YKL169C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL169C / YKL169C

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:4.68|P-value:9.63E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.33|P-value:2.82E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.96|P-value:7.87E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.95|P-value:8.10E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.52|P-value:1.60E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:5.72|P-value:2.78E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-6.22|P-value:5.80E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:7.46|P-value:1.66E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:12.00|P-value:7.80E-22 ID:SGTC_310|Compound:1273-0058|FD-Score:9.68|P-value:9.04E-15 ID:SGTC_330|Compound:1488-0319|FD-Score:3.97|P-value:7.74E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.54|P-value:2.00E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.64|P-value:1.11E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.25|P-value:3.54E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.63|P-value:5.54E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.32|P-value:3.86E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.54|P-value:2.01E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.88|P-value:9.83E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:6.22|P-value:3.95E-7 ID:SGTC_672|Compound:1441-0018|FD-Score:4.69|P-value:9.58E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.88|P-value:9.85E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.17|P-value:4.47E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.56|P-value:1.42E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.99|P-value:3.55E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.09|P-value:5.63E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.41|P-value:2.23E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-4.22|P-value:5.05E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.67|P-value:1.02E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.72|P-value:8.74E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.42|P-value:8.37E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.16|P-value:4.63E-4 ID:SGTC_1742|Compound:st038235|FD-Score:10.40|P-value:1.12E-16 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.68|P-value:1.30E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.89|P-value:9.67E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-4.04|P-value:8.30E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-4.00|P-value:9.31E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.83|P-value:6.00E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-4.32|P-value:3.76E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.78|P-value:9.60E-5 ID:SGTC_2423|Compound:st077119|FD-Score:5.83|P-value:1.83E-6 ID:SGTC_2449|Compound:5812982|FD-Score:-4.38|P-value:3.21E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.31|P-value:2.96E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.98|P-value:7.48E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.35|P-value:3.49E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.13|P-value:4.92E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.53|P-value:2.08E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.20|P-value:1.78E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.89|P-value:4.95E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-5.13|P-value:3.10E-5 ID:SGTC_2792|Compound:7535235|FD-Score:6.98|P-value:1.57E-8 ID:SGTC_2993|Compound:9054257|FD-Score:4.78|P-value:7.24E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-4.24|P-value:4.73E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:4.68|P-value:9.63E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.33|P-value:2.82E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.96|P-value:7.87E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.95|P-value:8.10E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.52|P-value:1.60E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:5.72|P-value:2.78E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-6.22|P-value:5.80E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:7.46|P-value:1.66E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:12.00|P-value:7.80E-22 ID:SGTC_310|Compound:1273-0058|FD-Score:9.68|P-value:9.04E-15 ID:SGTC_330|Compound:1488-0319|FD-Score:3.97|P-value:7.74E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.54|P-value:2.00E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.64|P-value:1.11E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.25|P-value:3.54E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.63|P-value:5.54E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.32|P-value:3.86E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.54|P-value:2.01E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.88|P-value:9.83E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:6.22|P-value:3.95E-7 ID:SGTC_672|Compound:1441-0018|FD-Score:4.69|P-value:9.58E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.88|P-value:9.85E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.17|P-value:4.47E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.56|P-value:1.42E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.99|P-value:3.55E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.09|P-value:5.63E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.41|P-value:2.23E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-4.22|P-value:5.05E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.67|P-value:1.02E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.72|P-value:8.74E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.42|P-value:8.37E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.16|P-value:4.63E-4 ID:SGTC_1742|Compound:st038235|FD-Score:10.40|P-value:1.12E-16 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.68|P-value:1.30E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.89|P-value:9.67E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-4.04|P-value:8.30E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-4.00|P-value:9.31E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.83|P-value:6.00E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-4.32|P-value:3.76E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.78|P-value:9.60E-5 ID:SGTC_2423|Compound:st077119|FD-Score:5.83|P-value:1.83E-6 ID:SGTC_2449|Compound:5812982|FD-Score:-4.38|P-value:3.21E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.31|P-value:2.96E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.98|P-value:7.48E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.35|P-value:3.49E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.13|P-value:4.92E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.53|P-value:2.08E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.20|P-value:1.78E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.89|P-value:4.95E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-5.13|P-value:3.10E-5 ID:SGTC_2792|Compound:7535235|FD-Score:6.98|P-value:1.57E-8 ID:SGTC_2993|Compound:9054257|FD-Score:4.78|P-value:7.24E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-4.24|P-value:4.73E-4

Top fitness defect scores for YKL169C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.00 5.3 µM 7.80E-22 149 9.77E-34
2 SGTC_1742 st038235 10.40 28.9 µM 1.12E-16 mitochondrial stress 9 1.69E-25
3 SGTC_310 1273-0058 9.68 1.1 µM 9.04E-15 mitochondrial stress 47 1.84E-22
4 SGTC_173 1273-0061 7.46 2.7 µM 1.66E-9 mitochondrial stress 79 4.31E-14
5 SGTC_2792 7535235 6.98 81.8 µM 1.57E-8 fatty acid desaturase (OLE1) 6 1.53E-12
6 SGTC_520 3584-0023 6.22 682.0 µM 3.95E-7 3 2.50E-10
7 SGTC_2423 st077119 5.83 87.2 µM 1.83E-6 2 2.79E-9
8 SGTC_148 3253-0744 5.72 288.0 µM 2.78E-6 4 5.41E-9
9 SGTC_1353 1498-1206 5.42 8.1 µM 8.37E-6 mitochondrial response to ROS 23 3.05E-8
10 SGTC_2630 antimycin a 5.20 100.0 µM 1.78E-5 mitochondrial processes 17 9.95E-8
11 SGTC_832 4083-0019 4.99 164.0 µM 3.55E-5 translation 38 2.95E-7
12 SGTC_2688 kanamycin b 4.89 96.7 µM 4.95E-5 calcium & mitochondrial duress 253 4.96E-7
13 SGTC_2250 alverine citrate 4.83 130.0 µM 6.00E-5 102 6.69E-7
14 SGTC_2993 9054257 4.78 71.4 µM 7.24E-5 fatty acid desaturase (OLE1) 23 8.98E-7
15 SGTC_1201 1889-3372 4.72 45.9 µM 8.74E-5 Golgi 4 1.21E-6
16 SGTC_672 1441-0018 4.69 53.7 µM 9.58E-5 9 1.39E-6
17 SGTC_19 0279-0214 4.68 38.4 µM 9.63E-5 TRP & mitochondrial translation 24 1.40E-6
18 SGTC_1197 1601-0112 4.67 267.0 µM 1.02E-4 4 1.52E-6
19 SGTC_422 cantharidin 4.64 155.0 µM 1.11E-4 cell wall signaling 42 1.74E-6
20 SGTC_831 k061-1017 4.56 217.0 µM 1.42E-4 translation 33 2.57E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.434 1.86E-153 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.409 4.81E-135 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.405 1.56E-132 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.389 2.80E-121 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.388 2.24E-120 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.386 3.75E-119 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.385 1.42E-118 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.378 8.54E-114 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.373 5.21E-111 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.372 1.35E-110 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.370 3.75E-109 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.368 5.79E-108 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.368 2.14E-107 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.367 3.41E-107 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.366 2.15E-106 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells