YKL157W / APE2

Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL157W / APE2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-5.33|P-value:7.99E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.18|P-value:9.40E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.62|P-value:1.85E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.67|P-value:1.70E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.45|P-value:3.76E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.37|P-value:4.58E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.58|P-value:2.39E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.44|P-value:3.94E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.80|P-value:1.02E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.12|P-value:2.78E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:-4.37|P-value:8.47E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:6.33|P-value:2.95E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:3.63|P-value:1.95E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.83|P-value:1.18E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.51|P-value:3.02E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.50|P-value:3.13E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:-3.91|P-value:5.96E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.96|P-value:5.38E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.92|P-value:6.35E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.28|P-value:6.84E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.23|P-value:8.20E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.43|P-value:7.35E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.20|P-value:8.96E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.33|P-value:5.78E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.84|P-value:8.74E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.22|P-value:8.33E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.60|P-value:2.19E-4 ID:SGTC_1697|Compound:st025554|FD-Score:5.07|P-value:3.54E-7 ID:SGTC_1722|Compound:st034304|FD-Score:-3.88|P-value:6.72E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.17|P-value:9.69E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.40|P-value:4.44E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.35|P-value:5.31E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.42|P-value:3.77E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.37|P-value:4.58E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.00|P-value:4.68E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.51|P-value:2.99E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.17|P-value:9.91E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.37|P-value:9.78E-6 ID:SGTC_2784|Compound:7567673|FD-Score:3.22|P-value:8.28E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.58|P-value:2.34E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.71|P-value:2.06E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.91|P-value:6.56E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-5.33|P-value:7.99E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.18|P-value:9.40E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.62|P-value:1.85E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.67|P-value:1.70E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.45|P-value:3.76E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.37|P-value:4.58E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.58|P-value:2.39E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.44|P-value:3.94E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.80|P-value:1.02E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.12|P-value:2.78E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:-4.37|P-value:8.47E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:6.33|P-value:2.95E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:3.63|P-value:1.95E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.83|P-value:1.18E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.51|P-value:3.02E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.50|P-value:3.13E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:-3.91|P-value:5.96E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.96|P-value:5.38E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.92|P-value:6.35E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.28|P-value:6.84E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.23|P-value:8.20E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.43|P-value:7.35E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.20|P-value:8.96E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.33|P-value:5.78E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.84|P-value:8.74E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.22|P-value:8.33E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.60|P-value:2.19E-4 ID:SGTC_1697|Compound:st025554|FD-Score:5.07|P-value:3.54E-7 ID:SGTC_1722|Compound:st034304|FD-Score:-3.88|P-value:6.72E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.17|P-value:9.69E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.40|P-value:4.44E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.35|P-value:5.31E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.42|P-value:3.77E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.37|P-value:4.58E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.00|P-value:4.68E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.51|P-value:2.99E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.17|P-value:9.91E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.37|P-value:9.78E-6 ID:SGTC_2784|Compound:7567673|FD-Score:3.22|P-value:8.28E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.58|P-value:2.34E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.71|P-value:2.06E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.91|P-value:6.56E-5

Top fitness defect scores for YKL157W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_777 1315-0167 6.33 517.0 µM 2.95E-10 Golgi 3 1.22E-10
2 SGTC_1697 st025554 5.07 27.7 µM 3.54E-7 15 1.97E-7
3 SGTC_788 1182-0090 4.83 188.0 µM 1.18E-6 endomembrane recycling 56 6.91E-7
4 SGTC_2789 5281112 4.71 71.4 µM 2.06E-6 17 1.24E-6
5 SGTC_1446 4239-0190 4.43 62.0 µM 7.35E-6 26 4.65E-6
6 SGTC_2398 5228213 4.37 48.8 µM 9.78E-6 iron homeostasis 28 6.26E-6
7 SGTC_756 0508-1999 4.12 28.3 µM 2.78E-5 RPP1 & pyrimidine depletion 18 1.86E-5
8 SGTC_2137 5261020 4.00 140.0 µM 4.68E-5 37 3.20E-5
9 SGTC_1159 4092-0538 3.96 61.2 µM 5.38E-5 29 3.70E-5
10 SGTC_1213 1315-0166 3.92 115.0 µM 6.35E-5 31 4.39E-5
11 SGTC_2975 9084847 3.91 53.7 µM 6.56E-5 23 4.54E-5
12 SGTC_1544 7-methoxy-4-methylcoumarin 3.84 105.0 µM 8.74E-5 21 6.12E-5
13 SGTC_748 0136-0228 3.80 77.9 µM 1.02E-4 redox potentiating 82 7.22E-5
14 SGTC_402 epigallocatechin gallate 3.67 10.0 µM 1.70E-4 39 1.22E-4
15 SGTC_778 3456-2434 3.63 196.0 µM 1.95E-4 mitochondrial response to ROS 88 1.42E-4
16 SGTC_1683 st010134 3.60 710.0 nM 2.19E-4 45 1.59E-4
17 SGTC_2787 5284540 3.58 71.4 µM 2.34E-4 39 1.71E-4
18 SGTC_441 propafenone 3.58 146.0 µM 2.39E-4 8 1.74E-4
19 SGTC_2138 5575593 3.51 77.7 µM 2.99E-4 19 2.20E-4
20 SGTC_833 3852-0053 3.51 558.0 µM 3.02E-4 26 2.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.72E-13 YER134C YER134C hom Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene
0.094 4.36E-8 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.093 5.80E-8 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.080 3.08E-6 YLL027W ISA1 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins
0.078 6.08E-6 YNL077W APJ1 hom Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.078 6.33E-6 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.078 6.89E-6 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.070 4.41E-5 YKL060C FBA1 het Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
0.069 6.34E-5 YOR263C_d YOR263C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
0.069 6.94E-5 YER169W RPH1 hom JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
0.068 7.46E-5 YHR125W_d YHR125W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.066 1.26E-4 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.066 1.41E-4 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.065 1.53E-4 YPR128C ANT1 hom Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
0.065 1.53E-4 YDR135C YCF1 hom Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR