YKL186C / MTR2

mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL186C / MTR2

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:5.27|P-value:1.11E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.57|P-value:2.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.80|P-value:8.02E-7 ID:SGTC_159|Compound:3970-0959|FD-Score:8.96|P-value:5.32E-19 ID:SGTC_182|Compound:3448-4371|FD-Score:3.32|P-value:5.78E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.80|P-value:7.19E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.24|P-value:5.75E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.90|P-value:6.68E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:4.54|P-value:4.25E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.65|P-value:1.76E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.01|P-value:4.24E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.37|P-value:3.61E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.67|P-value:1.65E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.29|P-value:4.89E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:4.96|P-value:5.61E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.92|P-value:4.35E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.83|P-value:8.94E-5 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.21|P-value:8.59E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.18|P-value:9.34E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.26|P-value:7.14E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.18|P-value:2.06E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:5.26|P-value:1.19E-7 ID:SGTC_1531|Compound:st059297|FD-Score:4.38|P-value:8.87E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.32|P-value:5.86E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.33|P-value:1.11E-5 ID:SGTC_1796|Compound:st049173|FD-Score:-3.16|P-value:7.68E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.80|P-value:1.00E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.76|P-value:1.14E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.16|P-value:2.28E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.40|P-value:4.44E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.98|P-value:4.91E-5 ID:SGTC_2275|Compound:7947463|FD-Score:-3.88|P-value:5.14E-5 ID:SGTC_2290|Compound:7904846|FD-Score:4.05|P-value:3.67E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.52|P-value:2.85E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.41|P-value:4.21E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.43|P-value:3.97E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.14|P-value:8.01E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.67|P-value:1.63E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.39|P-value:8.45E-6 ID:SGTC_2469|Compound:5655019|FD-Score:3.27|P-value:6.99E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.92|P-value:2.97E-9 ID:SGTC_2785|Compound:7756463|FD-Score:3.48|P-value:3.29E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.28|P-value:6.66E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.79|P-value:7.47E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.38|P-value:4.72E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.22|P-value:8.22E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.34|P-value:4.05E-4 ID:SGTC_3077|Compound:9117319|FD-Score:5.71|P-value:9.87E-9 ID:SGTC_3208|Compound:9114115|FD-Score:5.37|P-value:6.49E-8 ID:SGTC_3325|Compound:9138760|FD-Score:3.41|P-value:4.29E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:5.27|P-value:1.11E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.57|P-value:2.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.80|P-value:8.02E-7 ID:SGTC_159|Compound:3970-0959|FD-Score:8.96|P-value:5.32E-19 ID:SGTC_182|Compound:3448-4371|FD-Score:3.32|P-value:5.78E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.80|P-value:7.19E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.24|P-value:5.75E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.90|P-value:6.68E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:4.54|P-value:4.25E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.65|P-value:1.76E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.01|P-value:4.24E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.37|P-value:3.61E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.67|P-value:1.65E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.29|P-value:4.89E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:4.96|P-value:5.61E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.92|P-value:4.35E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.83|P-value:8.94E-5 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.21|P-value:8.59E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.18|P-value:9.34E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.26|P-value:7.14E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.18|P-value:2.06E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:5.26|P-value:1.19E-7 ID:SGTC_1531|Compound:st059297|FD-Score:4.38|P-value:8.87E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.32|P-value:5.86E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.33|P-value:1.11E-5 ID:SGTC_1796|Compound:st049173|FD-Score:-3.16|P-value:7.68E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.80|P-value:1.00E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.76|P-value:1.14E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.16|P-value:2.28E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.40|P-value:4.44E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.98|P-value:4.91E-5 ID:SGTC_2275|Compound:7947463|FD-Score:-3.88|P-value:5.14E-5 ID:SGTC_2290|Compound:7904846|FD-Score:4.05|P-value:3.67E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.52|P-value:2.85E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.41|P-value:4.21E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.43|P-value:3.97E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.14|P-value:8.01E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.67|P-value:1.63E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.39|P-value:8.45E-6 ID:SGTC_2469|Compound:5655019|FD-Score:3.27|P-value:6.99E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.92|P-value:2.97E-9 ID:SGTC_2785|Compound:7756463|FD-Score:3.48|P-value:3.29E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.28|P-value:6.66E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.79|P-value:7.47E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.38|P-value:4.72E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.22|P-value:8.22E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.34|P-value:4.05E-4 ID:SGTC_3077|Compound:9117319|FD-Score:5.71|P-value:9.87E-9 ID:SGTC_3208|Compound:9114115|FD-Score:5.37|P-value:6.49E-8 ID:SGTC_3325|Compound:9138760|FD-Score:3.41|P-value:4.29E-4

Top fitness defect scores for YKL186C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_159 3970-0959 8.96 50.0 µM 5.32E-19 4 1.66E-19 0.61
2 SGTC_2626 ethyl orsellinate 5.92 100.0 µM 2.97E-9 3 1.62E-9 1.25
3 SGTC_3077 9117319 5.71 49.5 µM 9.87E-9 1 5.56E-9 0.56
4 SGTC_3208 9114115 5.37 49.5 µM 6.49E-8 2 3.85E-8 0.43
5 SGTC_18 0111-0177 5.27 500.0 nM 1.11E-7 2 6.68E-8 1.01
6 SGTC_1473 k844-0725 5.26 134.0 µM 1.19E-7 2 7.19E-8 0.40
7 SGTC_856 0433-0016 4.96 11.3 µM 5.61E-7 2 3.53E-7 1.23
8 SGTC_502 l-744,832 4.54 89.3 µM 4.25E-6 calcium & mitochondrial duress 5 2.82E-6 0.16
9 SGTC_2467 5474540 4.39 200.0 µM 8.45E-6 4 5.73E-6 0.34
10 SGTC_1531 st059297 4.38 52.4 µM 8.87E-6 2 6.02E-6 0.33
11 SGTC_1769 st044406 4.33 64.4 µM 1.11E-5 5 7.58E-6 0.01
12 SGTC_1374 2889-5571 4.18 141.0 µM 2.06E-5 RSC complex & mRNA processing 37 1.43E-5 0.03
13 SGTC_1911 st060208 4.16 74.3 µM 2.28E-5 7 1.59E-5 0.18
14 SGTC_2290 7904846 4.05 200.0 µM 3.67E-5 13 2.59E-5 0.12
15 SGTC_518 1021-0119 4.01 62.6 µM 4.24E-5 ERG2 8 3.01E-5 0.29
16 SGTC_2168 5727979 3.98 200.0 µM 4.91E-5 5 3.50E-5 0.30
17 SGTC_408 cantharidin 3.90 100.0 µM 6.68E-5 cell wall signaling 11 4.80E-5 0.37
18 SGTC_1048 3161-0300 3.83 24.5 µM 8.94E-5 6 6.48E-5 0.27
19 SGTC_1862 st057513 3.80 3.8 µM 1.00E-4 6 7.29E-5 0.00
20 SGTC_1896 st058441 3.76 89.0 µM 1.14E-4 6 8.34E-5 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.65E-19 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.148 5.32E-18 YJR042W NUP85 het Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
0.148 6.64E-18 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.138 8.84E-16 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.136 2.88E-15 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.130 3.65E-14 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.108 4.08E-10 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.106 8.24E-10 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.097 1.98E-8 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.095 3.42E-8 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.092 1.06E-7 YGL172W NUP49 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
0.091 1.41E-7 YCL039W GID7 hom Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
0.089 2.09E-7 YJL112W MDV1 hom Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication
0.085 7.86E-7 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.085 9.41E-7 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress