YKR002W / PAP1

Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKR002W / PAP1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.29|P-value:4.68E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.20|P-value:6.39E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.04|P-value:2.75E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.08|P-value:9.72E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.11|P-value:8.61E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.30|P-value:5.05E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.15|P-value:7.60E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.73|P-value:8.67E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:-4.01|P-value:3.07E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.39|P-value:3.25E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.19|P-value:6.60E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.13|P-value:8.05E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.63|P-value:1.30E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.23|P-value:6.44E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.73|P-value:8.85E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.19|P-value:6.58E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.23|P-value:5.84E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.41|P-value:4.61E-6 ID:SGTC_1961|Compound:st076550|FD-Score:-3.85|P-value:6.15E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.37|P-value:3.55E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.49|P-value:2.25E-4 ID:SGTC_2069|Compound:5228469|FD-Score:5.26|P-value:6.41E-8 ID:SGTC_2071|Compound:5230951|FD-Score:-3.10|P-value:9.81E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.14|P-value:8.64E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.57|P-value:1.64E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.28|P-value:5.41E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.92|P-value:4.00E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.94|P-value:4.15E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.03|P-value:2.90E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.27|P-value:5.01E-4 ID:SGTC_2816|Compound:7982706|FD-Score:8.94|P-value:1.48E-19 ID:SGTC_2817|Compound:7995342|FD-Score:5.17|P-value:1.04E-7 ID:SGTC_2822|Compound:7994718|FD-Score:4.60|P-value:1.92E-6 ID:SGTC_3021|Compound:9087658|FD-Score:-3.35|P-value:4.22E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-4.10|P-value:2.14E-5 ID:SGTC_3042|Compound:9091578|FD-Score:-4.36|P-value:6.68E-6 ID:SGTC_3043|Compound:9092303|FD-Score:-3.42|P-value:3.26E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.13|P-value:8.21E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.22|P-value:6.49E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.90|P-value:4.45E-5 ID:SGTC_3171|Compound:9103192|FD-Score:3.40|P-value:3.07E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-7.29|P-value:1.59E-13 ID:SGTC_3272|Compound:9137413|FD-Score:3.13|P-value:8.15E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.34|P-value:4.30E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.29|P-value:4.68E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.20|P-value:6.39E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.04|P-value:2.75E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.08|P-value:9.72E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.11|P-value:8.61E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.30|P-value:5.05E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.15|P-value:7.60E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.73|P-value:8.67E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:-4.01|P-value:3.07E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.39|P-value:3.25E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.19|P-value:6.60E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.13|P-value:8.05E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.63|P-value:1.30E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.23|P-value:6.44E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.73|P-value:8.85E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.19|P-value:6.58E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.23|P-value:5.84E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.41|P-value:4.61E-6 ID:SGTC_1961|Compound:st076550|FD-Score:-3.85|P-value:6.15E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.37|P-value:3.55E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.49|P-value:2.25E-4 ID:SGTC_2069|Compound:5228469|FD-Score:5.26|P-value:6.41E-8 ID:SGTC_2071|Compound:5230951|FD-Score:-3.10|P-value:9.81E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.14|P-value:8.64E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.57|P-value:1.64E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.28|P-value:5.41E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.92|P-value:4.00E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.94|P-value:4.15E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.03|P-value:2.90E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.27|P-value:5.01E-4 ID:SGTC_2816|Compound:7982706|FD-Score:8.94|P-value:1.48E-19 ID:SGTC_2817|Compound:7995342|FD-Score:5.17|P-value:1.04E-7 ID:SGTC_2822|Compound:7994718|FD-Score:4.60|P-value:1.92E-6 ID:SGTC_3021|Compound:9087658|FD-Score:-3.35|P-value:4.22E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-4.10|P-value:2.14E-5 ID:SGTC_3042|Compound:9091578|FD-Score:-4.36|P-value:6.68E-6 ID:SGTC_3043|Compound:9092303|FD-Score:-3.42|P-value:3.26E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.13|P-value:8.21E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.22|P-value:6.49E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.90|P-value:4.45E-5 ID:SGTC_3171|Compound:9103192|FD-Score:3.40|P-value:3.07E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-7.29|P-value:1.59E-13 ID:SGTC_3272|Compound:9137413|FD-Score:3.13|P-value:8.15E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.34|P-value:4.30E-4

Top fitness defect scores for YKR002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2816 7982706 8.94 58.4 µM 1.48E-19 azole & statin 1 1.94E-19 4.19
2 SGTC_2069 5228469 5.26 200.0 µM 6.41E-8 2 7.29E-8 1.01
3 SGTC_2817 7995342 5.17 71.4 µM 1.04E-7 2 1.18E-7 0.54
4 SGTC_2822 7994718 4.60 71.4 µM 1.92E-6 6 2.14E-6 0.70
5 SGTC_1929 genistein trimethyl ether 4.41 50.5 µM 4.61E-6 3 5.10E-6 0.48
6 SGTC_2573 2',4'-dihydroxychalcone 3.92 15.0 µM 4.00E-5 15 4.37E-5 0.28
7 SGTC_3167 9103034 3.90 49.5 µM 4.45E-5 RPP1 & pyrimidine depletion 5 4.85E-5 0.41
8 SGTC_673 1082-0474 3.73 110.0 µM 8.67E-5 RSC complex & mRNA processing 56 9.41E-5 0.11
9 SGTC_1079 idarubicin 3.73 2.4 µM 8.85E-5 DNA damage response 7 9.62E-5 0.03
10 SGTC_1493 4348-0038 3.66 111.0 µM 1.16E-4 RSC complex & mRNA processing 40 1.25E-4 0.03
11 SGTC_937 3122-0005 3.63 46.7 µM 1.30E-4 7 1.41E-4 0.30
12 SGTC_2109 5483026 3.57 200.0 µM 1.64E-4 RSC complex & mRNA processing 40 1.77E-4 0.01
13 SGTC_1999 st074831 3.49 12.5 µM 2.25E-4 plasma membrane duress 18 2.43E-4 0.41
14 SGTC_609 0986-0026 3.48 86.3 µM 2.35E-4 calcium & mitochondrial duress 17 2.54E-4 0.02
15 SGTC_3171 9103192 3.40 49.5 µM 3.07E-4 5 3.31E-4 0.23
16 SGTC_820 1582-0060 3.39 59.9 µM 3.25E-4 16 3.50E-4 0.09
17 SGTC_1982 st072467 3.37 71.9 µM 3.55E-4 12 3.82E-4 0.01
18 SGTC_38 0929-0051 3.29 58.3 µM 4.68E-4 9 5.03E-4 0.06
19 SGTC_2796 7949634 3.27 45.5 µM 5.01E-4 15 5.37E-4 0.06
20 SGTC_1922 5578187 3.23 25.0 µM 5.84E-4 TRP & mitochondrial translation 12 6.26E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.63E-12 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.114 3.06E-11 YMR188C MRPS17 hom Mitochondrial ribosomal protein of the small subunit
0.112 8.38E-11 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.106 6.94E-10 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.104 1.53E-9 YMR277W FCP1 het Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
0.103 2.04E-9 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.099 9.72E-9 YHL026C_p YHL026C_p hom Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
0.096 2.43E-8 YFR012W-A_p YFR012W-A_p hom Putative protein of unknown function; identified by homology
0.093 7.17E-8 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.092 8.77E-8 YCR105W ADH7 hom NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
0.092 1.01E-7 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.091 1.27E-7 YCR009C RVS161 hom Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
0.089 2.17E-7 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.089 2.55E-7 YHR207C SET5 hom Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
0.088 3.55E-7 YDR196C CAB5 het Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies