YKL136W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL136W / YKL136W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.92|P-value:1.78E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.90|P-value:1.64E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.62|P-value:4.90E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.76|P-value:7.26E-8 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.70|P-value:3.80E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-6.48|P-value:1.30E-9 ID:SGTC_277|Compound:nystatin|FD-Score:-3.66|P-value:3.69E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:7.64|P-value:1.52E-12 ID:SGTC_320|Compound:4092-0846|FD-Score:4.11|P-value:9.06E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:4.17|P-value:7.36E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.78|P-value:5.38E-6 ID:SGTC_555|Compound:4296-0685|FD-Score:6.20|P-value:7.76E-9 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.75|P-value:2.75E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.42|P-value:3.88E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:4.79|P-value:6.39E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.65|P-value:4.42E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-4.71|P-value:7.36E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:5.16|P-value:1.25E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.94|P-value:1.42E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.44|P-value:2.65E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.93|P-value:1.45E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:-3.77|P-value:2.53E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.43|P-value:9.01E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.52|P-value:1.31E-9 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.79|P-value:2.80E-4 ID:SGTC_1745|Compound:st081495|FD-Score:7.07|P-value:5.31E-11 ID:SGTC_1750|Compound:st081859|FD-Score:13.90|P-value:3.90E-37 ID:SGTC_1753|Compound:st043925|FD-Score:3.82|P-value:2.49E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.18|P-value:6.94E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-4.27|P-value:4.19E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-3.42|P-value:8.05E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-4.89|P-value:3.45E-6 ID:SGTC_1953|Compound:st076800|FD-Score:7.46|P-value:4.63E-12 ID:SGTC_2006|Compound:4011487|FD-Score:3.40|P-value:9.98E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.46|P-value:2.37E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.18|P-value:3.98E-14 ID:SGTC_2777|Compound:climbazole|FD-Score:4.29|P-value:4.59E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:7.48|P-value:4.25E-12 ID:SGTC_3018|Compound:9082602|FD-Score:4.37|P-value:3.38E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.92|P-value:1.78E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.90|P-value:1.64E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.62|P-value:4.90E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.76|P-value:7.26E-8 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.70|P-value:3.80E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-6.48|P-value:1.30E-9 ID:SGTC_277|Compound:nystatin|FD-Score:-3.66|P-value:3.69E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:7.64|P-value:1.52E-12 ID:SGTC_320|Compound:4092-0846|FD-Score:4.11|P-value:9.06E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:4.17|P-value:7.36E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.78|P-value:5.38E-6 ID:SGTC_555|Compound:4296-0685|FD-Score:6.20|P-value:7.76E-9 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.75|P-value:2.75E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.42|P-value:3.88E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:4.79|P-value:6.39E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.65|P-value:4.42E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-4.71|P-value:7.36E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:5.16|P-value:1.25E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.94|P-value:1.42E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.44|P-value:2.65E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.93|P-value:1.45E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:-3.77|P-value:2.53E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.43|P-value:9.01E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.52|P-value:1.31E-9 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.79|P-value:2.80E-4 ID:SGTC_1745|Compound:st081495|FD-Score:7.07|P-value:5.31E-11 ID:SGTC_1750|Compound:st081859|FD-Score:13.90|P-value:3.90E-37 ID:SGTC_1753|Compound:st043925|FD-Score:3.82|P-value:2.49E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.18|P-value:6.94E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-4.27|P-value:4.19E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-3.42|P-value:8.05E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-4.89|P-value:3.45E-6 ID:SGTC_1953|Compound:st076800|FD-Score:7.46|P-value:4.63E-12 ID:SGTC_2006|Compound:4011487|FD-Score:3.40|P-value:9.98E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.46|P-value:2.37E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.18|P-value:3.98E-14 ID:SGTC_2777|Compound:climbazole|FD-Score:4.29|P-value:4.59E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:7.48|P-value:4.25E-12 ID:SGTC_3018|Compound:9082602|FD-Score:4.37|P-value:3.38E-5

Top fitness defect scores for YKL136W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 13.90 2.4 µM 3.90E-37 endomembrane recycling 26 5.43E-44
2 SGTC_2582 agaric acid 8.18 100.0 µM 3.98E-14 redox potentiating 100 1.44E-16
3 SGTC_312 4092-0653 7.64 6.8 µM 1.52E-12 ergosterol depletion effects on membrane 23 1.11E-14
4 SGTC_2778 tioconazole 7.48 65.1 nM 4.25E-12 ergosterol depletion effects on membrane 22 3.78E-14
5 SGTC_1953 st076800 7.46 12.1 µM 4.63E-12 5 4.18E-14
6 SGTC_1745 st081495 7.07 74.0 µM 5.31E-11 RNA processing & uracil transport 18 7.64E-13
7 SGTC_1597 7-benzyloxygramine 6.52 47.5 µM 1.31E-9 calcium & mitochondrial duress 45 3.49E-11
8 SGTC_555 4296-0685 6.20 37.0 µM 7.76E-9 ergosterol biosynthesis 1 2.89E-10
9 SGTC_207 4185-0010 5.76 4.5 µM 7.26E-8 endomembrane recycling 46 4.13E-9
10 SGTC_689 0833-0039 5.42 98.0 µM 3.88E-7 ergosterol depletion effects on membrane 18 3.04E-8
11 SGTC_984 1492-0255 5.16 2.9 µM 1.25E-6 SWF1 & branched chain AA biosynthesis 16 1.22E-7
12 SGTC_788 1182-0090 4.79 188.0 µM 6.39E-6 endomembrane recycling 57 8.49E-7
13 SGTC_2304 7443016 4.46 91.4 µM 2.37E-5 12 4.04E-6
14 SGTC_1072 oxiconazole 4.44 14.9 nM 2.65E-5 ergosterol depletion effects on membrane 43 4.60E-6
15 SGTC_3018 9082602 4.37 49.5 µM 3.38E-5 47 6.14E-6
16 SGTC_2777 climbazole 4.29 1.5 µM 4.59E-5 iron homeostasis 37 8.85E-6
17 SGTC_1911 st060208 4.18 74.3 µM 6.94E-5 30 1.44E-5
18 SGTC_363 0455-0021 4.17 3.1 µM 7.36E-5 azole & statin 59 1.55E-5
19 SGTC_320 4092-0846 4.11 5.3 µM 9.06E-5 ergosterol depletion effects on membrane 44 1.98E-5
20 SGTC_6 0844-0013 3.92 19.8 µM 1.78E-4 92 4.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.435 7.65E-155 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.423 7.27E-146 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.413 2.13E-138 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.400 7.78E-129 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.396 1.57E-126 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.364 6.71E-106 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.345 1.07E-94 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.294 1.08E-67 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.286 4.16E-64 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.280 1.23E-61 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.278 1.71E-60 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.277 4.93E-60 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.248 3.62E-48 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.242 6.87E-46 YPR153W YPR153W hom Putative protein of unknown function
0.233 1.43E-42 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p