YKL137W / CMC1

Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL137W / CMC1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.26|P-value:4.56E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.42|P-value:2.59E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.71|P-value:8.00E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.36|P-value:3.25E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-4.52|P-value:2.05E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.24|P-value:8.09E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.83|P-value:4.61E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:3.41|P-value:2.68E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.58|P-value:1.40E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.18|P-value:6.22E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.27|P-value:4.43E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.43|P-value:2.42E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.71|P-value:8.17E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.53|P-value:1.70E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.08|P-value:8.75E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.14|P-value:6.85E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:3.13|P-value:7.29E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.21|P-value:5.51E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-3.26|P-value:4.34E-4 ID:SGTC_1740|Compound:st038286|FD-Score:5.40|P-value:1.99E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:9.55|P-value:1.27E-22 ID:SGTC_2064|Compound:5220758|FD-Score:3.31|P-value:3.89E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.27|P-value:4.53E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.24|P-value:4.82E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.37|P-value:3.11E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.56|P-value:1.38E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.24|P-value:4.95E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.01|P-value:2.12E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-4.16|P-value:1.11E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.92|P-value:3.25E-5 ID:SGTC_2967|Compound:9089538|FD-Score:4.51|P-value:2.26E-6 ID:SGTC_2971|Compound:9092186|FD-Score:-3.84|P-value:4.49E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.26|P-value:4.60E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.54|P-value:1.58E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-3.57|P-value:1.35E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-4.98|P-value:1.91E-7 ID:SGTC_3140|Compound:9094243|FD-Score:-4.13|P-value:1.26E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.51|P-value:1.69E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.15|P-value:6.81E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.26|P-value:4.56E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.42|P-value:2.59E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.71|P-value:8.00E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.36|P-value:3.25E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-4.52|P-value:2.05E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.24|P-value:8.09E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.83|P-value:4.61E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:3.41|P-value:2.68E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.58|P-value:1.40E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.18|P-value:6.22E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.27|P-value:4.43E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.43|P-value:2.42E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.71|P-value:8.17E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.53|P-value:1.70E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.08|P-value:8.75E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.14|P-value:6.85E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:3.13|P-value:7.29E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.21|P-value:5.51E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-3.26|P-value:4.34E-4 ID:SGTC_1740|Compound:st038286|FD-Score:5.40|P-value:1.99E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:9.55|P-value:1.27E-22 ID:SGTC_2064|Compound:5220758|FD-Score:3.31|P-value:3.89E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.27|P-value:4.53E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.24|P-value:4.82E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.37|P-value:3.11E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.56|P-value:1.38E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.24|P-value:4.95E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.01|P-value:2.12E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-4.16|P-value:1.11E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.92|P-value:3.25E-5 ID:SGTC_2967|Compound:9089538|FD-Score:4.51|P-value:2.26E-6 ID:SGTC_2971|Compound:9092186|FD-Score:-3.84|P-value:4.49E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.26|P-value:4.60E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.54|P-value:1.58E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-3.57|P-value:1.35E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-4.98|P-value:1.91E-7 ID:SGTC_3140|Compound:9094243|FD-Score:-4.13|P-value:1.26E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.51|P-value:1.69E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.15|P-value:6.81E-4

Top fitness defect scores for YKL137W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1926 methyl fluorone black 9.55 53.6 µM 1.27E-22 DNA intercalators 4 6.43E-22
2 SGTC_1740 st038286 5.40 13.2 µM 1.99E-8 7 3.32E-8
3 SGTC_2967 9089538 4.51 49.9 µM 2.26E-6 18 3.23E-6
4 SGTC_471 1-acyl-paf 4.24 4.0 µM 8.09E-6 DNA intercalators 27 1.11E-5
5 SGTC_294 k038-0071 3.71 157.0 µM 8.00E-5 ubiquinone biosynthesis & proteasome 70 1.02E-4
6 SGTC_1434 4073-0095 3.71 163.0 µM 8.17E-5 13 1.04E-4
7 SGTC_1307 1187-1599 3.58 12.2 µM 1.40E-4 PDR1 18 1.75E-4
8 SGTC_2978 9011784 3.54 43.0 µM 1.58E-4 47 1.97E-4
9 SGTC_1459 k035-0031 3.53 35.7 µM 1.70E-4 DNA intercalators 35 2.11E-4
10 SGTC_1415 3966-0071 3.43 78.1 µM 2.42E-4 DNA intercalators 20 2.98E-4
11 SGTC_96 0929-0093 3.42 37.3 µM 2.59E-4 calcium & mitochondrial duress 29 3.18E-4
12 SGTC_775 4577-0580 3.41 57.3 µM 2.68E-4 17 3.28E-4
13 SGTC_2649 anisomycin 3.37 9.6 µM 3.11E-4 19 3.79E-4
14 SGTC_310 1273-0058 3.36 1.1 µM 3.25E-4 mitochondrial stress 307 3.96E-4
15 SGTC_2064 5220758 3.31 200.0 µM 3.89E-4 68 4.71E-4
16 SGTC_1412 3909-8563 3.27 178.0 µM 4.43E-4 25 5.34E-4
17 SGTC_2337 9009472 3.27 200.0 µM 4.53E-4 60 5.46E-4
18 SGTC_43 0570-0105 3.26 72.5 µM 4.56E-4 ERG2 155 5.49E-4
19 SGTC_2975 9084847 3.26 53.7 µM 4.60E-4 57 5.54E-4
20 SGTC_2677 mitomycin C 3.24 100.0 µM 4.95E-4 DNA damage response 26 5.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 3.94E-31 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.149 3.08E-18 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.141 3.01E-16 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.130 5.01E-14 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.129 5.58E-14 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.128 1.20E-13 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.126 2.68E-13 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.124 5.45E-13 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.124 6.24E-13 YML047W-A_d YML047W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 2.12E-12 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.120 2.97E-12 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.120 3.41E-12 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.119 4.02E-12 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.116 1.66E-11 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.112 8.97E-11 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters