 YAL020C ATS1 hom Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
0.088 3.56E-7 YNL292W PUS4 hom Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
0.086 5.88E-7 YHR017W YSC83 hom Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
0.086 6.34E-7 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.084 1.19E-6 YOR028C CIN5 hom Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication
0.084 1.20E-6 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.082 1.74E-6 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.081 2.79E-6 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.080 3.69E-6 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.077 8.21E-6 YBR079C RPG1 het eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
0.075 1.30E-5 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
0.072 3.35E-5 YGR224W AZR1 hom Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
0.071 3.94E-5 YJL082W IML2 hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication