YKL162C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL162C / YKL162C

Click on Significant Values for Screen Details ID:SGTC_281|Compound:1672-3440|FD-Score:3.35|P-value:5.60E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:2.75|P-value:7.71E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.03|P-value:2.19E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-2.85|P-value:4.73E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.75|P-value:7.11E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.24|P-value:8.55E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:2.95|P-value:3.43E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-2.72|P-value:8.03E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-2.98|P-value:2.80E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:2.68|P-value:9.99E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.29|P-value:6.82E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.45|P-value:3.16E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-2.84|P-value:5.01E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.28|P-value:7.87E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.32|P-value:6.45E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-4.92|P-value:6.00E-9 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.54|P-value:2.29E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.98|P-value:2.22E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-2.95|P-value:3.19E-4 ID:SGTC_1831|Compound:st055328|FD-Score:2.78|P-value:6.78E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.38|P-value:4.87E-5 ID:SGTC_1964|Compound:st076914|FD-Score:-3.43|P-value:3.49E-5 ID:SGTC_1996|Compound:st072960|FD-Score:2.92|P-value:3.79E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.06|P-value:1.29E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.67|P-value:1.05E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.77|P-value:7.18E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.81|P-value:5.72E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.45|P-value:3.58E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-2.85|P-value:4.85E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.72|P-value:8.74E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:2.97|P-value:3.14E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-4.40|P-value:1.80E-7 ID:SGTC_2652|Compound:actinonin|FD-Score:-2.74|P-value:7.53E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.11|P-value:1.55E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.04|P-value:2.11E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.03|P-value:2.40E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.21|P-value:1.01E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-2.91|P-value:3.75E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.00|P-value:2.54E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-2.85|P-value:4.87E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.79|P-value:6.22E-6 ID:SGTC_3018|Compound:9082602|FD-Score:5.11|P-value:1.93E-9 ID:SGTC_3086|Compound:9117350|FD-Score:3.55|P-value:2.17E-5 ID:SGTC_3099|Compound:9120367|FD-Score:4.49|P-value:1.16E-7 ID:SGTC_3129|Compound:9127257|FD-Score:-2.70|P-value:8.89E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.45|P-value:3.53E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.34|P-value:5.89E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-2.74|P-value:7.44E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.73|P-value:8.47E-6 ID:SGTC_281|Compound:1672-3440|FD-Score:3.35|P-value:5.60E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:2.75|P-value:7.71E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.03|P-value:2.19E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-2.85|P-value:4.73E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.75|P-value:7.11E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.24|P-value:8.55E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:2.95|P-value:3.43E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-2.72|P-value:8.03E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-2.98|P-value:2.80E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:2.68|P-value:9.99E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.29|P-value:6.82E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.45|P-value:3.16E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-2.84|P-value:5.01E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.28|P-value:7.87E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.32|P-value:6.45E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-4.92|P-value:6.00E-9 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.54|P-value:2.29E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.98|P-value:2.22E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-2.95|P-value:3.19E-4 ID:SGTC_1831|Compound:st055328|FD-Score:2.78|P-value:6.78E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.38|P-value:4.87E-5 ID:SGTC_1964|Compound:st076914|FD-Score:-3.43|P-value:3.49E-5 ID:SGTC_1996|Compound:st072960|FD-Score:2.92|P-value:3.79E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.06|P-value:1.29E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.67|P-value:1.05E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.77|P-value:7.18E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.81|P-value:5.72E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.45|P-value:3.58E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-2.85|P-value:4.85E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.72|P-value:8.74E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:2.97|P-value:3.14E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-4.40|P-value:1.80E-7 ID:SGTC_2652|Compound:actinonin|FD-Score:-2.74|P-value:7.53E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.11|P-value:1.55E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.04|P-value:2.11E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.03|P-value:2.40E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.21|P-value:1.01E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-2.91|P-value:3.75E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.00|P-value:2.54E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-2.85|P-value:4.87E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.79|P-value:6.22E-6 ID:SGTC_3018|Compound:9082602|FD-Score:5.11|P-value:1.93E-9 ID:SGTC_3086|Compound:9117350|FD-Score:3.55|P-value:2.17E-5 ID:SGTC_3099|Compound:9120367|FD-Score:4.49|P-value:1.16E-7 ID:SGTC_3129|Compound:9127257|FD-Score:-2.70|P-value:8.89E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.45|P-value:3.53E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.34|P-value:5.89E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-2.74|P-value:7.44E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.73|P-value:8.47E-6

Top fitness defect scores for YKL162C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3018 9082602 5.11 49.5 µM 1.93E-9 38 1.63E-7
2 SGTC_3099 9120367 4.49 49.5 µM 1.16E-7 10 3.63E-6
3 SGTC_1704 st028805 3.98 70.8 µM 2.22E-6 8 3.42E-5
4 SGTC_3013 9080133 3.79 71.4 µM 6.22E-6 23 7.48E-5
5 SGTC_3293 9120939 3.73 62.0 µM 8.47E-6 24 9.46E-5
6 SGTC_3086 9117350 3.55 49.5 µM 2.17E-5 9 1.94E-4
7 SGTC_1645 Cervolide 3.54 78.0 µM 2.29E-5 10 2.02E-4
8 SGTC_3219 9131112 3.45 49.5 µM 3.53E-5 Golgi 49 2.81E-4
9 SGTC_2585 alliin 3.45 100.0 µM 3.58E-5 46 2.84E-4
10 SGTC_1837 st055472 3.38 66.5 µM 4.87E-5 37 3.59E-4
11 SGTC_281 1672-3440 3.35 14.9 µM 5.60E-5 Golgi 15 3.99E-4
12 SGTC_3222 9128301 3.34 49.5 µM 5.89E-5 60S ribosome export 44 4.15E-4
13 SGTC_1587 estradiol valerate 3.32 56.1 µM 6.45E-5 29 4.45E-4
14 SGTC_1176 0848-0131 3.28 83.3 µM 7.87E-5 Golgi 39 5.18E-4
15 SGTC_2871 9038510 3.03 13.0 µM 2.40E-4 51 0.00121
16 SGTC_2645 abamectin 2.97 100.0 µM 3.14E-4 heme requiring 71 0.00149
17 SGTC_935 2996-0153 2.95 430.0 µM 3.43E-4 PDR1 67 0.00160
18 SGTC_1996 st072960 2.92 66.8 µM 3.79E-4 58 0.00172
19 SGTC_1831 st055328 2.78 12.0 µM 6.78E-4 heme biosynthesis & mitochondrial translocase 86 0.00269
20 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 2.77 3.7 µM 7.18E-4 251 0.00282

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 4.67E-24 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.140 3.59E-16 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.133 1.00E-14 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.127 1.61E-13 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.126 2.20E-13 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.125 3.16E-13 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.123 6.87E-13 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.123 7.51E-13 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.113 4.97E-11 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.110 1.59E-10 YPL067C_p YPL067C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
0.110 1.95E-10 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.109 2.66E-10 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.105 9.05E-10 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.104 1.37E-9 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.104 1.52E-9 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)