YKL155C / RSM22

Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL155C / RSM22

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.36|P-value:9.00E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.84|P-value:9.66E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:3.34|P-value:5.09E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:14.60|P-value:3.07E-47 ID:SGTC_150|Compound:3970-0969|FD-Score:4.25|P-value:1.42E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.21|P-value:8.18E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.20|P-value:8.07E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:7.37|P-value:2.04E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:5.42|P-value:4.94E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:17.40|P-value:8.09E-66 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.23|P-value:2.78E-16 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.23|P-value:7.73E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.60|P-value:1.85E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:17.80|P-value:4.48E-69 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.85|P-value:4.35E-9 ID:SGTC_581|Compound:0958-0271|FD-Score:5.47|P-value:3.73E-8 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-4.05|P-value:3.46E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.37|P-value:4.69E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.10|P-value:2.68E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.27|P-value:6.34E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:7.61|P-value:3.57E-14 ID:SGTC_879|Compound:0831-1030|FD-Score:3.75|P-value:1.13E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.58|P-value:3.31E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.91|P-value:5.90E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:-6.20|P-value:5.73E-10 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.89|P-value:6.73E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:-4.00|P-value:4.32E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.98|P-value:4.55E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.54|P-value:2.46E-4 ID:SGTC_1635|Compound:st007035|FD-Score:32.00|P-value:1.04E-217 ID:SGTC_1658|Compound:st012944|FD-Score:-4.45|P-value:6.36E-6 ID:SGTC_1660|Compound:st012960|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.14|P-value:9.96E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.56|P-value:2.35E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.22|P-value:1.67E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.54|P-value:3.98E-6 ID:SGTC_1757|Compound:st041620|FD-Score:3.85|P-value:7.61E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.06|P-value:3.32E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.22|P-value:7.80E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.85|P-value:7.59E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-4.99|P-value:4.71E-7 ID:SGTC_2144|Compound:5628481|FD-Score:3.35|P-value:4.94E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.09|P-value:2.88E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.17|P-value:9.13E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.34|P-value:5.02E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.17|P-value:9.03E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:11.70|P-value:8.75E-31 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.88|P-value:7.00E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:7.42|P-value:1.48E-13 ID:SGTC_2522|Compound:biochanin a|FD-Score:8.73|P-value:4.35E-18 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.03|P-value:3.84E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.75|P-value:7.85E-9 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.25|P-value:1.26E-7 ID:SGTC_2699|Compound:st077704|FD-Score:-3.18|P-value:9.02E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.46|P-value:3.45E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.38|P-value:8.07E-6 ID:SGTC_2929|Compound:9013348|FD-Score:3.52|P-value:2.70E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-4.03|P-value:3.81E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.46|P-value:3.36E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-4.55|P-value:3.95E-6 ID:SGTC_3045|Compound:9092950|FD-Score:5.02|P-value:3.97E-7 ID:SGTC_3294|Compound:9122953|FD-Score:-3.25|P-value:7.12E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.36|P-value:9.00E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.84|P-value:9.66E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:3.34|P-value:5.09E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:14.60|P-value:3.07E-47 ID:SGTC_150|Compound:3970-0969|FD-Score:4.25|P-value:1.42E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.21|P-value:8.18E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.20|P-value:8.07E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:7.37|P-value:2.04E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:5.42|P-value:4.94E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:17.40|P-value:8.09E-66 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.23|P-value:2.78E-16 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.23|P-value:7.73E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.60|P-value:1.85E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:17.80|P-value:4.48E-69 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.85|P-value:4.35E-9 ID:SGTC_581|Compound:0958-0271|FD-Score:5.47|P-value:3.73E-8 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-4.05|P-value:3.46E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.37|P-value:4.69E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.10|P-value:2.68E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.27|P-value:6.34E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:7.61|P-value:3.57E-14 ID:SGTC_879|Compound:0831-1030|FD-Score:3.75|P-value:1.13E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.58|P-value:3.31E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.91|P-value:5.90E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:-6.20|P-value:5.73E-10 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.89|P-value:6.73E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:-4.00|P-value:4.32E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.98|P-value:4.55E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.54|P-value:2.46E-4 ID:SGTC_1635|Compound:st007035|FD-Score:32.00|P-value:1.04E-217 ID:SGTC_1658|Compound:st012944|FD-Score:-4.45|P-value:6.36E-6 ID:SGTC_1660|Compound:st012960|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.14|P-value:9.96E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.56|P-value:2.35E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.22|P-value:1.67E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.54|P-value:3.98E-6 ID:SGTC_1757|Compound:st041620|FD-Score:3.85|P-value:7.61E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.06|P-value:3.32E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.22|P-value:7.80E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.85|P-value:7.59E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-4.99|P-value:4.71E-7 ID:SGTC_2144|Compound:5628481|FD-Score:3.35|P-value:4.94E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.09|P-value:2.88E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.17|P-value:9.13E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.34|P-value:5.02E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.17|P-value:9.03E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:11.70|P-value:8.75E-31 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.88|P-value:7.00E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:7.42|P-value:1.48E-13 ID:SGTC_2522|Compound:biochanin a|FD-Score:8.73|P-value:4.35E-18 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.03|P-value:3.84E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.75|P-value:7.85E-9 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.25|P-value:1.26E-7 ID:SGTC_2699|Compound:st077704|FD-Score:-3.18|P-value:9.02E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.46|P-value:3.45E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.38|P-value:8.07E-6 ID:SGTC_2929|Compound:9013348|FD-Score:3.52|P-value:2.70E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-4.03|P-value:3.81E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.46|P-value:3.36E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-4.55|P-value:3.95E-6 ID:SGTC_3045|Compound:9092950|FD-Score:5.02|P-value:3.97E-7 ID:SGTC_3294|Compound:9122953|FD-Score:-3.25|P-value:7.12E-4

Top fitness defect scores for YKL155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 32.00 42.4 µM 1.04E-217 6 3.53E-225
2 SGTC_386 1509-0011 17.80 3.1 µM 4.48E-69 13 2.23E-71
3 SGTC_236 1509-0011 17.40 5.3 µM 8.09E-66 73 5.22E-68
4 SGTC_134 0269-0018 14.60 6.9 µM 3.07E-47 19 8.70E-49
5 SGTC_2513 baicalein 11.70 25.6 µM 8.75E-31 calcium & mitochondrial duress 2 9.12E-32
6 SGTC_2522 biochanin a 8.73 4.9 µM 4.35E-18 RNA pol III & RNase P/MRP 1 1.23E-18
7 SGTC_275 trichlorophene 8.23 5.7 µM 2.78E-16 mitochondrial stress 72 9.06E-17
8 SGTC_876 0720-0963 7.61 56.8 µM 3.57E-14 1 1.37E-14
9 SGTC_2519 cryptotanshinone 7.42 88.0 µM 1.48E-13 heme biosynthesis & mitochondrial translocase 2 5.98E-14
10 SGTC_168 3970-0862 7.37 530.5 µM 2.04E-13 25 8.32E-14
11 SGTC_503 tyrphostin 8 5.85 294.0 µM 4.35E-9 TSC3-RPN4 4 2.48E-9
12 SGTC_2582 agaric acid 5.75 100.0 µM 7.85E-9 redox potentiating 174 4.56E-9
13 SGTC_365 0121-0052 5.60 13.6 µM 1.85E-8 mitochondrial response to ROS 18 1.10E-8
14 SGTC_581 0958-0271 5.47 211.0 µM 3.73E-8 19 2.28E-8
15 SGTC_173 1273-0061 5.42 2.7 µM 4.94E-8 mitochondrial stress 126 3.05E-8
16 SGTC_3045 9092950 5.02 49.5 µM 3.97E-7 8 2.62E-7
17 SGTC_116 0155-0182 4.84 31.8 µM 9.66E-7 mitochondrial response to ROS 44 6.57E-7
18 SGTC_942 3253-1115 4.58 227.0 µM 3.31E-6 13 2.34E-6
19 SGTC_1742 st038235 4.54 28.9 µM 3.98E-6 mitochondrial stress 96 2.83E-6
20 SGTC_2916 7875993 4.38 68.8 µM 8.07E-6 16 5.88E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.695 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.683 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.654 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.646 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.632 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.630 0 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.628 0 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.621 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.616 0 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.609 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.608 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.608 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.603 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.595 7.59E-321 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.579 7.58E-300 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases