YKL193C / SDS22

Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL193C / SDS22

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:5.68|P-value:2.97E-10 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.31|P-value:1.47E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:2.94|P-value:6.94E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-2.92|P-value:6.92E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.07|P-value:4.14E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-2.83|P-value:9.77E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.59|P-value:2.93E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:2.98|P-value:5.87E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:7.45|P-value:2.28E-16 ID:SGTC_168|Compound:3970-0862|FD-Score:6.01|P-value:2.80E-11 ID:SGTC_214|Compound:4373-3496|FD-Score:4.19|P-value:2.47E-6 ID:SGTC_276|Compound:colchicine|FD-Score:2.98|P-value:5.98E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:2.96|P-value:6.30E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:2.97|P-value:6.19E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:2.88|P-value:8.57E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.01|P-value:6.31E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.22|P-value:2.28E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.66|P-value:3.31E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.16|P-value:2.78E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:5.67|P-value:3.34E-10 ID:SGTC_914|Compound:3820-6779|FD-Score:-5.08|P-value:1.46E-8 ID:SGTC_919|Compound:tnp00227|FD-Score:4.93|P-value:3.96E-8 ID:SGTC_971|Compound:1315-0384|FD-Score:2.90|P-value:7.96E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.27|P-value:1.51E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.82|P-value:1.62E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.22|P-value:2.17E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.00|P-value:6.65E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.16|P-value:2.73E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.40|P-value:7.49E-7 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.06|P-value:4.15E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.05|P-value:4.32E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-2.84|P-value:9.36E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.20|P-value:2.49E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.32|P-value:1.52E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-2.85|P-value:9.11E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.40|P-value:1.07E-4 ID:SGTC_1921|Compound:5740136|FD-Score:2.85|P-value:9.47E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.22|P-value:2.26E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.46|P-value:8.33E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.17|P-value:2.79E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-4.04|P-value:5.05E-6 ID:SGTC_2323|Compound:6148992|FD-Score:3.62|P-value:3.98E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-2.93|P-value:6.82E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.39|P-value:1.10E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.77|P-value:1.01E-7 ID:SGTC_2525|Compound:harmine|FD-Score:-3.00|P-value:5.26E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.10|P-value:3.67E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.08|P-value:3.96E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.97|P-value:7.67E-6 ID:SGTC_2814|Compound:7977482|FD-Score:2.87|P-value:8.89E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.31|P-value:1.59E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.97|P-value:7.73E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-2.97|P-value:5.72E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-2.93|P-value:6.86E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.50|P-value:6.91E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-3.76|P-value:2.00E-5 ID:SGTC_2999|Compound:9069765|FD-Score:3.38|P-value:1.17E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.18|P-value:2.68E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.39|P-value:1.13E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.22|P-value:2.19E-6 ID:SGTC_3075|Compound:9116269|FD-Score:3.53|P-value:6.09E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.80|P-value:8.75E-8 ID:SGTC_3190|Compound:9110366|FD-Score:-3.55|P-value:5.24E-5 ID:SGTC_3193|Compound:9111931|FD-Score:4.11|P-value:3.83E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.08|P-value:4.00E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.09|P-value:4.32E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.91|P-value:1.03E-5 ID:SGTC_3217|Compound:9129673|FD-Score:8.87|P-value:2.13E-22 ID:SGTC_3221|Compound:9128209|FD-Score:6.44|P-value:1.16E-12 ID:SGTC_72|Compound:0744-0168|FD-Score:5.68|P-value:2.97E-10 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.31|P-value:1.47E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:2.94|P-value:6.94E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-2.92|P-value:6.92E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.07|P-value:4.14E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-2.83|P-value:9.77E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.59|P-value:2.93E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:2.98|P-value:5.87E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:7.45|P-value:2.28E-16 ID:SGTC_168|Compound:3970-0862|FD-Score:6.01|P-value:2.80E-11 ID:SGTC_214|Compound:4373-3496|FD-Score:4.19|P-value:2.47E-6 ID:SGTC_276|Compound:colchicine|FD-Score:2.98|P-value:5.98E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:2.96|P-value:6.30E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:2.97|P-value:6.19E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:2.88|P-value:8.57E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.01|P-value:6.31E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.22|P-value:2.28E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.66|P-value:3.31E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.16|P-value:2.78E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:5.67|P-value:3.34E-10 ID:SGTC_914|Compound:3820-6779|FD-Score:-5.08|P-value:1.46E-8 ID:SGTC_919|Compound:tnp00227|FD-Score:4.93|P-value:3.96E-8 ID:SGTC_971|Compound:1315-0384|FD-Score:2.90|P-value:7.96E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.27|P-value:1.51E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.82|P-value:1.62E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.22|P-value:2.17E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.00|P-value:6.65E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.16|P-value:2.73E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.40|P-value:7.49E-7 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.06|P-value:4.15E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.05|P-value:4.32E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-2.84|P-value:9.36E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.20|P-value:2.49E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.32|P-value:1.52E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-2.85|P-value:9.11E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.40|P-value:1.07E-4 ID:SGTC_1921|Compound:5740136|FD-Score:2.85|P-value:9.47E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.22|P-value:2.26E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.46|P-value:8.33E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.17|P-value:2.79E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-4.04|P-value:5.05E-6 ID:SGTC_2323|Compound:6148992|FD-Score:3.62|P-value:3.98E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-2.93|P-value:6.82E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.39|P-value:1.10E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.77|P-value:1.01E-7 ID:SGTC_2525|Compound:harmine|FD-Score:-3.00|P-value:5.26E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.10|P-value:3.67E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.08|P-value:3.96E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.97|P-value:7.67E-6 ID:SGTC_2814|Compound:7977482|FD-Score:2.87|P-value:8.89E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.31|P-value:1.59E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.97|P-value:7.73E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-2.97|P-value:5.72E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-2.93|P-value:6.86E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.50|P-value:6.91E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-3.76|P-value:2.00E-5 ID:SGTC_2999|Compound:9069765|FD-Score:3.38|P-value:1.17E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.18|P-value:2.68E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.39|P-value:1.13E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.22|P-value:2.19E-6 ID:SGTC_3075|Compound:9116269|FD-Score:3.53|P-value:6.09E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.80|P-value:8.75E-8 ID:SGTC_3190|Compound:9110366|FD-Score:-3.55|P-value:5.24E-5 ID:SGTC_3193|Compound:9111931|FD-Score:4.11|P-value:3.83E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.08|P-value:4.00E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.09|P-value:4.32E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.91|P-value:1.03E-5 ID:SGTC_3217|Compound:9129673|FD-Score:8.87|P-value:2.13E-22 ID:SGTC_3221|Compound:9128209|FD-Score:6.44|P-value:1.16E-12

Top fitness defect scores for YKL193C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3217 9129673 8.87 49.5 µM 2.13E-22 1 3.77E-19 2.81
2 SGTC_159 3970-0959 7.45 50.0 µM 2.28E-16 6 4.56E-14 0.64
3 SGTC_3221 9128209 6.44 49.5 µM 1.16E-12 1 6.12E-11 1.16
4 SGTC_168 3970-0862 6.01 530.5 µM 2.80E-11 17 9.01E-10 0.22
5 SGTC_72 0744-0168 5.68 198.4 µM 2.97E-10 RPP1 & pyrimidine depletion 3 6.60E-9 0.61
6 SGTC_911 3456-4043 5.67 236.0 µM 3.34E-10 mitochondrial processes 3 7.31E-9 0.63
7 SGTC_919 tnp00227 4.93 403.6 nM 3.96E-8 RNA pol III & RNase P/MRP 6 4.14E-7 0.06
8 SGTC_3076 9116187 4.80 49.5 µM 8.75E-8 4 8.10E-7 0.32
9 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.77 3.7 µM 1.01E-7 8 9.13E-7 0.02
10 SGTC_150 3970-0969 4.59 77.2 µM 2.93E-7 11 2.26E-6 0.14
11 SGTC_3050 9093513 4.22 49.5 µM 2.19E-6 6 1.24E-5 0.38
12 SGTC_214 4373-3496 4.19 70.0 µM 2.47E-6 14 1.37E-5 0.01
13 SGTC_3193 9111931 4.11 49.5 µM 3.83E-6 6 1.99E-5 0.14
14 SGTC_3200 9114385 4.09 49.5 µM 4.32E-6 19 2.20E-5 0.04
15 SGTC_748 0136-0228 4.01 77.9 µM 6.31E-6 redox potentiating 7 3.04E-5 0.34
16 SGTC_1201 1889-3372 4.00 45.9 µM 6.65E-6 Golgi 7 3.18E-5 0.13
17 SGTC_2768 sulfasalazine 3.97 50.2 µM 7.67E-6 9 3.59E-5 0.03
18 SGTC_2918 7977171 3.97 22.1 µM 7.73E-6 3 3.61E-5 0.06
19 SGTC_3209 9113616 3.91 49.5 µM 1.03E-5 4 4.60E-5 0.03
20 SGTC_1134 3477-0009 3.82 42.5 µM 1.62E-5 15 6.78E-5 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 6.04E-36 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.167 2.18E-22 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.154 2.76E-19 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.150 2.59E-18 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.148 7.63E-18 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.147 1.29E-17 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.143 7.04E-17 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.143 9.76E-17 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.140 4.94E-16 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.126 2.71E-13 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.125 4.15E-13 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.120 3.03E-12 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.112 7.70E-11 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.109 2.21E-10 YJR042W NUP85 het Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
0.108 4.03E-10 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain