YKL168C / KKQ8

Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL168C / KKQ8

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.21|P-value:2.43E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:3.17|P-value:3.00E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.16|P-value:3.15E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-2.96|P-value:6.33E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.72|P-value:3.02E-10 ID:SGTC_515|Compound:4092-1064|FD-Score:4.88|P-value:6.58E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.65|P-value:3.62E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.25|P-value:2.23E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.14|P-value:3.47E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:2.99|P-value:6.22E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.07|P-value:4.55E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.16|P-value:2.93E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:2.93|P-value:7.59E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.96|P-value:6.96E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.58|P-value:5.44E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.36|P-value:1.27E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.51|P-value:6.91E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.61|P-value:4.78E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.05|P-value:4.57E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.38|P-value:1.27E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.07|P-value:4.51E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.94|P-value:7.56E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-2.91|P-value:7.86E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.13|P-value:3.54E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.13|P-value:3.51E-6 ID:SGTC_1603|Compound:st002045|FD-Score:3.58|P-value:5.48E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:6.46|P-value:1.37E-12 ID:SGTC_1724|Compound:st037281|FD-Score:-6.08|P-value:2.01E-11 ID:SGTC_1735|Compound:st034310|FD-Score:4.05|P-value:5.79E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-3.18|P-value:2.74E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.88|P-value:1.33E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.36|P-value:1.40E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.29|P-value:1.71E-6 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.33|P-value:1.39E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.12|P-value:3.46E-4 ID:SGTC_1978|Compound:st071761|FD-Score:2.88|P-value:9.42E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.85|P-value:1.39E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:5.96|P-value:5.59E-11 ID:SGTC_2110|Compound:5483698|FD-Score:4.01|P-value:7.36E-6 ID:SGTC_2120|Compound:5538279|FD-Score:4.24|P-value:2.27E-6 ID:SGTC_2125|Compound:5246583|FD-Score:5.10|P-value:1.74E-8 ID:SGTC_2307|Compound:7538926|FD-Score:3.13|P-value:3.55E-4 ID:SGTC_2364|Compound:9055074|FD-Score:6.41|P-value:1.99E-12 ID:SGTC_2369|Compound:9071472|FD-Score:-4.47|P-value:6.08E-7 ID:SGTC_2440|Compound:5628896|FD-Score:2.97|P-value:6.56E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.59|P-value:3.43E-7 ID:SGTC_2602|Compound:kawain|FD-Score:3.08|P-value:4.42E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.09|P-value:4.13E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.15|P-value:3.01E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.52|P-value:7.05E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.44|P-value:9.77E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.11|P-value:3.56E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.38|P-value:1.06E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.24|P-value:2.13E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.53|P-value:4.72E-7 ID:SGTC_2964|Compound:9083345|FD-Score:3.03|P-value:5.20E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.13|P-value:3.63E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.21|P-value:2.43E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:3.17|P-value:3.00E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.16|P-value:3.15E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-2.96|P-value:6.33E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.72|P-value:3.02E-10 ID:SGTC_515|Compound:4092-1064|FD-Score:4.88|P-value:6.58E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.65|P-value:3.62E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.25|P-value:2.23E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.14|P-value:3.47E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:2.99|P-value:6.22E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.07|P-value:4.55E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.16|P-value:2.93E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:2.93|P-value:7.59E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.96|P-value:6.96E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.58|P-value:5.44E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.36|P-value:1.27E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.51|P-value:6.91E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.61|P-value:4.78E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.05|P-value:4.57E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.38|P-value:1.27E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.07|P-value:4.51E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.94|P-value:7.56E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-2.91|P-value:7.86E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.13|P-value:3.54E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.13|P-value:3.51E-6 ID:SGTC_1603|Compound:st002045|FD-Score:3.58|P-value:5.48E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:6.46|P-value:1.37E-12 ID:SGTC_1724|Compound:st037281|FD-Score:-6.08|P-value:2.01E-11 ID:SGTC_1735|Compound:st034310|FD-Score:4.05|P-value:5.79E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-3.18|P-value:2.74E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.88|P-value:1.33E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.36|P-value:1.40E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.29|P-value:1.71E-6 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.33|P-value:1.39E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.12|P-value:3.46E-4 ID:SGTC_1978|Compound:st071761|FD-Score:2.88|P-value:9.42E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.85|P-value:1.39E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:5.96|P-value:5.59E-11 ID:SGTC_2110|Compound:5483698|FD-Score:4.01|P-value:7.36E-6 ID:SGTC_2120|Compound:5538279|FD-Score:4.24|P-value:2.27E-6 ID:SGTC_2125|Compound:5246583|FD-Score:5.10|P-value:1.74E-8 ID:SGTC_2307|Compound:7538926|FD-Score:3.13|P-value:3.55E-4 ID:SGTC_2364|Compound:9055074|FD-Score:6.41|P-value:1.99E-12 ID:SGTC_2369|Compound:9071472|FD-Score:-4.47|P-value:6.08E-7 ID:SGTC_2440|Compound:5628896|FD-Score:2.97|P-value:6.56E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.59|P-value:3.43E-7 ID:SGTC_2602|Compound:kawain|FD-Score:3.08|P-value:4.42E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.09|P-value:4.13E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.15|P-value:3.01E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.52|P-value:7.05E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.44|P-value:9.77E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.11|P-value:3.56E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.38|P-value:1.06E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.24|P-value:2.13E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.53|P-value:4.72E-7 ID:SGTC_2964|Compound:9083345|FD-Score:3.03|P-value:5.20E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.13|P-value:3.63E-4

Top fitness defect scores for YKL168C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1718 roemerine 6.46 11.9 µM 1.37E-12 redox potentiating 14 5.39E-11
2 SGTC_2364 9055074 6.41 200.0 µM 1.99E-12 4 7.40E-11
3 SGTC_2091 4-phenylthiadiazole 5.96 200.0 µM 5.59E-11 2 1.28E-9
4 SGTC_514 4466-0038 5.72 2.6 nM 3.02E-10 cell wall 83 5.41E-9
5 SGTC_2125 5246583 5.10 200.0 µM 1.74E-8 tubulin folding & SWR complex 23 1.74E-7
6 SGTC_515 4092-1064 4.88 102.0 µM 6.58E-8 plasma membrane duress 40 5.43E-7
7 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.59 100.0 µM 3.43E-7 20 2.23E-6
8 SGTC_2963 9082507 4.53 9.0 µM 4.72E-7 16 2.93E-6
9 SGTC_2835 9006588 4.38 71.4 µM 1.06E-6 28 5.86E-6
10 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 4.33 14.9 µM 1.39E-6 5 7.41E-6
11 SGTC_1887 st057648 4.29 70.8 µM 1.71E-6 6 8.85E-6
12 SGTC_2120 5538279 4.24 152.0 µM 2.27E-6 15 1.13E-5
13 SGTC_1735 st034310 4.05 56.8 µM 5.79E-6 Golgi 24 2.52E-5
14 SGTC_2110 5483698 4.01 200.0 µM 7.36E-6 TSC3-RPN4 19 3.10E-5
15 SGTC_1738 st035555 3.88 74.0 µM 1.33E-5 TSC3-RPN4 32 5.16E-5
16 SGTC_1207 2099-0101 3.61 141.0 µM 4.78E-5 30 1.55E-4
17 SGTC_1080 nisoldipine 3.58 24.4 µM 5.44E-5 TSC3-RPN4 40 1.73E-4
18 SGTC_1603 st002045 3.58 67.8 µM 5.48E-5 TSC3-RPN4 23 1.74E-4
19 SGTC_2674 ligustilide 3.52 100.0 µM 7.05E-5 14 2.16E-4
20 SGTC_2833 9001315 3.44 45.5 µM 9.77E-5 amide catabolism 77 2.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 4.96E-25 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.166 5.07E-22 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.160 1.37E-20 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.148 8.40E-18 YGR211W ZPR1 het Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress
0.142 1.31E-16 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.140 4.97E-16 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.137 1.59E-15 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.136 2.27E-15 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.134 5.59E-15 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.130 4.52E-14 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.128 9.39E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.123 8.74E-13 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.122 1.31E-12 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.119 4.07E-12 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.119 4.50E-12 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p