| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.125 |
4.34E-13 |
YGR034W |
RPL26B |
hom |
Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication |
| 0.099 |
8.38E-9 |
YJR046W |
TAH11 |
het |
DNA replication licensing factor, required for pre-replication complex assembly |
| 0.094 |
5.15E-8 |
YKR058W |
GLG1 |
hom |
Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication |
| 0.092 |
9.63E-8 |
YJR035W |
RAD26 |
hom |
Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein |
| 0.086 |
5.86E-7 |
YNL176C_p |
TDA7_p |
hom |
Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele |
| 0.086 |
6.45E-7 |
YEL051W |
VMA8 |
hom |
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis |
| 0.086 |
6.79E-7 |
YER176W |
ECM32 |
hom |
DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes |
| 0.085 |
7.57E-7 |
YPL177C |
CUP9 |
hom |
Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
| 0.085 |
9.10E-7 |
YKR060W |
UTP30 |
hom |
Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit |
| 0.084 |
9.83E-7 |
YOL061W |
PRS5 |
hom |
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress |
| 0.080 |
3.08E-6 |
YJR050W |
ISY1 |
hom |
Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles |
| 0.080 |
3.10E-6 |
YNL096C |
RPS7B |
hom |
Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
| 0.080 |
3.16E-6 |
YEL040W |
UTR2 |
hom |
Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck |
| 0.079 |
4.08E-6 |
YJL131C |
AIM23 |
hom |
Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss |
| 0.077 |
9.12E-6 |
YAL016C-B_d |
YAL016C-B_d |
hom |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
