YKL164C / PIR1

O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL164C / PIR1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.76|P-value:5.79E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.53|P-value:1.82E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.48|P-value:2.15E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:4.95|P-value:2.07E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-5.38|P-value:2.58E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:-4.17|P-value:1.25E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.23|P-value:7.46E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:3.38|P-value:2.72E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.33|P-value:3.25E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.06|P-value:1.65E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.47|P-value:2.27E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.15|P-value:1.33E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.18|P-value:6.57E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-4.68|P-value:1.10E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.40|P-value:2.49E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.17|P-value:1.22E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-3.28|P-value:4.64E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-5.02|P-value:1.86E-7 ID:SGTC_1739|Compound:st037196|FD-Score:-5.39|P-value:2.34E-8 ID:SGTC_1747|Compound:st037496|FD-Score:4.07|P-value:1.58E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-4.45|P-value:3.36E-6 ID:SGTC_1887|Compound:st057648|FD-Score:3.52|P-value:1.58E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.44|P-value:2.55E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.28|P-value:3.83E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.49|P-value:2.17E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.18|P-value:5.89E-8 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.42|P-value:2.28E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.03|P-value:9.41E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.12|P-value:8.09E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.94|P-value:2.71E-5 ID:SGTC_3269|Compound:9137823|FD-Score:-3.45|P-value:2.48E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.56|P-value:1.58E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.76|P-value:5.79E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.53|P-value:1.82E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.48|P-value:2.15E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:4.95|P-value:2.07E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-5.38|P-value:2.58E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:-4.17|P-value:1.25E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.23|P-value:7.46E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:3.38|P-value:2.72E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.33|P-value:3.25E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.06|P-value:1.65E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.47|P-value:2.27E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.15|P-value:1.33E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.18|P-value:6.57E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-4.68|P-value:1.10E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.40|P-value:2.49E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.17|P-value:1.22E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-3.28|P-value:4.64E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-5.02|P-value:1.86E-7 ID:SGTC_1739|Compound:st037196|FD-Score:-5.39|P-value:2.34E-8 ID:SGTC_1747|Compound:st037496|FD-Score:4.07|P-value:1.58E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-4.45|P-value:3.36E-6 ID:SGTC_1887|Compound:st057648|FD-Score:3.52|P-value:1.58E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.44|P-value:2.55E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.28|P-value:3.83E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.49|P-value:2.17E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.18|P-value:5.89E-8 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.42|P-value:2.28E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.03|P-value:9.41E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.12|P-value:8.09E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.94|P-value:2.71E-5 ID:SGTC_3269|Compound:9137823|FD-Score:-3.45|P-value:2.48E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.56|P-value:1.58E-4

Top fitness defect scores for YKL164C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 5.18 100.0 µM 5.89E-8 11 1.10E-7
2 SGTC_162 k030-0015 4.95 37.8 µM 2.07E-7 iron homeostasis 11 3.67E-7
3 SGTC_2596 sinensetin 4.49 100.0 µM 2.17E-6 19 3.53E-6
4 SGTC_169 k015-0017 4.23 16.0 µM 7.46E-6 15 1.16E-5
5 SGTC_1747 st037496 4.07 66.6 µM 1.58E-5 16 2.39E-5
6 SGTC_392 N-ethylmaleimide 4.06 8.3 µM 1.65E-5 RNA pol III & RNase P/MRP 11 2.48E-5
7 SGTC_3221 9128209 3.94 49.5 µM 2.71E-5 13 4.02E-5
8 SGTC_6 0844-0013 3.76 19.8 µM 5.79E-5 106 8.33E-5
9 SGTC_1887 st057648 3.52 70.8 µM 1.58E-4 27 2.19E-4
10 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.42 100.0 µM 2.28E-4 56 3.11E-4
11 SGTC_1452 4194-0072 3.40 190.0 µM 2.49E-4 29 3.39E-4
12 SGTC_374 0880-0231 3.38 82.3 µM 2.72E-4 iron homeostasis 48 3.69E-4
13 SGTC_378 3970-0959 3.33 8.3 µM 3.25E-4 31 4.38E-4
14 SGTC_2216 7189485 3.28 200.0 µM 3.83E-4 9 5.13E-4
15 SGTC_375 3970-0961 3.11 9.3 µM 7.06E-4 tubulin folding & SWR complex 56 9.23E-4
16 SGTC_2633 5,7-dihydroxyisoflavone 3.03 100.0 µM 9.41E-4 70 0.00122
17 SGTC_2989 9073649 2.99 71.4 µM 0.00107 95 0.00138
18 SGTC_3275 9138069 2.95 49.5 µM 0.00125 25 0.00161
19 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 2.88 3.7 µM 0.00155 232 0.00197
20 SGTC_400 oxethazaine 2.86 37.5 µM 0.00166 calcium & mitochondrial duress 63 0.00211

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.220 7.23E-38 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.211 3.87E-35 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.171 1.94E-23 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.161 8.13E-21 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.159 2.68E-20 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.157 6.37E-20 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.156 1.19E-19 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.154 2.36E-19 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.151 1.34E-18 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.150 2.57E-18 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.149 4.20E-18 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.147 9.52E-18 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.143 1.06E-16 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.142 1.39E-16 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.138 9.92E-16 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes