YKR006C / MRPL13

Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR006C / MRPL13

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.36|P-value:5.26E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.57|P-value:3.23E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:3.57|P-value:2.50E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.61|P-value:2.16E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.40|P-value:5.75E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.20|P-value:8.93E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.14|P-value:3.03E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:4.24|P-value:1.86E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.79|P-value:1.11E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.38|P-value:4.93E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.70|P-value:4.31E-14 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.09|P-value:3.48E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.61|P-value:2.17E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.24|P-value:7.93E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.94|P-value:7.74E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.31|P-value:1.87E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.91|P-value:7.09E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:3.24|P-value:7.88E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.92|P-value:4.60E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.17|P-value:3.62E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.00|P-value:5.91E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.45|P-value:3.87E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.40|P-value:5.79E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.56|P-value:2.65E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.12|P-value:3.01E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.52|P-value:3.03E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.31|P-value:7.80E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.67|P-value:2.87E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:4.50|P-value:6.05E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.70|P-value:1.57E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.27|P-value:7.03E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.27|P-value:7.11E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.44|P-value:5.10E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.86|P-value:1.16E-6 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.48|P-value:6.48E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:6.18|P-value:1.01E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.69|P-value:2.60E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.23|P-value:8.28E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.52|P-value:3.82E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.75|P-value:1.94E-6 ID:SGTC_1765|Compound:st044815|FD-Score:4.33|P-value:1.26E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.28|P-value:8.47E-10 ID:SGTC_1801|Compound:st050089|FD-Score:4.17|P-value:2.44E-5 ID:SGTC_1803|Compound:st050068|FD-Score:5.04|P-value:4.96E-7 ID:SGTC_1945|Compound:st075991|FD-Score:3.37|P-value:5.01E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.01|P-value:5.63E-7 ID:SGTC_2187|Compound:6125751|FD-Score:3.17|P-value:9.88E-4 ID:SGTC_2196|Compound:6573537|FD-Score:-3.63|P-value:2.58E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.52|P-value:3.05E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.21|P-value:8.59E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.68|P-value:1.69E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.83|P-value:9.54E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.98|P-value:5.33E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.15|P-value:2.71E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.73|P-value:1.40E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.23|P-value:1.93E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-7.02|P-value:7.75E-12 ID:SGTC_2941|Compound:9056145|FD-Score:3.61|P-value:2.18E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.43|P-value:4.14E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.94|P-value:6.27E-5 ID:SGTC_3036|Compound:9090181|FD-Score:3.18|P-value:9.76E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.85|P-value:8.85E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.31|P-value:6.29E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.24|P-value:7.81E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-6.44|P-value:3.21E-10 ID:SGTC_3222|Compound:9128301|FD-Score:4.44|P-value:7.90E-6 ID:SGTC_3311|Compound:9131146|FD-Score:16.20|P-value:2.60E-55 ID:SGTC_3317|Compound:9138495|FD-Score:6.82|P-value:1.86E-11 ID:SGTC_3320|Compound:9137005|FD-Score:4.65|P-value:3.02E-6 ID:SGTC_3321|Compound:9137793|FD-Score:6.11|P-value:1.52E-9 ID:SGTC_3324|Compound:9138759|FD-Score:-6.51|P-value:2.06E-10 ID:SGTC_3330|Compound:9141424|FD-Score:5.22|P-value:2.01E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.36|P-value:5.26E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.57|P-value:3.23E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:3.57|P-value:2.50E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.61|P-value:2.16E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.40|P-value:5.75E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.20|P-value:8.93E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.14|P-value:3.03E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:4.24|P-value:1.86E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.79|P-value:1.11E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.38|P-value:4.93E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.70|P-value:4.31E-14 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.09|P-value:3.48E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.61|P-value:2.17E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.24|P-value:7.93E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.94|P-value:7.74E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.31|P-value:1.87E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.91|P-value:7.09E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:3.24|P-value:7.88E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.92|P-value:4.60E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.17|P-value:3.62E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.00|P-value:5.91E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.45|P-value:3.87E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.40|P-value:5.79E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.56|P-value:2.65E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.12|P-value:3.01E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.52|P-value:3.03E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.31|P-value:7.80E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.67|P-value:2.87E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:4.50|P-value:6.05E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.70|P-value:1.57E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.27|P-value:7.03E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.27|P-value:7.11E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.44|P-value:5.10E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.86|P-value:1.16E-6 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.48|P-value:6.48E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:6.18|P-value:1.01E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.69|P-value:2.60E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.23|P-value:8.28E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.52|P-value:3.82E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.75|P-value:1.94E-6 ID:SGTC_1765|Compound:st044815|FD-Score:4.33|P-value:1.26E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.28|P-value:8.47E-10 ID:SGTC_1801|Compound:st050089|FD-Score:4.17|P-value:2.44E-5 ID:SGTC_1803|Compound:st050068|FD-Score:5.04|P-value:4.96E-7 ID:SGTC_1945|Compound:st075991|FD-Score:3.37|P-value:5.01E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.01|P-value:5.63E-7 ID:SGTC_2187|Compound:6125751|FD-Score:3.17|P-value:9.88E-4 ID:SGTC_2196|Compound:6573537|FD-Score:-3.63|P-value:2.58E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.52|P-value:3.05E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.21|P-value:8.59E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.68|P-value:1.69E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.83|P-value:9.54E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.98|P-value:5.33E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:4.15|P-value:2.71E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.73|P-value:1.40E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.23|P-value:1.93E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-7.02|P-value:7.75E-12 ID:SGTC_2941|Compound:9056145|FD-Score:3.61|P-value:2.18E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.43|P-value:4.14E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.94|P-value:6.27E-5 ID:SGTC_3036|Compound:9090181|FD-Score:3.18|P-value:9.76E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.85|P-value:8.85E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.31|P-value:6.29E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.24|P-value:7.81E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-6.44|P-value:3.21E-10 ID:SGTC_3222|Compound:9128301|FD-Score:4.44|P-value:7.90E-6 ID:SGTC_3311|Compound:9131146|FD-Score:16.20|P-value:2.60E-55 ID:SGTC_3317|Compound:9138495|FD-Score:6.82|P-value:1.86E-11 ID:SGTC_3320|Compound:9137005|FD-Score:4.65|P-value:3.02E-6 ID:SGTC_3321|Compound:9137793|FD-Score:6.11|P-value:1.52E-9 ID:SGTC_3324|Compound:9138759|FD-Score:-6.51|P-value:2.06E-10 ID:SGTC_3330|Compound:9141424|FD-Score:5.22|P-value:2.01E-7

Top fitness defect scores for YKR006C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3311 9131146 16.20 2.9 µM 2.60E-55 cell wall 3 5.38E-59
2 SGTC_221 trifluoperazine 7.70 10.3 µM 4.31E-14 NEO1-PIK1 88 7.00E-15
3 SGTC_3317 9138495 6.82 8.8 µM 1.86E-11 10 4.56E-12
4 SGTC_1509 1326-1131 6.18 80.0 µM 1.01E-9 2 3.21E-10
5 SGTC_3321 9137793 6.11 26.8 µM 1.52E-9 cell wall 29 4.99E-10
6 SGTC_449 xestospongin c 5.92 11.2 µM 4.60E-9 NEO1-PIK1 20 1.62E-9
7 SGTC_64 000l-0018 5.57 272.1 µM 3.23E-8 ubiquinone biosynthesis & proteasome 92 1.30E-8
8 SGTC_3330 9141424 5.22 71.4 µM 2.01E-7 amide catabolism 8 9.07E-8
9 SGTC_146 3448-8650 5.14 53.1 µM 3.03E-7 NEO1-PIK1 80 1.41E-7
10 SGTC_1803 st050068 5.04 52.4 µM 4.96E-7 NEO1-PIK1 113 2.38E-7
11 SGTC_1953 st076800 5.01 12.1 µM 5.63E-7 25 2.72E-7
12 SGTC_467 ro 31-8220 5.00 72.8 µM 5.91E-7 calcium & mitochondrial duress 47 2.86E-7
13 SGTC_327 1273-0057 4.94 4.0 µM 7.74E-7 azole & statin 13 3.82E-7
14 SGTC_1419 3993-2473 4.86 62.6 µM 1.16E-6 5 5.89E-7
15 SGTC_1754 st042065 4.75 16.1 µM 1.94E-6 NEO1-PIK1 139 1.02E-6
16 SGTC_1597 7-benzyloxygramine 4.69 47.5 µM 2.60E-6 calcium & mitochondrial duress 78 1.38E-6
17 SGTC_923 1900-2434 4.67 73.3 µM 2.87E-6 RNA processing & uracil transport 19 1.54E-6
18 SGTC_3320 9137005 4.65 35.1 µM 3.02E-6 endomembrane recycling 6 1.62E-6
19 SGTC_951 1171-0579 4.50 82.7 µM 6.05E-6 cell wall 56 3.40E-6
20 SGTC_1436 4092-1007 4.48 8.3 µM 6.48E-6 8 3.66E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 1.53E-72 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.233 1.39E-42 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.231 9.55E-42 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.221 2.82E-38 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.214 4.06E-36 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.210 1.16E-34 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.203 1.68E-32 YHL009C YAP3 hom Basic leucine zipper (bZIP) transcription factor
0.198 4.10E-31 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.191 7.48E-29 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.189 1.78E-28 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.188 6.01E-28 YNL022C_p YNL022C_p hom Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis
0.183 1.31E-26 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.181 4.23E-26 YOL089C HAL9 hom Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication
0.179 1.17E-25 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.176 8.20E-25 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases