YKL183W / LOT5

Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL183W / LOT5

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.30|P-value:1.99E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.72|P-value:3.59E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.11|P-value:4.65E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.64|P-value:4.66E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:5.15|P-value:1.73E-8 ID:SGTC_433|Compound:pimozide|FD-Score:-4.73|P-value:2.29E-7 ID:SGTC_444|Compound:curcumin|FD-Score:3.07|P-value:4.90E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.68|P-value:4.02E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:3.01|P-value:6.19E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.44|P-value:1.10E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.35|P-value:1.63E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.50|P-value:8.79E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.25|P-value:2.83E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.35|P-value:1.58E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-5.86|P-value:2.01E-10 ID:SGTC_1147|Compound:3809-1045|FD-Score:2.98|P-value:7.03E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.74|P-value:1.93E-7 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.19|P-value:3.34E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.05|P-value:5.27E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:2.98|P-value:6.95E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-3.13|P-value:4.21E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.55|P-value:6.92E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.10|P-value:4.77E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.85|P-value:1.86E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.60|P-value:5.64E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-3.10|P-value:4.75E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.26|P-value:2.50E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-2.98|P-value:7.38E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.34|P-value:1.72E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.10|P-value:4.49E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.01|P-value:4.00E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.29|P-value:2.13E-4 ID:SGTC_2213|Compound:7173844|FD-Score:2.97|P-value:7.33E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.00|P-value:6.83E-4 ID:SGTC_2309|Compound:7664088|FD-Score:6.75|P-value:2.51E-13 ID:SGTC_2335|Compound:9018011|FD-Score:5.09|P-value:2.45E-8 ID:SGTC_2356|Compound:9061756|FD-Score:3.16|P-value:3.53E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-4.51|P-value:7.62E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.22|P-value:3.01E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.56|P-value:1.11E-12 ID:SGTC_2586|Compound:curcumin|FD-Score:3.69|P-value:3.83E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.08|P-value:4.74E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.24|P-value:2.58E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.93|P-value:8.30E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-2.96|P-value:8.11E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.96|P-value:8.19E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.56|P-value:7.44E-5 ID:SGTC_3139|Compound:9095020|FD-Score:3.54|P-value:7.43E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.43|P-value:1.01E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:3.30|P-value:1.99E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.72|P-value:3.59E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.11|P-value:4.65E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.64|P-value:4.66E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:5.15|P-value:1.73E-8 ID:SGTC_433|Compound:pimozide|FD-Score:-4.73|P-value:2.29E-7 ID:SGTC_444|Compound:curcumin|FD-Score:3.07|P-value:4.90E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.68|P-value:4.02E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:3.01|P-value:6.19E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.44|P-value:1.10E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.35|P-value:1.63E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.50|P-value:8.79E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.25|P-value:2.83E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.35|P-value:1.58E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-5.86|P-value:2.01E-10 ID:SGTC_1147|Compound:3809-1045|FD-Score:2.98|P-value:7.03E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.74|P-value:1.93E-7 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.19|P-value:3.34E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.05|P-value:5.27E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:2.98|P-value:6.95E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-3.13|P-value:4.21E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.55|P-value:6.92E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.10|P-value:4.77E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.85|P-value:1.86E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.60|P-value:5.64E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-3.10|P-value:4.75E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.26|P-value:2.50E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-2.98|P-value:7.38E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.34|P-value:1.72E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.10|P-value:4.49E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.01|P-value:4.00E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.29|P-value:2.13E-4 ID:SGTC_2213|Compound:7173844|FD-Score:2.97|P-value:7.33E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.00|P-value:6.83E-4 ID:SGTC_2309|Compound:7664088|FD-Score:6.75|P-value:2.51E-13 ID:SGTC_2335|Compound:9018011|FD-Score:5.09|P-value:2.45E-8 ID:SGTC_2356|Compound:9061756|FD-Score:3.16|P-value:3.53E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-4.51|P-value:7.62E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.22|P-value:3.01E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.56|P-value:1.11E-12 ID:SGTC_2586|Compound:curcumin|FD-Score:3.69|P-value:3.83E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.08|P-value:4.74E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.24|P-value:2.58E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.93|P-value:8.30E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-2.96|P-value:8.11E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.96|P-value:8.19E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.56|P-value:7.44E-5 ID:SGTC_3139|Compound:9095020|FD-Score:3.54|P-value:7.43E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.43|P-value:1.01E-6

Top fitness defect scores for YKL183W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2309 7664088 6.75 163.9 µM 2.51E-13 3 7.52E-12
2 SGTC_2583 asiatic acid 6.56 100.0 µM 1.11E-12 7 2.76E-11
3 SGTC_432 NS 1619 5.15 61.3 µM 1.73E-8 10 1.31E-7
4 SGTC_2335 9018011 5.09 154.2 µM 2.45E-8 10 1.77E-7
5 SGTC_2124 5246320 5.01 200.0 µM 4.00E-8 heme biosynthesis & mitochondrial translocase 8 2.72E-7
6 SGTC_1155 4088-0394 4.74 48.2 µM 1.93E-7 13 1.08E-6
7 SGTC_3154 9100113 4.43 49.5 µM 1.01E-6 20 4.62E-6
8 SGTC_1132 3456-3614 4.35 2.5 µM 1.58E-6 tubulin folding & SWR complex 27 6.85E-6
9 SGTC_1902 st060212 4.26 70.5 µM 2.50E-6 9 1.02E-5
10 SGTC_1730 st033808 3.85 45.1 µM 1.86E-5 34 5.98E-5
11 SGTC_2586 curcumin 3.69 80.0 µM 3.83E-5 iron homeostasis 62 1.13E-4
12 SGTC_450 aminopyrene 3.68 156.0 nM 4.02E-5 38 1.18E-4
13 SGTC_112 phenothiazine 3.64 287.2 µM 4.66E-5 unfolded protein response 18 1.34E-4
14 SGTC_1779 st039427 3.60 55.0 µM 5.64E-5 38 1.58E-4
15 SGTC_1525 8-methoxypsoralen 3.55 92.5 µM 6.92E-5 DNA damage response 48 1.89E-4
16 SGTC_3139 9095020 3.54 49.5 µM 7.43E-5 16 2.02E-4
17 SGTC_1102 cgs 12066b 3.50 26.1 µM 8.79E-5 endomembrane recycling 14 2.34E-4
18 SGTC_649 1123-0311 3.44 367.0 µM 1.10E-4 endomembrane recycling 102 2.86E-4
19 SGTC_834 0312-0008 3.35 75.7 µM 1.63E-4 NEO1 62 4.03E-4
20 SGTC_2031 5180455 3.34 200.0 µM 1.72E-4 25 4.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 9.45E-21 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.135 3.71E-15 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.130 4.41E-14 YFR052W RPN12 het Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
0.129 7.50E-14 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.127 1.44E-13 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.123 8.10E-13 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.119 3.92E-12 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.117 1.08E-11 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification
0.111 9.96E-11 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.111 1.23E-10 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.108 3.12E-10 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.108 3.16E-10 YOR025W HST3 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.107 5.19E-10 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.105 9.54E-10 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
0.105 1.11E-9 YJR084W YJR084W hom Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome