YKR004C / ECM9

Non-essential protein of unknown function

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKR004C / ECM9

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.05|P-value:9.44E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.38|P-value:3.33E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:3.49|P-value:1.79E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.54|P-value:7.09E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.24|P-value:4.64E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.72|P-value:6.95E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.26|P-value:4.27E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.36|P-value:3.00E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.13|P-value:6.92E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.38|P-value:1.40E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.41|P-value:2.45E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.49|P-value:8.71E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.66|P-value:8.01E-7 ID:SGTC_1650|Compound:st011916|FD-Score:3.15|P-value:6.62E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.05|P-value:9.42E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-3.49|P-value:8.85E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-3.43|P-value:1.14E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.60|P-value:1.15E-4 ID:SGTC_1825|Compound:st052143|FD-Score:-3.20|P-value:2.86E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.35|P-value:3.02E-4 ID:SGTC_1911|Compound:st060208|FD-Score:5.47|P-value:8.02E-9 ID:SGTC_2162|Compound:5663267|FD-Score:-2.95|P-value:7.16E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.54|P-value:7.12E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.60|P-value:1.15E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.63|P-value:4.75E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.02|P-value:1.10E-7 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.36|P-value:1.47E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.81|P-value:4.69E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.73|P-value:6.55E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-3.77|P-value:2.58E-5 ID:SGTC_2832|Compound:7992762|FD-Score:5.42|P-value:1.09E-8 ID:SGTC_2836|Compound:9010338|FD-Score:3.40|P-value:2.48E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.20|P-value:2.85E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.61|P-value:5.30E-5 ID:SGTC_2905|Compound:7799065|FD-Score:3.26|P-value:4.32E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.96|P-value:2.35E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.69|P-value:7.61E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.84|P-value:4.05E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.05|P-value:9.44E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.38|P-value:3.33E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:3.49|P-value:1.79E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.54|P-value:7.09E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.24|P-value:4.64E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.72|P-value:6.95E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.26|P-value:4.27E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.36|P-value:3.00E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.13|P-value:6.92E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.38|P-value:1.40E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.41|P-value:2.45E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.49|P-value:8.71E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.66|P-value:8.01E-7 ID:SGTC_1650|Compound:st011916|FD-Score:3.15|P-value:6.62E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.05|P-value:9.42E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-3.49|P-value:8.85E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-3.43|P-value:1.14E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.60|P-value:1.15E-4 ID:SGTC_1825|Compound:st052143|FD-Score:-3.20|P-value:2.86E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.35|P-value:3.02E-4 ID:SGTC_1911|Compound:st060208|FD-Score:5.47|P-value:8.02E-9 ID:SGTC_2162|Compound:5663267|FD-Score:-2.95|P-value:7.16E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.54|P-value:7.12E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.60|P-value:1.15E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.63|P-value:4.75E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.02|P-value:1.10E-7 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.36|P-value:1.47E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.81|P-value:4.69E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.73|P-value:6.55E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-3.77|P-value:2.58E-5 ID:SGTC_2832|Compound:7992762|FD-Score:5.42|P-value:1.09E-8 ID:SGTC_2836|Compound:9010338|FD-Score:3.40|P-value:2.48E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.20|P-value:2.85E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.61|P-value:5.30E-5 ID:SGTC_2905|Compound:7799065|FD-Score:3.26|P-value:4.32E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.96|P-value:2.35E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.69|P-value:7.61E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.84|P-value:4.05E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.44|P-value:2.19E-4

Top fitness defect scores for YKR004C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1911 st060208 5.47 74.3 µM 8.02E-9 3 2.25E-8 0.34
2 SGTC_2832 7992762 5.42 52.0 µM 1.09E-8 2 2.98E-8 0.14
3 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 5.02 92.6 µM 1.10E-7 5 2.53E-7 0.27
4 SGTC_1408 3909-7976 4.66 48.8 µM 8.01E-7 Golgi 4 1.60E-6 0.44
5 SGTC_120 rhodamine 6G 4.38 52.3 µM 3.33E-6 mitochondrial processes 15 5.99E-6 0.27
6 SGTC_2913 7966556 3.96 36.6 µM 2.35E-5 60S ribosome export 7 3.68E-5 0.05
7 SGTC_3245 9134821 3.84 49.5 µM 4.05E-5 3 6.12E-5 0.07
8 SGTC_2601 securinine 3.81 100.0 µM 4.69E-5 21 7.01E-5 0.01
9 SGTC_2607 solasodine 3.73 47.4 µM 6.55E-5 17 9.57E-5 0.17
10 SGTC_376 3970-0862 3.72 59.1 µM 6.95E-5 11 1.01E-4 0.17
11 SGTC_3203 9113543 3.69 49.5 µM 7.61E-5 11 1.10E-4 0.21
12 SGTC_2302 7771753 3.60 200.0 µM 1.15E-4 11 1.62E-4 0.03
13 SGTC_1819 st053448 3.60 58.6 µM 1.15E-4 amide catabolism 3 1.62E-4 0.23
14 SGTC_158 k038-0087 3.49 26.4 µM 1.79E-4 ubiquinone biosynthesis & proteasome 37 2.44E-4 0.12
15 SGTC_3274 9138298 3.44 49.5 µM 2.19E-4 9 2.95E-4 0.08
16 SGTC_893 0958-0369 3.41 48.9 µM 2.45E-4 7 3.27E-4 0.00
17 SGTC_2836 9010338 3.40 19.5 µM 2.48E-4 RPP1 & pyrimidine depletion 8 3.31E-4 0.05
18 SGTC_523 1934-0222 3.36 13.7 µM 3.00E-4 8 3.96E-4 0.05
19 SGTC_1909 st060837 3.35 51.5 µM 3.02E-4 10 3.98E-4 0.07
20 SGTC_378 3970-0959 3.26 8.3 µM 4.27E-4 7 5.51E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.34E-13 YGR034W RPL26B hom Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.099 8.38E-9 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.094 5.15E-8 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.092 9.63E-8 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.086 5.86E-7 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.086 6.45E-7 YEL051W VMA8 hom Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
0.086 6.79E-7 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.085 7.57E-7 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.085 9.10E-7 YKR060W UTP30 hom Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit
0.084 9.83E-7 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.080 3.08E-6 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.080 3.10E-6 YNL096C RPS7B hom Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.080 3.16E-6 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.079 4.08E-6 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.077 9.12E-6 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data