YKL160W / ELF1

Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL160W / ELF1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.18|P-value:1.19E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.12|P-value:7.79E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.44|P-value:2.49E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.29|P-value:7.37E-8 ID:SGTC_76|Compound:0433-0009|FD-Score:-4.30|P-value:9.99E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.61|P-value:1.74E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.29|P-value:7.35E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:4.31|P-value:6.70E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.52|P-value:2.66E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.21|P-value:7.44E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.00|P-value:3.55E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:3.81|P-value:5.96E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.84|P-value:5.30E-7 ID:SGTC_808|Compound:0711-0032|FD-Score:3.13|P-value:7.75E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.36|P-value:5.35E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.43|P-value:5.55E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.23|P-value:6.86E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.79|P-value:6.37E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.73|P-value:9.05E-7 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.86|P-value:4.69E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.37|P-value:3.23E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-6.35|P-value:1.31E-10 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.43|P-value:3.83E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.15|P-value:1.36E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.08|P-value:9.13E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:5.03|P-value:1.95E-7 ID:SGTC_1719|Compound:st032227|FD-Score:3.15|P-value:7.16E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.09|P-value:8.84E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.87|P-value:4.62E-7 ID:SGTC_2348|Compound:9022543|FD-Score:8.34|P-value:2.42E-17 ID:SGTC_2430|Compound:5571206|FD-Score:3.82|P-value:5.66E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.08|P-value:9.04E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.39|P-value:4.72E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.31|P-value:6.92E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.13|P-value:7.55E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.15|P-value:1.36E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.19|P-value:6.22E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.54|P-value:1.69E-4 ID:SGTC_2911|Compound:7942208|FD-Score:5.15|P-value:1.02E-7 ID:SGTC_2912|Compound:7964298|FD-Score:5.27|P-value:5.26E-8 ID:SGTC_2916|Compound:7875993|FD-Score:4.51|P-value:2.67E-6 ID:SGTC_2921|Compound:7974240|FD-Score:3.59|P-value:1.42E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.13|P-value:9.60E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.92|P-value:3.69E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.06|P-value:9.67E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.87|P-value:1.71E-9 ID:SGTC_3094|Compound:9117742|FD-Score:-3.84|P-value:6.86E-5 ID:SGTC_3137|Compound:9097352|FD-Score:6.71|P-value:7.01E-12 ID:SGTC_3202|Compound:9113761|FD-Score:3.06|P-value:9.52E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.18|P-value:1.19E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.12|P-value:7.79E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.44|P-value:2.49E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.29|P-value:7.37E-8 ID:SGTC_76|Compound:0433-0009|FD-Score:-4.30|P-value:9.99E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.61|P-value:1.74E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.29|P-value:7.35E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:4.31|P-value:6.70E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.52|P-value:2.66E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.21|P-value:7.44E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.00|P-value:3.55E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:3.81|P-value:5.96E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.84|P-value:5.30E-7 ID:SGTC_808|Compound:0711-0032|FD-Score:3.13|P-value:7.75E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.36|P-value:5.35E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.43|P-value:5.55E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.23|P-value:6.86E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.79|P-value:6.37E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.73|P-value:9.05E-7 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.86|P-value:4.69E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.37|P-value:3.23E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-6.35|P-value:1.31E-10 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.43|P-value:3.83E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.15|P-value:1.36E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.08|P-value:9.13E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:5.03|P-value:1.95E-7 ID:SGTC_1719|Compound:st032227|FD-Score:3.15|P-value:7.16E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.09|P-value:8.84E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.87|P-value:4.62E-7 ID:SGTC_2348|Compound:9022543|FD-Score:8.34|P-value:2.42E-17 ID:SGTC_2430|Compound:5571206|FD-Score:3.82|P-value:5.66E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.08|P-value:9.04E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.39|P-value:4.72E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.31|P-value:6.92E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.13|P-value:7.55E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.15|P-value:1.36E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.19|P-value:6.22E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.54|P-value:1.69E-4 ID:SGTC_2911|Compound:7942208|FD-Score:5.15|P-value:1.02E-7 ID:SGTC_2912|Compound:7964298|FD-Score:5.27|P-value:5.26E-8 ID:SGTC_2916|Compound:7875993|FD-Score:4.51|P-value:2.67E-6 ID:SGTC_2921|Compound:7974240|FD-Score:3.59|P-value:1.42E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.13|P-value:9.60E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.92|P-value:3.69E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.06|P-value:9.67E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.87|P-value:1.71E-9 ID:SGTC_3094|Compound:9117742|FD-Score:-3.84|P-value:6.86E-5 ID:SGTC_3137|Compound:9097352|FD-Score:6.71|P-value:7.01E-12 ID:SGTC_3202|Compound:9113761|FD-Score:3.06|P-value:9.52E-4

Top fitness defect scores for YKL160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2348 9022543 8.34 33.4 µM 2.42E-17 mitochondrial processes 3 3.59E-17
2 SGTC_3137 9097352 6.71 49.5 µM 7.01E-12 3 9.51E-12
3 SGTC_453 enantio-paf c16 6.52 10.0 µM 2.66E-11 34 3.58E-11
4 SGTC_2997 9067075 5.87 71.4 µM 1.71E-9 unfolded protein response 20 2.22E-9
5 SGTC_2912 7964298 5.27 10.9 µM 5.26E-8 cell wall 61 6.64E-8
6 SGTC_2911 7942208 5.15 15.6 µM 1.02E-7 mitochondrial response to ROS 3 1.28E-7
7 SGTC_1367 1812-0510 5.03 76.9 µM 1.95E-7 5 2.44E-7
8 SGTC_2233 sulbentine 4.87 40.4 µM 4.62E-7 38 5.72E-7
9 SGTC_1119 parthenolide 4.86 318.5 nM 4.69E-7 TSC3-RPN4 23 5.81E-7
10 SGTC_682 0kpi-0099 4.84 17.0 µM 5.30E-7 41 6.55E-7
11 SGTC_1042 0350-0096 4.73 82.0 µM 9.05E-7 TSC3-RPN4 9 1.11E-6
12 SGTC_2916 7875993 4.51 68.8 µM 2.67E-6 12 3.25E-6
13 SGTC_1213 1315-0166 4.43 115.0 µM 3.83E-6 18 4.64E-6
14 SGTC_2592 piperlongumine 4.39 83.3 µM 4.72E-6 TSC3-RPN4 24 5.72E-6
15 SGTC_975 1335-0046 4.36 28.5 µM 5.35E-6 RPP1 & pyrimidine depletion 25 6.47E-6
16 SGTC_210 3551-0445 4.31 56.8 µM 6.70E-6 53 8.09E-6
17 SGTC_2651 1327-0036 4.31 5.0 µM 6.92E-6 142 8.35E-6
18 SGTC_87 0100-0052 4.29 35.5 µM 7.35E-6 86 8.87E-6
19 SGTC_18 0111-0177 4.18 500.0 nM 1.19E-5 60 1.43E-5
20 SGTC_1356 1502-0781 4.15 85.8 µM 1.36E-5 fatty acid desaturase (OLE1) 13 1.63E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.252 1.26E-49 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.165 7.86E-22 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.157 7.79E-20 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.150 1.87E-18 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.150 2.91E-18 YMR277W FCP1 het Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
0.144 4.90E-17 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.143 7.29E-17 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.136 2.58E-15 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.136 3.39E-15 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.134 7.09E-15 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.127 1.87E-13 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.126 2.33E-13 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.125 3.30E-13 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.125 3.49E-13 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.121 2.16E-12 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway