YKL181W / PRS1

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL181W / PRS1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-4.31|P-value:7.04E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:4.06|P-value:2.21E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.21|P-value:6.17E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.11|P-value:1.77E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:5.07|P-value:1.72E-7 ID:SGTC_271|Compound:rotenone|FD-Score:3.77|P-value:7.56E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.17|P-value:7.20E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.29|P-value:1.22E-10 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.77|P-value:8.08E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:8.16|P-value:1.17E-16 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.44|P-value:2.70E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.62|P-value:1.35E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.49|P-value:3.22E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.82|P-value:6.04E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.70|P-value:9.85E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:4.02|P-value:2.66E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.99|P-value:8.57E-10 ID:SGTC_832|Compound:4083-0019|FD-Score:3.15|P-value:7.83E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.47|P-value:2.38E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.10|P-value:9.26E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.18|P-value:7.04E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.42|P-value:2.94E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.47|P-value:2.43E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.56|P-value:1.72E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.10|P-value:1.87E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:5.85|P-value:1.95E-9 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.86|P-value:5.01E-7 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.91|P-value:4.11E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.86|P-value:5.04E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.41|P-value:4.51E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.33|P-value:4.13E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.25|P-value:5.33E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.88|P-value:4.70E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.13|P-value:1.66E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.49|P-value:2.27E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.24|P-value:5.71E-4 ID:SGTC_1981|Compound:st071826|FD-Score:5.73|P-value:4.25E-9 ID:SGTC_1999|Compound:st074831|FD-Score:3.09|P-value:9.56E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.75|P-value:8.23E-5 ID:SGTC_2268|Compound:7933382|FD-Score:4.49|P-value:3.10E-6 ID:SGTC_2333|Compound:9017922|FD-Score:6.01|P-value:7.71E-10 ID:SGTC_2434|Compound:5670830|FD-Score:4.93|P-value:3.60E-7 ID:SGTC_2451|Compound:5856223|FD-Score:3.13|P-value:8.19E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.08|P-value:9.91E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.70|P-value:1.16E-6 ID:SGTC_2804|Compound:7954240|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.36|P-value:3.66E-4 ID:SGTC_2808|Compound:7946468|FD-Score:9.59|P-value:2.59E-22 ID:SGTC_2813|Compound:7971799|FD-Score:4.18|P-value:1.29E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.27|P-value:4.96E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.30|P-value:4.55E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-3.43|P-value:2.82E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.35|P-value:3.84E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.58|P-value:2.03E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.81|P-value:6.44E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.17|P-value:7.13E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.37|P-value:3.57E-4 ID:SGTC_3109|Compound:9122853|FD-Score:4.41|P-value:4.55E-6 ID:SGTC_3114|Compound:9122766|FD-Score:3.31|P-value:4.42E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.23|P-value:1.03E-5 ID:SGTC_3159|Compound:9100096|FD-Score:3.55|P-value:1.80E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.15|P-value:7.78E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.31|P-value:7.04E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:4.06|P-value:2.21E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.21|P-value:6.17E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.11|P-value:1.77E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:5.07|P-value:1.72E-7 ID:SGTC_271|Compound:rotenone|FD-Score:3.77|P-value:7.56E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.17|P-value:7.20E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.29|P-value:1.22E-10 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.77|P-value:8.08E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:8.16|P-value:1.17E-16 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.44|P-value:2.70E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.62|P-value:1.35E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.49|P-value:3.22E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.82|P-value:6.04E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.70|P-value:9.85E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:4.02|P-value:2.66E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.99|P-value:8.57E-10 ID:SGTC_832|Compound:4083-0019|FD-Score:3.15|P-value:7.83E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.47|P-value:2.38E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.10|P-value:9.26E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.18|P-value:7.04E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.42|P-value:2.94E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.47|P-value:2.43E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.56|P-value:1.72E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.10|P-value:1.87E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:5.85|P-value:1.95E-9 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.86|P-value:5.01E-7 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.91|P-value:4.11E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.86|P-value:5.04E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.41|P-value:4.51E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.33|P-value:4.13E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.25|P-value:5.33E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.88|P-value:4.70E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.13|P-value:1.66E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.49|P-value:2.27E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.24|P-value:5.71E-4 ID:SGTC_1981|Compound:st071826|FD-Score:5.73|P-value:4.25E-9 ID:SGTC_1999|Compound:st074831|FD-Score:3.09|P-value:9.56E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.75|P-value:8.23E-5 ID:SGTC_2268|Compound:7933382|FD-Score:4.49|P-value:3.10E-6 ID:SGTC_2333|Compound:9017922|FD-Score:6.01|P-value:7.71E-10 ID:SGTC_2434|Compound:5670830|FD-Score:4.93|P-value:3.60E-7 ID:SGTC_2451|Compound:5856223|FD-Score:3.13|P-value:8.19E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.08|P-value:9.91E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.70|P-value:1.16E-6 ID:SGTC_2804|Compound:7954240|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.36|P-value:3.66E-4 ID:SGTC_2808|Compound:7946468|FD-Score:9.59|P-value:2.59E-22 ID:SGTC_2813|Compound:7971799|FD-Score:4.18|P-value:1.29E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.27|P-value:4.96E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.30|P-value:4.55E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-3.43|P-value:2.82E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.35|P-value:3.84E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.58|P-value:2.03E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.81|P-value:6.44E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.17|P-value:7.13E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.37|P-value:3.57E-4 ID:SGTC_3109|Compound:9122853|FD-Score:4.41|P-value:4.55E-6 ID:SGTC_3114|Compound:9122766|FD-Score:3.31|P-value:4.42E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.23|P-value:1.03E-5 ID:SGTC_3159|Compound:9100096|FD-Score:3.55|P-value:1.80E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.15|P-value:7.78E-4

Top fitness defect scores for YKL181W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2808 7946468 9.59 45.5 µM 2.59E-22 1 4.48E-22
2 SGTC_422 cantharidin 8.16 155.0 µM 1.17E-16 cell wall signaling 10 1.74E-16
3 SGTC_358 0075-0058 6.29 9.4 µM 1.22E-10 17 1.54E-10
4 SGTC_2333 9017922 6.01 200.0 µM 7.71E-10 7 9.55E-10
5 SGTC_800 3448-7362 5.99 155.0 µM 8.57E-10 translation 50 1.06E-9
6 SGTC_1417 3966-0327 5.85 90.4 µM 1.95E-9 2 2.39E-9
7 SGTC_1981 st071826 5.73 47.0 µM 4.25E-9 1 5.16E-9
8 SGTC_258 haloperidol 5.07 50.8 µM 1.72E-7 fatty acid desaturase (OLE1) 14 2.00E-7
9 SGTC_2434 5670830 4.93 169.9 µM 3.60E-7 10 4.16E-7
10 SGTC_1424 4048-1941 4.86 275.0 µM 5.01E-7 9 5.76E-7
11 SGTC_1430 4049-0248 4.86 69.1 µM 5.04E-7 7 5.80E-7
12 SGTC_421 streptovitacin 4.77 30.0 mM 8.08E-7 10 9.25E-7
13 SGTC_2788 5282734 4.70 71.4 µM 1.16E-6 24 1.33E-6
14 SGTC_3067 9117431 4.58 49.5 µM 2.03E-6 1 2.30E-6
15 SGTC_2268 7933382 4.49 153.8 µM 3.10E-6 23 3.50E-6
16 SGTC_708 3448-5400 4.49 146.0 µM 3.22E-6 30 3.62E-6
17 SGTC_1482 3346-2049 4.41 8.5 µM 4.51E-6 21 5.06E-6
18 SGTC_3109 9122853 4.41 49.5 µM 4.55E-6 4 5.11E-6
19 SGTC_2813 7971799 4.18 71.4 µM 1.29E-5 16 1.43E-5
20 SGTC_1574 spiramycin 4.13 23.7 µM 1.66E-5 23 1.84E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.63E-15 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.129 7.95E-14 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.123 7.54E-13 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.122 1.06E-12 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.118 6.69E-12 YMR269W TMA23 hom Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
0.113 6.38E-11 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.112 9.09E-11 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.110 1.94E-10 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.109 2.58E-10 YLR052W IES3 hom Subunit of the INO80 chromatin remodeling complex
0.108 3.98E-10 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.106 6.48E-10 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.103 2.13E-9 YGR104C SRB5 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance
0.102 2.96E-9 YER056C-A RPL34A hom Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication
0.102 3.42E-9 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.102 3.48E-9 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication