YKL198C / PTK1

Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL198C / PTK1

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:-3.37|P-value:8.39E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.08|P-value:5.29E-5 ID:SGTC_185|Compound:k048-0037|FD-Score:3.79|P-value:1.59E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:4.56|P-value:7.65E-6 ID:SGTC_190|Compound:3970-0790|FD-Score:3.41|P-value:5.92E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.91|P-value:9.96E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.87|P-value:1.17E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.64|P-value:2.69E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.21|P-value:3.13E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.59|P-value:3.19E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.27|P-value:9.14E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.31|P-value:8.21E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.37|P-value:8.62E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.46|P-value:4.95E-4 ID:SGTC_1904|Compound:st060225|FD-Score:4.52|P-value:8.93E-6 ID:SGTC_1981|Compound:st071826|FD-Score:-4.03|P-value:8.45E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.51|P-value:5.31E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.12|P-value:4.49E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-4.46|P-value:1.55E-5 ID:SGTC_2316|Compound:5844804|FD-Score:-4.75|P-value:4.47E-6 ID:SGTC_2319|Compound:6033012|FD-Score:3.82|P-value:1.41E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.91|P-value:1.03E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.55|P-value:3.60E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.90|P-value:1.40E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.28|P-value:8.94E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.78|P-value:2.91E-6 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.94|P-value:1.36E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.89|P-value:1.21E-8 ID:SGTC_2707|Compound:st078556|FD-Score:-3.45|P-value:6.60E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.40|P-value:7.61E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.50|P-value:4.27E-4 ID:SGTC_2854|Compound:9024559|FD-Score:4.05|P-value:6.04E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.31|P-value:8.00E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.40|P-value:6.02E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.96|P-value:1.12E-4 ID:SGTC_3323|Compound:9138564|FD-Score:-4.61|P-value:8.16E-6 ID:SGTC_3324|Compound:9138759|FD-Score:-4.78|P-value:4.01E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-3.68|P-value:3.03E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.24|P-value:2.77E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.71|P-value:2.69E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.37|P-value:8.39E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.08|P-value:5.29E-5 ID:SGTC_185|Compound:k048-0037|FD-Score:3.79|P-value:1.59E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:4.56|P-value:7.65E-6 ID:SGTC_190|Compound:3970-0790|FD-Score:3.41|P-value:5.92E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.91|P-value:9.96E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.87|P-value:1.17E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.64|P-value:2.69E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.21|P-value:3.13E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.59|P-value:3.19E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.27|P-value:9.14E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.31|P-value:8.21E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.37|P-value:8.62E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.46|P-value:4.95E-4 ID:SGTC_1904|Compound:st060225|FD-Score:4.52|P-value:8.93E-6 ID:SGTC_1981|Compound:st071826|FD-Score:-4.03|P-value:8.45E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.51|P-value:5.31E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.12|P-value:4.49E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-4.46|P-value:1.55E-5 ID:SGTC_2316|Compound:5844804|FD-Score:-4.75|P-value:4.47E-6 ID:SGTC_2319|Compound:6033012|FD-Score:3.82|P-value:1.41E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.91|P-value:1.03E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.55|P-value:3.60E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.90|P-value:1.40E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.28|P-value:8.94E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.78|P-value:2.91E-6 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.94|P-value:1.36E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.89|P-value:1.21E-8 ID:SGTC_2707|Compound:st078556|FD-Score:-3.45|P-value:6.60E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.40|P-value:7.61E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.50|P-value:4.27E-4 ID:SGTC_2854|Compound:9024559|FD-Score:4.05|P-value:6.04E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.31|P-value:8.00E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.40|P-value:6.02E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.96|P-value:1.12E-4 ID:SGTC_3323|Compound:9138564|FD-Score:-4.61|P-value:8.16E-6 ID:SGTC_3324|Compound:9138759|FD-Score:-4.78|P-value:4.01E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-3.68|P-value:3.03E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.24|P-value:2.77E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.71|P-value:2.69E-4

Top fitness defect scores for YKL198C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2597 laccaic acid a 5.89 100.0 µM 1.21E-8 7 1.95E-9
2 SGTC_2558 carylophyllene oxide 4.94 100.0 µM 1.36E-6 3 3.81E-7
3 SGTC_2348 9022543 4.78 33.4 µM 2.91E-6 mitochondrial processes 16 8.91E-7
4 SGTC_189 3970-0742 4.56 2.1 µM 7.65E-6 4 2.62E-6
5 SGTC_1904 st060225 4.52 78.0 µM 8.93E-6 10 3.11E-6
6 SGTC_3329 9141233 4.24 27.6 µM 2.77E-5 11 1.09E-5
7 SGTC_384 k007-0144 4.21 5.2 µM 3.13E-5 ERAD & cell cycle 52 1.26E-5
8 SGTC_2131 toluylene red 4.12 5.3 µM 4.49E-5 60S ribosome export 19 1.87E-5
9 SGTC_133 0724-0033 4.08 378.9 µM 5.29E-5 27 2.25E-5
10 SGTC_2854 9024559 4.05 71.4 µM 6.04E-5 18 2.61E-5
11 SGTC_219 mitoxanthrone 3.91 164.4 µM 9.96E-5 DNA intercalators 52 4.55E-5
12 SGTC_2325 6158266 3.91 200.0 µM 1.03E-4 24 4.70E-5
13 SGTC_361 000s-0510 3.87 1.4 µM 1.17E-4 34 5.43E-5
14 SGTC_2319 6033012 3.82 152.6 µM 1.41E-4 tubulin folding & SWR complex 33 6.67E-5
15 SGTC_185 k048-0037 3.79 25.5 µM 1.59E-4 RSC & ERG11 14 7.67E-5
16 SGTC_382 3229-0966 3.64 23.2 µM 2.69E-4 33 1.37E-4
17 SGTC_551 k048-0028 3.59 34.9 µM 3.19E-4 30 1.65E-4
18 SGTC_2327 6189656 3.55 200.0 µM 3.60E-4 27 1.89E-4
19 SGTC_2819 7996655 3.50 46.4 µM 4.27E-4 33 2.29E-4
20 SGTC_1847 st056231 3.46 15.0 µM 4.95E-4 49 2.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 9.66E-20 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.103 1.90E-9 YER085C_p YER085C_p hom Putative protein of unknown function
0.102 2.66E-9 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.097 1.78E-8 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.097 1.81E-8 YKL084W HOT13 hom Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
0.086 6.82E-7 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.085 7.77E-7 YOR103C OST2 het Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.082 2.01E-6 YOR108W LEU9 hom Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication
0.078 6.56E-6 YOR219C STE13 hom Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.074 1.67E-5 YGR222W PET54 hom Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
0.073 2.28E-5 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.073 2.60E-5 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.072 2.90E-5 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.072 3.06E-5 YLR460C_p YLR460C_p hom Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine
0.069 6.52E-5 YIL004C BET1 het Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins