YKL192C / ACP1

Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL192C / ACP1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.43|P-value:9.91E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:2.89|P-value:8.74E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.69|P-value:1.73E-7 ID:SGTC_128|Compound:0906-2981|FD-Score:3.39|P-value:1.20E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.20|P-value:2.63E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.03|P-value:4.47E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.31|P-value:1.63E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-2.89|P-value:7.69E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.07|P-value:4.36E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.33|P-value:1.55E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.32|P-value:1.61E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.58|P-value:4.45E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:-2.96|P-value:5.82E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.57|P-value:4.74E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:3.82|P-value:1.66E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.11|P-value:3.35E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.35|P-value:1.38E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.61|P-value:2.25E-7 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.24|P-value:1.91E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.51|P-value:6.90E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.58|P-value:4.35E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.06|P-value:5.11E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.83|P-value:7.87E-8 ID:SGTC_1238|Compound:0333-0287|FD-Score:-4.68|P-value:1.56E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.86|P-value:9.67E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.38|P-value:1.24E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.11|P-value:3.28E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.41|P-value:1.09E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.90|P-value:8.33E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.00|P-value:5.63E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.06|P-value:4.53E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.79|P-value:1.56E-10 ID:SGTC_1720|Compound:st037298|FD-Score:3.28|P-value:1.85E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.34|P-value:1.04E-6 ID:SGTC_1735|Compound:st034310|FD-Score:-3.52|P-value:5.72E-5 ID:SGTC_1763|Compound:st044482|FD-Score:-3.66|P-value:3.10E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.73|P-value:2.64E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.33|P-value:1.53E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.36|P-value:1.34E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.33|P-value:1.30E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.05|P-value:4.66E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.96|P-value:6.72E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.83|P-value:1.62E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.00|P-value:5.77E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.80|P-value:1.84E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.73|P-value:1.36E-7 ID:SGTC_2369|Compound:9071472|FD-Score:3.56|P-value:5.56E-5 ID:SGTC_2424|Compound:5537928|FD-Score:4.22|P-value:2.35E-6 ID:SGTC_2445|Compound:5742597|FD-Score:-2.89|P-value:7.58E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.12|P-value:3.60E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.49|P-value:6.53E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.18|P-value:2.88E-6 ID:SGTC_2799|Compound:7812892|FD-Score:6.29|P-value:3.90E-12 ID:SGTC_2802|Compound:7925815|FD-Score:3.77|P-value:2.14E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.67|P-value:3.40E-5 ID:SGTC_2851|Compound:9015922|FD-Score:4.56|P-value:3.66E-7 ID:SGTC_2941|Compound:9056145|FD-Score:5.07|P-value:1.76E-8 ID:SGTC_2945|Compound:9067681|FD-Score:-3.69|P-value:2.62E-5 ID:SGTC_2946|Compound:9065502|FD-Score:5.24|P-value:6.39E-9 ID:SGTC_2968|Compound:9090663|FD-Score:3.31|P-value:1.64E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.14|P-value:3.27E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.05|P-value:5.56E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-5.31|P-value:3.21E-9 ID:SGTC_3254|Compound:9136651|FD-Score:2.96|P-value:6.78E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.03|P-value:4.46E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.43|P-value:9.91E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:2.89|P-value:8.74E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.69|P-value:1.73E-7 ID:SGTC_128|Compound:0906-2981|FD-Score:3.39|P-value:1.20E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.20|P-value:2.63E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.03|P-value:4.47E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.31|P-value:1.63E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-2.89|P-value:7.69E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.07|P-value:4.36E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.33|P-value:1.55E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.32|P-value:1.61E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.58|P-value:4.45E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:-2.96|P-value:5.82E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.57|P-value:4.74E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:3.82|P-value:1.66E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.11|P-value:3.35E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.35|P-value:1.38E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.61|P-value:2.25E-7 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.24|P-value:1.91E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.51|P-value:6.90E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.58|P-value:4.35E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.06|P-value:5.11E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.83|P-value:7.87E-8 ID:SGTC_1238|Compound:0333-0287|FD-Score:-4.68|P-value:1.56E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.86|P-value:9.67E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.38|P-value:1.24E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.11|P-value:3.28E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.41|P-value:1.09E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.90|P-value:8.33E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.00|P-value:5.63E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.06|P-value:4.53E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.79|P-value:1.56E-10 ID:SGTC_1720|Compound:st037298|FD-Score:3.28|P-value:1.85E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.34|P-value:1.04E-6 ID:SGTC_1735|Compound:st034310|FD-Score:-3.52|P-value:5.72E-5 ID:SGTC_1763|Compound:st044482|FD-Score:-3.66|P-value:3.10E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.73|P-value:2.64E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.33|P-value:1.53E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.36|P-value:1.34E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.33|P-value:1.30E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.05|P-value:4.66E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.96|P-value:6.72E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.83|P-value:1.62E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.00|P-value:5.77E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.80|P-value:1.84E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.73|P-value:1.36E-7 ID:SGTC_2369|Compound:9071472|FD-Score:3.56|P-value:5.56E-5 ID:SGTC_2424|Compound:5537928|FD-Score:4.22|P-value:2.35E-6 ID:SGTC_2445|Compound:5742597|FD-Score:-2.89|P-value:7.58E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.12|P-value:3.60E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.49|P-value:6.53E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.18|P-value:2.88E-6 ID:SGTC_2799|Compound:7812892|FD-Score:6.29|P-value:3.90E-12 ID:SGTC_2802|Compound:7925815|FD-Score:3.77|P-value:2.14E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.67|P-value:3.40E-5 ID:SGTC_2851|Compound:9015922|FD-Score:4.56|P-value:3.66E-7 ID:SGTC_2941|Compound:9056145|FD-Score:5.07|P-value:1.76E-8 ID:SGTC_2945|Compound:9067681|FD-Score:-3.69|P-value:2.62E-5 ID:SGTC_2946|Compound:9065502|FD-Score:5.24|P-value:6.39E-9 ID:SGTC_2968|Compound:9090663|FD-Score:3.31|P-value:1.64E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.14|P-value:3.27E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.05|P-value:5.56E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-5.31|P-value:3.21E-9 ID:SGTC_3254|Compound:9136651|FD-Score:2.96|P-value:6.78E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.03|P-value:4.46E-4

Top fitness defect scores for YKL192C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2799 7812892 6.29 81.8 µM 3.90E-12 superoxide 6 1.54E-10 0.52
2 SGTC_1635 st007035 5.79 42.4 µM 1.56E-10 5 3.51E-9 0.08
3 SGTC_2946 9065502 5.24 71.4 µM 6.39E-9 1 8.19E-8 1.44
4 SGTC_2941 9056145 5.07 11.2 µM 1.76E-8 3 1.94E-7 0.06
5 SGTC_1233 0325-0408 4.83 14.2 µM 7.87E-8 2 6.90E-7 0.34
6 SGTC_2344 7990960 4.73 77.0 µM 1.36E-7 27 1.10E-6 0.02
7 SGTC_120 rhodamine 6G 4.69 52.3 µM 1.73E-7 mitochondrial processes 10 1.35E-6 0.07
8 SGTC_2851 9015922 4.56 71.4 µM 3.66E-7 6 2.55E-6 0.08
9 SGTC_2424 5537928 4.22 59.2 µM 2.35E-6 7 1.24E-5 0.02
10 SGTC_145 3737-0113 4.20 38.4 µM 2.63E-6 DNA intercalators 43 1.36E-5 0.00
11 SGTC_2598 perillyl alcohol 4.18 100.0 µM 2.88E-6 7 1.47E-5 0.15
12 SGTC_1227 3909-8010 4.06 46.6 µM 5.11E-6 2 2.40E-5 0.83
13 SGTC_3205 9113483 4.05 49.5 µM 5.56E-6 6 2.58E-5 0.05
14 SGTC_2179 6298986 3.83 200.0 µM 1.62E-5 heme requiring 6 6.41E-5 0.03
15 SGTC_700 3453-2283 3.82 142.0 µM 1.66E-5 amide catabolism 8 6.55E-5 0.07
16 SGTC_2303 7774051 3.80 200.0 µM 1.84E-5 7 7.15E-5 0.14
17 SGTC_2802 7925815 3.77 54.5 µM 2.14E-5 9 8.12E-5 0.01
18 SGTC_1785 bathophenanthroline 3.73 24.0 µM 2.64E-5 heme requiring 25 9.73E-5 0.05
19 SGTC_2809 7964133 3.67 13.0 µM 3.40E-5 60S ribosome export 16 1.21E-4 0.30
20 SGTC_2369 9071472 3.56 200.0 µM 5.56E-5 7 1.84E-4 0.26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.60E-22 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.156 8.25E-20 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.151 1.22E-18 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.130 5.15E-14 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.128 1.06E-13 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.125 3.10E-13 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.125 3.79E-13 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.123 7.09E-13 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.122 1.17E-12 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.122 1.28E-12 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.119 3.77E-12 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.119 4.13E-12 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.112 8.26E-11 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.106 8.77E-10 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.105 1.07E-9 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205