YKL207W / EMC3

Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL207W / EMC3

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:7.76|P-value:2.63E-16 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-4.35|P-value:3.42E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.08|P-value:7.31E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.49|P-value:1.30E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:4.06|P-value:1.06E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.77|P-value:3.86E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:8.42|P-value:7.05E-19 ID:SGTC_180|Compound:1486-1293|FD-Score:5.10|P-value:4.79E-8 ID:SGTC_315|Compound:k915-0449|FD-Score:4.05|P-value:1.10E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.68|P-value:5.66E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:2.95|P-value:9.79E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.12|P-value:5.33E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:11.20|P-value:4.48E-32 ID:SGTC_568|Compound:1193-0097|FD-Score:2.95|P-value:9.58E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.35|P-value:2.21E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:5.32|P-value:1.33E-8 ID:SGTC_747|Compound:3448-8087|FD-Score:4.07|P-value:9.84E-6 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.07|P-value:1.29E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.00|P-value:8.21E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.54|P-value:1.02E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:4.48|P-value:1.38E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.14|P-value:5.96E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.15|P-value:4.78E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.88|P-value:2.40E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.28|P-value:3.56E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.37|P-value:2.04E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.11|P-value:6.65E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.54|P-value:1.28E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.62|P-value:7.45E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.02|P-value:7.66E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.97|P-value:8.98E-4 ID:SGTC_1750|Compound:st081859|FD-Score:10.20|P-value:8.65E-27 ID:SGTC_1817|Compound:st052116|FD-Score:-3.19|P-value:4.87E-4 ID:SGTC_1885|Compound:st057546|FD-Score:2.99|P-value:8.35E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.08|P-value:6.07E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.53|P-value:1.03E-6 ID:SGTC_2083|Compound:5306046|FD-Score:3.23|P-value:3.48E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.96|P-value:9.53E-4 ID:SGTC_2101|Compound:5377231|FD-Score:2.98|P-value:8.69E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.66|P-value:7.84E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.92|P-value:1.98E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.25|P-value:3.93E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.99|P-value:1.46E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.50|P-value:1.51E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-4.55|P-value:1.25E-6 ID:SGTC_2437|Compound:5741531|FD-Score:3.57|P-value:9.24E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:5.06|P-value:6.00E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.03|P-value:1.44E-10 ID:SGTC_2585|Compound:alliin|FD-Score:4.41|P-value:1.92E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.71|P-value:5.04E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.25|P-value:3.30E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.82|P-value:3.85E-5 ID:SGTC_2808|Compound:7946468|FD-Score:2.99|P-value:8.33E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.25|P-value:3.96E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.68|P-value:4.85E-7 ID:SGTC_2948|Compound:9070189|FD-Score:4.72|P-value:3.81E-7 ID:SGTC_2987|Compound:9018338|FD-Score:4.30|P-value:3.40E-6 ID:SGTC_3039|Compound:9090270|FD-Score:3.27|P-value:2.95E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.00|P-value:9.59E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.58|P-value:8.81E-5 ID:SGTC_3140|Compound:9094243|FD-Score:2.95|P-value:9.79E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-6.39|P-value:1.67E-11 ID:SGTC_3152|Compound:9099253|FD-Score:-4.25|P-value:5.40E-6 ID:SGTC_3173|Compound:9105693|FD-Score:-3.20|P-value:4.82E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.08|P-value:9.52E-6 ID:SGTC_3232|Compound:9132874|FD-Score:-3.25|P-value:3.96E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.34|P-value:2.73E-6 ID:SGTC_3237|Compound:9133362|FD-Score:4.65|P-value:5.60E-7 ID:SGTC_3240|Compound:9133527|FD-Score:4.94|P-value:1.15E-7 ID:SGTC_3289|Compound:9119912|FD-Score:-3.86|P-value:3.20E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.84|P-value:2.79E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:7.76|P-value:2.63E-16 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-4.35|P-value:3.42E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.08|P-value:7.31E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.49|P-value:1.30E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:4.06|P-value:1.06E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.77|P-value:3.86E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:8.42|P-value:7.05E-19 ID:SGTC_180|Compound:1486-1293|FD-Score:5.10|P-value:4.79E-8 ID:SGTC_315|Compound:k915-0449|FD-Score:4.05|P-value:1.10E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.68|P-value:5.66E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:2.95|P-value:9.79E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.12|P-value:5.33E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:11.20|P-value:4.48E-32 ID:SGTC_568|Compound:1193-0097|FD-Score:2.95|P-value:9.58E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.35|P-value:2.21E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:5.32|P-value:1.33E-8 ID:SGTC_747|Compound:3448-8087|FD-Score:4.07|P-value:9.84E-6 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.07|P-value:1.29E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.00|P-value:8.21E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.54|P-value:1.02E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:4.48|P-value:1.38E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.14|P-value:5.96E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.15|P-value:4.78E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.88|P-value:2.40E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.28|P-value:3.56E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.37|P-value:2.04E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.11|P-value:6.65E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.54|P-value:1.28E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.62|P-value:7.45E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.02|P-value:7.66E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.97|P-value:8.98E-4 ID:SGTC_1750|Compound:st081859|FD-Score:10.20|P-value:8.65E-27 ID:SGTC_1817|Compound:st052116|FD-Score:-3.19|P-value:4.87E-4 ID:SGTC_1885|Compound:st057546|FD-Score:2.99|P-value:8.35E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.08|P-value:6.07E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.53|P-value:1.03E-6 ID:SGTC_2083|Compound:5306046|FD-Score:3.23|P-value:3.48E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.96|P-value:9.53E-4 ID:SGTC_2101|Compound:5377231|FD-Score:2.98|P-value:8.69E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.66|P-value:7.84E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.92|P-value:1.98E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.25|P-value:3.93E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.99|P-value:1.46E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.50|P-value:1.51E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-4.55|P-value:1.25E-6 ID:SGTC_2437|Compound:5741531|FD-Score:3.57|P-value:9.24E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:5.06|P-value:6.00E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.03|P-value:1.44E-10 ID:SGTC_2585|Compound:alliin|FD-Score:4.41|P-value:1.92E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.71|P-value:5.04E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.25|P-value:3.30E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.82|P-value:3.85E-5 ID:SGTC_2808|Compound:7946468|FD-Score:2.99|P-value:8.33E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.25|P-value:3.96E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.68|P-value:4.85E-7 ID:SGTC_2948|Compound:9070189|FD-Score:4.72|P-value:3.81E-7 ID:SGTC_2987|Compound:9018338|FD-Score:4.30|P-value:3.40E-6 ID:SGTC_3039|Compound:9090270|FD-Score:3.27|P-value:2.95E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.00|P-value:9.59E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.58|P-value:8.81E-5 ID:SGTC_3140|Compound:9094243|FD-Score:2.95|P-value:9.79E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-6.39|P-value:1.67E-11 ID:SGTC_3152|Compound:9099253|FD-Score:-4.25|P-value:5.40E-6 ID:SGTC_3173|Compound:9105693|FD-Score:-3.20|P-value:4.82E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.08|P-value:9.52E-6 ID:SGTC_3232|Compound:9132874|FD-Score:-3.25|P-value:3.96E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.34|P-value:2.73E-6 ID:SGTC_3237|Compound:9133362|FD-Score:4.65|P-value:5.60E-7 ID:SGTC_3240|Compound:9133527|FD-Score:4.94|P-value:1.15E-7 ID:SGTC_3289|Compound:9119912|FD-Score:-3.86|P-value:3.20E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.84|P-value:2.79E-5

Top fitness defect scores for YKL207W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_562 3772-2733 11.20 112.0 µM 4.48E-32 ERG2 7 1.30E-29
2 SGTC_1750 st081859 10.20 2.4 µM 8.65E-27 endomembrane recycling 43 9.59E-25
3 SGTC_176 1486-1328 8.42 72.8 µM 7.05E-19 10 1.84E-17
4 SGTC_43 0570-0105 7.76 72.5 µM 2.63E-16 ERG2 18 4.29E-15
5 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 6.03 92.6 µM 1.44E-10 7 8.21E-10
6 SGTC_676 falcarinol 5.32 140.0 µM 1.33E-8 23 5.28E-8
7 SGTC_180 1486-1293 5.10 102.8 µM 4.79E-8 21 1.72E-7
8 SGTC_2529 gangaleoidin 5.06 93.6 µM 6.00E-8 8 2.12E-7
9 SGTC_3240 9133527 4.94 49.5 µM 1.15E-7 3 3.84E-7
10 SGTC_2948 9070189 4.72 9.4 µM 3.81E-7 plasma membrane duress 34 1.16E-6
11 SGTC_2896 9052656 4.68 71.4 µM 4.85E-7 endomembrane recycling 71 1.45E-6
12 SGTC_3237 9133362 4.65 49.5 µM 5.60E-7 20 1.65E-6
13 SGTC_2021 4019055 4.53 173.0 µM 1.03E-6 endomembrane recycling 89 2.89E-6
14 SGTC_59 0330-0160 4.49 1.3 µM 1.30E-6 84 3.59E-6
15 SGTC_961 1252-1571 4.48 372.0 µM 1.38E-6 19 3.78E-6
16 SGTC_2585 alliin 4.41 100.0 µM 1.92E-6 15 5.14E-6
17 SGTC_3234 9132280 4.34 49.5 µM 2.73E-6 10 7.10E-6
18 SGTC_2987 9018338 4.30 71.4 µM 3.40E-6 RPP1 & pyrimidine depletion 8 8.68E-6
19 SGTC_3231 9132313 4.08 49.5 µM 9.52E-6 6 2.24E-5
20 SGTC_747 3448-8087 4.07 38.7 µM 9.84E-6 22 2.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.447 2.48E-164 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.318 1.08E-79 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.314 1.07E-77 YCL045C EMC1 hom Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.276 1.68E-59 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.265 6.00E-55 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.243 3.90E-46 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.227 1.66E-40 YGL231C EMC4 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85
0.225 1.16E-39 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.206 1.82E-33 YPR153W YPR153W hom Putative protein of unknown function
0.202 2.58E-32 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.198 6.50E-31 YIL027C EMC5 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT
0.198 6.63E-31 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.184 5.80E-27 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.167 1.66E-22 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.165 7.57E-22 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport