YKL206C / ADD66

Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL206C / ADD66

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:-3.10|P-value:7.01E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.93|P-value:1.93E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:3.74|P-value:5.89E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.35|P-value:3.75E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:3.98|P-value:2.11E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.13|P-value:6.33E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.67|P-value:7.99E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.25|P-value:4.08E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.03|P-value:8.87E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.30|P-value:3.37E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.67|P-value:8.00E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.05|P-value:8.67E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.63|P-value:9.29E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:3.13|P-value:6.43E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.95|P-value:2.42E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.04|P-value:8.89E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.21|P-value:4.76E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.24|P-value:4.28E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.08|P-value:7.60E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.24|P-value:4.25E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.06|P-value:8.18E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.87|P-value:3.42E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.08|P-value:7.66E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.05|P-value:8.48E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.32|P-value:3.20E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.38|P-value:2.51E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.95|P-value:2.32E-5 ID:SGTC_2054|Compound:5233173|FD-Score:13.10|P-value:7.98E-42 ID:SGTC_2056|Compound:5235370|FD-Score:6.08|P-value:2.03E-10 ID:SGTC_2057|Compound:5236571|FD-Score:7.84|P-value:3.53E-16 ID:SGTC_2059|Compound:5238311|FD-Score:-7.69|P-value:1.22E-15 ID:SGTC_2142|Compound:5622915|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_2151|Compound:5563267|FD-Score:-5.48|P-value:8.11E-9 ID:SGTC_2155|Compound:5570423|FD-Score:-5.77|P-value:1.43E-9 ID:SGTC_2159|Compound:5658611|FD-Score:-3.01|P-value:9.57E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-7.79|P-value:5.29E-16 ID:SGTC_2184|Compound:6075246|FD-Score:5.42|P-value:1.24E-8 ID:SGTC_2305|Compound:7443522|FD-Score:-3.85|P-value:3.74E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.91|P-value:2.93E-5 ID:SGTC_2421|Compound:5690543|FD-Score:-3.61|P-value:1.00E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.95|P-value:2.37E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.85|P-value:3.60E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.42|P-value:2.11E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.06|P-value:8.16E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.12|P-value:6.70E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.76|P-value:5.39E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.88|P-value:3.24E-5 ID:SGTC_3324|Compound:9138759|FD-Score:-3.01|P-value:9.50E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.13|P-value:6.31E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.10|P-value:7.01E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.93|P-value:1.93E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:3.74|P-value:5.89E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.35|P-value:3.75E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:3.98|P-value:2.11E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.13|P-value:6.33E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.67|P-value:7.99E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.25|P-value:4.08E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.03|P-value:8.87E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.30|P-value:3.37E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.67|P-value:8.00E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.05|P-value:8.67E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.63|P-value:9.29E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:3.13|P-value:6.43E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.95|P-value:2.42E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.04|P-value:8.89E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.21|P-value:4.76E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.24|P-value:4.28E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.08|P-value:7.60E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.24|P-value:4.25E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.06|P-value:8.18E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.87|P-value:3.42E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.08|P-value:7.66E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.05|P-value:8.48E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.32|P-value:3.20E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.38|P-value:2.51E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.95|P-value:2.32E-5 ID:SGTC_2054|Compound:5233173|FD-Score:13.10|P-value:7.98E-42 ID:SGTC_2056|Compound:5235370|FD-Score:6.08|P-value:2.03E-10 ID:SGTC_2057|Compound:5236571|FD-Score:7.84|P-value:3.53E-16 ID:SGTC_2059|Compound:5238311|FD-Score:-7.69|P-value:1.22E-15 ID:SGTC_2142|Compound:5622915|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_2151|Compound:5563267|FD-Score:-5.48|P-value:8.11E-9 ID:SGTC_2155|Compound:5570423|FD-Score:-5.77|P-value:1.43E-9 ID:SGTC_2159|Compound:5658611|FD-Score:-3.01|P-value:9.57E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-7.79|P-value:5.29E-16 ID:SGTC_2184|Compound:6075246|FD-Score:5.42|P-value:1.24E-8 ID:SGTC_2305|Compound:7443522|FD-Score:-3.85|P-value:3.74E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.91|P-value:2.93E-5 ID:SGTC_2421|Compound:5690543|FD-Score:-3.61|P-value:1.00E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.95|P-value:2.37E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.85|P-value:3.60E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.42|P-value:2.11E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.06|P-value:8.16E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.12|P-value:6.70E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.76|P-value:5.39E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.88|P-value:3.24E-5 ID:SGTC_3324|Compound:9138759|FD-Score:-3.01|P-value:9.50E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.13|P-value:6.31E-4

Top fitness defect scores for YKL206C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2054 5233173 13.10 129.0 µM 7.98E-42 mitochondrial response to ROS 2 1.33E-39
2 SGTC_2057 5236571 7.84 38.3 µM 3.53E-16 RPP1 & pyrimidine depletion 4 2.22E-15
3 SGTC_2056 5235370 6.08 200.0 µM 2.03E-10 13 6.17E-10
4 SGTC_2184 6075246 5.42 200.0 µM 1.24E-8 5 3.02E-8
5 SGTC_64 000l-0018 4.93 272.1 µM 1.93E-7 ubiquinone biosynthesis & proteasome 110 4.04E-7
6 SGTC_74 000s-0487 3.98 160.3 µM 2.11E-5 21 3.43E-5
7 SGTC_756 0508-1999 3.95 28.3 µM 2.42E-5 RPP1 & pyrimidine depletion 26 3.90E-5
8 SGTC_2414 st077232 3.91 92.9 µM 2.93E-5 21 4.69E-5
9 SGTC_3271 9137798 3.88 49.5 µM 3.24E-5 7 5.16E-5
10 SGTC_1581 himbacine 3.87 57.9 µM 3.42E-5 Golgi 52 5.43E-5
11 SGTC_67 0335-0847 3.74 266.0 µM 5.89E-5 ubiquinone biosynthesis & proteasome 131 9.09E-5
12 SGTC_330 1488-0319 3.67 80.1 µM 7.99E-5 RPP1 & pyrimidine depletion 15 1.21E-4
13 SGTC_1520 flindersine 3.59 88.0 µM 1.13E-4 40 1.68E-4
14 SGTC_1825 st052143 3.38 62.6 µM 2.51E-4 28 3.59E-4
15 SGTC_1804 st050076 3.32 49.1 µM 3.20E-4 41 4.52E-4
16 SGTC_431 k089-0097 3.30 107.0 µM 3.37E-4 iron homeostasis 72 4.75E-4
17 SGTC_348 k064-0012 3.25 10.7 µM 4.08E-4 60S ribosome export 38 5.69E-4
18 SGTC_1482 3346-2049 3.24 8.5 µM 4.25E-4 46 5.91E-4
19 SGTC_1126 isoteolin 3.24 1.0 µM 4.28E-4 67 5.95E-4
20 SGTC_77 0828-0286 3.13 12.5 µM 6.33E-4 TSC3-RPN4 85 8.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.75E-15 YBL099W ATP1 hom Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.132 2.00E-14 YOR101W RAS1 hom GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress
0.123 8.51E-13 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.123 8.80E-13 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.119 4.40E-12 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 5.39E-12 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.110 1.67E-10 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.109 2.15E-10 YBR105C VID24 hom GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles
0.102 3.44E-9 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.099 9.02E-9 YER079W_p YER079W_p hom Putative protein of unknown function
0.099 1.03E-8 YDR477W SNF1 hom AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation
0.092 9.01E-8 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.092 9.34E-8 YPL003W ULA1 hom Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
0.091 1.27E-7 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.090 1.71E-7 YIR033W MGA2 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting