YKL143W / LTV1

Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL143W / LTV1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:6.17|P-value:4.95E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:3.88|P-value:5.35E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.80|P-value:2.28E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.33|P-value:8.02E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.53|P-value:2.06E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.92|P-value:9.62E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.73|P-value:1.94E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:5.05|P-value:2.57E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.37|P-value:7.12E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.52|P-value:2.09E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.73|P-value:9.57E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.16|P-value:1.66E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.38|P-value:6.34E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:3.43|P-value:2.90E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.17|P-value:7.23E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.00|P-value:3.30E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:5.99|P-value:1.50E-9 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.37|P-value:7.17E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.38|P-value:3.51E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.85|P-value:6.02E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.35|P-value:3.95E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.04|P-value:2.75E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.31|P-value:8.75E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.90|P-value:4.91E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.13|P-value:1.89E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.53|P-value:2.06E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.89|P-value:5.84E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.34|P-value:7.72E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.14|P-value:7.96E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.45|P-value:2.73E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.82|P-value:1.41E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.00|P-value:3.43E-7 ID:SGTC_1824|Compound:st053723|FD-Score:-3.31|P-value:8.74E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.17|P-value:1.60E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.30|P-value:9.04E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.68|P-value:1.17E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.17|P-value:7.27E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.53|P-value:3.21E-6 ID:SGTC_2062|Compound:5245942|FD-Score:4.62|P-value:2.12E-6 ID:SGTC_2074|Compound:5212007|FD-Score:-4.38|P-value:1.50E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.56|P-value:3.66E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.27|P-value:5.06E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-3.52|P-value:4.27E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.33|P-value:4.15E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.31|P-value:8.71E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.20|P-value:6.60E-4 ID:SGTC_2365|Compound:9042475|FD-Score:7.80|P-value:6.63E-15 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.43|P-value:5.10E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:-5.03|P-value:7.36E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.25|P-value:5.51E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.39|P-value:3.37E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-4.55|P-value:7.11E-6 ID:SGTC_2841|Compound:9004761|FD-Score:3.13|P-value:8.36E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.39|P-value:3.38E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.94|P-value:4.06E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-3.60|P-value:3.17E-4 ID:SGTC_3323|Compound:9138564|FD-Score:5.10|P-value:2.01E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:6.17|P-value:4.95E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:3.88|P-value:5.35E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.80|P-value:2.28E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.33|P-value:8.02E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.53|P-value:2.06E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.92|P-value:9.62E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.73|P-value:1.94E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:5.05|P-value:2.57E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.37|P-value:7.12E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.52|P-value:2.09E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.73|P-value:9.57E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.16|P-value:1.66E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.38|P-value:6.34E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:3.43|P-value:2.90E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.17|P-value:7.23E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.00|P-value:3.30E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:5.99|P-value:1.50E-9 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.37|P-value:7.17E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.38|P-value:3.51E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.85|P-value:6.02E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.35|P-value:3.95E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.04|P-value:2.75E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.31|P-value:8.75E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.90|P-value:4.91E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.13|P-value:1.89E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.53|P-value:2.06E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.89|P-value:5.84E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.34|P-value:7.72E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.14|P-value:7.96E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.45|P-value:2.73E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.82|P-value:1.41E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.00|P-value:3.43E-7 ID:SGTC_1824|Compound:st053723|FD-Score:-3.31|P-value:8.74E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.17|P-value:1.60E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.30|P-value:9.04E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.68|P-value:1.17E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.17|P-value:7.27E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.53|P-value:3.21E-6 ID:SGTC_2062|Compound:5245942|FD-Score:4.62|P-value:2.12E-6 ID:SGTC_2074|Compound:5212007|FD-Score:-4.38|P-value:1.50E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.56|P-value:3.66E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.27|P-value:5.06E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-3.52|P-value:4.27E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.33|P-value:4.15E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.31|P-value:8.71E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.20|P-value:6.60E-4 ID:SGTC_2365|Compound:9042475|FD-Score:7.80|P-value:6.63E-15 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.43|P-value:5.10E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:-5.03|P-value:7.36E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.25|P-value:5.51E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.39|P-value:3.37E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-4.55|P-value:7.11E-6 ID:SGTC_2841|Compound:9004761|FD-Score:3.13|P-value:8.36E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.39|P-value:3.38E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.94|P-value:4.06E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-3.60|P-value:3.17E-4 ID:SGTC_3323|Compound:9138564|FD-Score:5.10|P-value:2.01E-7

Top fitness defect scores for YKL143W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2365 9042475 7.80 200.0 µM 6.63E-15 3 3.00E-15
2 SGTC_18 0111-0177 6.17 500.0 nM 4.95E-10 16 3.40E-10
3 SGTC_836 0330-0104 5.99 1.4 µM 1.50E-9 4 1.07E-9
4 SGTC_118 0083-0097 5.53 135.3 µM 2.06E-8 translation 37 1.60E-8
5 SGTC_3323 9138564 5.10 53.9 µM 2.01E-7 4 1.69E-7
6 SGTC_343 4130-2827 5.05 29.8 µM 2.57E-7 15 2.18E-7
7 SGTC_1107 amlodipine 5.04 47.0 µM 2.75E-7 14 2.34E-7
8 SGTC_1730 st033808 5.00 45.1 µM 3.43E-7 11 2.93E-7
9 SGTC_1337 1486-1011 4.89 40.3 µM 5.84E-7 6 5.07E-7
10 SGTC_2062 5245942 4.62 200.0 µM 2.12E-6 3 1.91E-6
11 SGTC_2054 5233173 4.53 129.0 µM 3.21E-6 mitochondrial response to ROS 40 2.93E-6
12 SGTC_2498 4'-Methoxychalcone 4.43 54.6 µM 5.10E-6 RPP1 & pyrimidine depletion 23 4.72E-6
13 SGTC_708 3448-5400 4.38 146.0 µM 6.34E-6 34 5.91E-6
14 SGTC_1365 1672-3266 4.34 55.4 µM 7.72E-6 10 7.24E-6
15 SGTC_1844 rapamycin 4.17 4.0 nM 1.60E-5 146 1.54E-5
16 SGTC_625 k213-0058 4.16 121.0 µM 1.66E-5 translation 94 1.59E-5
17 SGTC_1223 0764-0573 4.13 147.0 µM 1.89E-5 16 1.81E-5
18 SGTC_831 k061-1017 4.00 217.0 µM 3.30E-5 translation 61 3.22E-5
19 SGTC_3043 9092303 3.94 49.5 µM 4.06E-5 17 3.99E-5
20 SGTC_1131 3454-3128 3.90 32.3 µM 4.91E-5 48 4.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.23E-16 YMR143W RPS16A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
0.134 7.42E-15 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.121 2.03E-12 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.118 5.97E-12 YHR034C PIH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.116 1.95E-11 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.115 2.24E-11 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.114 4.09E-11 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.109 2.79E-10 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.108 4.14E-10 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.107 4.97E-10 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.107 6.15E-10 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.106 7.99E-10 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.106 8.70E-10 YNL248C RPA49 hom RNA polymerase I subunit A49
0.105 1.11E-9 YJL177W RPL17B hom Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication
0.099 1.07E-8 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication