YKL138C / MRPL31

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL138C / MRPL31

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.83|P-value:1.65E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:5.49|P-value:7.63E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:5.40|P-value:1.15E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:6.21|P-value:2.88E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.91|P-value:4.20E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.87|P-value:3.31E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.15|P-value:7.27E-16 ID:SGTC_195|Compound:4234-0266|FD-Score:3.78|P-value:4.43E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.40|P-value:7.06E-32 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.35|P-value:1.40E-8 ID:SGTC_283|Compound:0987-0079|FD-Score:3.93|P-value:2.73E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:14.70|P-value:6.91E-38 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.65|P-value:9.10E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.67|P-value:2.09E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:6.06|P-value:5.77E-8 ID:SGTC_942|Compound:3253-1115|FD-Score:4.28|P-value:8.61E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:6.34|P-value:1.49E-8 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.85|P-value:5.02E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.69|P-value:5.93E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:5.77|P-value:2.25E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.59|P-value:7.97E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.70|P-value:5.61E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.66|P-value:6.40E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.15|P-value:1.33E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.61|P-value:2.62E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.71|P-value:1.79E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.12|P-value:1.47E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.51|P-value:9.99E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:-3.65|P-value:9.10E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.63|P-value:7.05E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.28|P-value:8.71E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:5.41|P-value:1.09E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-3.95|P-value:3.66E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.80|P-value:1.95E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.05|P-value:7.36E-6 ID:SGTC_1921|Compound:5740136|FD-Score:5.08|P-value:4.33E-6 ID:SGTC_1935|Compound:st074532|FD-Score:4.32|P-value:7.43E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-4.10|P-value:2.29E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-4.76|P-value:2.29E-5 ID:SGTC_2016|Compound:5121758|FD-Score:4.73|P-value:1.67E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-4.89|P-value:1.40E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:4.68|P-value:2.04E-5 ID:SGTC_2171|Compound:5739187|FD-Score:4.16|P-value:1.28E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.80|P-value:5.92E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.73|P-value:2.53E-5 ID:SGTC_2183|Compound:6420625|FD-Score:8.02|P-value:1.26E-12 ID:SGTC_2184|Compound:6075246|FD-Score:-5.60|P-value:7.62E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.00|P-value:2.18E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.57|P-value:3.03E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.77|P-value:4.57E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:10.70|P-value:8.47E-21 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.94|P-value:2.70E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.64|P-value:6.80E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.39|P-value:8.48E-5 ID:SGTC_2727|Compound:riluzole|FD-Score:4.60|P-value:2.72E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-4.33|P-value:1.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.73|P-value:7.18E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.63|P-value:6.98E-4 ID:SGTC_3031|Compound:9088762|FD-Score:5.01|P-value:5.55E-6 ID:SGTC_3033|Compound:9090887|FD-Score:9.99|P-value:1.52E-18 ID:SGTC_3205|Compound:9113483|FD-Score:3.92|P-value:2.89E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.69|P-value:8.10E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-4.54|P-value:4.99E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.67|P-value:8.72E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.83|P-value:1.65E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:5.49|P-value:7.63E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:5.40|P-value:1.15E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:6.21|P-value:2.88E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.91|P-value:4.20E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.87|P-value:3.31E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.15|P-value:7.27E-16 ID:SGTC_195|Compound:4234-0266|FD-Score:3.78|P-value:4.43E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.40|P-value:7.06E-32 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.35|P-value:1.40E-8 ID:SGTC_283|Compound:0987-0079|FD-Score:3.93|P-value:2.73E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:14.70|P-value:6.91E-38 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.65|P-value:9.10E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.67|P-value:2.09E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:6.06|P-value:5.77E-8 ID:SGTC_942|Compound:3253-1115|FD-Score:4.28|P-value:8.61E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:6.34|P-value:1.49E-8 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.85|P-value:5.02E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.69|P-value:5.93E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:5.77|P-value:2.25E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.59|P-value:7.97E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.70|P-value:5.61E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.66|P-value:6.40E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.15|P-value:1.33E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.61|P-value:2.62E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.71|P-value:1.79E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.12|P-value:1.47E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.51|P-value:9.99E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:-3.65|P-value:9.10E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.63|P-value:7.05E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.28|P-value:8.71E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:5.41|P-value:1.09E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-3.95|P-value:3.66E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.80|P-value:1.95E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.05|P-value:7.36E-6 ID:SGTC_1921|Compound:5740136|FD-Score:5.08|P-value:4.33E-6 ID:SGTC_1935|Compound:st074532|FD-Score:4.32|P-value:7.43E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-4.10|P-value:2.29E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-4.76|P-value:2.29E-5 ID:SGTC_2016|Compound:5121758|FD-Score:4.73|P-value:1.67E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-4.89|P-value:1.40E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:4.68|P-value:2.04E-5 ID:SGTC_2171|Compound:5739187|FD-Score:4.16|P-value:1.28E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.80|P-value:5.92E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.73|P-value:2.53E-5 ID:SGTC_2183|Compound:6420625|FD-Score:8.02|P-value:1.26E-12 ID:SGTC_2184|Compound:6075246|FD-Score:-5.60|P-value:7.62E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.00|P-value:2.18E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.57|P-value:3.03E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.77|P-value:4.57E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:10.70|P-value:8.47E-21 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.94|P-value:2.70E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.64|P-value:6.80E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.39|P-value:8.48E-5 ID:SGTC_2727|Compound:riluzole|FD-Score:4.60|P-value:2.72E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-4.33|P-value:1.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.73|P-value:7.18E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.63|P-value:6.98E-4 ID:SGTC_3031|Compound:9088762|FD-Score:5.01|P-value:5.55E-6 ID:SGTC_3033|Compound:9090887|FD-Score:9.99|P-value:1.52E-18 ID:SGTC_3205|Compound:9113483|FD-Score:3.92|P-value:2.89E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.69|P-value:8.10E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-4.54|P-value:4.99E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.67|P-value:8.72E-4

Top fitness defect scores for YKL138C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 14.70 1.1 µM 6.91E-38 mitochondrial stress 8 2.14E-49
2 SGTC_236 1509-0011 13.40 5.3 µM 7.06E-32 130 1.93E-41
3 SGTC_2598 perillyl alcohol 10.70 100.0 µM 8.47E-21 1 8.60E-27
4 SGTC_3033 9090887 9.99 49.5 µM 1.52E-18 fatty acid desaturase (OLE1) 2 8.16E-24
5 SGTC_173 1273-0061 9.15 2.7 µM 7.27E-16 mitochondrial stress 48 2.79E-20
6 SGTC_2183 6420625 8.02 130.5 µM 1.26E-12 mitochondrial processes 6 5.13E-16
7 SGTC_275 trichlorophene 6.35 5.7 µM 1.40E-8 mitochondrial stress 106 1.07E-10
8 SGTC_944 3370-0224 6.34 231.0 µM 1.49E-8 4 1.15E-10
9 SGTC_70 0141-0289 6.21 43.3 µM 2.88E-8 mitochondrial stress 73 2.73E-10
10 SGTC_767 0929-0023 6.06 86.0 µM 5.77E-8 TRP & mitochondrial translation 22 6.80E-10
11 SGTC_10 0279-0212 5.83 42.6 µM 1.65E-7 TRP & mitochondrial translation 32 2.69E-9
12 SGTC_1742 st038235 5.80 28.9 µM 1.95E-7 mitochondrial stress 50 3.36E-9
13 SGTC_1031 k035-0009 5.77 16.0 µM 2.25E-7 8 4.05E-9
14 SGTC_19 0279-0214 5.49 38.4 µM 7.63E-7 TRP & mitochondrial translation 14 1.99E-8
15 SGTC_1484 3473-2379 5.41 286.0 µM 1.09E-6 2 3.18E-8
16 SGTC_63 0099-0242 5.40 26.7 µM 1.15E-6 mitochondrial stress 41 3.40E-8
17 SGTC_1921 5740136 5.08 50.0 µM 4.33E-6 TRP & mitochondrial translation 31 1.92E-7
18 SGTC_3031 9088762 5.01 49.5 µM 5.55E-6 4 2.66E-7
19 SGTC_2016 5121758 4.73 140.0 µM 1.67E-5 redox potentiating 23 1.11E-6
20 SGTC_1188 1403-0014 4.71 4.6 µM 1.79E-5 mitochondrial stress 34 1.22E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.448 2.41E-164 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.430 1.04E-150 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.427 9.38E-149 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.424 9.53E-147 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.422 1.30E-144 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.422 2.61E-144 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.415 6.97E-140 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.411 6.94E-137 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.410 2.33E-136 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.401 1.01E-129 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.400 6.18E-129 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.400 6.34E-129 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.393 2.13E-124 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.393 3.09E-124 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.391 3.87E-123 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss