YKL153W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL153W / YKL153W

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.21|P-value:6.15E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:5.22|P-value:7.36E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:3.29|P-value:4.64E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.16|P-value:7.29E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.53|P-value:2.48E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.66|P-value:1.31E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.30|P-value:4.35E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.44|P-value:2.69E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.84|P-value:1.32E-15 ID:SGTC_780|Compound:0109-0199|FD-Score:3.19|P-value:6.53E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.08|P-value:9.45E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.27|P-value:4.83E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.68|P-value:5.17E-9 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.30|P-value:4.42E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.17|P-value:6.95E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.26|P-value:9.02E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.26|P-value:5.02E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.68|P-value:1.03E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-9.14|P-value:1.66E-20 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.10|P-value:8.93E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.61|P-value:1.36E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.47|P-value:2.41E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.44|P-value:2.66E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.07|P-value:9.78E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.52|P-value:1.97E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.55|P-value:1.75E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.13|P-value:8.11E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.22|P-value:5.91E-4 ID:SGTC_2470|Compound:5664817|FD-Score:-3.18|P-value:6.76E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.93|P-value:3.41E-7 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.74|P-value:8.35E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.89|P-value:4.33E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.74|P-value:8.20E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.64|P-value:1.19E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.17|P-value:9.66E-8 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.54|P-value:1.76E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.47|P-value:2.40E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.11|P-value:8.73E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.29|P-value:4.50E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-5.22|P-value:7.17E-8 ID:SGTC_2803|Compound:7707263|FD-Score:3.44|P-value:2.66E-4 ID:SGTC_2822|Compound:7994718|FD-Score:5.38|P-value:2.98E-8 ID:SGTC_2825|Compound:7998094|FD-Score:3.25|P-value:5.37E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.47|P-value:2.32E-4 ID:SGTC_3009|Compound:9080819|FD-Score:5.20|P-value:8.21E-8 ID:SGTC_3044|Compound:9093193|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.99|P-value:2.94E-5 ID:SGTC_3112|Compound:9123419|FD-Score:3.09|P-value:9.38E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.24|P-value:5.58E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-4.52|P-value:2.57E-6 ID:SGTC_3159|Compound:9100096|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_3202|Compound:9113761|FD-Score:7.10|P-value:4.14E-13 ID:SGTC_3210|Compound:9128157|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_3242|Compound:9133940|FD-Score:-4.15|P-value:1.46E-5 ID:SGTC_3257|Compound:9139206|FD-Score:-3.22|P-value:5.83E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.21|P-value:6.15E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:5.22|P-value:7.36E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:3.29|P-value:4.64E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.16|P-value:7.29E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.53|P-value:2.48E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.66|P-value:1.31E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.30|P-value:4.35E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.44|P-value:2.69E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.84|P-value:1.32E-15 ID:SGTC_780|Compound:0109-0199|FD-Score:3.19|P-value:6.53E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.08|P-value:9.45E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.27|P-value:4.83E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.68|P-value:5.17E-9 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.30|P-value:4.42E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.17|P-value:6.95E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.26|P-value:9.02E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.26|P-value:5.02E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.68|P-value:1.03E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-9.14|P-value:1.66E-20 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.10|P-value:8.93E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.61|P-value:1.36E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.47|P-value:2.41E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.44|P-value:2.66E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.07|P-value:9.78E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.52|P-value:1.97E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.55|P-value:1.75E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.13|P-value:8.11E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.22|P-value:5.91E-4 ID:SGTC_2470|Compound:5664817|FD-Score:-3.18|P-value:6.76E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.93|P-value:3.41E-7 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.74|P-value:8.35E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.89|P-value:4.33E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.74|P-value:8.20E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.64|P-value:1.19E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.17|P-value:9.66E-8 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.54|P-value:1.76E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.47|P-value:2.40E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.11|P-value:8.73E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.29|P-value:4.50E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-5.22|P-value:7.17E-8 ID:SGTC_2803|Compound:7707263|FD-Score:3.44|P-value:2.66E-4 ID:SGTC_2822|Compound:7994718|FD-Score:5.38|P-value:2.98E-8 ID:SGTC_2825|Compound:7998094|FD-Score:3.25|P-value:5.37E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.47|P-value:2.32E-4 ID:SGTC_3009|Compound:9080819|FD-Score:5.20|P-value:8.21E-8 ID:SGTC_3044|Compound:9093193|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.99|P-value:2.94E-5 ID:SGTC_3112|Compound:9123419|FD-Score:3.09|P-value:9.38E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.24|P-value:5.58E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-4.52|P-value:2.57E-6 ID:SGTC_3159|Compound:9100096|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_3202|Compound:9113761|FD-Score:7.10|P-value:4.14E-13 ID:SGTC_3210|Compound:9128157|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_3242|Compound:9133940|FD-Score:-4.15|P-value:1.46E-5 ID:SGTC_3257|Compound:9139206|FD-Score:-3.22|P-value:5.83E-4

Top fitness defect scores for YKL153W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3202 9113761 7.10 49.5 µM 4.14E-13 2 6.14E-13 1.83
2 SGTC_1129 3453-1384 5.68 223.0 µM 5.17E-9 5 6.66E-9 0.02
3 SGTC_2822 7994718 5.38 71.4 µM 2.98E-8 1 3.74E-8 0.70
4 SGTC_41 0478-0632 5.22 82.6 µM 7.36E-8 5 9.12E-8 0.07
5 SGTC_3009 9080819 5.20 71.4 µM 8.21E-8 2 1.01E-7 0.40
6 SGTC_2581 avocatin a 5.17 64.0 µM 9.66E-8 sphingolipid biosynthesis & PDR1 4 1.19E-7 1.01
7 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.93 63.6 µM 3.41E-7 3 4.13E-7 0.31
8 SGTC_344 k064-0035 4.53 6.4 µM 2.48E-6 60S ribosome export 4 2.92E-6 0.40
9 SGTC_1324 1418-0026 4.26 34.4 µM 9.02E-6 4 1.04E-5 0.62
10 SGTC_3082 9117008 3.99 49.5 µM 2.94E-5 3 3.34E-5 0.86
11 SGTC_2535 4',4'-dimethoxydalbergione 3.74 51.2 µM 8.35E-5 DNA damage response 2 9.34E-5 0.23
12 SGTC_1346 1488-2224 3.68 62.4 µM 1.03E-4 15 1.15E-4 0.04
13 SGTC_1468 k284-1086 3.61 134.0 µM 1.36E-4 DNA intercalators 12 1.51E-4 0.06
14 SGTC_3210 9128157 3.60 49.5 µM 1.42E-4 16 1.57E-4 0.03
15 SGTC_2502 avocadyne acetate 3.59 18.6 µM 1.49E-4 7 1.65E-4 0.16
16 SGTC_3159 9100096 3.55 49.5 µM 1.74E-4 8 1.92E-4 0.06
17 SGTC_1673 st016611 3.52 27.3 µM 1.97E-4 10 2.18E-4 0.25
18 SGTC_2827 7993847 3.47 71.4 µM 2.32E-4 11 2.56E-4 0.12
19 SGTC_2660 2',4'-dihydroxychalcone 3.47 17.1 µM 2.40E-4 7 2.64E-4 0.04
20 SGTC_1494 4358-1428 3.47 177.0 µM 2.41E-4 9 2.65E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 2.36E-19 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.146 1.90E-17 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.136 3.00E-15 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.125 3.60E-13 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.125 4.21E-13 YDR328C SKP1 het Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress
0.124 5.23E-13 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.123 1.02E-12 YER127W LCP5 het Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
0.123 1.02E-12 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.120 2.47E-12 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.118 6.91E-12 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.116 1.78E-11 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.115 2.29E-11 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.115 2.97E-11 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
0.114 3.24E-11 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.112 7.64E-11 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP