HIPHOP chemogenomics database

YKR006C / MRPL13

Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation

Zygosity: Homozygous strain

fixedexpanded
Profile for YKR006C / MRPL13

Click on Significant Values for Screen Details

Top fitness defect scores for YKR006C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3311	9131146	16.20	2.9 µM	2.60E-55	cell wall	3	5.38E-59
2	SGTC_221	trifluoperazine	7.70	10.3 µM	4.31E-14	NEO1-PIK1	88	7.00E-15
3	SGTC_3317	9138495	6.82	8.8 µM	1.86E-11		10	4.56E-12
4	SGTC_1509	1326-1131	6.18	80.0 µM	1.01E-9		2	3.21E-10
5	SGTC_3321	9137793	6.11	26.8 µM	1.52E-9	cell wall	29	4.99E-10
6	SGTC_449	xestospongin c	5.92	11.2 µM	4.60E-9	NEO1-PIK1	20	1.62E-9
7	SGTC_64	000l-0018	5.57	272.1 µM	3.23E-8	ubiquinone biosynthesis & proteasome	92	1.30E-8
8	SGTC_3330	9141424	5.22	71.4 µM	2.01E-7	amide catabolism	8	9.07E-8
9	SGTC_146	3448-8650	5.14	53.1 µM	3.03E-7	NEO1-PIK1	80	1.41E-7
10	SGTC_1803	st050068	5.04	52.4 µM	4.96E-7	NEO1-PIK1	113	2.38E-7
11	SGTC_1953	st076800	5.01	12.1 µM	5.63E-7		25	2.72E-7
12	SGTC_467	ro 31-8220	5.00	72.8 µM	5.91E-7	calcium & mitochondrial duress	47	2.86E-7
13	SGTC_327	1273-0057	4.94	4.0 µM	7.74E-7	azole & statin	13	3.82E-7
14	SGTC_1419	3993-2473	4.86	62.6 µM	1.16E-6		5	5.89E-7
15	SGTC_1754	st042065	4.75	16.1 µM	1.94E-6	NEO1-PIK1	139	1.02E-6
16	SGTC_1597	7-benzyloxygramine	4.69	47.5 µM	2.60E-6	calcium & mitochondrial duress	78	1.38E-6
17	SGTC_923	1900-2434	4.67	73.3 µM	2.87E-6	RNA processing & uracil transport	19	1.54E-6
18	SGTC_3320	9137005	4.65	35.1 µM	3.02E-6	endomembrane recycling	6	1.62E-6
19	SGTC_951	1171-0579	4.50	82.7 µM	6.05E-6	cell wall	56	3.40E-6
20	SGTC_1436	4092-1007	4.48	8.3 µM	6.48E-6		8	3.66E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.304	1.53E-72	YNL070W	TOM7	hom	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.233	1.39E-42	YBL022C	PIM1	hom	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.231	9.55E-42	YNR040W_p	YNR040W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.221	2.82E-38	YOR357C	SNX3	hom	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.214	4.06E-36	YBL006C	LDB7	hom	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.210	1.16E-34	YDL066W	IDP1	hom	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.203	1.68E-32	YHL009C	YAP3	hom	Basic leucine zipper (bZIP) transcription factor
0.198	4.10E-31	YGR202C	PCT1	hom	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.191	7.48E-29	YGR056W	RSC1	hom	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.189	1.78E-28	YJL154C	VPS35	hom	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.188	6.01E-28	YNL022C_p	YNL022C_p	hom	Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis
0.183	1.31E-26	YJL052W	TDH1	hom	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.181	4.23E-26	YOL089C	HAL9	hom	Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication
0.179	1.17E-25	YGL072C_d	YGL072C_d	hom	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.176	8.20E-25	YGL019W	CKB1	hom	Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases