YKL165C / MCD4

Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL165C / MCD4

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.75|P-value:9.60E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.06|P-value:3.40E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.73|P-value:9.02E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:5.46|P-value:3.10E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:5.48|P-value:2.84E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:4.88|P-value:2.66E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.82|P-value:7.97E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.27|P-value:2.02E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.58|P-value:7.54E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.41|P-value:1.13E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:5.33|P-value:5.09E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:4.20|P-value:2.58E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-5.38|P-value:3.45E-6 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.88|P-value:6.64E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.79|P-value:8.06E-7 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.00|P-value:4.69E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.85|P-value:7.17E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.04|P-value:3.65E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:7.79|P-value:5.19E-11 ID:SGTC_575|Compound:k072-0246|FD-Score:4.42|P-value:1.29E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.27|P-value:2.06E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.70|P-value:5.05E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:5.14|P-value:1.05E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:4.39|P-value:1.38E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:8.22|P-value:4.64E-12 ID:SGTC_760|Compound:0568-0725|FD-Score:-4.06|P-value:3.44E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.20|P-value:2.55E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:5.28|P-value:6.06E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:4.48|P-value:1.03E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:7.45|P-value:3.20E-10 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.17|P-value:9.25E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.77|P-value:9.17E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.85|P-value:2.95E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:5.83|P-value:6.82E-7 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.47|P-value:1.09E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.51|P-value:9.49E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.74|P-value:1.01E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:8.59|P-value:5.07E-13 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.74|P-value:9.96E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:5.12|P-value:1.10E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:5.25|P-value:6.84E-6 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.76|P-value:9.38E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.51|P-value:9.56E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:4.93|P-value:2.27E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.00|P-value:1.71E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:6.26|P-value:1.04E-7 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.82|P-value:7.97E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.75|P-value:9.61E-4 ID:SGTC_1602|Compound:st001878|FD-Score:-5.14|P-value:8.72E-6 ID:SGTC_1616|Compound:st002734|FD-Score:-3.99|P-value:4.23E-4 ID:SGTC_1629|Compound:st005085|FD-Score:9.94|P-value:8.05E-17 ID:SGTC_1637|Compound:st007924|FD-Score:3.84|P-value:7.48E-4 ID:SGTC_1638|Compound:st008370|FD-Score:5.60|P-value:1.71E-6 ID:SGTC_1660|Compound:st012960|FD-Score:5.56|P-value:2.04E-6 ID:SGTC_1700|Compound:st030840|FD-Score:3.80|P-value:8.40E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.40|P-value:1.35E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.26|P-value:2.13E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.93|P-value:5.80E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.17|P-value:2.82E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.80|P-value:8.45E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.87|P-value:6.77E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.16|P-value:2.90E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.20|P-value:2.55E-4 ID:SGTC_2077|Compound:5212015|FD-Score:6.94|P-value:4.26E-9 ID:SGTC_2078|Compound:5212016|FD-Score:-3.78|P-value:7.72E-4 ID:SGTC_2183|Compound:6420625|FD-Score:7.37|P-value:4.93E-10 ID:SGTC_2194|Compound:5927483|FD-Score:5.93|P-value:4.49E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.35|P-value:6.97E-8 ID:SGTC_2292|Compound:7671323|FD-Score:4.55|P-value:8.35E-5 ID:SGTC_2296|Compound:7971656|FD-Score:-3.81|P-value:7.07E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.70|P-value:4.24E-5 ID:SGTC_2300|Compound:7976697|FD-Score:3.85|P-value:7.18E-4 ID:SGTC_2312|Compound:7706453|FD-Score:9.68|P-value:4.86E-16 ID:SGTC_2336|Compound:9001819|FD-Score:10.30|P-value:6.43E-18 ID:SGTC_2431|Compound:5490079|FD-Score:4.10|P-value:3.51E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.80|P-value:7.83E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.93|P-value:5.70E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:8.21|P-value:4.70E-12 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:6.96|P-value:3.84E-9 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:8.61|P-value:4.50E-13 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.94|P-value:5.57E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.13|P-value:3.13E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.09|P-value:3.60E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.03|P-value:2.91E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:-5.29|P-value:4.97E-6 ID:SGTC_2780|Compound:5215298|FD-Score:8.29|P-value:3.08E-12 ID:SGTC_2782|Compound:7736369|FD-Score:4.42|P-value:1.28E-4 ID:SGTC_2785|Compound:7756463|FD-Score:6.33|P-value:7.70E-8 ID:SGTC_2786|Compound:7743617|FD-Score:6.40|P-value:5.55E-8 ID:SGTC_2790|Compound:5423970|FD-Score:12.80|P-value:8.93E-27 ID:SGTC_2968|Compound:9090663|FD-Score:4.00|P-value:4.69E-4 ID:SGTC_2993|Compound:9054257|FD-Score:5.51|P-value:2.46E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.97|P-value:1.94E-5 ID:SGTC_3036|Compound:9090181|FD-Score:5.45|P-value:3.19E-6 ID:SGTC_3041|Compound:9091929|FD-Score:4.90|P-value:2.46E-5 ID:SGTC_3091|Compound:9116372|FD-Score:3.98|P-value:4.95E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.04|P-value:4.12E-4 ID:SGTC_3147|Compound:9097027|FD-Score:7.98|P-value:1.83E-11 ID:SGTC_3155|Compound:9099265|FD-Score:5.12|P-value:1.13E-5 ID:SGTC_3159|Compound:9100096|FD-Score:4.43|P-value:1.23E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.75|P-value:9.60E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.06|P-value:3.40E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.73|P-value:9.02E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:5.46|P-value:3.10E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:5.48|P-value:2.84E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:4.88|P-value:2.66E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.82|P-value:7.97E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.27|P-value:2.02E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.58|P-value:7.54E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.41|P-value:1.13E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:5.33|P-value:5.09E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:4.20|P-value:2.58E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-5.38|P-value:3.45E-6 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.88|P-value:6.64E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.79|P-value:8.06E-7 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.00|P-value:4.69E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.85|P-value:7.17E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.04|P-value:3.65E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:7.79|P-value:5.19E-11 ID:SGTC_575|Compound:k072-0246|FD-Score:4.42|P-value:1.29E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.27|P-value:2.06E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.70|P-value:5.05E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:5.14|P-value:1.05E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:4.39|P-value:1.38E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:8.22|P-value:4.64E-12 ID:SGTC_760|Compound:0568-0725|FD-Score:-4.06|P-value:3.44E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.20|P-value:2.55E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:5.28|P-value:6.06E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:4.48|P-value:1.03E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:7.45|P-value:3.20E-10 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.17|P-value:9.25E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.77|P-value:9.17E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.85|P-value:2.95E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:5.83|P-value:6.82E-7 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.47|P-value:1.09E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.51|P-value:9.49E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.74|P-value:1.01E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:8.59|P-value:5.07E-13 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.74|P-value:9.96E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:5.12|P-value:1.10E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:5.25|P-value:6.84E-6 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.76|P-value:9.38E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.51|P-value:9.56E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:4.93|P-value:2.27E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.00|P-value:1.71E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:6.26|P-value:1.04E-7 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.82|P-value:7.97E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.75|P-value:9.61E-4 ID:SGTC_1602|Compound:st001878|FD-Score:-5.14|P-value:8.72E-6 ID:SGTC_1616|Compound:st002734|FD-Score:-3.99|P-value:4.23E-4 ID:SGTC_1629|Compound:st005085|FD-Score:9.94|P-value:8.05E-17 ID:SGTC_1637|Compound:st007924|FD-Score:3.84|P-value:7.48E-4 ID:SGTC_1638|Compound:st008370|FD-Score:5.60|P-value:1.71E-6 ID:SGTC_1660|Compound:st012960|FD-Score:5.56|P-value:2.04E-6 ID:SGTC_1700|Compound:st030840|FD-Score:3.80|P-value:8.40E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.40|P-value:1.35E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.26|P-value:2.13E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.93|P-value:5.80E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.17|P-value:2.82E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.80|P-value:8.45E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.87|P-value:6.77E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.16|P-value:2.90E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.20|P-value:2.55E-4 ID:SGTC_2077|Compound:5212015|FD-Score:6.94|P-value:4.26E-9 ID:SGTC_2078|Compound:5212016|FD-Score:-3.78|P-value:7.72E-4 ID:SGTC_2183|Compound:6420625|FD-Score:7.37|P-value:4.93E-10 ID:SGTC_2194|Compound:5927483|FD-Score:5.93|P-value:4.49E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.35|P-value:6.97E-8 ID:SGTC_2292|Compound:7671323|FD-Score:4.55|P-value:8.35E-5 ID:SGTC_2296|Compound:7971656|FD-Score:-3.81|P-value:7.07E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.70|P-value:4.24E-5 ID:SGTC_2300|Compound:7976697|FD-Score:3.85|P-value:7.18E-4 ID:SGTC_2312|Compound:7706453|FD-Score:9.68|P-value:4.86E-16 ID:SGTC_2336|Compound:9001819|FD-Score:10.30|P-value:6.43E-18 ID:SGTC_2431|Compound:5490079|FD-Score:4.10|P-value:3.51E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.80|P-value:7.83E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.93|P-value:5.70E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:8.21|P-value:4.70E-12 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:6.96|P-value:3.84E-9 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:8.61|P-value:4.50E-13 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.94|P-value:5.57E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.13|P-value:3.13E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.09|P-value:3.60E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.03|P-value:2.91E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:-5.29|P-value:4.97E-6 ID:SGTC_2780|Compound:5215298|FD-Score:8.29|P-value:3.08E-12 ID:SGTC_2782|Compound:7736369|FD-Score:4.42|P-value:1.28E-4 ID:SGTC_2785|Compound:7756463|FD-Score:6.33|P-value:7.70E-8 ID:SGTC_2786|Compound:7743617|FD-Score:6.40|P-value:5.55E-8 ID:SGTC_2790|Compound:5423970|FD-Score:12.80|P-value:8.93E-27 ID:SGTC_2968|Compound:9090663|FD-Score:4.00|P-value:4.69E-4 ID:SGTC_2993|Compound:9054257|FD-Score:5.51|P-value:2.46E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.97|P-value:1.94E-5 ID:SGTC_3036|Compound:9090181|FD-Score:5.45|P-value:3.19E-6 ID:SGTC_3041|Compound:9091929|FD-Score:4.90|P-value:2.46E-5 ID:SGTC_3091|Compound:9116372|FD-Score:3.98|P-value:4.95E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.04|P-value:4.12E-4 ID:SGTC_3147|Compound:9097027|FD-Score:7.98|P-value:1.83E-11 ID:SGTC_3155|Compound:9099265|FD-Score:5.12|P-value:1.13E-5 ID:SGTC_3159|Compound:9100096|FD-Score:4.43|P-value:1.23E-4

Top fitness defect scores for YKL165C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2790 5423970 12.80 71.4 µM 8.93E-27 endomembrane recycling 2 6.23E-38 6.46
2 SGTC_2336 9001819 10.30 198.7 µM 6.43E-18 heme biosynthesis & mitochondrial translocase 9 3.76E-25 0.74
3 SGTC_1629 st005085 9.94 44.9 µM 8.05E-17 RPP1 & pyrimidine depletion 1 1.44E-23 1.72
4 SGTC_2312 7706453 9.68 155.7 µM 4.86E-16 1 1.92E-22 4.64
5 SGTC_2574 2',4'-dihydroxychalcone 8.61 14.6 µM 4.50E-13 2 3.62E-18 2.76
6 SGTC_1215 3852-0577 8.59 11.2 µM 5.07E-13 1 4.30E-18 3.52
7 SGTC_2780 5215298 8.29 71.4 µM 3.08E-12 2 5.79E-17 2.15
8 SGTC_745 0469-0705 8.22 296.0 µM 4.64E-12 mitochondrial processes 5 1.04E-16 2.36
9 SGTC_2567 aureobasidin a 8.21 60.0 nM 4.70E-12 16 1.06E-16 0.28
10 SGTC_3147 9097027 7.98 49.5 µM 1.83E-11 1 7.54E-16 2.10
11 SGTC_562 3772-2733 7.79 112.0 µM 5.19E-11 ERG2 2 3.37E-15 0.26
12 SGTC_1064 honokiol 7.45 6.8 µM 3.20E-10 1 4.62E-14 1.17
13 SGTC_2183 6420625 7.37 130.5 µM 4.93E-10 mitochondrial processes 5 8.59E-14 0.73
14 SGTC_2573 2',4'-dihydroxychalcone 6.96 15.0 µM 3.84E-9 4 1.65E-12 0.33
15 SGTC_2077 5212015 6.94 200.0 µM 4.26E-9 2 1.91E-12 1.65
16 SGTC_2786 7743617 6.40 45.5 µM 5.55E-8 1 7.63E-11 1.20
17 SGTC_2233 sulbentine 6.35 40.4 µM 6.97E-8 21 1.06E-10 0.05
18 SGTC_2785 7756463 6.33 72.7 µM 7.70E-8 1 1.22E-10 0.47
19 SGTC_1533 dihydroergotamine mesylate 6.26 29.4 µM 1.04E-7 DNA intercalators 1 1.89E-10 0.95
20 SGTC_2615 purpurogallin-4-carboxylic acid 6.03 100.0 µM 2.91E-7 redox potentiating 2 8.24E-10 1.45

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.40E-31 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.119 4.83E-12 YMR123W PKR1 hom V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
0.118 7.80E-12 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.114 3.14E-11 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.107 4.35E-10 YNL131W TOM22 het Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
0.107 5.43E-10 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.106 7.58E-10 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.104 1.49E-9 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.103 2.46E-9 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.102 3.09E-9 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.102 3.48E-9 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.100 5.74E-9 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.100 6.87E-9 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.092 9.55E-8 YLR268W SEC22 hom R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.091 1.15E-7 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication