YKR005C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR005C / YKR005C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.87|P-value:3.43E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.46|P-value:2.54E-6 ID:SGTC_224|Compound:benfluorex|FD-Score:3.04|P-value:8.87E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.26|P-value:5.89E-6 ID:SGTC_271|Compound:rotenone|FD-Score:3.08|P-value:7.65E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.22|P-value:4.57E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:4.03|P-value:1.67E-5 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.12|P-value:6.51E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.39|P-value:2.62E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.57|P-value:1.21E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.14|P-value:6.10E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.86|P-value:3.59E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.47|P-value:1.92E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.14|P-value:6.54E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.42|P-value:2.18E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.49|P-value:1.61E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.66|P-value:8.34E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.64|P-value:3.43E-9 ID:SGTC_1124|Compound:fisetin|FD-Score:4.96|P-value:1.73E-7 ID:SGTC_1149|Compound:3909-7961|FD-Score:-3.12|P-value:7.17E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.01|P-value:1.31E-7 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.22|P-value:4.53E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.00|P-value:1.91E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.42|P-value:2.17E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.09|P-value:7.20E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.94|P-value:2.53E-5 ID:SGTC_1696|Compound:st025591|FD-Score:3.37|P-value:2.58E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.36|P-value:3.68E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.32|P-value:3.12E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.66|P-value:8.28E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.93|P-value:2.60E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.69|P-value:7.28E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.61|P-value:1.03E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.71|P-value:6.64E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.05|P-value:8.40E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.66|P-value:8.11E-5 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.20|P-value:4.97E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.19|P-value:8.97E-6 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.50|P-value:1.58E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.34|P-value:4.05E-6 ID:SGTC_2850|Compound:9015429|FD-Score:3.14|P-value:6.09E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.15|P-value:5.92E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.32|P-value:3.43E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.63|P-value:1.01E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.84|P-value:3.94E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.34|P-value:2.96E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.50|P-value:1.58E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.08|P-value:7.67E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.87|P-value:3.43E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.46|P-value:2.54E-6 ID:SGTC_224|Compound:benfluorex|FD-Score:3.04|P-value:8.87E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.26|P-value:5.89E-6 ID:SGTC_271|Compound:rotenone|FD-Score:3.08|P-value:7.65E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.22|P-value:4.57E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:4.03|P-value:1.67E-5 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.12|P-value:6.51E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.39|P-value:2.62E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.57|P-value:1.21E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.14|P-value:6.10E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.86|P-value:3.59E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.47|P-value:1.92E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.14|P-value:6.54E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.42|P-value:2.18E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.49|P-value:1.61E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.66|P-value:8.34E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.64|P-value:3.43E-9 ID:SGTC_1124|Compound:fisetin|FD-Score:4.96|P-value:1.73E-7 ID:SGTC_1149|Compound:3909-7961|FD-Score:-3.12|P-value:7.17E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.01|P-value:1.31E-7 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.22|P-value:4.53E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.00|P-value:1.91E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.42|P-value:2.17E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.09|P-value:7.20E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.94|P-value:2.53E-5 ID:SGTC_1696|Compound:st025591|FD-Score:3.37|P-value:2.58E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.36|P-value:3.68E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.32|P-value:3.12E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.66|P-value:8.28E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.93|P-value:2.60E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.69|P-value:7.28E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.61|P-value:1.03E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.71|P-value:6.64E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.05|P-value:8.40E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.66|P-value:8.11E-5 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.20|P-value:4.97E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.19|P-value:8.97E-6 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.50|P-value:1.58E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.34|P-value:4.05E-6 ID:SGTC_2850|Compound:9015429|FD-Score:3.14|P-value:6.09E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.15|P-value:5.92E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.32|P-value:3.43E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.63|P-value:1.01E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.84|P-value:3.94E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.34|P-value:2.96E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.50|P-value:1.58E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.08|P-value:7.67E-4

Top fitness defect scores for YKR005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1118 chelidonine 5.64 707.5 nM 3.43E-9 2 8.67E-9
2 SGTC_1155 4088-0394 5.01 48.2 µM 1.31E-7 7 2.75E-7
3 SGTC_1124 fisetin 4.96 1.2 µM 1.73E-7 13 3.60E-7
4 SGTC_1714 st033236 4.36 13.6 µM 3.68E-6 14 6.55E-6
5 SGTC_2785 7756463 4.34 72.7 µM 4.05E-6 19 7.17E-6
6 SGTC_241 5hr heat shock (37°C) + cantharidin 4.26 155.4 µM 5.89E-6 cell wall signaling 62 1.02E-5
7 SGTC_307 1501-1223 4.03 22.3 µM 1.67E-5 13 2.76E-5
8 SGTC_1203 3992-3522 4.00 103.0 µM 1.91E-5 30 3.13E-5
9 SGTC_1651 st011928 3.94 86.1 µM 2.53E-5 RSC complex & mRNA processing 13 4.09E-5
10 SGTC_1917 st066507 3.93 28.5 µM 2.60E-5 Golgi 35 4.19E-5
11 SGTC_10 0279-0212 3.87 42.6 µM 3.43E-5 TRP & mitochondrial translation 130 5.46E-5
12 SGTC_691 1548-0686 3.86 185.0 µM 3.59E-5 38 5.71E-5
13 SGTC_3130 9127414 3.84 49.5 µM 3.94E-5 23 6.23E-5
14 SGTC_2091 4-phenylthiadiazole 3.71 200.0 µM 6.64E-5 19 1.02E-4
15 SGTC_1958 st076513 3.69 41.9 µM 7.28E-5 60S ribosome export 38 1.12E-4
16 SGTC_2343 7990716 3.66 14.8 µM 8.11E-5 26 1.24E-4
17 SGTC_1907 st060210 3.66 83.7 µM 8.28E-5 33 1.26E-4
18 SGTC_1106 tegaserod maleate 3.66 11.7 µM 8.34E-5 34 1.27E-4
19 SGTC_2024 5144227 3.61 134.0 µM 1.03E-4 49 1.55E-4
20 SGTC_635 k038-0028 3.57 24.7 µM 1.21E-4 ubiquinone biosynthesis & proteasome 58 1.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.46E-10 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.103 2.17E-9 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.094 4.51E-8 YFR057W_p YFR057W_p hom Putative protein of unknown function
0.092 8.50E-8 YPL083C SEN54 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.090 1.64E-7 YOR032C HMS1 hom Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
0.089 2.14E-7 YKL057C NUP120 hom Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160
0.082 2.11E-6 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.081 2.99E-6 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.076 9.69E-6 YLL049W LDB18 hom Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24
0.075 1.37E-5 YIL067C_p YIL067C_p hom Uncharacterized protein of unknown function
0.073 2.05E-5 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.071 3.46E-5 YLL053C_p YLL053C_p hom Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
0.069 5.91E-5 YFR018C_p YFR018C_p hom Putative protein of unknown function
0.069 6.74E-5 YKL197C PEX1 hom AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
0.069 7.04E-5 YLR070C XYL2 hom Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect