YKL174C / TPO5

Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL174C / TPO5

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-2.94|P-value:7.34E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.47|P-value:8.24E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:-4.76|P-value:1.23E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.98|P-value:6.22E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.88|P-value:1.27E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:-2.88|P-value:8.99E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.09|P-value:4.07E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.03|P-value:5.14E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.05|P-value:5.61E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.21|P-value:2.48E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.60|P-value:4.69E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.13|P-value:3.71E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.03|P-value:2.47E-8 ID:SGTC_1113|Compound:artemisinin|FD-Score:-2.94|P-value:7.09E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.87|P-value:9.15E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.97|P-value:6.32E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.42|P-value:1.04E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:2.87|P-value:9.16E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-6.61|P-value:3.93E-13 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.17|P-value:2.96E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-2.88|P-value:9.05E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.98|P-value:7.79E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.32|P-value:1.60E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.67|P-value:3.48E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.30|P-value:1.68E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.07|P-value:4.33E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.20|P-value:2.63E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.05|P-value:4.78E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.31|P-value:1.52E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-2.99|P-value:5.91E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-2.90|P-value:8.41E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.81|P-value:1.85E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-3.47|P-value:8.63E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-4.73|P-value:1.50E-7 ID:SGTC_1947|Compound:st076332|FD-Score:-3.80|P-value:1.95E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-3.00|P-value:5.66E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.09|P-value:4.08E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.92|P-value:1.07E-5 ID:SGTC_2260|Compound:7964312|FD-Score:4.24|P-value:2.14E-6 ID:SGTC_2318|Compound:6029776|FD-Score:2.91|P-value:8.03E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.90|P-value:1.14E-5 ID:SGTC_2463|Compound:5473429|FD-Score:2.88|P-value:8.84E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.79|P-value:1.97E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.88|P-value:8.75E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.87|P-value:6.20E-8 ID:SGTC_2591|Compound:skatole|FD-Score:-2.99|P-value:5.94E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.83|P-value:7.99E-8 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.00|P-value:5.60E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.05|P-value:5.44E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-3.10|P-value:3.86E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.02|P-value:5.23E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.69|P-value:3.05E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-3.81|P-value:1.78E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-2.87|P-value:9.41E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-4.46|P-value:6.64E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.94|P-value:7.34E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.47|P-value:8.24E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:-4.76|P-value:1.23E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.98|P-value:6.22E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.88|P-value:1.27E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:-2.88|P-value:8.99E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.09|P-value:4.07E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.03|P-value:5.14E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.05|P-value:5.61E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.21|P-value:2.48E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.60|P-value:4.69E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.13|P-value:3.71E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.03|P-value:2.47E-8 ID:SGTC_1113|Compound:artemisinin|FD-Score:-2.94|P-value:7.09E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.87|P-value:9.15E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.97|P-value:6.32E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.42|P-value:1.04E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:2.87|P-value:9.16E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-6.61|P-value:3.93E-13 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.17|P-value:2.96E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-2.88|P-value:9.05E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.98|P-value:7.79E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.32|P-value:1.60E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.67|P-value:3.48E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.30|P-value:1.68E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.07|P-value:4.33E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.20|P-value:2.63E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.05|P-value:4.78E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.31|P-value:1.52E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-2.99|P-value:5.91E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-2.90|P-value:8.41E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.81|P-value:1.85E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-3.47|P-value:8.63E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-4.73|P-value:1.50E-7 ID:SGTC_1947|Compound:st076332|FD-Score:-3.80|P-value:1.95E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-3.00|P-value:5.66E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.09|P-value:4.08E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.92|P-value:1.07E-5 ID:SGTC_2260|Compound:7964312|FD-Score:4.24|P-value:2.14E-6 ID:SGTC_2318|Compound:6029776|FD-Score:2.91|P-value:8.03E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.90|P-value:1.14E-5 ID:SGTC_2463|Compound:5473429|FD-Score:2.88|P-value:8.84E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.79|P-value:1.97E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.88|P-value:8.75E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.87|P-value:6.20E-8 ID:SGTC_2591|Compound:skatole|FD-Score:-2.99|P-value:5.94E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.83|P-value:7.99E-8 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.00|P-value:5.60E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.05|P-value:5.44E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-3.10|P-value:3.86E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.02|P-value:5.23E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.69|P-value:3.05E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-3.81|P-value:1.78E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-2.87|P-value:9.41E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-4.46|P-value:6.64E-7

Top fitness defect scores for YKL174C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2586 curcumin 4.87 80.0 µM 6.20E-8 iron homeostasis 33 5.49E-7
2 SGTC_2600 tangeritin 4.83 88.0 µM 7.99E-8 14 6.82E-7
3 SGTC_2260 7964312 4.24 200.0 µM 2.14E-6 9 1.13E-5
4 SGTC_1079 idarubicin 4.13 2.4 µM 3.71E-6 DNA damage response 19 1.81E-5
5 SGTC_2625 euphol 4.05 100.0 µM 5.44E-6 26 2.52E-5
6 SGTC_945 3381-0768 4.05 11.3 µM 5.61E-6 endomembrane recycling 33 2.59E-5
7 SGTC_1355 1499-0035 3.98 1.7 µM 7.79E-6 17 3.43E-5
8 SGTC_2329 6138490 3.90 200.0 µM 1.14E-5 33 4.73E-5
9 SGTC_500 h-89 3.88 112.0 µM 1.27E-5 cell wall signaling 32 5.19E-5
10 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 3.79 19.9 µM 1.97E-5 redox potentiating 11 7.58E-5
11 SGTC_3125 9127534 3.69 49.5 µM 3.05E-5 15 1.10E-4
12 SGTC_1068 loratadine 3.60 26.9 µM 4.69E-5 34 1.60E-4
13 SGTC_39 0986-0283 3.47 58.4 µM 8.24E-5 calcium & mitochondrial duress 54 2.59E-4
14 SGTC_1248 0469-0687 3.42 58.6 µM 1.04E-4 51 3.16E-4
15 SGTC_1589 2',5'-dimethoxyflavone 3.30 47.2 µM 1.68E-4 43 4.76E-4
16 SGTC_1597 7-benzyloxygramine 3.07 47.5 µM 4.33E-4 calcium & mitochondrial duress 210 0.00107
17 SGTC_3039 9090270 3.02 49.5 µM 5.23E-4 RPP1 & pyrimidine depletion 37 0.00126
18 SGTC_2621 lithochol-11-enic acid 3.00 100.0 µM 5.60E-4 79 0.00134
19 SGTC_1239 0337-0584 2.97 35.4 µM 6.32E-4 unfolded protein response 115 0.00149
20 SGTC_2318 6029776 2.91 164.0 µM 8.03E-4 89 0.00183

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 6.90E-32 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.196 1.88E-30 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.172 1.26E-23 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.162 4.09E-21 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.152 6.37E-19 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.152 8.28E-19 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.149 4.30E-18 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.148 7.39E-18 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.146 1.55E-17 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.144 5.03E-17 YDR242W AMD2 hom Putative amidase
0.138 1.01E-15 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.130 3.70E-14 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.126 1.99E-13 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.126 2.55E-13 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.120 2.58E-12 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome