YKL134C / OCT1

Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL134C / OCT1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.28|P-value:7.05E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.70|P-value:1.64E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:8.17|P-value:1.40E-15 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.98|P-value:7.01E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:7.53|P-value:1.68E-13 ID:SGTC_165|Compound:k038-0023|FD-Score:5.75|P-value:1.28E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:10.70|P-value:3.72E-25 ID:SGTC_179|Compound:1273-0063|FD-Score:3.22|P-value:8.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.44|P-value:2.33E-10 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.21|P-value:2.23E-7 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.56|P-value:3.33E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-4.14|P-value:3.79E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:3.44|P-value:4.09E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.61|P-value:5.21E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.82|P-value:1.30E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.57|P-value:2.58E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.86|P-value:8.75E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.83|P-value:1.02E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.54|P-value:5.38E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.49|P-value:3.42E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.19|P-value:9.46E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.28|P-value:7.16E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.36|P-value:5.42E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.82|P-value:1.06E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.66|P-value:1.86E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.58|P-value:2.54E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.22|P-value:8.84E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.17|P-value:2.71E-7 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.59|P-value:4.20E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.69|P-value:1.66E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.28|P-value:7.15E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.53|P-value:2.98E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.80|P-value:1.14E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.28|P-value:8.83E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.62|P-value:2.69E-8 ID:SGTC_1761|Compound:st044296|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.71|P-value:1.99E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.54|P-value:7.17E-6 ID:SGTC_1885|Compound:st057546|FD-Score:4.42|P-value:8.96E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.16|P-value:3.50E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.24|P-value:1.91E-7 ID:SGTC_2239|Compound:6685329|FD-Score:-5.73|P-value:2.00E-8 ID:SGTC_2245|Compound:6637752|FD-Score:-3.90|P-value:9.65E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.31|P-value:6.35E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.69|P-value:1.72E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-6.62|P-value:1.13E-10 ID:SGTC_2402|Compound:5553605|FD-Score:3.74|P-value:1.42E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.38|P-value:1.06E-5 ID:SGTC_2482|Compound:5981709|FD-Score:-3.51|P-value:3.96E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.53|P-value:2.98E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.45|P-value:4.89E-4 ID:SGTC_2526|Compound:patulin|FD-Score:6.51|P-value:1.52E-10 ID:SGTC_2544|Compound:sphondin|FD-Score:3.56|P-value:2.69E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.32|P-value:1.39E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.60|P-value:2.87E-8 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.90|P-value:9.86E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.78|P-value:1.12E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.26|P-value:9.46E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.88|P-value:1.11E-6 ID:SGTC_2813|Compound:7971799|FD-Score:7.52|P-value:1.81E-13 ID:SGTC_2814|Compound:7977482|FD-Score:3.80|P-value:1.13E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.30|P-value:8.16E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.85|P-value:9.18E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.25|P-value:9.67E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.42|P-value:3.76E-10 ID:SGTC_3267|Compound:9137951|FD-Score:-3.43|P-value:5.30E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.28|P-value:7.05E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.70|P-value:1.64E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:8.17|P-value:1.40E-15 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.98|P-value:7.01E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:7.53|P-value:1.68E-13 ID:SGTC_165|Compound:k038-0023|FD-Score:5.75|P-value:1.28E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:10.70|P-value:3.72E-25 ID:SGTC_179|Compound:1273-0063|FD-Score:3.22|P-value:8.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.44|P-value:2.33E-10 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.21|P-value:2.23E-7 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.56|P-value:3.33E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-4.14|P-value:3.79E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:3.44|P-value:4.09E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.61|P-value:5.21E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.82|P-value:1.30E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.57|P-value:2.58E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.86|P-value:8.75E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.83|P-value:1.02E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.54|P-value:5.38E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.49|P-value:3.42E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.19|P-value:9.46E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.28|P-value:7.16E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.36|P-value:5.42E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.82|P-value:1.06E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.66|P-value:1.86E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.58|P-value:2.54E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.22|P-value:8.84E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.17|P-value:2.71E-7 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.59|P-value:4.20E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.69|P-value:1.66E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.28|P-value:7.15E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.53|P-value:2.98E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.80|P-value:1.14E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.28|P-value:8.83E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.62|P-value:2.69E-8 ID:SGTC_1761|Compound:st044296|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.71|P-value:1.99E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.54|P-value:7.17E-6 ID:SGTC_1885|Compound:st057546|FD-Score:4.42|P-value:8.96E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.16|P-value:3.50E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.24|P-value:1.91E-7 ID:SGTC_2239|Compound:6685329|FD-Score:-5.73|P-value:2.00E-8 ID:SGTC_2245|Compound:6637752|FD-Score:-3.90|P-value:9.65E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.31|P-value:6.35E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.69|P-value:1.72E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-6.62|P-value:1.13E-10 ID:SGTC_2402|Compound:5553605|FD-Score:3.74|P-value:1.42E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.38|P-value:1.06E-5 ID:SGTC_2482|Compound:5981709|FD-Score:-3.51|P-value:3.96E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.53|P-value:2.98E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.45|P-value:4.89E-4 ID:SGTC_2526|Compound:patulin|FD-Score:6.51|P-value:1.52E-10 ID:SGTC_2544|Compound:sphondin|FD-Score:3.56|P-value:2.69E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.32|P-value:1.39E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.60|P-value:2.87E-8 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.90|P-value:9.86E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.78|P-value:1.12E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.26|P-value:9.46E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.88|P-value:1.11E-6 ID:SGTC_2813|Compound:7971799|FD-Score:7.52|P-value:1.81E-13 ID:SGTC_2814|Compound:7977482|FD-Score:3.80|P-value:1.13E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.30|P-value:8.16E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.85|P-value:9.18E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.25|P-value:9.67E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.42|P-value:3.76E-10 ID:SGTC_3267|Compound:9137951|FD-Score:-3.43|P-value:5.30E-4

Top fitness defect scores for YKL134C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 10.70 2.7 µM 3.72E-25 mitochondrial stress 34 8.11E-27
2 SGTC_86 0417-1630 8.17 471.9 µM 1.40E-15 ubiquinone biosynthesis & proteasome 58 1.53E-16
3 SGTC_158 k038-0087 7.53 26.4 µM 1.68E-13 ubiquinone biosynthesis & proteasome 52 2.61E-14
4 SGTC_2813 7971799 7.52 71.4 µM 1.81E-13 1 2.84E-14
5 SGTC_2526 patulin 6.51 37.6 µM 1.52E-10 22 3.84E-11
6 SGTC_236 1509-0011 6.44 5.3 µM 2.33E-10 280 6.10E-11
7 SGTC_2759 disulfiram 5.78 3.4 µM 1.12E-8 6 3.83E-9
8 SGTC_165 k038-0023 5.75 64.4 µM 1.28E-8 ubiquinone biosynthesis & proteasome 27 4.45E-9
9 SGTC_1758 st042942 5.62 75.2 µM 2.69E-8 3 9.81E-9
10 SGTC_2688 kanamycin b 5.60 96.7 µM 2.87E-8 calcium & mitochondrial duress 188 1.05E-8
11 SGTC_2183 6420625 5.24 130.5 µM 1.91E-7 mitochondrial processes 25 7.98E-8
12 SGTC_275 trichlorophene 5.21 5.7 µM 2.23E-7 mitochondrial stress 155 9.45E-8
13 SGTC_1371 2421-0008 5.17 32.7 µM 2.71E-7 mitochondrial processes 11 1.16E-7
14 SGTC_2807 7945238 4.88 52.0 µM 1.11E-6 11 5.26E-7
15 SGTC_1509 1326-1131 4.59 80.0 µM 4.20E-6 6 2.17E-6
16 SGTC_831 k061-1017 4.54 217.0 µM 5.38E-6 translation 34 2.84E-6
17 SGTC_1885 st057546 4.42 99.9 µM 8.96E-6 12 4.89E-6
18 SGTC_2418 pentamidine 4.38 31.7 µM 1.06E-5 mitochondrial processes 31 5.83E-6
19 SGTC_2573 2',4'-dihydroxychalcone 4.32 15.0 µM 1.39E-5 37 7.82E-6
20 SGTC_735 3076-0345 3.86 636.0 µM 8.75E-5 30 5.56E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.284 3.97E-63 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.279 4.84E-61 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.274 7.93E-59 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.273 2.77E-58 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.271 2.09E-57 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.270 6.18E-57 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.269 1.44E-56 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.266 1.29E-55 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.265 4.87E-55 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.265 5.91E-55 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.256 1.83E-51 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.254 2.18E-50 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.253 3.16E-50 YDR175C RSM24 hom Mitochondrial ribosomal protein of the small subunit
0.253 4.10E-50 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.253 4.37E-50 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress