YKL152C / GPM1

Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL152C / GPM1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.36|P-value:7.52E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.45|P-value:4.74E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.21|P-value:1.39E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.15|P-value:1.85E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.77|P-value:1.01E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:2.95|P-value:4.26E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-9.96|P-value:1.11E-29 ID:SGTC_173|Compound:1273-0061|FD-Score:2.92|P-value:4.78E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.24|P-value:1.23E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.72|P-value:1.27E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:2.85|P-value:6.29E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:2.74|P-value:9.84E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-4.55|P-value:1.40E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:4.29|P-value:6.11E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:2.97|P-value:3.83E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:2.90|P-value:5.17E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.39|P-value:6.30E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:5.15|P-value:2.95E-9 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.76|P-value:1.10E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.87|P-value:6.08E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-3.58|P-value:2.60E-5 ID:SGTC_1115|Compound:galangin|FD-Score:2.80|P-value:7.76E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.53|P-value:3.29E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:2.95|P-value:4.31E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.41|P-value:5.98E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.07|P-value:2.56E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:2.92|P-value:4.70E-4 ID:SGTC_1571|Compound:st070080|FD-Score:2.85|P-value:6.28E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.69|P-value:1.46E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.15|P-value:1.87E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.39|P-value:6.15E-5 ID:SGTC_1892|Compound:st058411|FD-Score:-3.00|P-value:3.52E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-5.57|P-value:1.53E-10 ID:SGTC_1962|Compound:st076595|FD-Score:-3.21|P-value:1.44E-4 ID:SGTC_1975|Compound:st070967|FD-Score:2.98|P-value:3.72E-4 ID:SGTC_2243|Compound:6634756|FD-Score:2.84|P-value:6.65E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-4.07|P-value:2.11E-6 ID:SGTC_2290|Compound:7904846|FD-Score:-2.87|P-value:5.87E-4 ID:SGTC_2315|Compound:7733312|FD-Score:2.96|P-value:4.07E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.08|P-value:2.46E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.14|P-value:1.94E-4 ID:SGTC_2456|Compound:5770359|FD-Score:2.77|P-value:8.76E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.46|P-value:2.26E-7 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.57|P-value:2.80E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.99|P-value:3.68E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:2.95|P-value:4.17E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.24|P-value:1.26E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.40|P-value:3.30E-7 ID:SGTC_2808|Compound:7946468|FD-Score:-3.67|P-value:1.71E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-4.15|P-value:1.39E-6 ID:SGTC_2815|Compound:7968870|FD-Score:3.06|P-value:2.70E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.10|P-value:2.28E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-2.82|P-value:7.34E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.11|P-value:2.27E-4 ID:SGTC_2936|Compound:9038235|FD-Score:5.42|P-value:4.27E-10 ID:SGTC_3028|Compound:9087778|FD-Score:-4.38|P-value:3.68E-7 ID:SGTC_3033|Compound:9090887|FD-Score:3.57|P-value:2.70E-5 ID:SGTC_3035|Compound:9091303|FD-Score:2.79|P-value:8.04E-4 ID:SGTC_3072|Compound:9116419|FD-Score:2.80|P-value:7.54E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.92|P-value:4.86E-4 ID:SGTC_3104|Compound:9120930|FD-Score:2.80|P-value:7.60E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.21|P-value:1.00E-6 ID:SGTC_3202|Compound:9113761|FD-Score:4.36|P-value:4.00E-7 ID:SGTC_3270|Compound:9137563|FD-Score:2.85|P-value:6.25E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.36|P-value:7.52E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.45|P-value:4.74E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.21|P-value:1.39E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.15|P-value:1.85E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.77|P-value:1.01E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:2.95|P-value:4.26E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-9.96|P-value:1.11E-29 ID:SGTC_173|Compound:1273-0061|FD-Score:2.92|P-value:4.78E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.24|P-value:1.23E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.72|P-value:1.27E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:2.85|P-value:6.29E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:2.74|P-value:9.84E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-4.55|P-value:1.40E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:4.29|P-value:6.11E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:2.97|P-value:3.83E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:2.90|P-value:5.17E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.39|P-value:6.30E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:5.15|P-value:2.95E-9 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.76|P-value:1.10E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.87|P-value:6.08E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-3.58|P-value:2.60E-5 ID:SGTC_1115|Compound:galangin|FD-Score:2.80|P-value:7.76E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.53|P-value:3.29E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:2.95|P-value:4.31E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.41|P-value:5.98E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.07|P-value:2.56E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:2.92|P-value:4.70E-4 ID:SGTC_1571|Compound:st070080|FD-Score:2.85|P-value:6.28E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.69|P-value:1.46E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.15|P-value:1.87E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.39|P-value:6.15E-5 ID:SGTC_1892|Compound:st058411|FD-Score:-3.00|P-value:3.52E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-5.57|P-value:1.53E-10 ID:SGTC_1962|Compound:st076595|FD-Score:-3.21|P-value:1.44E-4 ID:SGTC_1975|Compound:st070967|FD-Score:2.98|P-value:3.72E-4 ID:SGTC_2243|Compound:6634756|FD-Score:2.84|P-value:6.65E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-4.07|P-value:2.11E-6 ID:SGTC_2290|Compound:7904846|FD-Score:-2.87|P-value:5.87E-4 ID:SGTC_2315|Compound:7733312|FD-Score:2.96|P-value:4.07E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.08|P-value:2.46E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.14|P-value:1.94E-4 ID:SGTC_2456|Compound:5770359|FD-Score:2.77|P-value:8.76E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.46|P-value:2.26E-7 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.57|P-value:2.80E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.99|P-value:3.68E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:2.95|P-value:4.17E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.24|P-value:1.26E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.40|P-value:3.30E-7 ID:SGTC_2808|Compound:7946468|FD-Score:-3.67|P-value:1.71E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-4.15|P-value:1.39E-6 ID:SGTC_2815|Compound:7968870|FD-Score:3.06|P-value:2.70E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.10|P-value:2.28E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-2.82|P-value:7.34E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.11|P-value:2.27E-4 ID:SGTC_2936|Compound:9038235|FD-Score:5.42|P-value:4.27E-10 ID:SGTC_3028|Compound:9087778|FD-Score:-4.38|P-value:3.68E-7 ID:SGTC_3033|Compound:9090887|FD-Score:3.57|P-value:2.70E-5 ID:SGTC_3035|Compound:9091303|FD-Score:2.79|P-value:8.04E-4 ID:SGTC_3072|Compound:9116419|FD-Score:2.80|P-value:7.54E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.92|P-value:4.86E-4 ID:SGTC_3104|Compound:9120930|FD-Score:2.80|P-value:7.60E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.21|P-value:1.00E-6 ID:SGTC_3202|Compound:9113761|FD-Score:4.36|P-value:4.00E-7 ID:SGTC_3270|Compound:9137563|FD-Score:2.85|P-value:6.25E-4

Top fitness defect scores for YKL152C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2936 9038235 5.42 15.6 µM 4.27E-10 2 2.91E-8 0.20
2 SGTC_899 1083-0020 5.15 478.0 µM 2.95E-9 2 1.33E-7 1.47
3 SGTC_2565 isoliquiritigenin 4.46 100.0 µM 2.26E-7 7 4.08E-6 0.03
4 SGTC_2807 7945238 4.40 52.0 µM 3.30E-7 2 5.50E-6 0.59
5 SGTC_3202 9113761 4.36 49.5 µM 4.00E-7 7 6.39E-6 0.28
6 SGTC_690 glyoxal 4.29 20.3 µM 6.11E-7 24 8.94E-6 0.34
7 SGTC_101 0490-5701 3.77 117.5 µM 1.01E-5 6 8.22E-5 0.46
8 SGTC_390 dec-rvkr-cmk 3.72 16.7 µM 1.27E-5 calcium & mitochondrial duress 10 9.86E-5 0.05
9 SGTC_1743 st037606 3.69 46.4 µM 1.46E-5 10 1.10E-4 0.06
10 SGTC_3033 9090887 3.57 49.5 µM 2.70E-5 fatty acid desaturase (OLE1) 23 1.79E-4 0.00
11 SGTC_90 0870-0863 3.45 4.6 µM 4.74E-5 7 2.80E-4 0.02
12 SGTC_1837 st055472 3.39 66.5 µM 6.15E-5 4 3.44E-4 0.09
13 SGTC_898 1000-0849 3.39 28.3 µM 6.30E-5 6 3.50E-4 0.01
14 SGTC_372 0155-0182 3.24 15.9 µM 1.23E-4 mitochondrial response to ROS 13 5.94E-4 0.05
15 SGTC_99 0109-0120 3.21 622.8 µM 1.39E-4 11 6.55E-4 0.12
16 SGTC_100 0086-0128 3.15 49.6 µM 1.85E-4 copper-dependent oxidative stress 19 8.24E-4 0.01
17 SGTC_1788 fluconazole 3.15 20.0 µM 1.87E-4 azole & statin 17 8.30E-4 9.35E-5
18 SGTC_2877 9040724 3.10 71.4 µM 2.28E-4 6 9.72E-4 0.02
19 SGTC_2409 alverine citrate 3.08 64.0 µM 2.46E-4 23 0.00103 0.17
20 SGTC_1360 1598-0022 3.07 39.8 µM 2.56E-4 ERG2 27 0.00107 0.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 1.02E-27 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.182 2.53E-26 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.171 2.10E-23 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.165 6.11E-22 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.159 1.88E-20 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.157 4.99E-20 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.137 1.68E-15 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.135 4.95E-15 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.132 1.58E-14 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.123 7.22E-13 YOL133W HRT1 het RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
0.118 6.84E-12 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.115 2.36E-11 YKR068C BET3 het Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
0.111 1.25E-10 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.110 1.47E-10 YOR075W UFE1 het t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
0.110 1.52E-10 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated