YKL202W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL202W / YKL202W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.23|P-value:3.11E-9 ID:SGTC_324|Compound:1315-0088|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.10|P-value:2.68E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.33|P-value:7.31E-7 ID:SGTC_490|Compound:phenamil|FD-Score:-3.19|P-value:2.64E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.84|P-value:9.57E-6 ID:SGTC_890|Compound:0929-0006|FD-Score:2.91|P-value:5.81E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.92|P-value:6.25E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.20|P-value:2.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.37|P-value:1.22E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.41|P-value:7.33E-7 ID:SGTC_1152|Compound:3909-8331|FD-Score:2.84|P-value:7.50E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.14|P-value:2.29E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.59|P-value:4.65E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.20|P-value:2.48E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:2.78|P-value:9.45E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:2.90|P-value:5.93E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.22|P-value:1.62E-4 ID:SGTC_1615|Compound:st002656|FD-Score:-4.23|P-value:1.96E-6 ID:SGTC_1676|Compound:st018489|FD-Score:-3.86|P-value:1.30E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.61|P-value:2.85E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.23|P-value:2.19E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.79|P-value:1.22E-5 ID:SGTC_1756|Compound:st041558|FD-Score:3.23|P-value:1.55E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-2.97|P-value:6.32E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-2.86|P-value:9.37E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.01|P-value:3.92E-4 ID:SGTC_2047|Compound:4141938|FD-Score:2.77|P-value:9.82E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.30|P-value:1.62E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.13|P-value:2.36E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.35|P-value:6.61E-7 ID:SGTC_2425|Compound:5628681|FD-Score:2.98|P-value:4.34E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.45|P-value:6.05E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.10|P-value:2.52E-6 ID:SGTC_2505|Compound:galangin|FD-Score:-3.06|P-value:4.31E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-16.80|P-value:1.53E-76 ID:SGTC_2909|Compound:7941780|FD-Score:3.53|P-value:4.13E-5 ID:SGTC_2925|Compound:9010536|FD-Score:2.77|P-value:9.57E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-2.91|P-value:7.84E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.01|P-value:3.89E-4 ID:SGTC_3124|Compound:9127567|FD-Score:2.84|P-value:7.62E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.98|P-value:4.37E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.45|P-value:5.93E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:5.23|P-value:3.11E-9 ID:SGTC_324|Compound:1315-0088|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.10|P-value:2.68E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.33|P-value:7.31E-7 ID:SGTC_490|Compound:phenamil|FD-Score:-3.19|P-value:2.64E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.84|P-value:9.57E-6 ID:SGTC_890|Compound:0929-0006|FD-Score:2.91|P-value:5.81E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.92|P-value:6.25E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.20|P-value:2.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.37|P-value:1.22E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.41|P-value:7.33E-7 ID:SGTC_1152|Compound:3909-8331|FD-Score:2.84|P-value:7.50E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.14|P-value:2.29E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.59|P-value:4.65E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.20|P-value:2.48E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:2.78|P-value:9.45E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:2.90|P-value:5.93E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.22|P-value:1.62E-4 ID:SGTC_1615|Compound:st002656|FD-Score:-4.23|P-value:1.96E-6 ID:SGTC_1676|Compound:st018489|FD-Score:-3.86|P-value:1.30E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.61|P-value:2.85E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.23|P-value:2.19E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.79|P-value:1.22E-5 ID:SGTC_1756|Compound:st041558|FD-Score:3.23|P-value:1.55E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-2.97|P-value:6.32E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-2.86|P-value:9.37E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.01|P-value:3.92E-4 ID:SGTC_2047|Compound:4141938|FD-Score:2.77|P-value:9.82E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.30|P-value:1.62E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.13|P-value:2.36E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.35|P-value:6.61E-7 ID:SGTC_2425|Compound:5628681|FD-Score:2.98|P-value:4.34E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.45|P-value:6.05E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.10|P-value:2.52E-6 ID:SGTC_2505|Compound:galangin|FD-Score:-3.06|P-value:4.31E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-16.80|P-value:1.53E-76 ID:SGTC_2909|Compound:7941780|FD-Score:3.53|P-value:4.13E-5 ID:SGTC_2925|Compound:9010536|FD-Score:2.77|P-value:9.57E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-2.91|P-value:7.84E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.01|P-value:3.89E-4 ID:SGTC_3124|Compound:9127567|FD-Score:2.84|P-value:7.62E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.98|P-value:4.37E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.45|P-value:5.93E-5

Top fitness defect scores for YKL202W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 5.23 19.8 µM 3.11E-9 29 8.41E-8
2 SGTC_2419 paclitaxel 4.35 166.5 µM 6.61E-7 28 6.89E-6
3 SGTC_391 gliotoxin 4.33 8.3 µM 7.31E-7 48 7.47E-6
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.10 3.7 µM 2.52E-6 78 2.07E-5
5 SGTC_1029 k015-0030 3.92 64.7 µM 6.25E-6 29 4.37E-5
6 SGTC_521 r062-0005 3.84 13.8 µM 9.57E-6 16 6.20E-5
7 SGTC_1753 st043925 3.79 64.0 µM 1.22E-5 11 7.57E-5
8 SGTC_1680 diphenhydramine 3.61 100.0 µM 2.85E-5 NEO1 40 1.53E-4
9 SGTC_2909 7941780 3.53 10.5 µM 4.13E-5 30 2.07E-4
10 SGTC_3160 9100216 3.45 49.5 µM 5.93E-5 13 2.79E-4
11 SGTC_2429 5902844 3.45 64.4 µM 6.05E-5 50 2.83E-4
12 SGTC_1756 st041558 3.23 35.5 µM 1.55E-4 25 6.15E-4
13 SGTC_1520 flindersine 3.22 88.0 µM 1.62E-4 59 6.38E-4
14 SGTC_1198 1612-1005 3.14 86.7 µM 2.29E-4 38 8.50E-4
15 SGTC_2359 9039622 3.13 200.0 µM 2.36E-4 endomembrane recycling 59 8.69E-4
16 SGTC_366 0181-0206 3.10 4.3 µM 2.68E-4 Golgi 87 9.66E-4
17 SGTC_3080 9117754 3.01 49.5 µM 3.89E-4 53 0.00131
18 SGTC_2040 5100729 3.01 123.0 µM 3.92E-4 78 0.00132
19 SGTC_2425 5628681 2.98 7.8 µM 4.34E-4 78 0.00144
20 SGTC_3126 9127922 2.98 49.5 µM 4.37E-4 fatty acid desaturase (OLE1) 85 0.00145

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.343 1.67E-93 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.258 4.14E-52 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.249 1.98E-48 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.248 2.46E-48 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.245 4.77E-47 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.243 4.18E-46 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.240 2.64E-45 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.237 5.00E-44 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.224 1.45E-39 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.221 1.56E-38 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.216 7.92E-37 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.207 9.53E-34 YMR145C NDE1 hom Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.206 1.95E-33 YLR254C NDL1 hom Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
0.204 8.47E-33 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.203 1.66E-32 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p