YKL175W / ZRT3

Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL175W / ZRT3

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.05|P-value:6.11E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.20|P-value:3.41E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.37|P-value:1.85E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:-2.96|P-value:9.48E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:6.45|P-value:4.22E-12 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.37|P-value:1.75E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:-3.16|P-value:4.56E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.21|P-value:3.28E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:7.78|P-value:9.31E-17 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.92|P-value:9.80E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.86|P-value:2.16E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:7.41|P-value:2.23E-15 ID:SGTC_576|Compound:1073-0113|FD-Score:4.14|P-value:5.77E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:4.53|P-value:7.95E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.15|P-value:4.05E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.77|P-value:3.24E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.06|P-value:6.68E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.21|P-value:4.10E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:3.63|P-value:5.83E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.52|P-value:9.58E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.74|P-value:2.56E-7 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.08|P-value:6.22E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.58|P-value:7.26E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.01|P-value:7.78E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:5.15|P-value:2.49E-8 ID:SGTC_1476|Compound:4112-3294|FD-Score:6.94|P-value:1.05E-13 ID:SGTC_1567|Compound:st069303|FD-Score:3.11|P-value:4.87E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.01|P-value:6.85E-4 ID:SGTC_1637|Compound:st007924|FD-Score:2.97|P-value:8.15E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.81|P-value:2.72E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.99|P-value:1.15E-5 ID:SGTC_1740|Compound:st038286|FD-Score:4.19|P-value:4.45E-6 ID:SGTC_1749|Compound:st037932|FD-Score:-3.59|P-value:8.29E-5 ID:SGTC_1912|Compound:st060209|FD-Score:2.96|P-value:8.45E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.09|P-value:5.98E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.48|P-value:1.12E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.26|P-value:3.14E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-5.66|P-value:1.30E-9 ID:SGTC_2282|Compound:7944268|FD-Score:4.49|P-value:9.52E-7 ID:SGTC_2424|Compound:5537928|FD-Score:-3.15|P-value:4.79E-4 ID:SGTC_2482|Compound:5981709|FD-Score:7.00|P-value:6.27E-14 ID:SGTC_2804|Compound:7954240|FD-Score:3.88|P-value:1.95E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.12|P-value:6.16E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.61|P-value:7.50E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.06|P-value:5.82E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.75|P-value:4.08E-5 ID:SGTC_3296|Compound:9122258|FD-Score:4.00|P-value:1.13E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.05|P-value:6.11E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.20|P-value:3.41E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.37|P-value:1.85E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:-2.96|P-value:9.48E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:6.45|P-value:4.22E-12 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.37|P-value:1.75E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:-3.16|P-value:4.56E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.21|P-value:3.28E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:7.78|P-value:9.31E-17 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.92|P-value:9.80E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.86|P-value:2.16E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:7.41|P-value:2.23E-15 ID:SGTC_576|Compound:1073-0113|FD-Score:4.14|P-value:5.77E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:4.53|P-value:7.95E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.15|P-value:4.05E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.77|P-value:3.24E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.06|P-value:6.68E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.21|P-value:4.10E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:3.63|P-value:5.83E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.52|P-value:9.58E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.74|P-value:2.56E-7 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.08|P-value:6.22E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.58|P-value:7.26E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.01|P-value:7.78E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:5.15|P-value:2.49E-8 ID:SGTC_1476|Compound:4112-3294|FD-Score:6.94|P-value:1.05E-13 ID:SGTC_1567|Compound:st069303|FD-Score:3.11|P-value:4.87E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.01|P-value:6.85E-4 ID:SGTC_1637|Compound:st007924|FD-Score:2.97|P-value:8.15E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.81|P-value:2.72E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.99|P-value:1.15E-5 ID:SGTC_1740|Compound:st038286|FD-Score:4.19|P-value:4.45E-6 ID:SGTC_1749|Compound:st037932|FD-Score:-3.59|P-value:8.29E-5 ID:SGTC_1912|Compound:st060209|FD-Score:2.96|P-value:8.45E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.09|P-value:5.98E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.48|P-value:1.12E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.26|P-value:3.14E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-5.66|P-value:1.30E-9 ID:SGTC_2282|Compound:7944268|FD-Score:4.49|P-value:9.52E-7 ID:SGTC_2424|Compound:5537928|FD-Score:-3.15|P-value:4.79E-4 ID:SGTC_2482|Compound:5981709|FD-Score:7.00|P-value:6.27E-14 ID:SGTC_2804|Compound:7954240|FD-Score:3.88|P-value:1.95E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.12|P-value:6.16E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.61|P-value:7.50E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.06|P-value:5.82E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.75|P-value:4.08E-5 ID:SGTC_3296|Compound:9122258|FD-Score:4.00|P-value:1.13E-5

Top fitness defect scores for YKL175W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_309 k408-0051 7.78 1.5 µM 9.31E-17 5 3.67E-15
2 SGTC_535 2293-4129 7.41 48.2 µM 2.23E-15 NEO1 15 6.34E-14
3 SGTC_2482 5981709 7.00 142.7 µM 6.27E-14 PDR1 5 1.26E-12
4 SGTC_1476 4112-3294 6.94 3.3 µM 1.05E-13 60S ribosome export 1 2.01E-12
5 SGTC_207 4185-0010 6.45 4.5 µM 4.22E-12 endomembrane recycling 43 5.50E-11
6 SGTC_1270 0831-1170 5.15 17.3 µM 2.49E-8 2 1.33E-7
7 SGTC_1010 4112-3296 4.74 15.2 µM 2.56E-7 9 1.07E-6
8 SGTC_632 0781-2353 4.53 4.7 µM 7.95E-7 Golgi 23 2.97E-6
9 SGTC_2282 7944268 4.49 200.0 µM 9.52E-7 RPP1 & pyrimidine depletion 18 3.49E-6
10 SGTC_124 0136-0217 4.37 7.1 µM 1.85E-6 mitochondrial stress 48 6.33E-6
11 SGTC_829 1635-0120 4.21 117.0 µM 4.10E-6 DNA damage response 34 1.30E-5
12 SGTC_1740 st038286 4.19 13.2 µM 4.45E-6 21 1.39E-5
13 SGTC_576 1073-0113 4.14 22.7 µM 5.77E-6 redox potentiating 58 1.76E-5
14 SGTC_2809 7964133 4.12 13.0 µM 6.16E-6 60S ribosome export 33 1.87E-5
15 SGTC_3296 9122258 4.00 64.0 µM 1.13E-5 redox potentiating 23 3.22E-5
16 SGTC_1707 st032323 3.99 6.3 µM 1.15E-5 DNA damage response 56 3.28E-5
17 SGTC_2804 7954240 3.88 19.5 µM 1.95E-5 32 5.26E-5
18 SGTC_512 prima-1 3.86 270.0 µM 2.16E-5 DNA intercalators 26 5.77E-5
19 SGTC_1702 st027038 3.81 51.0 µM 2.72E-5 14 7.09E-5
20 SGTC_722 3534-0461 3.77 190.0 µM 3.24E-5 PDR1 43 8.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.249 1.33E-48 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.204 1.06E-32 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.136 2.14E-15 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.124 5.79E-13 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.115 2.64E-11 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.114 4.60E-11 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.108 3.61E-10 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.104 1.57E-9 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.100 6.56E-9 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.097 1.57E-8 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.096 2.43E-8 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.096 2.58E-8 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.094 5.60E-8 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.093 6.35E-8 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.092 9.42E-8 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress