YKL180W / RPL17A

Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL180W / RPL17A

Click on Significant Values for Screen Details ID:SGTC_99|Compound:0109-0120|FD-Score:5.69|P-value:1.43E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.75|P-value:3.16E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.46|P-value:7.79E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.86|P-value:2.23E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.73|P-value:3.38E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.42|P-value:4.90E-7 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.36|P-value:9.06E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:4.33|P-value:4.24E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.88|P-value:4.57E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-6.33|P-value:2.12E-8 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.87|P-value:4.71E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.75|P-value:3.12E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.58|P-value:5.88E-9 ID:SGTC_545|Compound:4218-0007|FD-Score:4.26|P-value:5.52E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.78|P-value:6.21E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.63|P-value:1.36E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.27|P-value:5.31E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.29|P-value:8.69E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.05|P-value:2.64E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:4.51|P-value:2.15E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.61|P-value:4.99E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.02|P-value:2.85E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:6.49|P-value:2.63E-9 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.84|P-value:6.04E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.50|P-value:2.24E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.91|P-value:4.10E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.06|P-value:1.10E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.72|P-value:7.47E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.89|P-value:1.96E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.61|P-value:2.07E-7 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.30|P-value:4.77E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.68|P-value:3.92E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-4.21|P-value:1.53E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.59|P-value:4.02E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-5.13|P-value:4.95E-6 ID:SGTC_1812|Compound:st052057|FD-Score:3.52|P-value:6.61E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-3.99|P-value:3.19E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-5.06|P-value:6.35E-6 ID:SGTC_2006|Compound:4011487|FD-Score:3.42|P-value:8.79E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.32|P-value:4.47E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.40|P-value:9.37E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.65|P-value:4.34E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.46|P-value:6.35E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.65|P-value:4.37E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.49|P-value:5.63E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.58|P-value:5.45E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.40|P-value:9.34E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.41|P-value:8.99E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.56|P-value:4.40E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.42|P-value:8.75E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.57|P-value:5.50E-4 ID:SGTC_3145|Compound:9085516|FD-Score:6.98|P-value:1.82E-10 ID:SGTC_3152|Compound:9099253|FD-Score:-4.70|P-value:2.68E-5 ID:SGTC_3171|Compound:9103192|FD-Score:3.81|P-value:2.58E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.83|P-value:5.33E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.73|P-value:3.34E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-6.42|P-value:1.34E-8 ID:SGTC_3291|Compound:9121177|FD-Score:6.80|P-value:4.99E-10 ID:SGTC_3295|Compound:9122362|FD-Score:4.60|P-value:1.50E-5 ID:SGTC_3339|Compound:9145883|FD-Score:-4.41|P-value:7.70E-5 ID:SGTC_3343|Compound:9148379|FD-Score:-4.87|P-value:1.37E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-5.58|P-value:7.29E-7 ID:SGTC_3346|Compound:9158254|FD-Score:3.51|P-value:6.70E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:5.69|P-value:1.43E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.75|P-value:3.16E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.46|P-value:7.79E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.86|P-value:2.23E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.73|P-value:3.38E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.42|P-value:4.90E-7 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.36|P-value:9.06E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:4.33|P-value:4.24E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.88|P-value:4.57E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-6.33|P-value:2.12E-8 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.87|P-value:4.71E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.75|P-value:3.12E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.58|P-value:5.88E-9 ID:SGTC_545|Compound:4218-0007|FD-Score:4.26|P-value:5.52E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.78|P-value:6.21E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.63|P-value:1.36E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.27|P-value:5.31E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.29|P-value:8.69E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.05|P-value:2.64E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:4.51|P-value:2.15E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.61|P-value:4.99E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.02|P-value:2.85E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:6.49|P-value:2.63E-9 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.84|P-value:6.04E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.50|P-value:2.24E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.91|P-value:4.10E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.06|P-value:1.10E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.72|P-value:7.47E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.89|P-value:1.96E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.61|P-value:2.07E-7 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.30|P-value:4.77E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.68|P-value:3.92E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-4.21|P-value:1.53E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.59|P-value:4.02E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-5.13|P-value:4.95E-6 ID:SGTC_1812|Compound:st052057|FD-Score:3.52|P-value:6.61E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-3.99|P-value:3.19E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-5.06|P-value:6.35E-6 ID:SGTC_2006|Compound:4011487|FD-Score:3.42|P-value:8.79E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.32|P-value:4.47E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.40|P-value:9.37E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.65|P-value:4.34E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.46|P-value:6.35E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.65|P-value:4.37E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.49|P-value:5.63E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.58|P-value:5.45E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.40|P-value:9.34E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.41|P-value:8.99E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.56|P-value:4.40E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.42|P-value:8.75E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.57|P-value:5.50E-4 ID:SGTC_3145|Compound:9085516|FD-Score:6.98|P-value:1.82E-10 ID:SGTC_3152|Compound:9099253|FD-Score:-4.70|P-value:2.68E-5 ID:SGTC_3171|Compound:9103192|FD-Score:3.81|P-value:2.58E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.83|P-value:5.33E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.73|P-value:3.34E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-6.42|P-value:1.34E-8 ID:SGTC_3291|Compound:9121177|FD-Score:6.80|P-value:4.99E-10 ID:SGTC_3295|Compound:9122362|FD-Score:4.60|P-value:1.50E-5 ID:SGTC_3339|Compound:9145883|FD-Score:-4.41|P-value:7.70E-5 ID:SGTC_3343|Compound:9148379|FD-Score:-4.87|P-value:1.37E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-5.58|P-value:7.29E-7 ID:SGTC_3346|Compound:9158254|FD-Score:3.51|P-value:6.70E-4

Top fitness defect scores for YKL180W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3145 9085516 6.98 49.5 µM 1.82E-10 fatty acid desaturase (OLE1) 2 1.49E-12 0.82
2 SGTC_3291 9121177 6.80 71.4 µM 4.99E-10 1 5.29E-12 3.36
3 SGTC_1136 pergolide 6.49 1.1 µM 2.63E-9 3 4.25E-11 0.70
4 SGTC_99 0109-0120 5.69 622.8 µM 1.43E-7 1 6.31E-9 0.73
5 SGTC_1390 3413-2614 5.61 145.0 µM 2.07E-7 fatty acid desaturase (OLE1) 2 1.00E-8 0.33
6 SGTC_258 haloperidol 5.42 50.8 µM 4.90E-7 fatty acid desaturase (OLE1) 6 2.93E-8 0.05
7 SGTC_832 4083-0019 5.29 164.0 µM 8.69E-7 translation 13 5.97E-8 0.22
8 SGTC_1131 3454-3128 5.02 32.3 µM 2.85E-6 5 2.62E-7 0.26
9 SGTC_1177 0983-0204 4.84 23.6 µM 6.04E-6 3 6.66E-7 0.45
10 SGTC_596 1155-0152 4.63 116.0 µM 1.36E-5 TRP & mitochondrial translation 4 1.82E-6 0.34
11 SGTC_3295 9122362 4.60 53.6 µM 1.50E-5 4 2.06E-6 0.17
12 SGTC_980 1473-0395 4.51 201.0 µM 2.15E-5 1 3.21E-6 0.19
13 SGTC_1204 4049-0315 4.50 18.3 µM 2.24E-5 6 3.39E-6 0.17
14 SGTC_285 1486-1325 4.33 46.0 µM 4.24E-5 4 7.46E-6 0.52
15 SGTC_2112 5488546 4.32 200.0 µM 4.47E-5 TSC3-RPN4 5 7.95E-6 0.25
16 SGTC_1484 3473-2379 4.30 286.0 µM 4.77E-5 1 8.61E-6 0.39
17 SGTC_800 3448-7362 4.27 155.0 µM 5.31E-5 translation 43 9.84E-6 0.00
18 SGTC_545 4218-0007 4.26 221.0 µM 5.52E-5 5 1.03E-5 0.11
19 SGTC_1254 0550-0035 4.06 264.0 µM 1.10E-4 7 2.41E-5 0.29
20 SGTC_1360 1598-0022 3.89 39.8 µM 1.96E-4 ERG2 10 4.93E-5 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.53E-24 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.169 9.72E-23 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.167 2.78E-22 YPL235W RVB2 het ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.160 1.48E-20 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.148 7.97E-18 YPL142C_d YPL142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
0.147 1.12E-17 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.142 1.43E-16 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.124 6.00E-13 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.121 1.90E-12 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.121 2.37E-12 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.120 2.70E-12 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.118 7.87E-12 YPR016C TIF6 het Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
0.115 2.16E-11 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.115 2.85E-11 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.114 3.35E-11 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5