YKL141W / SDH3

Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL141W / SDH3

Click on Significant Values for Screen Details ID:SGTC_80|Compound:0159-0065|FD-Score:4.11|P-value:3.40E-6 ID:SGTC_83|Compound:0170-0301|FD-Score:2.86|P-value:8.27E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.36|P-value:1.13E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-5.94|P-value:7.19E-11 ID:SGTC_94|Compound:0334-0113|FD-Score:-2.90|P-value:9.50E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.32|P-value:1.39E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-2.91|P-value:9.14E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.65|P-value:1.90E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:4.09|P-value:3.86E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.09|P-value:3.47E-4 ID:SGTC_500|Compound:h-89|FD-Score:2.94|P-value:6.24E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.65|P-value:2.72E-7 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.00|P-value:6.41E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.39|P-value:1.34E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.42|P-value:1.18E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.97|P-value:9.82E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.38|P-value:3.27E-9 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.78|P-value:1.34E-7 ID:SGTC_918|Compound:glabranin|FD-Score:4.05|P-value:4.59E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.97|P-value:9.58E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.91|P-value:9.09E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.89|P-value:1.02E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.51|P-value:4.01E-7 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.07|P-value:3.74E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.98|P-value:5.40E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.17|P-value:3.38E-4 ID:SGTC_2190|Compound:6049624|FD-Score:5.52|P-value:8.35E-10 ID:SGTC_2196|Compound:6573537|FD-Score:2.99|P-value:5.13E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-2.98|P-value:7.07E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.43|P-value:8.52E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.35|P-value:1.46E-6 ID:SGTC_2437|Compound:5741531|FD-Score:6.19|P-value:7.27E-12 ID:SGTC_2442|Compound:5158906|FD-Score:3.18|P-value:2.45E-4 ID:SGTC_2449|Compound:5812982|FD-Score:4.15|P-value:2.83E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-3.44|P-value:1.11E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:2.91|P-value:7.04E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.00|P-value:4.88E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.29|P-value:1.52E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.66|P-value:3.06E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.55|P-value:6.97E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.27|P-value:1.46E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-2.97|P-value:7.21E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.87|P-value:8.06E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.44|P-value:8.05E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.31|P-value:1.40E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.47|P-value:7.22E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.40|P-value:1.32E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.37|P-value:1.51E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.26|P-value:2.38E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-2.95|P-value:7.88E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.50|P-value:6.25E-7 ID:SGTC_3154|Compound:9100113|FD-Score:3.86|P-value:1.18E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.03|P-value:5.85E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:4.11|P-value:3.40E-6 ID:SGTC_83|Compound:0170-0301|FD-Score:2.86|P-value:8.27E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.36|P-value:1.13E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-5.94|P-value:7.19E-11 ID:SGTC_94|Compound:0334-0113|FD-Score:-2.90|P-value:9.50E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.32|P-value:1.39E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-2.91|P-value:9.14E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.65|P-value:1.90E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:4.09|P-value:3.86E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.09|P-value:3.47E-4 ID:SGTC_500|Compound:h-89|FD-Score:2.94|P-value:6.24E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.65|P-value:2.72E-7 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.00|P-value:6.41E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.39|P-value:1.34E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.42|P-value:1.18E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.97|P-value:9.82E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.38|P-value:3.27E-9 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.78|P-value:1.34E-7 ID:SGTC_918|Compound:glabranin|FD-Score:4.05|P-value:4.59E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.97|P-value:9.58E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.91|P-value:9.09E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.89|P-value:1.02E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.51|P-value:4.01E-7 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.07|P-value:3.74E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.98|P-value:5.40E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.17|P-value:3.38E-4 ID:SGTC_2190|Compound:6049624|FD-Score:5.52|P-value:8.35E-10 ID:SGTC_2196|Compound:6573537|FD-Score:2.99|P-value:5.13E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-2.98|P-value:7.07E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.43|P-value:8.52E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.35|P-value:1.46E-6 ID:SGTC_2437|Compound:5741531|FD-Score:6.19|P-value:7.27E-12 ID:SGTC_2442|Compound:5158906|FD-Score:3.18|P-value:2.45E-4 ID:SGTC_2449|Compound:5812982|FD-Score:4.15|P-value:2.83E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-3.44|P-value:1.11E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:2.91|P-value:7.04E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.00|P-value:4.88E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.29|P-value:1.52E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.66|P-value:3.06E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.55|P-value:6.97E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.27|P-value:1.46E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-2.97|P-value:7.21E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.87|P-value:8.06E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.44|P-value:8.05E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.31|P-value:1.40E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.47|P-value:7.22E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.40|P-value:1.32E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.37|P-value:1.51E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.26|P-value:2.38E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-2.95|P-value:7.88E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.50|P-value:6.25E-7 ID:SGTC_3154|Compound:9100113|FD-Score:3.86|P-value:1.18E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.03|P-value:5.85E-4

Top fitness defect scores for YKL141W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2437 5741531 6.19 144.2 µM 7.27E-12 1 3.05E-10 1.11
2 SGTC_2190 6049624 5.52 200.0 µM 8.35E-10 1 1.70E-8 1.86
3 SGTC_343 4130-2827 4.65 29.8 µM 1.90E-7 3 1.69E-6 0.92
4 SGTC_1144 3486-0183 4.51 12.5 µM 4.01E-7 1 3.20E-6 0.60
5 SGTC_2724 maprotiline 4.27 69.6 µM 1.46E-6 ERG2 3 9.58E-6 0.09
6 SGTC_2449 5812982 4.15 45.8 µM 2.83E-6 4 1.68E-5 0.26
7 SGTC_80 0159-0065 4.11 512.2 µM 3.40E-6 1 1.96E-5 0.93
8 SGTC_359 0081-0058 4.09 15.9 µM 3.86E-6 60S ribosome export 12 2.18E-5 8.89E-4
9 SGTC_918 glabranin 4.05 770.7 nM 4.59E-6 5 2.53E-5 0.06
10 SGTC_1136 pergolide 3.89 1.1 µM 1.02E-5 19 4.97E-5 0.02
11 SGTC_3154 9100113 3.86 49.5 µM 1.18E-5 14 5.63E-5 9.52E-4
12 SGTC_2690 usnic acid 3.66 100.0 µM 3.06E-5 8 1.27E-4 0.20
13 SGTC_2935 9038016 3.47 30.0 µM 7.22E-5 11 2.63E-4 0.08
14 SGTC_2780 5215298 3.44 71.4 µM 8.05E-5 20 2.88E-4 0.04
15 SGTC_2231 micatex 3.43 6.8 µM 8.52E-5 11 3.02E-4 0.12
16 SGTC_85 0868-0259 3.36 160.1 µM 1.13E-4 60S ribosome export 11 3.85E-4 0.01
17 SGTC_112 phenothiazine 3.32 287.2 µM 1.39E-4 unfolded protein response 9 4.58E-4 0.10
18 SGTC_2846 9008642 3.31 19.5 µM 1.40E-4 13 4.62E-4 0.01
19 SGTC_2588 indole-3-carbinol 3.29 100.0 µM 1.52E-4 16 4.95E-4 0.04
20 SGTC_2442 5158906 3.18 48.5 µM 2.45E-4 6 7.41E-4 0.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.58E-31 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.183 1.39E-26 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.178 2.44E-25 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.167 2.41E-22 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.161 6.08E-21 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.158 2.81E-20 YLR267W_p BOP2_p hom Protein of unknown function
0.151 1.68E-18 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.147 9.55E-18 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.144 4.88E-17 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.143 7.82E-17 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.142 1.11E-16 YNL301C RPL18B hom Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication
0.136 2.78E-15 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.135 4.05E-15 YOL084W PHM7 hom Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress
0.134 5.43E-15 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.133 1.09E-14 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes