HIPHOP chemogenomics database
YKL134C / OCT1 
Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YKL134C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.284 | 3.97E-63 | YLR201C | COQ9 | hom | Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes |
| 0.279 | 4.84E-61 | YML061C | PIF1 | hom | DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells |
| 0.274 | 7.93E-59 | YNL177C | MRPL22 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.273 | 2.77E-58 | YPL040C | ISM1 | hom | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |
| 0.271 | 2.09E-57 | YLR202C_d | YLR202C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron |
| 0.270 | 6.18E-57 | YNR041C | COQ2 | hom | Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis |
| 0.269 | 1.44E-56 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
| 0.266 | 1.29E-55 | YML110C | COQ5 | hom | 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes |
| 0.265 | 4.87E-55 | YMR097C | MTG1 | hom | Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals |
| 0.265 | 5.91E-55 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.256 | 1.83E-51 | YMR257C | PET111 | hom | Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane |
| 0.254 | 2.18E-50 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
| 0.253 | 3.16E-50 | YDR175C | RSM24 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.253 | 4.10E-50 | YMR282C | AEP2 | hom | Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader |
| 0.253 | 4.37E-50 | YKL170W | MRPL38 | hom | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress |