YKL161C / KDX1

Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL161C / KDX1

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-3.98|P-value:1.13E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:6.70|P-value:3.50E-10 ID:SGTC_169|Compound:k015-0017|FD-Score:5.46|P-value:2.61E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:4.54|P-value:1.48E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:3.91|P-value:1.66E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.89|P-value:1.78E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:4.08|P-value:8.84E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.05|P-value:1.71E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.42|P-value:7.50E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.39|P-value:8.31E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-4.59|P-value:1.06E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.61|P-value:4.53E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-5.10|P-value:1.18E-6 ID:SGTC_1853|Compound:st056710|FD-Score:3.69|P-value:3.54E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.90|P-value:1.73E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.95|P-value:1.25E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.64|P-value:3.68E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.51|P-value:6.35E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-3.48|P-value:6.36E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-5.70|P-value:6.54E-8 ID:SGTC_2456|Compound:5770359|FD-Score:4.50|P-value:1.76E-5 ID:SGTC_2465|Compound:5809242|FD-Score:4.22|P-value:5.31E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.19|P-value:5.96E-5 ID:SGTC_2711|Compound:st079103|FD-Score:-4.65|P-value:8.45E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.69|P-value:8.36E-8 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.87|P-value:1.89E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.58|P-value:4.45E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.66|P-value:3.93E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.75|P-value:2.89E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.70|P-value:2.99E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.98|P-value:1.13E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:6.70|P-value:3.50E-10 ID:SGTC_169|Compound:k015-0017|FD-Score:5.46|P-value:2.61E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:4.54|P-value:1.48E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:3.91|P-value:1.66E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.89|P-value:1.78E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:4.08|P-value:8.84E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.05|P-value:1.71E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.42|P-value:7.50E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.39|P-value:8.31E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-4.59|P-value:1.06E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.61|P-value:4.53E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-5.10|P-value:1.18E-6 ID:SGTC_1853|Compound:st056710|FD-Score:3.69|P-value:3.54E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.90|P-value:1.73E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.95|P-value:1.25E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.64|P-value:3.68E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.51|P-value:6.35E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-3.48|P-value:6.36E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-5.70|P-value:6.54E-8 ID:SGTC_2456|Compound:5770359|FD-Score:4.50|P-value:1.76E-5 ID:SGTC_2465|Compound:5809242|FD-Score:4.22|P-value:5.31E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.19|P-value:5.96E-5 ID:SGTC_2711|Compound:st079103|FD-Score:-4.65|P-value:8.45E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.69|P-value:8.36E-8 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.87|P-value:1.89E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.58|P-value:4.45E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.66|P-value:3.93E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.75|P-value:2.89E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.70|P-value:2.99E-4

Top fitness defect scores for YKL161C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_162 k030-0015 6.70 37.8 µM 3.50E-10 iron homeostasis 2 1.03E-11
2 SGTC_2762 leflunomide 5.69 42.1 µM 8.36E-8 6 6.38E-9
3 SGTC_169 k015-0017 5.46 16.0 µM 2.61E-7 3 2.42E-8
4 SGTC_391 gliotoxin 5.05 8.3 µM 1.71E-6 37 2.19E-7
5 SGTC_170 4197-0004 4.54 226.0 µM 1.48E-5 10 2.76E-6
6 SGTC_2456 5770359 4.50 74.5 µM 1.76E-5 10 3.38E-6
7 SGTC_2465 5809242 4.22 33.2 µM 5.31E-5 1 1.23E-5
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.19 3.7 µM 5.96E-5 72 1.41E-5
9 SGTC_382 3229-0966 4.08 23.2 µM 8.84E-5 16 2.23E-5
10 SGTC_193 1273-0060 3.91 1.6 µM 1.66E-4 ergosterol biosynthesis 9 4.67E-5
11 SGTC_1929 genistein trimethyl ether 3.90 50.5 µM 1.73E-4 14 4.90E-5
12 SGTC_374 0880-0231 3.89 82.3 µM 1.78E-4 iron homeostasis 23 5.04E-5
13 SGTC_2768 sulfasalazine 3.87 50.2 µM 1.89E-4 18 5.41E-5
14 SGTC_2961 9083290 3.75 32.5 µM 2.89E-4 24 8.91E-5
15 SGTC_1853 st056710 3.69 91.2 µM 3.54E-4 amide catabolism 36 1.13E-4
16 SGTC_2956 9076196 3.66 2.5 µM 3.93E-4 29 1.28E-4
17 SGTC_1718 roemerine 3.61 11.9 µM 4.53E-4 redox potentiating 70 1.51E-4
18 SGTC_2349 9023730 3.51 187.1 µM 6.35E-4 45 2.23E-4
19 SGTC_241 5hr heat shock (37°C) + cantharidin 3.36 155.4 µM 0.00102 cell wall signaling 99 3.88E-4
20 SGTC_1852 st056254 3.36 31.4 µM 0.00103 25 3.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.06E-22 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.131 2.74E-14 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.127 1.80E-13 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.125 3.75E-13 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.121 1.92E-12 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.120 3.27E-12 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.120 3.87E-12 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.119 5.51E-12 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.118 6.39E-12 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.118 6.87E-12 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.117 1.17E-11 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.117 1.23E-11 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.116 1.72E-11 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.109 2.15E-10 YKL149C DBR1 hom RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
0.108 3.70E-10 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress