HIPHOP chemogenomics database
YKR002W / PAP1 
Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YKR002W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.121 | 1.63E-12 | YKL154W | SRP102 | het | Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane |
| 0.114 | 3.06E-11 | YMR188C | MRPS17 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.112 | 8.38E-11 | YLR004C | THI73 | hom | Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs |
| 0.106 | 6.94E-10 | YGR127W_p | YGR127W_p | hom | Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response |
| 0.104 | 1.53E-9 | YMR277W | FCP1 | het | Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) |
| 0.103 | 2.04E-9 | YML100W-A_p | YML100W-A_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.099 | 9.72E-9 | YHL026C_p | YHL026C_p | hom | Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) |
| 0.096 | 2.43E-8 | YFR012W-A_p | YFR012W-A_p | hom | Putative protein of unknown function; identified by homology |
| 0.093 | 7.17E-8 | YJL069C | UTP18 | het | Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data |
| 0.092 | 8.77E-8 | YCR105W | ADH7 | hom | NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance |
| 0.092 | 1.01E-7 | YOR057W | SGT1 | het | Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress |
| 0.091 | 1.27E-7 | YCR009C | RVS161 | hom | Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress |
| 0.089 | 2.17E-7 | YGL098W | USE1 | het | Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p |
| 0.089 | 2.55E-7 | YHR207C | SET5 | hom | Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus |
| 0.088 | 3.55E-7 | YDR196C | CAB5 | het | Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies |