YKL196C / YKT6

Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL196C / YKT6

Click on Significant Values for Screen Details ID:SGTC_125|Compound:0133-0007|FD-Score:-3.03|P-value:3.33E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.34|P-value:8.98E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:3.08|P-value:2.25E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:8.81|P-value:1.01E-23 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.79|P-value:8.69E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.66|P-value:1.96E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.45|P-value:4.35E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-2.84|P-value:7.29E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.42|P-value:5.09E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:6.45|P-value:1.38E-13 ID:SGTC_971|Compound:1315-0384|FD-Score:2.75|P-value:8.66E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:2.83|P-value:6.33E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.46|P-value:5.24E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-2.95|P-value:4.69E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.53|P-value:1.38E-7 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.39|P-value:7.02E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:2.81|P-value:6.92E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.94|P-value:4.95E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-2.96|P-value:4.59E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.37|P-value:7.68E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.02|P-value:2.99E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.48|P-value:3.91E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.84|P-value:6.49E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-3.12|P-value:2.28E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.62|P-value:1.94E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.50|P-value:2.16E-10 ID:SGTC_1968|Compound:st069590|FD-Score:3.21|P-value:1.33E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-4.13|P-value:1.72E-6 ID:SGTC_1995|Compound:st072814|FD-Score:2.90|P-value:4.75E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-4.00|P-value:3.49E-6 ID:SGTC_2179|Compound:6298986|FD-Score:2.89|P-value:5.00E-4 ID:SGTC_2190|Compound:6049624|FD-Score:2.97|P-value:3.59E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.96|P-value:4.57E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.16|P-value:1.95E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-2.96|P-value:4.44E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-6.61|P-value:4.90E-14 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-4.09|P-value:2.17E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.00|P-value:3.24E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:2.95|P-value:3.93E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-2.95|P-value:4.70E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.98|P-value:3.44E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.88|P-value:5.12E-6 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.93|P-value:4.09E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.41|P-value:5.31E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-2.97|P-value:4.31E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.92|P-value:4.20E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-2.93|P-value:5.16E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.94|P-value:4.03E-4 ID:SGTC_2846|Compound:9008642|FD-Score:4.59|P-value:9.36E-8 ID:SGTC_2871|Compound:9038510|FD-Score:3.03|P-value:2.83E-4 ID:SGTC_2916|Compound:7875993|FD-Score:2.96|P-value:3.83E-4 ID:SGTC_2943|Compound:9068529|FD-Score:2.92|P-value:4.54E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-8.44|P-value:9.46E-22 ID:SGTC_3088|Compound:9117578|FD-Score:4.42|P-value:2.61E-7 ID:SGTC_3094|Compound:9117742|FD-Score:-3.45|P-value:5.49E-5 ID:SGTC_3229|Compound:9132204|FD-Score:2.97|P-value:3.66E-4 ID:SGTC_3248|Compound:9135562|FD-Score:2.90|P-value:4.85E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.06|P-value:2.97E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.09|P-value:2.67E-4 ID:SGTC_3272|Compound:9137413|FD-Score:2.86|P-value:5.58E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.03|P-value:3.33E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.34|P-value:8.98E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:3.08|P-value:2.25E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:8.81|P-value:1.01E-23 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.79|P-value:8.69E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.66|P-value:1.96E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.45|P-value:4.35E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-2.84|P-value:7.29E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.42|P-value:5.09E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:6.45|P-value:1.38E-13 ID:SGTC_971|Compound:1315-0384|FD-Score:2.75|P-value:8.66E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:2.83|P-value:6.33E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.46|P-value:5.24E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-2.95|P-value:4.69E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.53|P-value:1.38E-7 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.39|P-value:7.02E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:2.81|P-value:6.92E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.94|P-value:4.95E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-2.96|P-value:4.59E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.37|P-value:7.68E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.02|P-value:2.99E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.48|P-value:3.91E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.84|P-value:6.49E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-3.12|P-value:2.28E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.62|P-value:1.94E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.50|P-value:2.16E-10 ID:SGTC_1968|Compound:st069590|FD-Score:3.21|P-value:1.33E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-4.13|P-value:1.72E-6 ID:SGTC_1995|Compound:st072814|FD-Score:2.90|P-value:4.75E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-4.00|P-value:3.49E-6 ID:SGTC_2179|Compound:6298986|FD-Score:2.89|P-value:5.00E-4 ID:SGTC_2190|Compound:6049624|FD-Score:2.97|P-value:3.59E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.96|P-value:4.57E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.16|P-value:1.95E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-2.96|P-value:4.44E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-6.61|P-value:4.90E-14 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-4.09|P-value:2.17E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.00|P-value:3.24E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:2.95|P-value:3.93E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-2.95|P-value:4.70E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.98|P-value:3.44E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.88|P-value:5.12E-6 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.93|P-value:4.09E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.41|P-value:5.31E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-2.97|P-value:4.31E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.92|P-value:4.20E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-2.93|P-value:5.16E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.94|P-value:4.03E-4 ID:SGTC_2846|Compound:9008642|FD-Score:4.59|P-value:9.36E-8 ID:SGTC_2871|Compound:9038510|FD-Score:3.03|P-value:2.83E-4 ID:SGTC_2916|Compound:7875993|FD-Score:2.96|P-value:3.83E-4 ID:SGTC_2943|Compound:9068529|FD-Score:2.92|P-value:4.54E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-8.44|P-value:9.46E-22 ID:SGTC_3088|Compound:9117578|FD-Score:4.42|P-value:2.61E-7 ID:SGTC_3094|Compound:9117742|FD-Score:-3.45|P-value:5.49E-5 ID:SGTC_3229|Compound:9132204|FD-Score:2.97|P-value:3.66E-4 ID:SGTC_3248|Compound:9135562|FD-Score:2.90|P-value:4.85E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.06|P-value:2.97E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.09|P-value:2.67E-4 ID:SGTC_3272|Compound:9137413|FD-Score:2.86|P-value:5.58E-4

Top fitness defect scores for YKL196C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_341 1486-1430 8.81 230.0 µM 1.01E-23 4 6.51E-19 0.23
2 SGTC_948 3448-0295 6.45 75.3 µM 1.38E-13 3 5.78E-11 1.04
3 SGTC_1965 Pectolinarigenin 5.50 58.4 µM 2.16E-10 RPP1 & pyrimidine depletion 2 1.86E-8 0.60
4 SGTC_2846 9008642 4.59 19.5 µM 9.36E-8 4 2.20E-6 0.63
5 SGTC_1213 1315-0166 4.53 115.0 µM 1.38E-7 11 2.98E-6 0.11
6 SGTC_3088 9117578 4.42 49.5 µM 2.61E-7 amide catabolism 2 4.93E-6 0.85
7 SGTC_2720 fluspirilene 3.93 36.9 µM 4.09E-6 ERG2 5 4.31E-5 0.41
8 SGTC_2787 5284540 3.92 71.4 µM 4.20E-6 9 4.40E-5 0.23
9 SGTC_2719 novobiocin 3.88 32.6 µM 5.12E-6 2 5.14E-5 0.75
10 SGTC_1679 4130-1276 3.84 6.7 µM 6.49E-6 Golgi 26 6.19E-5 0.02
11 SGTC_1960 st011366 3.62 51.8 µM 1.94E-5 6 1.47E-4 0.07
12 SGTC_1619 st003326 3.48 88.7 µM 3.91E-5 60S ribosome export 8 2.55E-4 0.25
13 SGTC_936 3005-4620 3.45 401.0 µM 4.35E-5 5 2.78E-4 0.11
14 SGTC_947 3447-0010 3.42 211.0 µM 5.09E-5 7 3.14E-4 0.07
15 SGTC_2724 maprotiline 3.41 69.6 µM 5.31E-5 ERG2 9 3.25E-4 0.06
16 SGTC_1968 st069590 3.21 43.6 µM 1.33E-4 23 6.73E-4 0.02
17 SGTC_307 1501-1223 3.08 22.3 µM 2.25E-4 9 0.00102 0.08
18 SGTC_2871 9038510 3.03 13.0 µM 2.83E-4 15 0.00122 0.04
19 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.02 19.1 µM 2.99E-4 10 0.00128 0.03
20 SGTC_2588 indole-3-carbinol 3.00 100.0 µM 3.24E-4 20 0.00136 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 8.85E-28 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.152 9.26E-19 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.151 1.36E-18 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.137 1.51E-15 YGL137W SEC27 het Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
0.130 4.95E-14 YBR089W_d YBR089W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.130 5.08E-14 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.124 4.82E-13 YDR052C DBF4 het Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
0.124 5.74E-13 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.124 6.05E-13 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.123 7.74E-13 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.122 1.39E-12 YJL002C OST1 het Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.118 6.92E-12 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.116 1.60E-11 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.115 2.06E-11 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.112 7.81E-11 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress