YKL159C / RCN1

Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL159C / RCN1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.09|P-value:6.68E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.19|P-value:6.95E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:7.26|P-value:2.35E-14 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.56|P-value:4.94E-12 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.53|P-value:1.26E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.72|P-value:5.63E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.09|P-value:6.63E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.50|P-value:1.51E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:3.81|P-value:3.81E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.16|P-value:5.15E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.16|P-value:7.84E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:3.72|P-value:5.63E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.93|P-value:2.21E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.08|P-value:6.88E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.93|P-value:2.21E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.10|P-value:1.03E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.10|P-value:6.39E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.97|P-value:1.28E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.65|P-value:7.61E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.05|P-value:7.74E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.06|P-value:1.29E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.15|P-value:8.16E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.81|P-value:3.73E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.69|P-value:6.47E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.72|P-value:4.87E-7 ID:SGTC_1895|Compound:st058434|FD-Score:3.35|P-value:2.49E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.31|P-value:2.99E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.26|P-value:3.58E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.25|P-value:5.20E-6 ID:SGTC_2179|Compound:6298986|FD-Score:-3.13|P-value:5.91E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.44|P-value:1.77E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-4.45|P-value:2.00E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-5.61|P-value:2.98E-9 ID:SGTC_2343|Compound:7990716|FD-Score:-3.15|P-value:5.51E-4 ID:SGTC_2401|Compound:5128683|FD-Score:5.40|P-value:1.05E-8 ID:SGTC_2402|Compound:5553605|FD-Score:3.60|P-value:9.33E-5 ID:SGTC_2403|Compound:6032726|FD-Score:5.14|P-value:4.66E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.13|P-value:8.90E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.80|P-value:3.91E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.70|P-value:6.09E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.40|P-value:2.14E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.99|P-value:9.41E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.57|P-value:1.05E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.06|P-value:7.55E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.24|P-value:3.86E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.33|P-value:2.69E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.09|P-value:6.55E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.72|P-value:5.52E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.25|P-value:3.74E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.11|P-value:6.12E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.32|P-value:2.80E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.16|P-value:5.16E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.09|P-value:6.68E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.19|P-value:6.95E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:7.26|P-value:2.35E-14 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.56|P-value:4.94E-12 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.53|P-value:1.26E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.72|P-value:5.63E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.09|P-value:6.63E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.50|P-value:1.51E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:3.81|P-value:3.81E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.16|P-value:5.15E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.16|P-value:7.84E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:3.72|P-value:5.63E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.93|P-value:2.21E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.08|P-value:6.88E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.93|P-value:2.21E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.10|P-value:1.03E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.10|P-value:6.39E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.97|P-value:1.28E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.65|P-value:7.61E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.05|P-value:7.74E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.06|P-value:1.29E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.15|P-value:8.16E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.81|P-value:3.73E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.69|P-value:6.47E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.72|P-value:4.87E-7 ID:SGTC_1895|Compound:st058434|FD-Score:3.35|P-value:2.49E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.31|P-value:2.99E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.26|P-value:3.58E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.25|P-value:5.20E-6 ID:SGTC_2179|Compound:6298986|FD-Score:-3.13|P-value:5.91E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.44|P-value:1.77E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-4.45|P-value:2.00E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-5.61|P-value:2.98E-9 ID:SGTC_2343|Compound:7990716|FD-Score:-3.15|P-value:5.51E-4 ID:SGTC_2401|Compound:5128683|FD-Score:5.40|P-value:1.05E-8 ID:SGTC_2402|Compound:5553605|FD-Score:3.60|P-value:9.33E-5 ID:SGTC_2403|Compound:6032726|FD-Score:5.14|P-value:4.66E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.13|P-value:8.90E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.80|P-value:3.91E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.70|P-value:6.09E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.40|P-value:2.14E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.99|P-value:9.41E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.57|P-value:1.05E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.06|P-value:7.55E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.24|P-value:3.86E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.33|P-value:2.69E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.09|P-value:6.55E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.72|P-value:5.52E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.25|P-value:3.74E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.11|P-value:6.12E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.32|P-value:2.80E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.16|P-value:5.16E-4

Top fitness defect scores for YKL159C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 7.26 9.0 µM 2.35E-14 cell wall 156 1.89E-13
2 SGTC_255 tunicamycin 6.56 200.5 nM 4.94E-12 unfolded protein response 25 2.73E-11
3 SGTC_2401 5128683 5.40 200.0 µM 1.05E-8 13 3.38E-8
4 SGTC_2403 6032726 5.14 181.2 µM 4.66E-8 15 1.35E-7
5 SGTC_1789 tunicamycin 4.72 25.0 nM 4.87E-7 unfolded protein response 30 1.20E-6
6 SGTC_582 0987-0078 4.50 156.0 µM 1.51E-6 calcium & mitochondrial duress 49 3.45E-6
7 SGTC_2167 5876490 4.25 200.0 µM 5.20E-6 24 1.09E-5
8 SGTC_797 k781-0471 4.16 270.0 µM 7.84E-6 RPP1 & pyrimidine depletion 14 1.60E-5
9 SGTC_1407 3909-7909 4.15 12.3 µM 8.16E-6 60S ribosome export 10 1.66E-5
10 SGTC_2582 agaric acid 4.13 100.0 µM 8.90E-6 redox potentiating 295 1.80E-5
11 SGTC_1073 triclabendazole 4.10 3.1 µM 1.03E-5 23 2.07E-5
12 SGTC_893 0958-0369 3.93 48.9 µM 2.21E-5 23 4.19E-5
13 SGTC_1071 trifluoperazine 3.93 6.3 µM 2.21E-5 27 4.20E-5
14 SGTC_1573 oleylamine 3.81 1.1 µM 3.73E-5 29 6.83E-5
15 SGTC_700 3453-2283 3.81 142.0 µM 3.81E-5 amide catabolism 28 6.96E-5
16 SGTC_2617 dihydrotanshinone i 3.80 20.8 µM 3.91E-5 copper-dependent oxidative stress 49 7.13E-5
17 SGTC_3148 9097893 3.72 49.5 µM 5.52E-5 44 9.85E-5
18 SGTC_390 dec-rvkr-cmk 3.72 16.7 µM 5.63E-5 calcium & mitochondrial duress 33 1.00E-4
19 SGTC_807 1315-0151 3.72 48.0 µM 5.63E-5 35 1.00E-4
20 SGTC_2738 aclarubicin 3.70 5.5 µM 6.09E-5 RNA pol III & RNase P/MRP 14 1.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 7.07E-43 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.226 3.98E-40 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.209 2.19E-34 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.203 2.01E-32 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.186 2.15E-27 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.181 5.25E-26 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.179 1.54E-25 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.175 2.37E-24 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.171 1.94E-23 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.164 1.53E-21 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.163 2.59E-21 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.158 3.19E-20 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.151 1.55E-18 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.148 6.40E-18 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.148 6.67E-18 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together