YKL154W / SRP102

Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL154W / SRP102

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.83|P-value:2.68E-7 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.28|P-value:3.64E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.29|P-value:3.45E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.16|P-value:5.11E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.06|P-value:7.32E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.07|P-value:7.03E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.23|P-value:5.71E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.41|P-value:2.00E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.00|P-value:9.13E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.87|P-value:2.90E-5 ID:SGTC_1777|Compound:st045864|FD-Score:-3.27|P-value:3.80E-4 ID:SGTC_1793|Compound:st048256|FD-Score:-3.08|P-value:7.63E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.24|P-value:3.73E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.66|P-value:7.14E-5 ID:SGTC_2083|Compound:5306046|FD-Score:-3.02|P-value:9.15E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-4.34|P-value:3.75E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.57|P-value:1.18E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.06|P-value:8.05E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.08|P-value:7.50E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.38|P-value:2.44E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.00|P-value:1.62E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.63|P-value:7.55E-7 ID:SGTC_2822|Compound:7994718|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.49|P-value:1.43E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-4.47|P-value:1.95E-6 ID:SGTC_2851|Compound:9015922|FD-Score:-3.60|P-value:1.04E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.20|P-value:4.37E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.43|P-value:2.02E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.16|P-value:5.10E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.28|P-value:3.21E-4 ID:SGTC_2990|Compound:9074105|FD-Score:7.00|P-value:1.92E-13 ID:SGTC_2992|Compound:9074591|FD-Score:7.78|P-value:3.62E-16 ID:SGTC_3001|Compound:9076041|FD-Score:3.35|P-value:2.53E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.16|P-value:5.60E-4 ID:SGTC_3163|Compound:9099914|FD-Score:2.98|P-value:9.88E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.14|P-value:5.51E-4 ID:SGTC_3206|Compound:9114350|FD-Score:2.99|P-value:9.30E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.73|P-value:6.04E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.11|P-value:6.78E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.83|P-value:2.68E-7 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.28|P-value:3.64E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.29|P-value:3.45E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.16|P-value:5.11E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.06|P-value:7.32E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.07|P-value:7.03E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.23|P-value:5.71E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.41|P-value:2.00E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.00|P-value:9.13E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.87|P-value:2.90E-5 ID:SGTC_1777|Compound:st045864|FD-Score:-3.27|P-value:3.80E-4 ID:SGTC_1793|Compound:st048256|FD-Score:-3.08|P-value:7.63E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.24|P-value:3.73E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.66|P-value:7.14E-5 ID:SGTC_2083|Compound:5306046|FD-Score:-3.02|P-value:9.15E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-4.34|P-value:3.75E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.57|P-value:1.18E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.06|P-value:8.05E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.08|P-value:7.50E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.38|P-value:2.44E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.00|P-value:1.62E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.63|P-value:7.55E-7 ID:SGTC_2822|Compound:7994718|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.49|P-value:1.43E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-4.47|P-value:1.95E-6 ID:SGTC_2851|Compound:9015922|FD-Score:-3.60|P-value:1.04E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.20|P-value:4.37E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.43|P-value:2.02E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.16|P-value:5.10E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.28|P-value:3.21E-4 ID:SGTC_2990|Compound:9074105|FD-Score:7.00|P-value:1.92E-13 ID:SGTC_2992|Compound:9074591|FD-Score:7.78|P-value:3.62E-16 ID:SGTC_3001|Compound:9076041|FD-Score:3.35|P-value:2.53E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.16|P-value:5.60E-4 ID:SGTC_3163|Compound:9099914|FD-Score:2.98|P-value:9.88E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.14|P-value:5.51E-4 ID:SGTC_3206|Compound:9114350|FD-Score:2.99|P-value:9.30E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.73|P-value:6.04E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.11|P-value:6.78E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.47|P-value:1.55E-4

Top fitness defect scores for YKL154W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2992 9074591 7.78 71.4 µM 3.62E-16 1 3.62E-15 2.98
2 SGTC_2990 9074105 7.00 71.4 µM 1.92E-13 1 1.26E-12 1.58
3 SGTC_16 erodoxin 4.83 22.8 µM 2.68E-7 unfolded protein response 22 6.83E-7 0.25
4 SGTC_2817 7995342 4.63 71.4 µM 7.55E-7 3 1.80E-6 0.27
5 SGTC_827 3253-0474 4.23 693.0 µM 5.71E-6 5 1.19E-5 0.19
6 SGTC_2816 7982706 4.00 58.4 µM 1.62E-5 azole & statin 12 3.14E-5 0.12
7 SGTC_1690 st023502 3.87 41.2 µM 2.90E-5 calcium & mitochondrial duress 2 5.42E-5 0.22
8 SGTC_2044 5102272 3.66 200.0 µM 7.14E-5 11 1.26E-4 0.02
9 SGTC_109 0132-0036 3.51 33.7 µM 1.34E-4 4 2.27E-4 0.03
10 SGTC_2830 7992007 3.49 71.4 µM 1.43E-4 14 2.40E-4 0.21
11 SGTC_3327 9140648 3.47 26.9 µM 1.55E-4 22 2.59E-4 0.02
12 SGTC_1025 k007-0731 3.43 70.0 µM 1.82E-4 5 3.00E-4 0.33
13 SGTC_1017 4239-0030 3.41 168.0 µM 2.00E-4 5 3.29E-4 0.31
14 SGTC_3001 9076041 3.35 71.4 µM 2.53E-4 9 4.09E-4 0.03
15 SGTC_2989 9073649 3.28 71.4 µM 3.21E-4 18 5.12E-4 0.13
16 SGTC_2923 7992654 3.28 58.1 µM 3.32E-4 Golgi 12 5.27E-4 0.02
17 SGTC_1880 MG-132 3.24 525.0 µM 3.73E-4 26 5.88E-4 0.15
18 SGTC_2854 9024559 3.20 71.4 µM 4.37E-4 16 6.82E-4 0.02
19 SGTC_2822 7994718 3.19 71.4 µM 4.54E-4 12 7.07E-4 0.05
20 SGTC_2943 9068529 3.16 45.3 µM 5.10E-4 19 7.87E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.24E-18 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.149 4.59E-18 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.138 1.04E-15 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.137 1.43E-15 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.134 5.69E-15 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.121 1.63E-12 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.118 8.01E-12 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.117 1.19E-11 YKR022C NTR2 het Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
0.114 3.93E-11 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.112 7.65E-11 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.102 2.86E-9 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.100 5.74E-9 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.097 1.94E-8 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.095 3.28E-8 YFR002W NIC96 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
0.093 6.27E-8 YPL199C_p YPL199C_p hom Putative protein of unknown function, predicted to be palmitoylated