YKL203C / TOR2

PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL203C / TOR2

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:2.66|P-value:5.13E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.59|P-value:3.93E-12 ID:SGTC_160|Compound:3453-0671|FD-Score:3.02|P-value:9.85E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.20|P-value:6.62E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:-2.66|P-value:7.65E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.96|P-value:5.50E-7 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:2.53|P-value:8.73E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-2.89|P-value:2.85E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.15|P-value:8.56E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.51|P-value:9.33E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:2.63|P-value:5.71E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:2.98|P-value:1.15E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.89|P-value:5.04E-17 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.09|P-value:1.12E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-2.87|P-value:3.06E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.05|P-value:1.35E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-2.61|P-value:9.43E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-5.66|P-value:5.00E-12 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.40|P-value:2.45E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-2.94|P-value:2.28E-4 ID:SGTC_917|Compound:harmaline|FD-Score:2.56|P-value:7.76E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.84|P-value:1.17E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:2.56|P-value:7.79E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.83|P-value:1.27E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:2.65|P-value:5.26E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.41|P-value:1.32E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.29|P-value:6.76E-8 ID:SGTC_1149|Compound:3909-7961|FD-Score:-2.81|P-value:4.03E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.21|P-value:1.18E-7 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.15|P-value:8.47E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.27|P-value:8.07E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.99|P-value:8.84E-7 ID:SGTC_1433|Compound:4060-0023|FD-Score:-2.82|P-value:3.91E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.80|P-value:2.70E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.84|P-value:1.15E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.32|P-value:5.52E-8 ID:SGTC_1675|Compound:st018485|FD-Score:-2.89|P-value:2.83E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.30|P-value:2.40E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.74|P-value:3.69E-6 ID:SGTC_1724|Compound:st037281|FD-Score:-4.72|P-value:7.31E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:21.20|P-value:1.66E-146 ID:SGTC_1873|Compound:rapamycin|FD-Score:7.56|P-value:1.26E-20 ID:SGTC_1909|Compound:st060837|FD-Score:2.57|P-value:7.44E-4 ID:SGTC_1972|Compound:st070201|FD-Score:2.71|P-value:4.04E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.87|P-value:9.61E-7 ID:SGTC_2211|Compound:7117706|FD-Score:3.20|P-value:4.00E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-3.03|P-value:1.49E-4 ID:SGTC_2293|Compound:7624732|FD-Score:2.73|P-value:3.68E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.00|P-value:1.07E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.21|P-value:3.89E-5 ID:SGTC_2411|Compound:st077133|FD-Score:5.86|P-value:3.60E-13 ID:SGTC_2413|Compound:inermin|FD-Score:2.74|P-value:3.53E-4 ID:SGTC_2461|Compound:5755302|FD-Score:2.92|P-value:1.56E-4 ID:SGTC_2465|Compound:5809242|FD-Score:-3.79|P-value:2.81E-6 ID:SGTC_2469|Compound:5655019|FD-Score:3.96|P-value:5.82E-7 ID:SGTC_2472|Compound:5377652|FD-Score:2.85|P-value:2.14E-4 ID:SGTC_2505|Compound:galangin|FD-Score:2.79|P-value:2.77E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-4.33|P-value:1.01E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:17.90|P-value:1.81E-105 ID:SGTC_2689|Compound:tacrolimus|FD-Score:2.68|P-value:4.52E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.90|P-value:8.26E-7 ID:SGTC_2714|Compound:st079313|FD-Score:-2.66|P-value:7.71E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.92|P-value:1.59E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.02|P-value:9.61E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.04|P-value:1.43E-4 ID:SGTC_2817|Compound:7995342|FD-Score:2.60|P-value:6.49E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-2.96|P-value:2.06E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.63|P-value:3.96E-6 ID:SGTC_2845|Compound:9003024|FD-Score:2.78|P-value:2.96E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-5.66|P-value:5.15E-12 ID:SGTC_3180|Compound:9109287|FD-Score:-2.66|P-value:7.61E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.66|P-value:5.13E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.59|P-value:3.93E-12 ID:SGTC_160|Compound:3453-0671|FD-Score:3.02|P-value:9.85E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.20|P-value:6.62E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:-2.66|P-value:7.65E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.96|P-value:5.50E-7 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:2.53|P-value:8.73E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-2.89|P-value:2.85E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.15|P-value:8.56E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.51|P-value:9.33E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:2.63|P-value:5.71E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:2.98|P-value:1.15E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.89|P-value:5.04E-17 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.09|P-value:1.12E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-2.87|P-value:3.06E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.05|P-value:1.35E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-2.61|P-value:9.43E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-5.66|P-value:5.00E-12 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.40|P-value:2.45E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-2.94|P-value:2.28E-4 ID:SGTC_917|Compound:harmaline|FD-Score:2.56|P-value:7.76E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.84|P-value:1.17E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:2.56|P-value:7.79E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.83|P-value:1.27E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:2.65|P-value:5.26E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.41|P-value:1.32E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.29|P-value:6.76E-8 ID:SGTC_1149|Compound:3909-7961|FD-Score:-2.81|P-value:4.03E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.21|P-value:1.18E-7 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.15|P-value:8.47E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.27|P-value:8.07E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.99|P-value:8.84E-7 ID:SGTC_1433|Compound:4060-0023|FD-Score:-2.82|P-value:3.91E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.80|P-value:2.70E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.84|P-value:1.15E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.32|P-value:5.52E-8 ID:SGTC_1675|Compound:st018485|FD-Score:-2.89|P-value:2.83E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.30|P-value:2.40E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.74|P-value:3.69E-6 ID:SGTC_1724|Compound:st037281|FD-Score:-4.72|P-value:7.31E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:21.20|P-value:1.66E-146 ID:SGTC_1873|Compound:rapamycin|FD-Score:7.56|P-value:1.26E-20 ID:SGTC_1909|Compound:st060837|FD-Score:2.57|P-value:7.44E-4 ID:SGTC_1972|Compound:st070201|FD-Score:2.71|P-value:4.04E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.87|P-value:9.61E-7 ID:SGTC_2211|Compound:7117706|FD-Score:3.20|P-value:4.00E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-3.03|P-value:1.49E-4 ID:SGTC_2293|Compound:7624732|FD-Score:2.73|P-value:3.68E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.00|P-value:1.07E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.21|P-value:3.89E-5 ID:SGTC_2411|Compound:st077133|FD-Score:5.86|P-value:3.60E-13 ID:SGTC_2413|Compound:inermin|FD-Score:2.74|P-value:3.53E-4 ID:SGTC_2461|Compound:5755302|FD-Score:2.92|P-value:1.56E-4 ID:SGTC_2465|Compound:5809242|FD-Score:-3.79|P-value:2.81E-6 ID:SGTC_2469|Compound:5655019|FD-Score:3.96|P-value:5.82E-7 ID:SGTC_2472|Compound:5377652|FD-Score:2.85|P-value:2.14E-4 ID:SGTC_2505|Compound:galangin|FD-Score:2.79|P-value:2.77E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-4.33|P-value:1.01E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:17.90|P-value:1.81E-105 ID:SGTC_2689|Compound:tacrolimus|FD-Score:2.68|P-value:4.52E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.90|P-value:8.26E-7 ID:SGTC_2714|Compound:st079313|FD-Score:-2.66|P-value:7.71E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.92|P-value:1.59E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.02|P-value:9.61E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.04|P-value:1.43E-4 ID:SGTC_2817|Compound:7995342|FD-Score:2.60|P-value:6.49E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-2.96|P-value:2.06E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.63|P-value:3.96E-6 ID:SGTC_2845|Compound:9003024|FD-Score:2.78|P-value:2.96E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-5.66|P-value:5.15E-12 ID:SGTC_3180|Compound:9109287|FD-Score:-2.66|P-value:7.61E-4

Top fitness defect scores for YKL203C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1844 rapamycin 21.20 4.0 nM 1.66E-146 2 9.68E-100 5.98
2 SGTC_2679 rapamycin 17.90 1.0 nM 1.81E-105 1 6.33E-72 3.45
3 SGTC_1873 rapamycin 7.56 2.0 nM 1.26E-20 6 2.00E-14 0.61
4 SGTC_2411 st077133 5.86 39.9 µM 3.60E-13 RNA pol III & RNase P/MRP 14 2.28E-9 0.11
5 SGTC_159 3970-0959 5.59 50.0 µM 3.93E-12 9 1.16E-8 0.20
6 SGTC_1562 morin hydrate 4.32 59.1 µM 5.52E-8 6 7.66E-6 0.28
7 SGTC_1134 3477-0009 4.29 42.5 µM 6.76E-8 8 8.79E-6 0.16
8 SGTC_1298 1079-1278 4.27 263.0 µM 8.07E-8 DNA damage response 3 9.92E-6 0.01
9 SGTC_1165 k072-0275 4.21 30.3 µM 1.18E-7 9 1.29E-5 0.11
10 SGTC_305 1682-2595 3.96 20.8 µM 5.50E-7 RNA processing & uracil transport 6 3.67E-5 0.04
11 SGTC_2469 5655019 3.96 90.8 µM 5.82E-7 3 3.81E-5 0.63
12 SGTC_2703 st077852 3.90 53.4 µM 8.26E-7 8 4.85E-5 0.46
13 SGTC_2021 4019055 3.87 173.0 µM 9.61E-7 endomembrane recycling 34 5.37E-5 0.04
14 SGTC_1510 1123-0200 3.84 71.5 µM 1.15E-6 17 6.06E-5 0.08
15 SGTC_972 1319-0219 3.84 195.0 µM 1.17E-6 6 6.16E-5 0.09
16 SGTC_978 1416-0512 3.83 87.4 µM 1.27E-6 redox potentiating 10 6.51E-5 0.27
17 SGTC_2835 9006588 3.63 71.4 µM 3.96E-6 13 1.41E-4 0.21
18 SGTC_1058 3448-5425 3.41 97.3 µM 1.32E-5 15 3.22E-4 0.03
19 SGTC_1694 st024011 3.30 44.9 µM 2.40E-5 ERG2 16 4.85E-4 0.07
20 SGTC_2382 9035899 3.21 200.0 µM 3.89E-5 60S ribosome export 11 6.74E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.583 1.33E-304 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.492 2.78E-204 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.474 7.35E-188 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.455 9.09E-171 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.409 7.17E-136 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.405 1.02E-132 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.403 2.37E-131 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.395 1.45E-125 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.394 7.14E-125 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.375 1.06E-112 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.371 3.72E-109 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.364 3.17E-105 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.349 1.59E-96 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.330 4.45E-86 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.327 5.05E-84 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis